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#33453566   2021/01/05 To Up

Recent advances in neoadjuvant immunotherapy for urothelial bladder cancer: What to expect in the near future.

Urothelial bladder cancer (UC) is the most common malignancy involving the urinary system and represents a significant health problem. Immunotherapy has been used for decades for UC with intravesical bacillus Calmette-Guérin (BCG) set as the standard of care for non-muscle-invasive bladder cancer (NMIBC). The advent of immune checkpoint inhibitors (ICIs) has completely transformed the treatment landscape of bladder cancer enabling to expand the treatment strategies. Novel ICIs have successfully shown improved outcomes on metastatic disease to such an extent that the standard of care paradigm has changed leading to the development of different trials with the aim of determining whether ICIs may have a role in early disease. The localized muscle-invasive bladder cancer (MIBC) scenario remains challenging since the recurrence rate continues to be high despite all therapeutic efforts. This article will review the current experience of ICIs in the neoadjuvant setting of UC, the clinical trials landscape and finally, an insight of what to expect in the immediate and mid-term future.
M Rey-Cárdenas, F Guerrero-Ramos, A Gómez de Liaño Lista, A Carretero-González, H Bote, M Herrera-Juárez, L Carril-Ajuria, M Martín-Soberón, J M Sepulveda, E G Billalabeitia, D Castellano, G de Velasco

2567 related Products with: Recent advances in neoadjuvant immunotherapy for urothelial bladder cancer: What to expect in the near future.



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#33453542   2021/01/07 To Up

Metaproteomics reveals the molecular mechanism underlying bloom maintenance of a marine dinoflagellate under low ambient CO and inorganic nutrients.

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Hao Zhang, Hong-Kai Xu, Shu-Feng Zhang, Youping Zhou, Yan-Bin He, Shady Amin, Jian-Wei Chen, Ke-Qiang Yan, Lin Lin, Si-Qi Liu, Da-Zhi Wang

1183 related Products with: Metaproteomics reveals the molecular mechanism underlying bloom maintenance of a marine dinoflagellate under low ambient CO and inorganic nutrients.

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#33453524   2021/01/06 To Up

Anatomical and functional outcomes of uterus preservation and pelvic organ prolapse repair with vaginal trocar-less mesh kit (Endofast): A retrospective study of 239 patients.

The aim of the study was to assess safety and long term efficacy as well as short and long term complications of vaginal prolapse mesh repair using single incision trocar-less system while preserving the uterus.
Rachel Zangen, Inbar Ben Shachar, Naama Marcus

2000 related Products with: Anatomical and functional outcomes of uterus preservation and pelvic organ prolapse repair with vaginal trocar-less mesh kit (Endofast): A retrospective study of 239 patients.

100ug25 mg100.00 ul1000 tests200ug10 mg2.5 mg 5 G2.5 mg1,000 tests100ug1 mg

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#33453516   2021/01/13 To Up

Good mid-term outcome of the rotating hinge knee in primary total knee arthroplasty - Results of a single center cohort of 106 knees with a median follow-up of 6.3 years.

The prognosis of complex primary total knee arthroplasty (TKA) with severe deformity and ligament deficiency is not clear. There is a paucity of evidence in the current literature on treatment outcomes of the rotating hinge knee implants in primary TKA. The aim of this study was to determine the mid-term clinical, radiographic, and health-related quality of life (HRQoL) outcomes in patients who had undergone complex primary TKA using single hinged knee replacement.
Jake von Hintze, Mika Niemeläinen, Harri Sintonen, Jyrki Nieminen, Antti Eskelinen

2267 related Products with: Good mid-term outcome of the rotating hinge knee in primary total knee arthroplasty - Results of a single center cohort of 106 knees with a median follow-up of 6.3 years.

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#33453513   2021/01/13 To Up

The Medial Rotation Knee replacement: Clinical and radiological results of a multi-centre surveillance study at five years.

The Medial Rotation Knee (MRK) has one of the lowest revision rates of total knee replacement designs in the National Joint Registry. While survival is one metric of performance of implants, patient-reported outcomes, combined with clinical and radiological evaluation, allow more complete analysis. We report the five-year results of a prospective, multi-centre surveillance study of the MRK.
Jeremy I Webb, Rebecca S Stoner, Irrum Afzal, Chris R Evans, Gareth Scott, Richard E Field

1228 related Products with: The Medial Rotation Knee replacement: Clinical and radiological results of a multi-centre surveillance study at five years.



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#33453493   2020/12/31 To Up

A novel approach based on multiple fish species and water column compartments in assessing vertical microlitter distribution and composition.

