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#33091956 
2020/10/22
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Circulating Liver Function Markers and Colorectal Cancer Risk: A Prospective Cohort Study in the UK Biobank.
Evidence links the liver to development of colorectal cancer (CRC). However, it remains unknown how liver function may influence CRC risk in the general population. We conducted a prospective cohort study in the UK Biobank of 375,693 participants who provided blood samples in 2006-2010. Circulating levels of liver function markers [alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBIL), gamma glutamyltransferase (GGT), alkaline phosphatase (ALP), total protein (TP), and albumin (ALB)] were measured. Incident cancer cases were identified through linkage to the national cancer registry up to 2019. Repeated biomarker measurements were available from a subset of 11,320 participants who were re-assessed in 2012-2013. After a median follow-up of 10.0 years, we documented 2,662 cases of CRC. Circulating levels of ALT, AST, TBIL, GGT, TP, and ALB at baseline were inversely associated with CRC risk (P<.01), with multivariable hazard ratio (95% confidence interval) comparing decile 10 versus 1 of 0.62 (0.51-0.75), 0.63 (0.53-0.75), 0.85 (0.72-1.02), 0.74 (0.61-0.89), 0.70 (0.59-0.84), and 0.66 (0.55-0.79), respectively. Strengthened associations were found after recalibration for repeated measurements. The associations appeared stronger for proximal colon cancer than distal colon cancer and rectal cancer, but consistent for early-, mid-, and late-onset CRC. In a large cohort of general population, the UK Biobank, higher circulating levels of ALT, AST, TBIL, GGT, TP, and ALB, largely within the normal range, were associated with a lower risk of CRC. The findings support a link between liver function and CRC, and may spur future research on the gut-microbiota-liver axis. This article is protected by copyright. All rights reserved.Ming-Ming He, Zhe Fang, Dong Hang, Feng Wang, Georgios Polychronidis, Liang Wang, Chun-Han Lo, Kai Wang, Rong Zhong, Markus D Knudsen, Scott G Smith, Rui-Hua Xu, Mingyang Song
1153 related Products with: Circulating Liver Function Markers and Colorectal Cancer Risk: A Prospective Cohort Study in the UK Biobank.
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#33091603 2020/10/19
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The effect of Pacemaker Implantation After Transcatheter Aortic Valve Replacement on Long- and Mid -term mortality.
Transcatheter aortic valve replacement (TAVR) has become quite common. Atrioventricular conduction defects remain a frequent complication resulting with permanent pacemaker (PPM) implantation. Past studies showed conflicting results regarding PPM effect on mortality.Aviram Hochstadt, Ilan Merdler, Yael Meridor, Arie L Schwartz, Merav Ingbir, Eihab Ghantous, Ofer Havakuk, Anna Mazo, Arie Steinvil, Ariel Finkelstein, Sami Viskin, Raphael Rosso
1174 related Products with: The effect of Pacemaker Implantation After Transcatheter Aortic Valve Replacement on Long- and Mid -term mortality.
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#33091518 2020/10/19
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Analyses of hemodialysis arteriovenous fistula geometric configuration and its associations with maturation and reintervention.
An arteriovenous fistula (AVF) is the preferred vascular access for chronic hemodialysis, yet the rates of AVF maturation failure and reintervention remain high. We investigated the AVF geometric parameters and their associations with AVF physiologic maturation and reintervention in a prospective multi-center study.Yong He, Hannah Northrup, Prabir Roy-Chaudhury, Alfred K Cheung, Scott A Berceli, Yan-Ting Shiu
2558 related Products with: Analyses of hemodialysis arteriovenous fistula geometric configuration and its associations with maturation and reintervention.
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#33091514 2020/10/19
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Revascularization of occluded renal artery stent-grafts following complex endovascular aortic repair and its impact on renal function.
Acute occlusion of the renal bridging stent-grafts after fenestrated/branched endovascular aortic repair (F/B-EVAR) is an acknowledged complication with high morbidity often resulting to chronic dialysis dependence. The feasibility and effect of timely or late (≥6 hours of ischemia) renal artery revascularization has not been adequately reported in the literature.N Konstantinou, T Kölbel, N Dias, E Verhoeven, A Wanhainen, M Gargiulo, K Oikonomou, F Verzini, F Heidemann, B Sonesson, A Katsargyris, K Mani, C Fernandez, E Gallitto, K Pfister, M A Ruffino, E R Tenorio, F Speziale, S Haulon, G S Oderich, N Tsilimparis