Search results for: N-Acetyl-S-(2,5-dimethylbenzene)-L-cysteine-d3 C13H14D3NO3S CAS:
#38500822 2024/03/01 To Up
High-frequency neural activity dysregulation is associated with sleep and psychiatric disorders in BMAL1-deficient animal models.
Sleep disturbance led by BMAL1-deficiency has been recognized both in rodent and non-human primate models. Yet it remained unclear how their diurnal brain oscillations were affected upon BMAL1 ablation and what caused the discrepancy in the quantity of sleep between the two species. Here, we investigated diurnal electroencephalographs of BMAL1-deficient mice and cynomolgus monkeys at young adult age and uncovered a shared defect of dysregulated high-frequency oscillations by Kullback-Leibler divergence analysis. We found beta and gamma oscillations were significantly disturbed in a day versus night manner in BMAL1-deficient monkeys, while in mice the beta band difference was less evident. Notably, the dysregulation of beta oscillations was particularly associated with psychiatric behaviors in BMAL1-deficient monkeys, including the occurrence of self-injuring and delusion-like actions. As such psychiatric phenotypes were challenging to uncover in rodent models, our results offered a unique method to study the correlation between circadian clock dysregulation and psychiatric disorders.Yu Sun, Mingzhu Zhong, Niannian Xu, Xueting Zhang, Huanhuan Sun, Yan Wang, Yong Lu, Yanhong Nie, Qing Li, Qiang Sun, Jian Jiang, Yun-Chi Tang, Hung-Chun Chang
2747 related Products with: High-frequency neural activity dysregulation is associated with sleep and psychiatric disorders in BMAL1-deficient animal models.
400Tests900 tests0.1ml (1mg/ml)100ug Lyophilized100ug Lyophilized96 assays 100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug LyophilizedRelated Pathways
#38500582 2024/03/04 To Up
Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in TB-31.
Abscisic acid (ABA) is a conserved and important "sesquiterpene signaling molecule" widely distributed in different organisms with unique biological functions. ABA coordinates reciprocity and competition between microorganisms and their hosts. In addition, ABA also regulates immune and stress responses in plants and animals. Therefore, ABA has a wide range of applications in agriculture, medicine and related fields. The plant pathogenic ascomycete has been extensively studied as a model strain for ABA production. Nevertheless, there is a relative dearth of research regarding the regulatory mechanism governing ABA biosynthesis in . Here, we discovered that H3K9 methyltransferase BcDIM5 is physically associated with the H3K14 deacetylase BcHda1. Deletion of and in the high ABA-producing TB-31 led to severe impairment of ABA synthesis. The combined analysis of RNA-seq and ChIP-seq has revealed that the absence of BcDIM5 and BcHda1 has resulted in significant global deficiencies in the normal distribution and level of H3K9me3 modification. In addition, we found that the cause of the decreased ABA production in the Δ and Δ mutants was due to cluster gene repression caused by the emergence of hyper-H3K9me3 in the ABA gene cluster. We concluded that the ABA gene cluster is co-regulated by BcDIM5 and BcHda1, which are essential for the normal distribution of the TB-31 ABA gene cluster H3K9me3. This work expands our understanding of the complex regulatory network of ABA biosynthesis and provides a theoretical basis for genetic improvement of high-yielding ABA strains.Zhao Wei, Dan Shu, Xiaonan Hou, Tianfu Li, Zhemin Li, Di Luo, Jie Yang, Hong Tan
1268 related Products with: Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in TB-31.
48 assays 96 assays 48 assays 96 assays 48 assays 96 assays 5mg5mg50 ug10mg100 µg10mgRelated Pathways
#38500015 // To Up
The dual roles of dissimilatory iron reduction in the carbon cycle: The "iron mesh" effect can increase inorganic carbon sequestration.
