Search results for: MVD
#39365159 
2024/10/04
To Up
Effects of human amniotic membrane on the angiogenesis and healing of ischemic wounds in a rat model.
Although the human amniotic membrane (hAM) has been demonstrated to promote angiogenesis, its efficacy in healing ischemic wounds remains unknown. Therefore, the current study aimed to evaluate the potential of hAM as a dressing for treating ischemic wounds. The inferior abdominal wall arteries and veins of male rats were divided, and an ischemic wound was created on each side of the abdominal wall. Of the two ischemic wounds created, only one was covered with hAM, and its wound healing effect was determined by measuring the wound area. Angiogenesis was assessed by measuring microvessel density (MVD). On day 5, the mean wound area changed from 400 mm to 335.4 (260-450) mm in the hAM group and to 459 (306-570) mm in the control group ( = 0.0051). MVD was 19.0 (10.4-24.6) in the hAM group and 15.1 (10.6-20.8) in the control group ( = 0.0026). No significant differences in local pro- and anti-inflammatory cytokine levels were observed between the two groups. Histological examination revealed no rejection of the transplanted hAM. Therefore, the hAM may serve as a novel wound dressing that can promote angiogenesis and healing in ischemic wounds.Masato Sato, Kazuaki Tokodai, Kaoru Okada, Hiroyuki Ogasawara, Miyako Tanaka, Tetsuro Hoshiai, Masatoshi Saito, Hirofumi Sugawara, Daijirou Akamatsu, Michiaki Unno, Masafumi Goto, Takashi Kamei
1056 related Products with: Effects of human amniotic membrane on the angiogenesis and healing of ischemic wounds in a rat model.
4 Membranes/Box4 Membranes/Box4 Membranes/Box4 Membranes/Box4 Membranes/Box50ug4 Membranes/Box4 Membranes/Box4 Membranes/Box4 Membranes/Box4 Membranes/Box50ug
Related Pathways
#39359841 2024/09/04
To Up
Chiari malformation and its influence on trigeminal neuralgia: a systematic review.
In order to properly understand the correlation between TN and Chiari malformation type I (CMI), it is imperative to delve into the underlying processes and develop efficacious treatment strategies.Amr Badary, Yasser F Almealawy, William A Florez-Perdomo, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Arwa Salam Alabide, Sura N Alrubaye, Aalaa Saleh, Anil Ergen, Bipin Chaurasia, Mohammed A Azab, Oday Atallah
2630 related Products with: Chiari malformation and its influence on trigeminal neuralgia: a systematic review.
0.1 mg25 mg 5 G1 mg2.5 mg 5 G100ug1 g0.2 mg96 wells (1 kit)100ug50 ug
Related Pathways
#39347110 2024/09/27
To Up
Role of physiology in the management of multivessel disease among patients with acute coronary syndrome.
Multivessel coronary artery disease (CAD), defined as ≥50% stenosis in 2 or more epicardial arteries, is associated with a high burden of morbidity and mortality in acute coronary syndrome (ACS) patients. A salient challenge for managing this cohort is selecting the optimal revascularisation strategy, for which the use of coronary physiology has been increasingly recognised. Fractional flow reserve (FFR) is an invasive, pressure wire-based, physiological index measuring the functional significance of coronary lesions. Understanding this can help practitioners evaluate which lesions could induce myocardial ischaemia and, thus, decide which vessels require urgent revascularisation. Non-hyperaemic physiology-based indices, such as instantaneous wave-free ratio (iFR), provide valid alternatives to FFR. While FFR and iFR are recommended by international guidelines in stable CAD, there is ongoing discussion regarding the role of physiology in patients with ACS and multivessel disease (MVD); growing evidence supports FFR use in the latter. Compelling findings show FFR-guided complete percutaneous coronary intervention (PCI) can reduce adverse cardiovascular events, mortality, and repeat revascularisations in ACS and MVD patients compared to angiography-based PCI. However, FFR is limited in identifying non-flow-limiting vulnerable plaques, which can disadvantage high-risk patients. Here, integrating coronary physiology assessment with intracoronary imaging in decision-making can improve outcomes and quality of life. Further research into novel physiology-based tools in ACS and MVD is needed. This review aims to highlight the key evidence surrounding the role of FFR and other functional indices in guiding PCI strategy in ACS and MVD patients.Nandine Ganzorig, Graziella Pompei, Kenny Jenkins, Wanqi Wang, Francesca Rubino, Kieran Gill, Vijay Kunadian
2597 related Products with: Role of physiology in the management of multivessel disease among patients with acute coronary syndrome.
