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#33652327   2021/02/16 To Up

Exploring the role of anger in nonsuicidal self-injury in veterans.

Up to 14% of veterans engage in nonsuicidal self-injury (NSSI) in their lifetime and this behavior is a relatively strong predictor of suicidal behavior compared to other identified risk factors. Further, NSSI is a clinically relevant behavior in its own right; it is associated with more severe psychopathology as well as bodily harm that sometimes requires medical intervention. Therefore, a better understanding of NSSI may help inform suicide prevention efforts as well as mental healthcare strategies for veterans. Anger may be relevant to understanding NSSI in veterans. Over 60% of veterans report difficulties managing anger and this emotion is strongly associated with engagement in NSSI. However, no research has explored the extent to which anger is present prior to NSSI or whether anger is associated with specific NSSI methods or functions in veterans. The purpose of this study was to explore whether anger was associated with engagement in specific NSSI methods, and whether anger uniquely predicted any functions of NSSI while controlling for the presence of other basic negative emotions (fear and sadness). An existing dataset of 61 veterans who reported engaging in NSSI in the past year was analyzed. Results indicated anger was the most common emotional antecedent to NSSI. Further, anger was associated with several methods of NSSI including burning oneself with a cigarette, carving pictures, designs or other marks into skin, sticking sharp objects into skin, severely scratching oneself, head banging, punching oneself, and punching walls or objects. Finally, when controlling for the presence of other negative emotions, anger was associated with engaging in NSSI to relieve tension, stop feeling numb, communicate with others, feel alive, get help from others, and prove to oneself how bad things are. These results highlight the importance of assessing and treating dysregulated anger in veterans who engage in self-harming behavior.
Clair Cassiello-Robbins, Kirsten H Dillon, Daniel V Blalock, Patrick S Calhoun, Jean C Beckham, Nathan A Kimbrel

1427 related Products with: Exploring the role of anger in nonsuicidal self-injury in veterans.

196T 100 UG

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#33652254   2021/02/08 To Up

Challenges and practices on waste management and disposal during COVID-19 pandemic.

The COVID-19 pandemic has imposed a global emergency and also has raised issues with waste management practices. This study emphasized the challenges of increased waste disposal during the COVID-19 crisis and its response practices. Data obtained from the scientific research papers, publications from the governments and multilateral organizations, and media reports were used to quantify the effect of the pandemic towards waste generation. A huge increase in the amount of used personal protective equipments (facemasks, gloves, and other protective stuffs) and wide distribution of infectious wastes from hospitals, health care facilities, and quarantined households was found. The amount of food and plastic waste also increased during the pandemic. These factors caused waste treatment facilities to be overwhelmed, forcing emergency treatment and disposals (e.g., co-disposal in a municipal solid waste incinerator, cement kilns, industrial furnaces, and deep burial) to ramp up processing capacity. This paper discussed the ways the operation of those facilities must be improved to cope with the challenge of handling medical waste, as well as working around the restrictions imposed due to COVID-19. The study also highlights the need for short, mid, and longer-term responses towards waste management during the pandemic. Furthermore, the practices discussed in this paper may provide an option for alternative approaches and development of sustainable strategies for mitigating similar pandemics in the future.
Dwi Hantoko, Xiaodong Li, Agamuthu Pariatamby, Kunio Yoshikawa, Mika Horttanainen, Mi Yan

1703 related Products with: Challenges and practices on waste management and disposal during COVID-19 pandemic.

200ug10 mg200 1000 tests200ul25 mg100 mg1000 TESTS/0.65ml10 mg10 mg100ug

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#33652099   2021/02/27 To Up

Corticotropin-releasing hormone reduces basal estradiol production in zebrafish follicular cells.