Dissimilatory iron reduction (DIR) can drive the release of organic carbon (OC) as carbon dioxide (CO ) by mediating electron transfer between organic compounds and microbes. However, DIR is also crucial for carbon sequestration, which can affect inorganic-carbon redistribution via iron abiotic-phase transformation. The formation conditions of modern carbonate-bearing iron minerals (IC ) and their potential as a CO sink are still unclear. A natural environment with modern IC , such as karst lake sediment, could be a good analog to explore the regulation of microbial iron reduction and sequential mineral formation. We find that high porosity is conducive to electron transport and dissimilatory iron-reducing bacteria activity, which can increase the iron reduction rate. The iron-rich environment with high calcium and OC can form a large sediment pore structure to support rapid DIR, which is conducive to the formation and growth of IC . Our results further demonstrate that the minimum DIR threshold suitable for IC formation is 6.65 μmol g dw day . DIR is the dominant pathway (average 66.93%) of organic anaerobic mineralization, and the abiotic-phase transformation of Fe reduces CO emissions by ~41.79%. Our findings indicate that as part of the carbon cycle, DIR not only drives mineralization reactions but also traps carbon, increasing the stability of carbon sinks. Considering the wide geographic distribution of DIR and IC , our findings suggest that the "iron mesh" effect may become an increasingly important vector of carbon sequestration.Cheng Zhao, Fan Xun, Biao Li, Xiaotong Han, Huan Liu, Yingxun Du, Qinglong L Wu, Peng Xing
1765 related Products with: The dual roles of dissimilatory iron reduction in the carbon cycle: The "iron mesh" effect can increase inorganic carbon sequestration.
1 25 GRelated Pathways
#38499840 2024/03/19 To Up
Ultrasensitive colorimetric detection of Staphylococcus aureus using wheat germ agglutinin and IgY as a dual-recognition strategy.
A novel colorimetric platform was designed for the determination of S. aureus by utilizing a dual-recognition strategy, where wheat germ agglutinin (WGA)-functionalized magnetic beads were served as separation elements to capture and enrich S. aureus efficiently from the matrix. Horseradish peroxidase (HRP) labeled chicken anti-protein A IgY (HRP-IgY) was used to label the captured S. aureus. A chicken IgY was introduced as a signal tracer to bind with staphylococcal protein A (SPA) on the surface of S. aureus, which can circumvent the interference from protein G-producing Streptococcus. Subsequently, the colorimetric signal was achieved by an HRP-catalyzed reaction, which was amplified by HRP-IgY bound by approximately 80,000 SPA molecules on one S. aureus. The entire detection process could be accomplished within 90 min. Under optimal conditions, the linear response of different S. aureus concentrations ranged from 7.8 × 10 to 2.0 × 10 CFU/mL and the limit of detection reached down to 3.9 × 10 CFU/mL. Some common non-target bacteria yielded negative results, indicating the excellent specificity of the method. The developed strategy was successfully applied to the determination of S. aureus in various types of samples with satisfactory recoveries. Therefore, the novel dual-recognition strategy possessed the advantages of high sensitivity, specificity, and low cost and exhibited considerable potential as a promising tool to defend public health.Yun Zhang, Ge Tian, Xueni Sun, Xiaoli Yang, Yi Zhang, Wenqing Tan, Liangwei Duan, Shunxiang Gao, Junping Yu
1516 related Products with: Ultrasensitive colorimetric detection of Staphylococcus aureus using wheat germ agglutinin and IgY as a dual-recognition strategy.
100tests100tests100tests100tests100tests100tests100tests100tests100testsRelated Pathways
#38499798 2024/03/18 To Up
International nomenclature guidelines for the IL-1 family of cytokines and receptors.