500 tests1-99 mg/ml/ea price x 2500 tests96 tests 50 UG
Related Pathways
#39346685 2024/09/17
To Up
Impact of the completeness of revascularization and high bleeding risk status in acute coronary syndrome patients with multi-vessel disease: A retrospective analysis.
To investigate the long-term mortality of acute coronary syndrome (ACS) patients with multivessel disease according to the level of completeness of revascularization (CR) and high-bleeding risk (HBR) status.Tanawat Attachaipanich, Phasakorn Putchagarn, Tasalak Thonghong, Krit Leemasawat, Panupong Pota, Aekapat Phoksiri, Srun Kuanprasert, Pannipa Suwannasom
1280 related Products with: Impact of the completeness of revascularization and high bleeding risk status in acute coronary syndrome patients with multi-vessel disease: A retrospective analysis.
4 Arrays/Slide1-99 mg/ml/ea price x 24 Membranes/Box2 Pieces/Box4 Membranes/Box2 Pieces/Box4 Arrays/Slide
Related Pathways
#39346554 2024/09/27
To Up
Microvascular Decompression: An Effective Approach for Trigeminal Neuralgia Caused by a Dolichoectatic Basilar Artery after Multiple Treatment Failures.
Trigeminal neuralgia (TN), characterized by recurrent episodes of intense facial pain, poses diagnostic and therapeutic challenges. TN can be triggered by many factors, with rare cases (< 0.05% of the general population) associated with vertebrobasilar dolichoectasia (VBD). Our study analyzes a 74-year-old male patient with 10 years of constant unbearable left-sided facial pain, unresponsive to medications and multiple glycerol rhizotomies, performed in other centers which prompted the patient to seek care at our clinic. The confirmation of left-sided VBD by magnetic resonance imaging, computed tomography angiography, and the patient's overall satisfactory health status favored open surgery with microvascular decompression (MVD). We performed a retrosigmoid suboccipital craniotomy to reach the cerebellopontine angle, ensuring that it is the dolichoectatic basilar artery applying compression to the trigeminal nerve. We inserted a shredded Teflon implant into the trigeminal cistern following its opening. Care was exercised to ensure that there were no remaining factors causing compression. Postoperatively, pain relief was achieved, sustained at an 8-month follow-up. Treating TN arising from VBD can be difficult. The patient's overall health status and assessment play a key role in determining the appropriate course of treatment. Opting for MVD is the optimal and most effective choice, regardless of age, according to the recent literature. In cases where surgery is not feasible, the treatment options will involve medications and less invasive therapeutic approaches such as peripheral rhizotomies or stereotactic radiosurgery. Our case highlights the efficacy of MVD in addressing TN associated with VBD, underscoring the need for advanced treatment modalities and expertise in managing complex cases.Filippos Chelmis, Paraskevas Pakataridis, Iliana Sorotou, Anastasios Tzineris, Christo Ranguelov
1385 related Products with: Microvascular Decompression: An Effective Approach for Trigeminal Neuralgia Caused by a Dolichoectatic Basilar Artery after Multiple Treatment Failures.
16 Arrays/Slide25 16 Arrays/Slide100μg16 Arrays/Slide16 Arrays/Slide16 Arrays/Slide
Related Pathways
#39342410 2024/09/28
To Up
The relative and combined ability of triglyceride-glucose index and stress hyperglycemia ratio to predict major adverse cardio-cerebral events in patients with multivessel coronary artery disease.
