Search results for: MPP3
#38533476 
2024/03/21
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Identification of Shared Signature Genes and Immune Microenvironment Subtypes for Heart Failure and Chronic Kidney Disease Based on Machine Learning.
A complex interrelationship exists between Heart Failure (HF) and chronic kidney disease (CKD). This study aims to clarify the molecular mechanisms of the organ-to-organ interplay between heart failure and CKD, as well as to identify extremely sensitive and specific biomarkers.Xuefu Wang, Jin Rao, Xiangyu Chen, Zhinong Wang, Yufeng Zhang
2061 related Products with: Identification of Shared Signature Genes and Immune Microenvironment Subtypes for Heart Failure and Chronic Kidney Disease Based on Machine Learning.
1000 25 mg100.00 ul96T100ul50 mg10 mg1000 tests100ug100ug500 tests
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#38332914 2024/01/25
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The 'analysis of gene expression and biomarkers for point-of-care decision support in Sepsis' study; temporal clinical parameter analysis and validation of early diagnostic biomarker signatures for severe inflammation andsepsis-SIRS discrimination.
Early diagnosis of sepsis and discrimination from SIRS is crucial for clinicians to provide appropriate care, management and treatment to critically ill patients. We describe identification of mRNA biomarkers from peripheral blood leukocytes, able to identify severe, systemic inflammation (irrespective of origin) and differentiate Sepsis from SIRS, in adult patients within a multi-center clinical study.Tamas Szakmany, Eleanor Fitzgerald, Harriet N Garlant, Tony Whitehouse, Tamas Molnar, Sanjoy Shah, Dong Ling Tong, Judith E Hall, Graham R Ball, Karen E Kempsell
2410 related Products with: The 'analysis of gene expression and biomarkers for point-of-care decision support in Sepsis' study; temporal clinical parameter analysis and validation of early diagnostic biomarker signatures for severe inflammation andsepsis-SIRS discrimination.
100 G250 mg
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#37837213 2023/10/13
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In vitro caries-preventive effect of a mineralization-promoting peptide combined with fluoride gel on sound primary teeth.
Mineralization-promoting peptide-3 (MPP3) is a new biomimetic remineralization agent.Merve Yaşar, Cenkhan Bal, Merve Aksoy, Mustafa Güngörmüş, Kaan Orhan
2260 related Products with: In vitro caries-preventive effect of a mineralization-promoting peptide combined with fluoride gel on sound primary teeth.
20 50 50 ug100ug96 tests96 tests50 200ul200ul100ug100 μg
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#37356954 //
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[Chronic Injury of Mice Bone Marrow Multipotent Hematopoietic Progenitor Cells Induced by Ionizing Radiation].
To explore the chronic injury and its possible mechanism of ionizing radiation on multipotent hematopoietic progenitor cells (MPPs) by determining the related indicators of MPPs in bone marrow of mice post-radiation.Ying-Ying Luan, Juan Yang, Shuo Yang, Han-Cheng Fan, Zi-Hao Yang, Jin-Fu Zhang, Rong Deng, Hua Wang, Hui-Hong Zeng, Li-Jian Shao
2906 related Products with: [Chronic Injury of Mice Bone Marrow Multipotent Hematopoietic Progenitor Cells Induced by Ionizing Radiation].
0.1ml (1mg/ml)1mg1 mg100 µg50 ug0.1 mg
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#37115584 2023/04/26
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Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production.