Corticotropin-releasing hormone (CRH) plays a key regulatory role in coordinating the regulation of endocrine, autonomic nervous, immune, and reproductive systems. Two CRH (CRHα and CRHβ) and their receptors (CRHR1 and CRHR2) had been identified in zebrafish. However, their functions remained uncovered in the ovary of zebrafish. Therefore, this study aimed to determine whether CRH acts directly on the ovary to regulate steroidogenesis in cultured zebrafish follicular cells. Firstly, CRH and its receptors are expressed in the zebrafish ovary. The expression profile of CRHβ fluctuated during ovarian development in zebrafish, and the highest CRHα mRNA levels were observed at the mature follicle. The highest CRHR1 and CRHR2 mRNA levels existed in mid-vitellogenic (MV) and early vitellogenic (EV) stages, respectively. In primary cultured zebrafish follicular cells, both of the CRHα and CRHβ inhibited expression of hsd17b3 mRNA levels and decreased content of estradiol (E2) in the medium. Furthermore, CRH activated p38MAPK and p38MAPK inhibitor SB203580 attenuated the phosphorylation of p38MAPK induced by CRHα. Simultaneously, SB203580 changed the effect of CRH on cyp19a1a expression but not hsd17b1 and hsd17b3. SB203580 alone or combined with CRH inhibited the E2 content. Finally, the CRHR inhibitor α-helical 9-41 also blocked the phosphorylation of p38MAPK induced by CRHα but did not change the inhibitory effect of CRH on the mRNA expression of the steroidogenic gene and the content of E2 in the culture medium. Taken together, our findings suggest that the anti-steroidogenic effects of CRH may be mediated partly through activation of the p38MAPK signaling pathway.
Hong Zhou, Aqin Chen, Weiqun Lu

1824 related Products with: Corticotropin-releasing hormone reduces basal estradiol production in zebrafish follicular cells.

96 assays96 tests96 tests100 μg200 1x10e7 cells1 mg100 µg-10 ug100 μg96 wells

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#33652093   2021/02/27 To Up

A National Survey of Challenges Faced by Hospices during the Opioid Crisis: Estimates of Pain Medication Shortages, Missing Medications, and Opioids Left in the Home Post-Death.

No national data exist on hospice medication shortages, the frequency that opioid medications go missing, and drug disposal practices.
John G Cagle, Mary Lynn McPherson, Jodi J Frey, Paul Sacco, Orrin D Ware, Diane Hoffmann, Jack M Guralnik

2324 related Products with: A National Survey of Challenges Faced by Hospices during the Opioid Crisis: Estimates of Pain Medication Shortages, Missing Medications, and Opioids Left in the Home Post-Death.

1100ug Lyophilized

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#33652056   2021/02/27 To Up

Utility of Follow up Cervical Length Screening in Low Risk Women with Cervical Length 26-29mm.

In women with a prior preterm birth, a protocol for serial cervical length screening has been studied and recommended for identification and treatment of short cervix. Cervical length screening has been suggested for low risk singletons in order to treat short cervix vaginal progesterone and reduce preterm birth. However, specific protocols for single versus serial cervical length ultrasound in this population are not established. Cost effectiveness of universal cervical length screening depends on the cost of screening; follow up of borderline measurements can contribute to increased costs with uncertain benefit.
Rupsa C Boelig, Varsha Kripalu, Sarah L Chen, Yuri Cruz, Amanda Roman, Vincenzo Berghella

2667 related Products with: Utility of Follow up Cervical Length Screening in Low Risk Women with Cervical Length 26-29mm.



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#33651940   2021/03/02 To Up

Optical Tuning of Resistance Switching in Polycrystalline Gallium Phosphide Thin Films.

The nanoscale resistive switching characteristics of gallium phosphide (GaP) thin films directly grown on Si are investigated as a function of incident light. The formation of conductive channels along the grain boundaries is attributed to the presence of point defects and structural disorder, which provide the ideal environment to enable the filamentary switching process. Both first-principles calculations and UV-vis and photoluminescence spectroscopy strongly point to the possibility of mid-gap electronic states in the polycrystalline GaP film due to such defects. To study the photonic excitation, photoconductive atomic force microscopy (phAFM) measurement is conducted. We observe photocurrents even for incident photon energies lower than the band gap, consistent with the presence of mid-gap electronic states; the photocurrents increase in direct proportion to the incident photon energy with a concomitant decrease in the filament resistance. This demonstrates GaP directly integrated on Si can be a promising photonic resistive switching materials system.
Fran Kurnia, Jan Seidel, Judy N Hart, Nagarajan Valanoor

1127 related Products with: Optical Tuning of Resistance Switching in Polycrystalline Gallium Phosphide Thin Films.

