Search results for: Morphogenic
#34509519 2021/09/09 To Up
Polygalacto-fucopyranose biopolymer structured nanoparticle conjugate attenuates glucocorticoid-induced osteoporosis: An in vivo study.Naturally occurring polysaccharide-structured nanoparticles have developed as promising materials for treatment of bone health disorders. Silver nanoparticle (ST-Ag) structured from sulfated polygalacto-fucopyranose comprising of recurring structural entities of 2-SO-Î±-(1â¯ââ¯3)-fucopyranose and 6-O-acetyl-Î²-(1â¯ââ¯4)-galactopyranose isolated from marine macroalga Sargassum tenerrimum demonstrated potential activities associated with osteogenesis. Subsequent treatment with ST-Ag, activity of alkaline phosphatase (63â¯mU/mg) was raised in osteoblast stem cells (human mesenchymal, hMSC) than that in control (30â¯mU/mg). Concentrated development of mineralized nodule on the surface of hMSC was apparent following treatment with ST-Ag. Increased population of bone morphogenic protein-2 (23%) and osteocalcin cells (50%) on M2 macrophages were apparent following treatment with ST-Ag (0.25â¯mg/mL). Glucocorticoid-induced in vivo animal model studies of ST-Ag exhibited significant recovery of serum biochemical parameters along with serum estradiol and parathyroid hormone compared to disease control. Disease-induced groups treated with ST-Ag showed the disappearance of osteoporotic cavities in the trabecular bone. Following treatment with ST-Ag, serum calcium and phosphorus contents were significantly recovered.
Kajal Chakraborty, Shubhajit Dhara
1400 related Products with: Polygalacto-fucopyranose biopolymer structured nanoparticle conjugate attenuates glucocorticoid-induced osteoporosis: An in vivo study.100ug100ug100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug100ug100ug100ug100ug100ug Lyophilized
#34508721 2021/09/09 To Up
Silk sericin application increases bone morphogenic protein-2/4 expression via a toll-like receptor-mediated pathway.Bone morphogenic protein-2/4 (BMP-2/4) is an osteoinductive protein that accelerates osteogenesis when administered to bony defects. Sericin is produced by silkworms, and has a biological activity that differs depending on the degumming method used. Our results indicated that the high molecular weight fraction of silk sericin (MWÂ >Â 30Â kDa) obtained via sonication had a more abundant Î²-sheet structure than the low molecular weight fraction. Administration of the Î²-sheet structure silk sericin increased BMP-2/4 expression in a dose-dependent manner in RAW264.7 cells and human monocytes. This sericin increased the expression levels of toll-like receptor (TLR)-2, TLR-3, and TLR-4 in RAW264.7 cells. Application of a TLR-2 antibody or TLR pathway blocker decreased BMP-2/4 expression following sericin administration. In the animal model, the bone volume and BMP-2/4 expression were higher in rats treated with a sericin-incorporated gelatin sponge than in rats treated with a gelatin sponge alone or a sponge-incorporated with denatured sericin. In conclusion, sericin with a more abundant Î²-sheet structure increased BMP-2/4 expression and bone formation better than sericin with a less abundant Î²-sheet structure.
You-Young Jo, HaeYong Kweon, Dae-Won Kim, Kyunghwa Baek, Weon-Sik Chae, Yei-Jin Kang, Ji-Hyeon Oh, Seong-Gon Kim, Umberto Garagiola
1974 related Products with: Silk sericin application increases bone morphogenic protein-2/4 expression via a toll-like receptor-mediated pathway.100ul100ug 100ul100ug Lyophilized100ug Lyophilized100ug Lyophilized100 μg100ug Lyophilized100ug Lyophilized100ug Lyophilized100 μg100μg
#34489410 2021/09/06 To Up
BMP8 and activated brown adipose tissue in human newborns.The classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowledge about its physiological features at this stage of life is rather limited. This has been mainly due to the lack of appropriate investigation methods, ethically suitable for neonates. Here, we have applied non-invasive infrared thermography (IRT) to investigate neonatal BAT activity. Our data show that BAT temperature correlates with body temperature and that mild cold stimulus promotes BAT activation in newborns. Notably, a single short-term cold stimulus during the first day of life improves the body temperature adaption to a subsequent cold event. Finally, we identify that bone morphogenic protein 8B (BMP8B) is associated with the BAT thermogenic response in neonates. Overall, our data uncover key features of the setup of BAT thermogenesis in newborns.
