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#32770811   2020/08/08 To Up

Using the Knowledge-to-Action framework to understand experiences of breastfeeding guideline implementation: a qualitative study.

to examine the perceptions and experiences of healthcare professionals and mothers in relation to the implementation of a breastfeeding clinical practice guideline (CPG).
Antonio Jesús Ramos-Morcillo, David Harillo-Acevedo, Maria Ruzafa-Martinez

1240 related Products with: Using the Knowledge-to-Action framework to understand experiences of breastfeeding guideline implementation: a qualitative study.

1 module1 mg100 ug1 ml1 module1 kit(96 Wells)

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#32770789   2020/08/08 To Up

Disulfide-linked allosteric modulators for multi-cycle kinetic control of DNA-based nanodevices.

Nature employs sulfur switches, i.e. redox-active disulfides, to kinetically control biological pathways in a highly efficient and reversible way. Inspired by this mechanism we describe here a DNA-based synthetic nanodevice that acts as a sulfur switch and can be temporally controlled though redox regulation. To do this we rationally designed disulfide DNA strands (modulators) that hybridize to a ligand-binding DNA nanodevice and act as redox-active allosteric regulators inducing the nanodevice to release or load its ligand. Upon reduction, the allosteric modulator spontaneously de-hybridizes from the nanodevice and, as a result, its effect is transient. The system is reversible and has an unprecedented high tolerance to waste products and displays transient behavior for over 40 cycles without significant loss of efficiency. Kinetic control of DNA-based ligand-binding nanodevices through purely chemical reactions paves the way for temporal regulation of more complex chemical pathways.
Erica Del Grosso, Irene Ponzo, Giulio Ragazzon, Leonard J Prins, Francesco Ricci

1347 related Products with: Disulfide-linked allosteric modulators for multi-cycle kinetic control of DNA-based nanodevices.

2 Pieces/BoxTwo 96-Well Microplate Ki 5 G100 μg100ug Lyophilized1

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#32770774   2020/08/08 To Up

Intersexual differences in density-dependent dispersal and their evolutionary drivers.

Dispersal is well recognised as a major driver of evolutionary processes in local populations. Nevertheless, dispersal abilities should also be perceived as a life history trait, being subject to evolutionary changes in response to various drivers. Empirical studies investigating these drivers rarely consider that they may influence male and female dispersal differently. The purpose of our study was to document intersexual differences in density-dependent emigration from local habitat patches. As a model system we used a metapopulation of Maculinea (Phengaris) teleius butterfly, in which densities of both sexes vary greatly throughout the flying season. Following intensive mark-release-recapture surveys, the parameters and predictors of dispersal were analysed with the Virtual Migration model and the multi-state recapture model. The emigration rate in males was substantially higher in the early season, especially at smaller habitat patches. With the proportion of females increasing with the season progression, males became reluctant to emigrate from their natal patches. In turn, higher female emigration in the later part of the season was most strongly associated with female tendency to reduce intraspecific competition experienced by their offspring. Our findings provide evidence for the impact of reproductive strategies on dispersal in both sexes. The difference in reproductive strategies of males and females explain sex-biased dispersal in different parts of the season, which carries important implications for metapopulation functioning.
Elisa Plazio, Tomasz Margol, Piotr Nowicki

2019 related Products with: Intersexual differences in density-dependent dispersal and their evolutionary drivers.

1 mg

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#32770720   2020/08/08 To Up

Model Informed Dosing Regimen and Phase I Results of the Anti-PD-1 Antibody Budigalimab (ABBV-181).

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John Powderly, Alexander Spira, Shunsuke Kondo, Toshihiko Doi, Jason J Luke, Drew Rasco, Bo Gao, Minna Tanner, Philippe A Cassier, Anas Gazzah, Antoine Italiano, Diego Tosi, Daniel E Afar, Apurvasena Parikh, Benjamin Engelhardt, Stefan Englert, Stacie L Lambert, Sreeneeranj Kasichayanula, Sven Mensing, Rajeev Menon, Gregory Vosganian, Anthony Tolcher

1960 related Products with: Model Informed Dosing Regimen and Phase I Results of the Anti-PD-1 Antibody Budigalimab (ABBV-181).

100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#32770598   2020/08/08 To Up

Neutrophil/lymphocyte ratio predicts in-hospital complications in Takotsubo syndrome. Results from a prospective multi-center registry.

