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#35973807   2022/08/16 To Up

Computed Tomography Embolus Texture Analysis as a Prognostic Marker of Acute Pulmonary Embolism.

Texture analysis is a quantitative imaging analysis that provides novel biomarkers beyond conventional image reading. Our aim was to use texture analysis of pulmonary emboli derived from thoracic computed tomography for prediction of mortality and prognosis of acute pulmonary embolism (PE). Overall, 216 patients (116 female, 53.7%) were included in the analysis. Texture analysis was calculated on axial slices of the contrast enhanced pulmonary angiography of the proximal embolus. Clinical scores, serological parameters, need for intubation, intensive care unit (ICU) admission and mortality was assessed and correlated with the texture features. In the correlation analysis, there were several associations with mortality in days, the highest for the parameter S(0,5)SumVarnc ( = -0.43, < 0.001). Another parameter, S(3,-3)AngScMom correlated with sepsis-related organ failure assessment score (SOFA)-score ( = 0.31, < 0.001). Several texture features correlated with venous lactate and glucose levels. In discrimination analysis, there were significant differences in regard to texture features between survivors and non-survivors and between patients with and without the need for ICU admission ( = 0.02, respectively). These results highlight the potential clinical benefit of texture features in patients with acute PE as novel imaging biomarkers. Further studies are needed to validate these results.
Jakob Leonhardi, Nikolaos Bailis, Marianne Lerche, Timm Denecke, Alexey Surov, Hans-Jonas Meyer

2690 related Products with: Computed Tomography Embolus Texture Analysis as a Prognostic Marker of Acute Pulmonary Embolism.



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#35973802   2022/08/16 To Up

Association of baseline soluble immune checkpoints with the risk of relapse in PR3-ANCA vasculitis following induction of remission.

We investigated whether soluble immune checkpoints (sICPs) predict treatment resistance, relapse and infections in patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV).
Gabriele Gamerith, Finn Mildner, Peter A Merkel, Kristina Harris, Laura Cooney, Noha Lim, Robert Spiera, Philip Seo, Carol A Langford, Gary S Hoffman, E William St Clair, Fernando C Fervenza, Paul Monach, Steven R Ytterberg, Duvuru Geetha, Arno Amann, Dominik Wolf, Ulrich Specks, John H Stone, Andreas Kronbichler

2670 related Products with: Association of baseline soluble immune checkpoints with the risk of relapse in PR3-ANCA vasculitis following induction of remission.

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#35973801   2022/08/16 To Up

Prospective observational study of amino-terminal brain natriuretic peptide levels in obese and non-obese women during pregnancy.

NT-proBNP, a marker of ventricular dysfunction, varies by BMI outside of pregnancy. This study aimed to determine whether obesity affects NT-proBNP levels in pregnancy.
Anna Denoble, Julia Moyett, Sarah Goldstein, Cary C Ward, Tracy Truong, Alaattin Erkanli, Andra James, Chad Grotegut

2237 related Products with: Prospective observational study of amino-terminal brain natriuretic peptide levels in obese and non-obese women during pregnancy.

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#35973728   2022/08/16 To Up

The Effect of Gender-Affirming Hormone Therapy on Measures of Kidney Function: A Systematic Review and Meta-Analysis.

Gender-affirming hormone therapy modifies body composition and lean muscle mass in transgender persons. We sought to characterize the change in serum creatinine, other kidney function biomarkers, and GFR in transgender persons initiating masculinizing and feminizing gender-affirming hormone therapy.
Emily Krupka, Sarah Curtis, Thomas Ferguson, Reid Whitlock, Nicole Askin, Adam C Millar, Marshall Dahl, Raymond Fung, Sofia B Ahmed, Navdeep Tangri, Michael Walsh, David Collister

1068 related Products with: The Effect of Gender-Affirming Hormone Therapy on Measures of Kidney Function: A Systematic Review and Meta-Analysis.

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#35973626   2022/08/13 To Up

Decrease in acute periprosthetic joint infections incidence with vancomycin loaded calcium sulfate beads in patients with non-modifiable risk factors. A randomized clinical trial.

The influence of local antibiotic therapy in orthopedic surgery remains unclear. In this trial, we evaluated the incidence of periprosthetic joint infections (PJI), after local or intravenous (IV) antibiotic prophylaxis. The aim of this intervention was to compare the PJI incidence in a population with non-modifiable risk factors after local prophylaxis with vancomycin loaded calcium sulfate beads versus a control group.
Julio Carlos Vélez de Lachica, Susana Serrano Reyes, Juan Antonio Pages Ureña, Miguel Angel Ruiz Fragoso

1959 related Products with: Decrease in acute periprosthetic joint infections incidence with vancomycin loaded calcium sulfate beads in patients with non-modifiable risk factors. A randomized clinical trial.