Adela Urisarri, Ismael GonzÃ¡lez-GarcÃa, Ãnxela EstÃ©vez-Salguero, MarÃa P Pata, Edward Milbank, Noemi LÃ³pez, Natalia MandiÃ¡, Carmen Grijota-Martinez, Carlos A Salgado, RubÃ©n Nogueiras, Carlos DiÃ©guez, Francesc Villarroya, JosÃ©-Manuel FernÃ¡ndez-Real, MarÃa L Couce, Miguel LÃ³pez100 μg96T1 mg
#34483952 2021/08/16 To Up
Epithelial Bone Morphogenic Protein 2 and 4 Are Indispensable for Tooth Development.The and expressed in root mesenchyme were essential for the patterning and cellular differentiation of tooth root. The role of the epithelium-derived Bmps in tooth root development, however, had not been reported. In this study, we found that the double abrogation of and from mouse epithelium caused short root anomaly (SRA). The ; ; mice exhibited a persistent Hertwig's Epithelial Root Sheath (HERS) with the reduced cell death, and the down-regulated BMP-Smad4 and Erk signaling pathways. Moreover, the expression in the HERS, the Shh-Gli1 signaling, and expression in the root mesenchyme of the ; ; mice were also decreased, indicating a disrupted epithelium- mesenchyme interaction between HERS and root mesenchyme. Such disruption suppressed the and expression in the root mesenchyme, indicating an impairment on the differentiation and maturation of root odontoblasts. The impaired differentiation and maturation of root odontoblasts could be rescued partially by transgenic . Therefore, although required in a low dosage and with a functional redundancy, the epithelial Bmp2 and Bmp4 were indispensable for the HERS degeneration, as well as the differentiation and maturation of root mesenchyme.
Haibin Mu, Xin Liu, Shuoshuo Geng, Dian Su, Heran Chang, Lili Li, Han Jin, Xiumei Wang, Ying Li, Bin Zhang, Xiaohua Xie
2719 related Products with: Epithelial Bone Morphogenic Protein 2 and 4 Are Indispensable for Tooth Development.100μg100μg1 mg10ìg100μg200ul250ul200ug25ml 500100ug1 g
#34456283 2021/08/27 To Up
The Effects of Local Alendronate With or Without Recombinant Human Bone Morphogenetic Protein 2 on Dental Implant Stability and Marginal Bone Level: A Randomized Controlled Study.The aim of this study was to evaluate the effects of local application of bisphosphonate gel and recombinant human bone morphogenic protein 2 gel, on titanium dental implant stability and marginal bone level. Twenty-seven patients with upper and lower missing posterior tooth/teeth were included in the study with a total of 71 implants that were used for rehabilitation. The implants were randomly divided into 4 groups: 3 study groups and 1 control. Group1; local application of bisphosphonate gel, group 2; local application of recombinant human bone morphogenic protein 2 gel, group 3; local application of a mixed formula of both gels. The gel application was immediately preimplant insertion, group 4; implant insertion without application of any medication. Using resonance frequency analyzer, implant stability was measured 4 times; primary, 8 weeks (second stage surgery), 12 weeks, and at least 14 weeks post functional loading. The level of the marginal bone around each implant were assessed using cone beam computed tomography. Four implants failed. Generally, there was a similar pattern of changes in implant stability over the study period in all groups and the stability was dependent on the healing time with no significant difference between groups. There was no significant treatment effect regarding marginal bone level differences of study groups against control, although there were significant differences on palatal and mesiodistal surfaces among the study (test) groups.
Dhuha A Al-Assaf, Salwan Y Bede
1672 related Products with: The Effects of Local Alendronate With or Without Recombinant Human Bone Morphogenetic Protein 2 on Dental Implant Stability and Marginal Bone Level: A Randomized Controlled Study.10ìg5 ug10ìg5 ug200ul5 ug5 ug100ug100 μg100ug100ug100ug
#34448941 2021/08/27 To Up
Earliest migratory cephalic NC cells are potent to differentiate into dental ectomesenchyme of the two lungfish dentitions: tetrapodomorph ancestral condition of unconstrained capability of mesencephalic NC cells to form oral teeth.Reciprocal interactions between epithelial and neural crest-derived mesenchymal cells have been recognized in the evolutionary modulation of tetrapod odontodes, skeletal structures that include the teeth and tooth-integrated basal tissue. Using cell-tracking experiments, it has been demonstrated that mandibular neural crest cells, labelled during migration, extensively populate dental papillae of all tooth phenotypes of the lobe-finned fish, the Australian lungfish (Neoceratodus forsteri). Here, I report on an extension of this experimental study that earliest migrating NC cells are able to differentiate into odontogenic ectomesenchyme. Using vital dye cell-tracking to mark the mesencephalic neural crest prior to migration, I have found that the corresponding population of earliest migratory cells selectively relocated to dental papillae of both temporary and permanent dentitions of Neoceratodus. I noticed a gradient in distribution of the labelled cells which populated posterior teeth, pterygoid and prearticular (including associated trabecular and Meckelian cartilages; major relocation) much more densely than those in anterior marginal positions, temporary and vomeral permanent teeth (minor relocation). Contrary to mice and zebrafish, the odontogenic potency of mesencephalic neural crest cells is already programmed at the onset of the migration event in lungfish. This may imply that the morphogenic potential of mesencephalic neural crest cells to form teeth has been heterochronically shifted and constrained to later migratory populations of neural crest cells during the developmental evolution of derived tetrapods, or/and arrested in their expression in the oral development of some modern osteichthyans.
