Only in Titles

Search results for: Myoglobin

paperclip

#34313417   2021/07/27 To Up

Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite.

Interdisciplinary research at the interface of chemistry, physiology, and biomedicine have uncovered pivotal roles of nitric oxide (NO) as a signaling molecule that regulates vascular tone, platelet aggregation, and other pathways relevant to human health and disease. Heme is central to physiological NO signaling, serving as the active site for canonical NO biosynthesis in nitric oxide synthase (NOS) enzymes and as the highly selective NO binding site in the soluble guanylyl cyclase receptor. Outside of the primary NOS-dependent biosynthetic pathway, other hemoproteins, including hemoglobin and myoglobin, generate NO via the reduction of nitrite. This auxiliary hemoprotein reaction unlocks a "second axis" of NO signaling in which nitrite serves as a stable NO reservoir. In this Forum Article, we highlight these NO-dependent physiological pathways and examine complex chemical and biochemical reactions that govern NO and nitrite signaling in vivo. We focus on hemoprotein-dependent reaction pathways that generate and consume NO in the presence of nitrite and consider intermediate nitrogen oxides, including NO, NO, and -nitrosothiols, that may facilitate nitrite-based signaling in blood vessels and tissues. We also discuss emergent therapeutic strategies that leverage our understanding of these key reaction pathways to target NO signaling and treat a wide range of diseases.
Matthew R Dent, Anthony W DeMartino, Jesús Tejero, Mark T Gladwin

2817 related Products with: Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite.

100 100 200 assays100Tests1002 x 96 assays11002 x 96 well plate100 96tests10 mg

Related Pathways

paperclip

#34313253   2021/07/26 To Up

The Role of Alpha-1-Acid Glycoprotein in the Diagnosis and Treatment of Crush Syndrome-Induced Acute Kidney Injury.

Crush syndrome (CS) is the most common cause of deaths following earthquakes and other disasters. The pathogenesis of CS has yet to be fully elucidated. Thus, clinical choice of ideal drug treatments for CS remains deficient.
Qi Lv, Manman Long, Xin Wang, Jie Shi, Pengtao Wang, Xiaoqin Guo, Jie Song, Adam C Midgley, Haojun Fan, Shike Hou

2757 related Products with: The Role of Alpha-1-Acid Glycoprotein in the Diagnosis and Treatment of Crush Syndrome-Induced Acute Kidney Injury.

1100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized5 ml100ug Lyophilized

Related Pathways

paperclip

#34307986   2021/05/12 To Up

Vancomycin-Associated Tubular Casts and Vancomycin Nephrotoxicity.

Vancomycin nephrotoxicity is frequent and may be due to drug-induced acute tubular necrosis (ATN) or tubulointerstitial nephritis (TIN). Vancomycin-associated tubular cast (VTC) was recently described and may represent a novel cause of vancomycin nephrotoxicity. However, much is still unknown about VTC.
Ngoentra Tantranont, Yosu Luque, Mary Hsiao, Claire Haute, Lillian Gaber, Roberto Barrios, Horacio E Adrogue, Aïssata Niasse, Luan D Truong

1954 related Products with: Vancomycin-Associated Tubular Casts and Vancomycin Nephrotoxicity.

1 ml0.5 ml0.2 mL 1 G100ug200ul25 mg2.5 mg1000 tests10 mg100ug10 mg

Related Pathways

paperclip

#34299527   2021/07/13 To Up

Label-Free Electrochemical Sensor Based on Manganese Doped Titanium Dioxide Nanoparticles for Myoglobin Detection: Biomarker for Acute Myocardial Infarction.

A label free electrochemical sensor based on pure titanium oxide and manganese (Mn)-doped titanium oxide (TiO) nanoparticles are fabricated and characterized for the sensitive detection of myoglobin (Mb) levels to analyze the cardiovascular infarction. Pristine and Mn-doped TiO nanoparticles were synthesized via the sol-gel method and characterized in order to understand their structure, morphologies, composition and optical properties. The structural properties revealed that the pure- and doped-TiO nanoparticles possess different TiO planes. FTIR studies confirm the formation of metal oxide nanoparticles by exhibiting a well-defined peak in the range of 600-650 cm. The values of the optical band gap, estimated from UV-Vis spectroscopy, are decreased for the Mn-doped TiO nanoparticles. UV-Vis spectra in the presence of myoglobin (Mb) indicated interaction between the TiO nanoparticles and myoglobin. The SPE electrodes were then fabricated by printing powder film over the working electrode and tested for label-free electrochemical detection of myoglobin (Mb) in the concentration range of 0-15 nM Mb. The fabricated electrochemical sensor exhibited a high sensitivity of 100.40 μA-cmnM with a lowest detection limit of 0.013 nM (0.22 ng/mL) and a response time of ≤10 ms for sample S3. An interference study with cyt-c and Human Serum Albumin (HSA) of the sensors show the selective response towards Mb in 1:1 mixture.
Adel Al Fatease, Mazharul Haque, Ahmad Umar, Shafeeque G Ansari, Yahya Alhamhoom, Abdullatif Bin Muhsinah, Mater H Mahnashi, Wenjuan Guo, Zubaida A Ansari

2635 related Products with: Label-Free Electrochemical Sensor Based on Manganese Doped Titanium Dioxide Nanoparticles for Myoglobin Detection: Biomarker for Acute Myocardial Infarction.

