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#33096583   2020/10/23 To Up

Elucidating the Impact of Childhood, Adulthood, and Cumulative Lifetime Trauma Exposure on Psychiatric Symptoms in Early Schizophrenia Spectrum Disorders.

Cumulative lifetime trauma has a profound impact on the development of schizophrenia spectrum disorders. However, few studies have determined participants' most distressing (i.e., "worst") life event in childhood or adulthood or examined whether this event contributes to poorer clinical outcomes. The present study aimed to (a) determine the associations between the worst life event and demographic/clinical variables and (b) examine the associations between the worst life event and psychiatric symptoms (i.e., positive, negative, depressive, and anxiety symptoms). Participants (N = 150) were outpatients newly diagnosed with schizophrenia spectrum disorders who were assessed for lifetime trauma exposure, positive and negative symptoms of schizophrenia, and symptoms of depression and anxiety. Multinomial logistic regression analysis was conducted to examine the associations between demographic and clinical variables and worst life events (none, childhood, or adulthood). Multiple linear regression analyses were performed to examine the associations between worst life events and psychiatric symptoms. More participants reported that their worst life event occurred during adulthood (31.1%) than childhood (21.3%). Adulthood trauma was associated with male gender, older age, non-Chinese ethnicity, and psychiatric comorbidities; childhood trauma was associated with a family history of depression/anxiety. Adulthood trauma was significantly associated with more severe positive psychotic symptoms, f = 0.19, whereas childhood and adulthood trauma exposure were both significantly associated with more severe depressive and anxiety symptoms, f s = 0.19 and 0.25, respectively. Our findings underscore the importance of conducting assessments for worst life events and the associated risk factors to develop meaningful formulations and appropriate trauma-focused treatment plans.
Jianlin Liu, Rathi Mahendran, Siow Ann Chong, Mythily Subramaniam

2096 related Products with: Elucidating the Impact of Childhood, Adulthood, and Cumulative Lifetime Trauma Exposure on Psychiatric Symptoms in Early Schizophrenia Spectrum Disorders.

96T

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#33096578   2020/10/23 To Up

Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers.

Skeletal muscle is a major site for whole-body glucose disposal, and determination of skeletal muscle glucose uptake is an important metabolic measurement, particularly in research focussed on interventions that impact muscle insulin sensitivity. Calculating arterial-venous difference in blood glucose can be used as an indirect measure for assessing glucose uptake. However, the possibility of multiple tissues contributing to the composition of venous blood, and the differential in glucose uptake kinetics between tissue types, suggests that sampling from different vein sites could influence the estimation of glucose uptake. This study aimed to determine the impact of venous cannula position on calculated forearm glucose uptake following an oral glucose challenge in resting and post-exercise states.
Cécile Bétry, Aline V Nixon, Paul L Greenhaff, Elizabeth J Simpson

2987 related Products with: Antecubital Vein Cannula Position Impacts Assessment of Forearm Glucose Uptake During an Oral Glucose Challenge in Healthy Volunteers.

2 Pieces/Box2 ml 1KG200ul 1KG1 ml 1 G200ul96 assays 100 G200ul

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#33096560   2020/10/22 To Up

Tracking Preschoolers' Lifestyle Behaviors and Testing Maternal Sociodemographics and BMI in Predicting Child Obesity Risk.

Longitudinal data investigating tracking of children's lifestyle behaviors and predictors of childhood obesity are limited.
Kanita Kunaratnam, Mark Halaki, Li M Wen, Louise A Baur, Victoria M Flood

1280 related Products with: Tracking Preschoolers' Lifestyle Behaviors and Testing Maternal Sociodemographics and BMI in Predicting Child Obesity Risk.

10 mg10 mg100 mg100ug1,000 tests200ug1 mg1000 tests100ug1000 TESTS/0.65ml100ug

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#33096557   2020/10/23 To Up

An Expression of Concern from The Journal of Nutrition's Editorial Office about: High-dose ω-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial.


Ebrahim Kouchaki, Maryam Afarini, Javad Abolhassani, Naghmeh Mirhosseini, Fereshteh Bahmani, Seyed Ali Masoud, Zatollah Asemi

2784 related Products with: An Expression of Concern from The Journal of Nutrition's Editorial Office about: High-dose ω-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial.



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#33096556   2020/10/23 To Up

Associations of human milk oligosaccharides and bioactive proteins with infant growth and development among Malawian mother-infant dyads.

Human milk oligosaccharides (HMOs) and bioactive breast milk proteins have many beneficial properties. Information is sparse regarding associations between these milk constituents and infant growth and development in lower-income countries.
Josh M Jorgensen, Rebecca Young, Per Ashorn, Ulla Ashorn, David Chaima, Jasmine C C Davis, Elisha Goonatilleke, Chiza Kumwenda, Carlito B Lebrilla, Kenneth Maleta, Elizabeth L Prado, John Sadalaki, Sarah M Totten, Lauren D Wu, Angela M Zivkovic, Kathryn G Dewey

2313 related Products with: Associations of human milk oligosaccharides and bioactive proteins with infant growth and development among Malawian mother-infant dyads.

100ul200 1000 0.1 mg1 ml105.00 ug50510010

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#33096554   2020/10/22 To Up

A Whole-Diet Approach Affects Not Only Fasting but Also Postprandial Cardiometabolic Risk Markers in Overweight and Obese Adults: A Randomized Controlled Trial.

