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#33091916   2020/10/22 To Up

Tissue Inhibitor of Metalloproteinases-2 Mediates Kidney Injury during Sepsis.

Urinary tissue inhibitor of metalloproteinases (TIMP)-2 has been identified as a predictive marker for acute kidney injury (AKI), including sepsis-associated AKI (S-AKI). Whether TIMP-2 might be causally related to AKI and hence represent a viable drug target is unclear.
Xiaoyan Wen, Jicheng Zhang, Xiaojian Wan, Alicia A Frank, Xin Qu, John A Kellum

2182 related Products with: Tissue Inhibitor of Metalloproteinases-2 Mediates Kidney Injury during Sepsis.

100.00 ug10mg100 ul96T100 μg20mg

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#33091888   2020/10/22 To Up

Novel application of autologous micrografts in a collagen-glycosaminoglycan scaffold for diabetic wound healing.

Therapeutic strategies that successfully combine two techniques-autologous micrografting and biodegradable scaffolds-offer great potential for improved wound repair and decreased scarring. In this study we evaluate the efficacy of a novel modification of a collagen-glycosaminoglycan scaffold with autologous micrografts using a murine dorsal wound model.
Adriana C Panayi, Valentin Haug, Qinxin Liu, Mengfan Wu, Mehran Karvar, Shimpo Aoki, Chenhao Ma, Ryoko Hamaguchi, Yori Endo, Dennis P Orgill

1284 related Products with: Novel application of autologous micrografts in a collagen-glycosaminoglycan scaffold for diabetic wound healing.

0.1ml100ug Lyophilized25 µg 100ul1mg0.1ml 100ul 100ul96 samples 100ul0.1 mg 100ul

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#33091854   2020/10/15 To Up

Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFκB signaling pathway.

Microglia-mediated neuroinflammation is one of the most prominent characteristics of multiple sclerosis (MS), a chronic demyelination disease. As one of the main active ingredients in Astragali radix, total flavonoids of Astragalus (TFA) has multiple pharmacological effects such as immunomodulation, anti-inflammation and and anti-tumor. However, little is known about whether TFA could inhibit microglia-mediated neuroinflammation in MS.
Liu Yang, Xinyan Han, Faping Xing, Hui Wu, Hailian Shi, Fei Huang, Qi Xu, Xiaojun Wu

2647 related Products with: Total flavonoids of astragalus attenuates experimental autoimmune encephalomyelitis by suppressing the activation and inflammatory responses of microglia via JNK/AKT/NFκB signaling pathway.

1.5 x 10^6 cells2 Pieces/Box2 Pieces/Box2 Pieces/Box1 mg1.5x10(6) cells2 Pieces/Box2 Pieces/Box2 Pieces/BoxInhibitors

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#33091819   2020/10/19 To Up

Bifunctional macromolecule activating both OX40 and interferon-α signaling displays potent therapeutic effects in mouse HBV and tumor models.

Combinatory enhancement of innate and adaptive immune responses is a promising strategy in immunotherapeutic drug development. Bifunctional macromolecules that simultaneously target two mechanisms may provide additional advantages over the combination of targeting two single pathways. Interferon alpha (IFNα) has been used clinically against viral infection such as the chronic infection of hepatitis B virus (CHB) as well as some types of cancers. OX40 is a costimulatory immune checkpoint molecule involved in the activation of T lymphocytes. To test whether simultaneously activating IFNα and OX40 signaling pathway could produce a synergistic therapeutic effect on CHB and tumors, we designed a bifunctional fusion protein composed of a mouse OX40 agonistic monoclonal antibody (OX86) and a mouse IFNα4, joined by a flexible (GGGGS) linker. This fusion protein, termed OX86-IFN, can activate both IFNα and OX40. We demonstrated that OX86-IFN could effectively activate T lymphocytes in the peripheral blood of mice. Furthermore, we showed that OX86-IFN had superior therapeutic effect to monotherapies in HBV hydrodynamic transfection and syngeneic tumor models. Collectively, our data suggests that simultaneously targeting interferon and OX40 signaling pathways by bifunctional molecule OX86-IFN elicits potent antiviral and antitumor activities, which could provide a new strategy in developing therapeutic agents against viral infection and tumors.
Shifu Mo, Liyun Gu, Wei Xu, Jia Liu, Dong Ding, Zhichao Wang, Jie Yang, Lingdong Kong, Yong Zhao

1094 related Products with: Bifunctional macromolecule activating both OX40 and interferon-α signaling displays potent therapeutic effects in mouse HBV and tumor models.