2x96 well plate5L 500 G5 g30 Samples250 ml 100ul96T100μg100 mg

Related Pathways

paperclip

#34291915   2021/07/22 To Up

Size-Selective VAILase Proteolysis Provides Dynamic Insights into Protein Structures.

Monitoring the dynamic alterations of protein structures within an aqueous solution remains enormously challenging. In this study, we describe a size-selective VAILase proteolysis (SVP)-mass spectrometry (MS) strategy to probe the protein structure changes without strict control of the proteolysis kinetics. The unique conformation selectivity of SVP depends on the uniform nano-sized entrance pores of the VAILase hexameric cage as well as the six inherent molecular rulers in the VAILase-substrate recognition and cleavage. The dynamic insights into subtle conformation alterations of both myoglobin unfolding transition and Aurora kinase A-inhibitor binding are successfully captured using the SVP strategy, which matches well with the results in the molecular dynamics simulation. Our work provides a new paradigm of size-selective native proteolysis for exploring the aqueous protein structure-function relationships.
Binwen Sun, Ji Lv, Jin Chen, Zheyi Liu, Ye Zhou, Lin Liu, Yan Jin, Fangjun Wang

1354 related Products with: Size-Selective VAILase Proteolysis Provides Dynamic Insights into Protein Structures.

0,2 ml500 ul 500 ul 50mg1mg1 Set501 Set20.1ml (1mg/ml)10001 Set

Related Pathways

paperclip

#34284270   2021/06/24 To Up

Naringin induces skeletal muscle fiber type transformation via AMPK/PGC-1α signaling pathway in mice and C2C12 myotubes.

A large number of studies have shown that polyphenols can regulate skeletal muscle fiber type transformation through AMPK signal. However, the effects and mechanism of naringin (a natural polyphenol) on muscle fiber type transformation still remains unclear. Thus, we hypothesized that naringin would induce the transformation of skeletal muscle fibers from type II to type I by AMPK signaling. C2C12 myotubes and BALB/c mice models were used to test this hypothesis. We found that naringin significantly increased the protein expression of slow myosin heavy chain (MyHC), myoglobin and troponin I type I slow skeletal (Troponin I-SS) and the activities of succinate dehydrogenase (SDH) and malate dehydrogenase (MDH), and significantly decreased fast MyHC protein expression and lactate dehydrogenase (LDH) activity, accompanied by the activation of AMPK and the activity of peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) in mice and C2C12 myotubes. Further inhibition of AMPK activity by compound C showed that the above effects were significantly inhibited in C2C12 myotubes. In conclusion, naringin promotes the transformation of skeletal muscle fibers from type II to type I through AMPK/PGC-1α signaling pathway, which not only enriches the nutritional and physiological functions of naringin, but also provides a theoretical basis for the regulation of muscle fiber type transformation by nutritional approaches.
Yonghong Xue, Zhiqing Huang, Xiaoling Chen, Gang Jia, Hua Zhao, Guangmang Liu

2140 related Products with: Naringin induces skeletal muscle fiber type transformation via AMPK/PGC-1α signaling pathway in mice and C2C12 myotubes.

2 Pieces/Box2 Pieces/Box11 inhibitors2 Pieces/BoxInhibitors2 Pieces/Box2 Pieces/Box2 Pieces/Box8 inhibitors2 Pieces/Box14 inhibitors2 Pieces/Box

Related Pathways

paperclip

#34279832   // To Up

SARS-CoV-2 Infection and the Kidneys: An Evolving Picture.