Several hematological indices including subtypes of leukocytes populations have been associated with cardiovascular outcome. Takotsubo syndrome (TTS) is a form of acute heart failure syndrome featured by several in-hospital complications (IHCs).
Francesco Santoro, Francesca Guastafierro, Tecla Zimotti, Adriana Mallardi, Alessandra Leopizzi, Michele Cannone, Matteo Di Biase, Natale Daniele Brunetti

1929 related Products with: Neutrophil/lymphocyte ratio predicts in-hospital complications in Takotsubo syndrome. Results from a prospective multi-center registry.

200 100 μg100 assays200

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#32770328   2020/08/07 To Up

Study on the Molecular Mechanisms Against Human Breast Cancer from Insight of Elemental Distribution in Tissue Based on Laser-Induced Breakdown Spectroscopy (LIBS).

The role of elements in physiological and pathological metabolic processes remains an unmet challenge in biomedical research and clinical applications. Herein, a visual elemental imaging of tumor tissue platform of a laser-induced breakdown spectroscopy (LIBS) was developed to initially understand anti-tumor mechanisms. The relative enrichment degree and heterogeneous spatial distributions of four elements (calcium, sodium, copper, and magnesium) of tumor tissue from different treated could be easy to visualize. In particular, significant differences in the distribution of elements were observed in tumor tissue from drug-loading complex (hydrogel/DOX) treatment group. Correspondingly, the analysis of histopathological morphology showed that the morphology and density of tumor tissue in hydrogel/DOX treatment group changed obviously by using hematoxylin and eosin (H&E) staining assay, meanwhile cleaved caspase-3 (caspase-3) and tumor necrosis factor (TNF-α) were expressed at high levels tumors tissue in hydrogel/DOX treatment group by using immunohistochemical (IHC) staining. These results would endow different biological elements with incredible potential to study the mechanisms of anti-tumor, which opens new direction and perspectives for the multi-elemental mapping of biological tissues, especially in clinic application. The integrated platform of DNA nanohydrogel drug carrier-based anti-tumor treatment combined with LIBS elemental imaging, via tail intravenous injection of saline, hydrogel, DOX, and hydrogel/DOX in breast cancer xenograft tumor mice. (A) The workflow is outlined starting from nanohydrogel drug carrier-based anti-tumor treatment. (B) Schematic diagram of LIBS imaging platform.
Hongyan Wei, Zhao Zhao, Qingyu Lin, Yixiang Duan

2271 related Products with: Study on the Molecular Mechanisms Against Human Breast Cancer from Insight of Elemental Distribution in Tissue Based on Laser-Induced Breakdown Spectroscopy (LIBS).



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#32770321   2020/08/07 To Up

Towards the Automatic Localization of the Irritative Zone Through Magnetic Source Imaging.

The present work aims at validating a Bayesian multi-dipole modeling algorithm (SESAME) in the clinical scenario consisting of localizing the generators of single interictal epileptiform discharges from resting state magnetoencephalographic recordings. We use the results of Equivalent Current Dipole fitting, performed by an expert user, as a benchmark, and compare the results of SESAME with those of two widely used source localization methods, RAP-MUSIC and wMNE. In addition, we investigate the relation between post-surgical outcome and concordance of the surgical plan with the cerebral lobes singled out by the methods. Unlike dipole fitting, the tested algorithms do not rely on any subjective channel selection and thus contribute towards making source localization more unbiased and automatic. We show that the two dipolar methods, SESAME and RAP-MUSIC, generally agree with dipole fitting in terms of identified cerebral lobes and that the results of the former are closer to the fitted equivalent current dipoles than those of the latter. In addition, for all the tested methods and particularly for SESAME, concordance with surgical plan is a good predictor of seizure freedom while discordance is not a good predictor of poor post-surgical outcome. The results suggest that the dipolar methods, especially SESAME, represent a reliable and more objective alternative to manual dipole fitting for clinical applications in the field of epilepsy surgery.
Gianvittorio Luria, Dunja Duran, Elisa Visani, Davide Rossi Sebastiano, Alberto Sorrentino, Laura Tassi, Alice Granvillano, Silvana Franceschetti, Ferruccio Panzica

2139 related Products with: Towards the Automatic Localization of the Irritative Zone Through Magnetic Source Imaging.

100ul2100 U1100.00 ul200 units500IU

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