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#33651843   2021/03/02 To Up

Correction: Climate and land-use as the main drivers of recent environmental change in a mid-altitude mountain lake, Romanian Carpathians.

[This corrects the article DOI: 10.1371/journal.pone.0239209.].
Aritina Haliuc, Krisztina Buczkó, Simon M Hutchinson, Éva Ács, Enikő K Magyari, Janos Korponai, Robert-Csaba Begy, Daniela Vasilache, Michal Zak, Daniel Veres

1259 related Products with: Correction: Climate and land-use as the main drivers of recent environmental change in a mid-altitude mountain lake, Romanian Carpathians.

900 tests100 μg50 ul100 assays96 samples100 assays0.1ml (1mg/ml)196 assays 100 μg

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#33651818   2021/03/02 To Up

Impact of sampling depth on pathogen detection in pit latrines.

Wastewater based epidemiology (WBE) is increasingly used to provide decision makers with actionable data about community health. WBE efforts to date have primarily focused on sewer-transported wastewater in high-income countries, but at least 1.8 billion people in low- and middle-income countries (LMIC) use onsite sanitation systems such as pit latrines and septic tanks. Like wastewater, fecal sludges from such systems offer similar advantages in community pathogen monitoring and other epidemiological applications. To evaluate the distribution of enteric pathogens inside pit latrines-which could inform sampling methods for WBE in LMIC settings unserved by sewers-we collected fecal sludges from the surface, mid-point, and maximum-depth of 33 pit latrines in urban and peri-urban Malawi and analyzed the 99 samples for 20 common enteric pathogens via multiplex quantitative reverse transcription PCR. Using logistic regression adjusted for household population, latrine sharing, the presence of a concrete floor or slab, water source, and anal cleansing materials, we found no significant difference in the odds of detecting the 20 pathogens from the mid-point (adjusted odds ratio, aOR = 1.1; 95% confidence interval = 0.73, 1.6) and surface samples (aOR = 0.80, 95% CI = 0.54, 1.2) compared with those samples taken from the maximum depth. Our results suggest that, for the purposes of routine pathogen monitoring, pit latrine sampling depth does not strongly influence the odds of detecting enteric pathogens by molecular methods. A single sample from the pit latrines' surface, or a composite of surface samples, may be preferred as the most recent material contributed to the pit and may be easiest to collect.
Drew Capone, Petros Chigwechokha, Francis L de Los Reyes, Rochelle H Holm, Benjamin B Risk, Elizabeth Tilley, Joe Brown

2552 related Products with: Impact of sampling depth on pathogen detection in pit latrines.

100 μg1 Set100ug100 μg1 Set1 Set

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#33651793   2021/03/02 To Up

Using deep neural networks to evaluate object vision tasks in rats.

In the last two decades rodents have been on the rise as a dominant model for visual neuroscience. This is particularly true for earlier levels of information processing, but a number of studies have suggested that also higher levels of processing such as invariant object recognition occur in rodents. Here we provide a quantitative and comprehensive assessment of this claim by comparing a wide range of rodent behavioral and neural data with convolutional deep neural networks. These networks have been shown to capture hallmark properties of information processing in primates through a succession of convolutional and fully connected layers. We find that performance rodent object vision tasks can be captured using low to mid-level convolutional layers only, without any convincing evidence for the need of higher layers known to simulate complex object recognition in primates. Our approach also reveals surprising insights on assumptions made before, for example, that the best performing animals would be the ones using the most abstract representations-which we show to likely be incorrect. Our findings suggest a road ahead for further studies aiming at quantifying and establishing the richness of representations underlying information processing in animal models at large.
Kasper Vinken, Hans Op de Beeck

2905 related Products with: Using deep neural networks to evaluate object vision tasks in rats.

96 wells (1 kit)1 mg1 kit 1 G1mg500 gm.100 μg

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