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#36826998 2023/02/24 To Up
Mutant NPM1 maintains RASGRP3 protein stability via interaction with MID1 to promote acute myeloid leukemia cell proliferation and autophagy.Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy with high mortality in the world. NPM1 gene mutations are a frequent occurrence in AML leading to abnormal autophagy. While the mechanism of NPM1 mutation-driven AML pathogenesis remains to be fully elucidated.
Youping Wang, Chi Pan, Xia Zhang, Aiqi Zhao, Ying Dong