The assessment of the distribution and composition of microlitter in the sea is a great challenge. Biological indicators can be an irreplaceable tool since they measure microlitter levels in their environments in a way that is virtually impossible to replicate by direct physical measurements. Furthermore, trends can provide policymakers with statistically robust analysis. We looked into the capacity of multiple fish species to describe the distribution and composition of microlitter vertically across different compartments of the water column. A total of 502 individuals from six selected species (Scomber scombrus, Oblada melanura, Spicara smaris, Boops boops, Merluccius merluccius and Mullus barbatus) were collected on the western side of Sardinia island and allocated to three compartments: surface, mid-water and bottom. The species of the surface exhibited a higher frequency of occurrence (41.89%) of microlitter ingestion, compared to those of the mid-water and bottom (19.60%; 22.58%). A significant difference in the average number of ingested microlitter was found between the surface and the bottom compartment. All the microlitter fragments found were analysed through Fourier Transform Infrared Spectroscopy (FTIR). The comparison of the expected buoyancies of the polymers identified puth faith in the allocation of the species to the respective compartments. Therefore, considering the Marine Strategy Framework Directive objective, this approach could be useful in assessing microlitter distribution and composition vertically across the water column.
Luca Palazzo, Stefania Coppa, Andrea Camedda, Mariacristina Cocca, Francesca De Falco, Alvise Vianello, Giorgio Massaro, Giuseppe Andrea de Lucia

2237 related Products with: A novel approach based on multiple fish species and water column compartments in assessing vertical microlitter distribution and composition.

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#33453458   2021/01/04 To Up

The relationship between gestational weight gain, maternal upper-body subcutaneous fat changes and infant birth size: A pilot observational study amongst women with obesity.

It is widely acknowledged that maternal obesity and excessive gestational weight gain (GWG) are associated with increased risk of fetal macrosomia and recent studies have suggested a role for the timing and composition of GWG.
Kathy M Redfern, Heidi J Hollands, Joanne Hosking, C Ross Welch, Jonathan H Pinkney, Gail A Rees

1349 related Products with: The relationship between gestational weight gain, maternal upper-body subcutaneous fat changes and infant birth size: A pilot observational study amongst women with obesity.

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#33453216   2021/01/13 To Up

Functional role of carbon dioxide on intermittent hypoxia induced respiratory response following mid-cervical contusion in the rat.

Intermittent hypoxia induces respiratory neuroplasticity to enhance respiratory motor outputs and is a potential rehabilitative strategy to improve respiratory function following cervical spinal injury. The present study was designed to evaluate the functional role of intermittent and sustained carbon dioxide (CO) on intermittent hypoxia-induced ventilatory responses in rats with mid-cervical spinal contusion. The breathing pattern of unanesthetized rats at the subchronic and chronic injured stages was measured in response to one of the following treatments: (1) Intermittent hypercapnic-hypoxia (10 × 5 min 10%O + 4%CO with 5 min normoxia interval); (2) Intermittent hypoxia with sustained hypercapnia (10 × 5 min 10%O + 4%CO with 5 min 21%O + 4%CO interval); (3) Intermittent hypoxia (10 × 5 min 10%O with 5 min normoxia interval); (4) Intermittent hypercapnia (10 × 5 min 21%O + 4%CO with 5 min normoxia interval); (5) Sustained hypercapnia (100 min, 21% O + 4% CO); (6) Sustained normoxia (100 min, 21% O). The results demonstrated that intermittent hypoxia associated with intermittent hypercapnia or sustained hypercapnia induced a greater ventilatory response than sustained hypercapnia during stimulus exposure. The tidal volume was significantly enhanced to a similar magnitude following intermittent hypercapnic-hypoxia, intermittent hypoxia with sustained hypercapnia, and intermittent hypoxia in subchronically injured animals; however, only intermittent hypercapnic-hypoxia and intermittent hypoxia were able to evoke long-term facilitation of the tidal volume at the chronic injured stage. These results suggest that mild intermittent hypercapnia did not further enhance the therapeutic effectiveness of intermittent hypoxia-induced respiratory recovery in mid-cervical contused animals. However, sustained hypercapnia associated with intermittent hypoxia may blunt ventilatory responses following intermittent hypoxia at the chronic injured stage.
Mei-Tsen Lin, Stéphane Vinit, Kun-Ze Lee

1439 related Products with: Functional role of carbon dioxide on intermittent hypoxia induced respiratory response following mid-cervical contusion in the rat.

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#33453117   2021/01/16 To Up

Heterogeneity in Husbands' and Wives' Physical Pain Trajectories over Mid-Later Years: Biopsychosocial Stratification and Implications for Later Life Well-Being.

The present study investigated pain trajectories of husbands and wives over their mid-later years, the grouping of these trajectories, and differences in baseline biopsychosocial profiles and health and well-being outcomes in later years across the pain trajectory groups.
Kandauda A S Wickrama, Tae Kyoung Lee, Catherine Walker O'Neal

1167 related Products with: Heterogeneity in Husbands' and Wives' Physical Pain Trajectories over Mid-Later Years: Biopsychosocial Stratification and Implications for Later Life Well-Being.

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