2078 related Products with: Earliest migratory cephalic NC cells are potent to differentiate into dental ectomesenchyme of the two lungfish dentitions: tetrapodomorph ancestral condition of unconstrained capability of mesencephalic NC cells to form oral teeth.100 extractions1.00 flask 5 G1 mg10 ug1 module
#34440650 2021/07/24 To Up
Macrophage as a Peripheral Pain Regulator.A neuroimmune crosstalk is involved in somatic and visceral pathological pain including inflammatory and neuropathic components. Apart from microglia essential for spinal and supraspinal pain processing, the interaction of bone marrow-derived infiltrating macrophages and/or tissue-resident macrophages with the primary afferent neurons regulates pain signals in the peripheral tissue. Recent studies have uncovered previously unknown characteristics of tissue-resident macrophages, such as their origins and association with regulation of pain signals. Peripheral nerve macrophages and intestinal resident macrophages, in addition to adult monocyte-derived infiltrating macrophages, secrete a variety of mediators, such as tumor necrosis factor-Î±, interleukin (IL)-1Î², IL-6, high mobility group box 1 and bone morphogenic protein 2 (BMP2), that regulate the excitability of the primary afferents. Neuron-derived mediators including neuropeptides, ATP and macrophage-colony stimulating factor regulate the activity or polarization of diverse macrophages. Thus, macrophages have multitasks in homeostatic conditions and participate in somatic and visceral pathological pain by interacting with neurons.
Risa Domoto, Fumiko Sekiguchi, Maho Tsubota, Atsufumi Kawabata1 kit100 assays10 Plates/Unit251 kit(96 Wells)500 assays96100μg1000 assays1 kit50 assays
#34435185 2021/06/11 To Up
BMP antagonists in tissue development and disease.Bone morphogenic proteins (BMPs) are important growth regulators in embryogenesis and postnatal homeostasis. Their tight regulation is crucial for successful embryonic development as well as tissue homeostasis in the adult organism. BMP inhibition by natural extracellular biologic antagonists represents the most intensively studied mechanistic concept of BMP growth factor regulation. It was shown to be critical for numerous developmental programs, including germ layer specification and spatiotemporal gradients required for the establishment of the dorsal-ventral axis and organ formation. The importance of BMP antagonists for extracellular matrix homeostasis is illustrated by the numerous human connective tissue disorders caused by their mutational inactivation. Here, we will focus on the known functional interactions targeting BMP antagonists to the ECM and discuss how these interactions influence BMP antagonist activity. Moreover, we will provide an overview about the current concepts and investigated molecular mechanisms modulating BMP inhibitor function in the context of development and disease.
Annkatrin Correns, Laura-Marie A Zimmermann, Clair Baldock, Gerhard Sengle
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#34422900 2021/06/28 To Up
Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway.Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing unremitting extracellular matrix deposition. Transforming growth factor-Î² (TGF-Î²) superfamily involves bone morphogenetic proteins (BMPs) and TGF-Î², and the balance between the activation of TGF-Î²-dependent SMADs (Smad2/3) and BMP-dependent SMADs (Smad1/5/8) is essential for fibrosis process. , initially identified as a TGF-Î²-inducible gene, encodes a small secreted glycoprotein belonging to a group of matricellular proteins, its role in lung fibrosis is not clear. Here, we identified Gremlin2 as a key regulator of fibroblast activation. Gremlin2 was highly expressed in the serum and lung tissues in IPF patients. Bleomycin-induced lung fibrosis model exhibited high expression of Gremlin2 in the bronchoalveolar lavage fluid (BALF) and lung tissue. Isolation of primary cells from bleomycin-induced fibrosis lung showed a good correlation of Gremlin2 and Acta2 (Î±-SMA) expressions. Overexpression of Gremlin2 in human fetal lung fibroblast 1 (HFL-1) cells increased its invasion and migration. Furthermore, Gremlin2 regulates fibrosis functions through mediating TGF-Î²/BMP signaling, in which Gremlin2 may activate TGF-Î² signaling and inhibit BMP signaling. Therefore, we provided and evidence to demonstrate that Gremlin2 may be a potential therapeutic target for the treatment of IPF.
Caijuan Huan, Wangting Xu, Yaru Liu, Kexin Ruan, Yueli Shi, Hongqiang Cheng, Xue Zhang, Yuehai Ke, Jianying Zhou
1627 related Products with: Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway.100μg100μg100μg0.5mg2ug100 100ug1mg100ug100 ug100 μg
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