Hematopoietic stem cells (HSC) and downstream lineage-biased multipotent progenitors (MPP) tailor blood production and control myelopoiesis on demand. Recent lineage tracing analyses revealed MPPs to be major functional contributors to steady-state hematopoiesis. However, we still lack a precise resolution of myeloid differentiation trajectories and cellular heterogeneity in the MPP compartment. Here, we found that myeloid-biased MPP3 are functionally and molecularly heterogeneous, with a distinct subset of myeloid-primed secretory cells with high endoplasmic reticulum (ER) volume and FcγR expression. We show that FcγR+/ERhigh MPP3 are a transitional population serving as a reservoir for rapid production of granulocyte/macrophage progenitors (GMP), which directly amplify myelopoiesis through inflammation-triggered secretion of cytokines in the local bone marrow (BM) microenvironment. Our results identify a novel regulatory function for a secretory MPP3 subset that controls myeloid differentiation through lineage-priming and cytokine production and acts as a self-reinforcing amplification compartment in inflammatory stress and disease conditions.Yoon-A Kang, Hyojung Paik, Si Yi Zhang, Jonathan J Chen, Oakley C Olson, Carl A Mitchell, Amelie Collins, James W Swann, Matthew R Warr, Rong Fan, Emmanuelle Passegué
2371 related Products with: Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production.
100.00 ug100.00 ug50 ug100 μg24 wells24 wells5 x 50 ug500 ml 25 ml 1 mg100ug Lyophilized
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#36048017 2022/09/01
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EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors.
Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) generate all cells of the blood system. Despite their multipotency, MPPs display poorly understood lineage bias. Here, we examine whether lineage-specifying transcription factors, such as the B-lineage determinant EBF1, regulate lineage preference in early progenitors. We detect low-level EBF1 expression in myeloid-biased MPP3 and lymphoid-biased MPP4 cells, coinciding with expression of the myeloid determinant C/EBPα. Hematopoietic deletion of Ebf1 results in enhanced myelopoiesis and reduced HSC repopulation capacity. Ebf1-deficient MPP3 and MPP4 cells exhibit an augmented myeloid differentiation potential and a transcriptome with an enriched C/EBPα signature. Correspondingly, EBF1 binds the Cebpa enhancer, and the deficiency and overexpression of Ebf1 in MPP3 and MPP4 cells lead to an up- and downregulation of Cebpa expression, respectively. In addition, EBF1 primes the chromatin of B-lymphoid enhancers specifically in MPP3 cells. Thus, our study implicates EBF1 in regulating myeloid/lymphoid fate bias in MPPs by constraining C/EBPα-driven myelopoiesis and priming the B-lymphoid fate.Aurelie Lenaerts, Iwo Kucinski, Ward Deboutte, Marta Derecka, Pierre Cauchy, Thomas Manke, Berthold Göttgens, Rudolf Grosschedl
2618 related Products with: EBF1 primes B-lymphoid enhancers and limits the myeloid bias in murine multipotent progenitors.
1100 μg100ug Lyophilized
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#36001072 2022/08/24
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Identification of the Differentiation Stages of Living Cells from the Six Most Immature Murine Hematopoietic Cell Populations by Multivariate Analysis of Single-Cell Raman Spectra.
Efforts to expand hematopoietic stem and progenitor cells (HSPCs) in vitro are motivated by their use in the treatment of leukemias and other blood and immune system diseases. The combinations of extrinsic cues within the hematopoietic stem cell (HSC) niche that lead to HSC fate decisions remain unknown. New noninvasive and location-specific techniques are needed to enable identification of the differentiation stages of individual hematopoietic cells on biomaterial microarray screening platforms that minimize the usage of rare HSCs. Here, we show that a combination of Raman microspectroscopy and partial least-squares discriminant analysis (PLS-DA) enables the location-specific identification of individual living cells from the six most immature hematopoietic cell populations, HSC, multipotent progenitor (MPP)-1, MPP-2, MPP-3, common myeloid progenitor, and common lymphoid progenitor. Better than 90% accuracy was achieved. We show that the accuracy of this differentiation stage identification was based on spectral features associated with cell biochemistries. This work establishes that PLS-DA can capture the subtle spectral variations between as many as six closely related cell populations in the presence of potentially significant within-population spectral variation. This noninvasive approach can be used to screen HSC fate decisions elicited by extrinsic cues within biomaterial microarray screening platforms.Isamar Pastrana-Otero, Sayani Majumdar, Aidan E Gilchrist, Brendan A C Harley, Mary L Kraft