Since December 2019, a novel coronavirus known as Severe Acute Respiratory Virus 2 (SARS-CoV-2) has caused an outbreak of a respiratory illness worldwide. Even though SARS-CoV-2 primarily affects the respiratory system, other organs such as the heart and kidneys are implicated. The pathophysiology of Acute Kidney Injury (AKI) in coronavirus 2019 (COVID-19) patients is not clearly defined. Direct kidney injury results from virus entry through angiotensin-converting enzyme-2 (ACE2) receptors which are highly expressed by the podocytes and proximal convoluted tubules, as suggested by "viral-like" particles on electron microscopy. However, the link between the presence of viral particles in kidney tissue and kidney injury has not been fully explained. Furthermore, it is also hypothesized that collapsing focal segmental glomerulosclerosis (FSGS), myoglobin toxicity, sepsis-linked, and glomeruli fibrin thrombi is part of the mechanism for AKI. Reported cases link FSGS and high-risk apolipoprotein 1 (APOL1) alleles in patients of African ancestry. Typically, these patients present with AKI and nephrotic-range proteinuria. The rate of AKI in hospitalized patients is high and associated with a higher mortality rate in older patients with comorbidities. Even higher mortality is now being reported in patients with chronic kidney disease and kidney transplant recipients due to immune system dysfunction. Herein, we review the current literature on kidney disease and pathogenesis in COVID-19 patients.
Jaya A George, Siyabonga Khoza

2925 related Products with: SARS-CoV-2 Infection and the Kidneys: An Evolving Picture.

200ug200ul10 mg200ul200ug200ul200ul200ul200ul200ul100 mg100ug Lyophilized

Related Pathways

paperclip

#34266452   2021/07/15 To Up

A randomized open-label trial to evaluate the efficacy and safety of triple therapy with aspirin, atorvastatin, and nicorandil in hospitalised patients with SARS Cov-2 infection: A structured summary of a study protocol for a randomized controlled trial.

The pathophysiology of SARS-Cov-2 is characterized by inflammation, immune dysregulation, coagulopathy, and endothelial dysfunction. No single therapeutic agent can target all these pathophysiologic substrates. Moreover, the current therapies are not fully effective in reducing mortality in moderate and severe disease. Hence, we aim to evaluate the combination of drugs (aspirin, atorvastatin, and nicorandil) with anti-inflammatory, antithrombotic, immunomodulatory, and vasodilator properties as adjuvant therapy in covid- 19.
Ambudhar Sharma, Charu Sharma, Sujeet Raina, Balraj Singh, Devendra Singh Dadhwal, Vinay Dogra, Swatantra Gupta, Shyam Bhandari, Vivek Sood

1998 related Products with: A randomized open-label trial to evaluate the efficacy and safety of triple therapy with aspirin, atorvastatin, and nicorandil in hospitalised patients with SARS Cov-2 infection: A structured summary of a study protocol for a randomized controlled trial.

200ug200ug200ul10 mg200ul

Related Pathways

paperclip

#34263442   2021/07/14 To Up

Effects of Danhong Injection () on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study.

To evaluate the effect of Danhong Injection (, DH) on the index of microcirculatory resistance (IMR) and myocardial injury in patients with unstable angina undergoing elective percutaneous coronary intervention (PCI).
Wen-Long Xing, Yong-Jian Wu, Hong-Xu Liu, Qing-Rong Liu, Qi Zhou, Ai-Yong Li, Zhu-Hua Zhang, Xuan Li

1614 related Products with: Effects of Danhong Injection () on Peri-Procedural Myocardial Injury and Microcirculatory Resistance in Patients with Unstable Angina Undergoing Elective Percutaneous Coronary Intervention: A Pilot Randomized Study.

100ug10 mg96T100ug100 μg100ug Lyophilized100 μg100 μg100 μg100ug Lyophilized100ug50 ug

Related Pathways

paperclip

#34262464   2021/06/28 To Up

Therapeutic Impact of Costus () Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice.

Breast cancer remains the most common cause of cancer deaths among women globally. Ehrlich solid tumor (EST) is a transplantable tumor model for simulating breast cancer. This study aims to describe the protective role of costus () root against EST-induced cardiac toxicity. Forty female mice were randomly and equally divided into four groups (G1, control group; G2, costus group; G3, EST group; G4, EST + costus). The results showed that compared to the control, EST induced a significant increase in lactate dehydrogenase, creatine kinase, creatine kinase myoglobin, aspartate aminotransferase, and alkaline phosphatase activities; in potassium, chloride ion, cholesterol, triglyceride, and low density lipoprotein levels; in DNA damage and cardiac injury; and in p53 and vascular endothelial growth factor expression. Conversely, EST induced a significant decrease in sodium ion and high density lipoprotein levels and Ki67 expression compared to the control. Treatment of EST with costus improved cardiac toxicity, lipid profiles, electrolytes, and apoptosis, and protected against EST. This indicates the potential benefits of costus as an adjuvant in the prevention and treatment of cardiac toxicity.
Rehab M Elgharabawy, Ibrahim El Tantawy El Sayed, Nada Abd-Allah Rezk, Ehab Tousson

1459 related Products with: Therapeutic Impact of Costus () Against Ehrlich Solid Tumor-Induced Cardiac Toxicity and DNA Damage in Female Mice.

96 assays 100ul5 mg5 mg

Related Pathways