Joseph M Gaballa, Jesper Falkesgaard Højen, Dennis M De Graaf, Jesus Amo-Aparicio, Carlo Marchetti, Giulio Cavalli, Alberto Dinarello, Suzhao Li, Michaele Francesco Corbisiero, Isak W Tengesdal, Jasmina S Redzic, Tania Azam, William S Webber, Karl A Pankratz, Makenna J May, Fabio Cominelli, Elan Z Eisenmesser, Soohyun Kim, Charles A Dinarello, Diana Boraschi
1808 related Products with: International nomenclature guidelines for the IL-1 family of cytokines and receptors.
1 g100ug100μg100 mg 100ul 100ul100ug100ug Lyophilized100ug100ug Lyophilized100ul100ugRelated Pathways
-
No related Items
#38499792 2024/03/19 To Up
Nutrient allocation patterns of Picea crassifolia on the eastern margin of the Qinghai-Tibet Plateau.
It can provide a basis for decision making for the conservation and sustainable use of forest ecosystems in mountains to understand the stoichiometric properties and nutrient allocation strategies of major tree species. However, the plant nutrient allocation strategies under different environmental gradients in forest systems of arid and semi-arid mountains are not fully understand. Therefore, three typical regions in the Qilian Mountains on the eastern edge of the Qinghai-Tibet Plateau were selected based on precipitation and temperature gradients, and the stoichiometric characteristics and nutrient allocation strategies of Qinghai spruce (Picea crassifolia) of the dominant tree species under different environmental gradients were investigated. The results showed that (1) the stoichiometric characteristics of plant tissues were different in the three regions. (2) The importance of each tissue in the plant nutrient allocation varied in different regions, showing that the plant roots are more important in the warm-wet region, while the plant leaves, branches and trunks are more important in the transition and hot-dry regions. (3) The influencing factors affecting plant nutrient allocation strategies were inconsistent across regions, which showed that plant nutrient allocation strategies in the warm-wet and transition region were mainly influenced by soil factors, while they were more influenced by climatic factors in the hot-dry region. The patterns of plant nutrient allocation strategies and drivers under different environmental gradients could help us better understand the ecological adaptation mechanism and physiological adjustment mechanism of forest ecosystem in mountains.Jingjing Wu, Liang Jiao, Xichen Che, Xuli Zhu, Xin Yuan
1385 related Products with: Nutrient allocation patterns of Picea crassifolia on the eastern margin of the Qinghai-Tibet Plateau.
1250 IU100.00 ul 100 G1500 Units 100ulRelated Pathways
#38499771 2024/03/18 To Up
Decomposition of an odorant in olfactory perception and neural representation.
Molecules-the elementary units of substances-are commonly considered the units of processing in olfactory perception, giving rise to undifferentiated odour objects invariant to environmental variations. By selectively perturbing the processing of chemical substructures with adaptation ('the psychologist's microelectrode') in a series of psychophysical and neuroimaging experiments (458 participants), we show that two perceptually distinct odorants sharing part of their structural features become significantly less discernible following adaptation to a third odorant containing their non-shared structural features, in manners independent of olfactory intensity, valence, quality or general olfactory adaptation. The effect is accompanied by reorganizations of ensemble activity patterns in the posterior piriform cortex that parallel subjective odour quality changes, in addition to substructure-based neural adaptations in the anterior piriform cortex and amygdala. Central representations of odour quality and the perceptual outcome thus embed submolecular structural information and are malleable by recent olfactory encounters.Yuting Ye, Yanqing Wang, Yuan Zhuang, Huibang Tan, Zhentao Zuo, Hanqi Yun, Kaiqi Yuan, Wen Zhou
2667 related Products with: Decomposition of an odorant in olfactory perception and neural representation.
100ug Lyophilized100 μg1 Set1 Set1 Set100ug100ug Lyophilized1 Set1000 TESTS/0.65ml100ug Lyophilized0.1ml (1mg/ml)100 μgRelated Pathways
#38499575 2024/03/18 To Up
Dynamics of extrachromosomal circular DNA in rice.