Cardiovascular disease continues to be the leading cause of global mortality and disability, particularly posing elevated risks in patients diagnosed with multivessel disease (MVD). Efficient risk stratification in MVD patients is crucial for improving prognosis, prompting investigation into novel biomarkers such as the triglyceride-glucose index (TyG index) and the stress hyperglycemia ratio (SHR).Mingyang Li, Xiaodong Cui, Yan Zhang, Jiachun Lang, Tianxu Hao, Yihang Su, Yuecheng Hu
2440 related Products with: The relative and combined ability of triglyceride-glucose index and stress hyperglycemia ratio to predict major adverse cardio-cerebral events in patients with multivessel coronary artery disease.
1 mg100 96 tests1000 tests1.00 flask100ug
Related Pathways
#39338991 2024/09/15
To Up
HIV Modulates Osteoblast Differentiation via Upregulation of RANKL and Vitronectin.
Bone loss is a prevalent characteristic among people with HIV (PWH). We focused on mesenchymal stem cells (MSCs) and osteoblasts, examining their susceptibility to different HIV strains (R5- and X4-tropic) and the subsequent effects on bone tissue homeostasis. Our findings suggest that MSCs and osteoblasts are susceptible to R5- and X4-tropic HIV but do not support productive HIV replication. HIV exposure during the osteoblast differentiation process revealed that the virus could not alter mineral and organic matrix deposition. However, the reduction in runt-related transcription factor 2 (RUNX2) transcription, the increase in the transcription of nuclear receptor activator ligand kappa B (RANKL), and the augmentation of vitronectin deposition strongly suggested that X4- and R5-HIV could affect bone homeostasis. This study highlights the HIV ability to alter MSCs' differentiation into osteoblasts, critical for maintaining bone and adipose tissue homeostasis and function.Rosa Nicole Freiberger, Cynthia Alicia Marcela López, María Belén Palma, Cintia Cevallos, Franco Agustin Sviercz, Patricio Jarmoluk, Marcela Nilda García, Jorge Quarleri, M Victoria Delpino
1469 related Products with: HIV Modulates Osteoblast Differentiation via Upregulation of RANKL and Vitronectin.
5ug0.05 mg10mg25 x 2 ml100ug Lyophilized10,000 assays1mg200ug50 ug1000 assays10μg/vial1000
Related Pathways
#39333340 2024/09/27
To Up
Impact of microvascular decompression on wall shear stress in responsible arteries in trigeminal neuralgia and hemifacial spasm.
Microvascular decompression (MVD) has proven efficacy in trigeminal neuralgia (TN) and hemifacial spasm (HFS). This study utilized computational fluid dynamics (CFD) to investigate the impact of MVD on wall shear stress (WSS) of responsible arteries (RAs) at the neurovascular contact (NVC). A total of 21 cases (10 TN, 11 HFS) were analyzed, involving RAs at NVC validated through intraoperative photographs. Hemodynamic parameters (WSS, vessel diameter, flow rate, pressure drop) was calculated using CFD for the RAs based on 3D silent-magnetic resonance angiograms. The NVC was segmented into NVC-proximal, NVC-site, and NVC-distal portions using simulated 3D CFD images that correlated with surgical observations. WSS ratios of NVC-site to NVC-proximal (NVC-site/proximal) was calculated both before and after MVD. Prior to MVD, WSS in the RA at the NVC displayed a peaked curve with a maximum at NVC-site; however, post MVD, it presented a smooth curve without peaks. The WSS ratio exhibited a significant decrease after MVD. The impact of MVD on WSS of RAs at NVC was evaluated in both TN and HFS cases. Analyzing the hemodynamics of RAs through CFD and identifying WSS peaks at NVC portions before MVD provided a more detailed and localized understanding of the morphologically depicted NVC.Toru Satoh, Yoichi Sawada, Isao Date, Takao Yasuhara, Kentaro Fujii