100.00 ug100.00 ug1.00 mg20ug100ug100ug100.00 ug10 8 Sample Kit

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#33091778   2020/10/19 To Up

Bisphenol A exposure increases epididymal susceptibility to infection in mice.

Male fertility is linked with several well-orchestrated events including spermatogenesis, epididymal maturation, capacitation, the acrosome reaction, fertilization, and beyond. However, the detrimental effects of bisphenol A (BPA) on sperm maturation compared to spermatogenesis and sperm cells remain unclear. Therefore, this study was to investigate whether pubertal exposure to BPA induces male infertility via interruption of the immune response in the epididymis. CD-1 male mice (5 weeks old) were treated daily with vehicle (corn oil) and 50 mg BPA/kg-BW for 6 weeks by oral gavage. Following BPA exposure, we observed decreased intraepithelial projection of basal cells, indicative of changes to the luminal environment. We also observed decreased projection of macrophages and protrusion of apoptotic cells into the lumen induced by incomplete phagocytosis of apoptotic cells in the caput epididymis. Exposure to BPA also reduced the anti- and pro-inflammatory cytokines IL-10, IL-6, IFN-γ, and IL-7 in the epididymis, while the chemotaxis-associated cytokines CCL12, CCL17, CXCL16, and MCP-1 increased. This study suggests two possible mechanisms for BPA induction of male infertility. First, exposure to BPA may induce an imbalance of immune homeostasis by disrupting the ability of basal cells to perceive environmental changes. Second, exposure to BPA may lead to collapse of macrophage phagocytosis via downregulation of intraepithelial projection and inflammatory-related cytokines. In conclusion, the observed potential pathways can lead to autoimmune disorders such epididymitis and orchitis.
Yoo-Jin Park, Won-Ki Pang, Do-Yeal Ryu, Elikanah Olusayo Adegoke, Md Saidur Rahman, Myung-Geol Pang

1209 related Products with: Bisphenol A exposure increases epididymal susceptibility to infection in mice.

100 1 kit25 100 μg

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#33091767   2020/10/19 To Up

Hypermethylation of WNT3A gene and non-syndromic cleft lip and/or palate in association with in utero exposure to lead: A mediation analysis.

We aim to investigate association between WNT3A methylation and risk of non-syndromic cleft lip and/or palate (NSCL/P), and examine mediating effect of WNT3A methylation on the association of NSCL/P and lead (Pb) exposure in fetuses.
Wenlei Yang, Yingnan Guo, Wenli Ni, Tian Tian, Lei Jin, Jufen Liu, Zhiwen Li, Aiguo Ren, Linlin Wang

1725 related Products with: Hypermethylation of WNT3A gene and non-syndromic cleft lip and/or palate in association with in utero exposure to lead: A mediation analysis.

1 kit1100 μg

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#33091630   2020/10/16 To Up

Characterization of GASA-1, a new vaccine candidate antigen of Babesia bovis.

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Daniela A Flores, Anabel E Rodriguez, Mariela L Tomazic, Susana Torioni de Echaide, Ignacio Echaide, Patricia Zamorano, Cecilia Langellotti, Flabio R Araujo, Peter Rolls, Leonhard Schnittger, Monica Florin-Christensen

1185 related Products with: Characterization of GASA-1, a new vaccine candidate antigen of Babesia bovis.

6 ml Ready-to-use 1 mL100 50ul (1mg/ml)0.1 mg10.1ml (1mg/ml)50ul100 ug100 µg96T0.1ml

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#33091626   2020/10/19 To Up

Autocrine negative feed-back regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT.

Long chain fatty acids (LCFAs) released from adipocytes inhibit lipolysis through an unclear mechanism. We hypothesized that the LCFA receptor, FFAR4 (GPR120), which is highly expressed in adipocytes could be involved in this feed-back regulation.
Anna Sofie Husted, Jeppe H Ekberg, Emma Tripp, Tinne A D Nissen, Stijn Meijnikman, Shannon L O'Brien, Trond Ulven, Yair Acherman, Sjoerd C Bruin, Max Nieuwdorp, Zach Gerhart-Hines, Davide Calebiro, Lars O Dragsted, Thue W Schwartz

1584 related Products with: Autocrine negative feed-back regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT.

100 μg96 wells2 Pieces/Box300 units 5 G96 wells96 wells100ug Lyophilized50 ug100 μg1 Set2 Pieces/Box

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