Current dietary recommendations for cardiovascular disease (CVD) prevention focus more on dietary patterns than on single nutrients. However, randomized controlled trials using whole-diet approaches to study effects on both fasting and postprandial CVD risk markers are limited.
Eva Fechner, Lena Bilet, Harry P F Peters, Patrick Schrauwen, Ronald P Mensink

2983 related Products with: A Whole-Diet Approach Affects Not Only Fasting but Also Postprandial Cardiometabolic Risk Markers in Overweight and Obese Adults: A Randomized Controlled Trial.

100 μg 25 G 100 G100 μg25 mg25 mg100 μg1 mg4 Membranes/Box100 μg

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#33096548   2020/10/24 To Up

Predicting enhancer-promoter interactions by deep learning and matching heuristic.

Enhancer-promoter interactions (EPIs) play an important role in transcriptional regulation. Recently, machine learning-based methods have been widely used in the genome-scale identification of EPIs due to their promising predictive performance. In this paper, we propose a novel method, termed EPI-DLMH, for predicting EPIs with the use of DNA sequences only. EPI-DLMH consists of three major steps. First, a two-layer convolutional neural network is used to learn local features, and an bidirectional gated recurrent unit network is used to capture long-range dependencies on the sequences of promoters and enhancers. Second, an attention mechanism is used for focusing on relatively important features. Finally, a matching heuristic mechanism is introduced for the exploration of the interaction between enhancers and promoters. We use benchmark datasets in evaluating and comparing the proposed method with existing methods. Comparative results show that our model is superior to currently existing models in multiple cell lines. Specifically, we found that the matching heuristic mechanism introduced into the proposed model mainly contributes to the improvement of performance in terms of overall accuracy. Additionally, compared with existing models, our model is more efficient with regard to computational speed.
Xiaoping Min, Congmin Ye, Xiangrong Liu, Xiangxiang Zeng

2955 related Products with: Predicting enhancer-promoter interactions by deep learning and matching heuristic.

50 ug 1 mg 30 ml 1,000 tests200ug100ug5mg25 mg100 ul

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#33096543   2020/10/23 To Up

Klotho, PTSD, and advanced epigenetic age in cortical tissue.

This study examined the klotho (KL) longevity gene polymorphism rs9315202 and psychopathology, including posttraumatic stress disorder (PTSD), depression, and alcohol-use disorders, in association with advanced epigenetic age in three postmortem cortical tissue regions: dorsolateral and ventromedial prefrontal cortices and motor cortex. Using data from the VA National PTSD Brain Bank (n = 117), we found that rs9315202 interacted with PTSD to predict advanced epigenetic age in motor cortex among the subset of relatively older (>=45 years), white non-Hispanic decedents (corrected p = 0.014, n = 42). An evaluation of 211 additional common KL variants revealed that only variants in linkage disequilibrium with rs9315202 showed similarly high levels of significance. Alcohol abuse was nominally associated with advanced epigenetic age in motor cortex (p = 0.039, n = 114). The rs9315202 SNP interacted with PTSD to predict decreased KL expression via DNAm age residuals in motor cortex among older white non-Hispanics decedents (indirect β = -0.198, p = 0.027). Finally, in dual-luciferase enhancer reporter system experiments, we found that inserting the minor allele of rs9315202 in a human kidney cell line HK-2 genomic DNA resulted in a change in KL transcriptional activities, likely operating via long noncoding RNA in this region. This was the first study to examine multiple forms of psychopathology in association with advanced DNA methylation age across several brain regions, to extend work concerning the association between rs9315202 and advanced epigenetic to brain tissue, and to identify the effects of rs9315202 on KL gene expression. KL augmentation holds promise as a therapeutic intervention to slow the pace of cellular aging, disease onset, and neuropathology, particularly in older, stressed populations.
Erika J Wolf, Ci-Di Chen, Xiang Zhao, Zhenwei Zhou, Filomene G Morrison, Nikolaos P Daskalakis, Annjanette Stone, Steven Schichman, Jaclyn Garza Grenier, Dana Fein-Schaffer, Bertrand R Huber, , Carmela R Abraham, Mark W Miller, Mark W Logue

2786 related Products with: Klotho, PTSD, and advanced epigenetic age in cortical tissue.

50 UG

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#33096528   2020/10/23 To Up

Traumatic axonal injury on clinical MRI: association with the Glasgow Coma Scale score at scene of injury or at admission and prolonged posttraumatic amnesia.

The aim in this study was to investigate if MRI findings of traumatic axonal injury (TAI) after traumatic brain injury (TBI) are related to the admission Glasgow Coma Scale (GCS) score and prolonged duration of posttraumatic amnesia (PTA).
Hans Kristian Moe, Turid Follestad, Nada Andelic, Asta Kristine Håberg, Anne-Mari Holte Flusund, Kjell Arne Kvistad, Elin Hildrum Saksvoll, Øystein Olsen, Sebastian Abel-Grüner, Oddrun Sandrød, Toril Skandsen, Anne Vik, Kent Gøran Moen

1893 related Products with: Traumatic axonal injury on clinical MRI: association with the Glasgow Coma Scale score at scene of injury or at admission and prolonged posttraumatic amnesia.

10reactions 100 ul100ul50 ul5 mg100ul0.5 mg100ul440 μg100ul100ug Lyophilized

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