The genome's dynamic nature, exemplified by elements like extrachromosomal circular DNA (eccDNA), is crucial for biodiversity and adaptation. Yet, the role of eccDNA in plants, particularly rice, remains underexplored. Here, we identify 25,598 eccDNAs, unveiling the widespread presence of eccDNA across six rice tissues and revealing its formation as a universal and random process. Interestingly, we discover that direct repeats play a pivotal role in eccDNA formation, pointing to a unique origin mechanism. Despite eccDNA's prevalence in coding sequences, its impact on gene expression is minimal, implying its roles beyond gene regulation. We also observe the association between eccDNA's formation and minor chromosomal deletions, providing insights of its possible function in regulating genome stability. Further, we discover eccDNA specifically accumulated in rice leaves, which may be associated with DNA damage caused by environmental stressors like intense light. In summary, our research advances understanding of eccDNA's role in the genomic architecture and offers valuable insights for rice cultivation and breeding.Jundong Zhuang, Yaoxin Zhang, Congcong Zhou, Danlin Fan, Tao Huang, Qi Feng, Yiqi Lu, Yan Zhao, Qiang Zhao, Bin Han, Tingting Lu
1526 related Products with: Dynamics of extrachromosomal circular DNA in rice.
100ug1 Set1 Set1 Set25 mg1 Set500 tests10 10Related Pathways
#38499551 2024/03/18 To Up
Ultrafast magnetization enhancement via the dynamic spin-filter effect of type-II Weyl nodes in a kagome ferromagnet.
The magnetic type-II Weyl semimetal (MWSM) CoSnS has recently been found to host a variety of remarkable phenomena including surface Fermi-arcs, giant anomalous Hall effect, and negative flat band magnetism. However, the dynamic magnetic properties remain relatively unexplored. Here, we investigate the ultrafast spin dynamics of CoSnS crystal using time-resolved magneto-optical Kerr effect and reflectivity spectroscopies. We observe a transient magnetization behavior, consisting of spin-flipping dominated fast demagnetization, slow demagnetization due to overall half-metallic electronic structures, and an unexpected ultrafast magnetization enhancement lasting hundreds of picoseconds upon femtosecond laser excitation. By combining temperature-, pump fluence-, and pump polarization-dependent measurements, we unambiguously demonstrate the correlation between the ultrafast magnetization enhancement and the Weyl nodes. Our theoretical modelling suggests that the excited electrons are spin-polarized when relaxing, leading to the enhanced spin-up density of states near the Fermi level and the consequently unusual magnetization enhancement. Our results reveal the unique role of the Weyl properties of CoSnS in femtosecond laser-induced spin dynamics.Xianyang Lu, Zhiyong Lin, Hanqi Pi, Tan Zhang, Guanqi Li, Yuting Gong, Yu Yan, Xuezhong Ruan, Yao Li, Hui Zhang, Lin Li, Liang He, Jing Wu, Rong Zhang, Hongming Weng, Changgan Zeng, Yongbing Xu
2714 related Products with: Ultrafast magnetization enhancement via the dynamic spin-filter effect of type-II Weyl nodes in a kagome ferromagnet.
100 μg96T1 mL1100.00 ug1 mLRelated Pathways
#38499468 2024/03/18 To Up
Optimizing Molecular Crystallinity and Suppressing Electron-Phonon Coupling in Completely Non-fused Ring Electron Acceptors for Organic Solar Cells.
HTingting Dai, Ailing Tang, Yuhan Meng, Chuanqi Dong, Peiqing Cong, Jiahao Lu, Jimin Du, Yufei Zhong, Erjun Zhou
2203 related Products with: Optimizing Molecular Crystallinity and Suppressing Electron-Phonon Coupling in Completely Non-fused Ring Electron Acceptors for Organic Solar Cells.
2 ml96 tests1.00 flask 1 G-100 µg1x10e7 cells100ug Lyophilized96 wells1 mg1.00 flaskRelated Pathways
-
No related Items
Contact Us:
Belgium
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45 Fax 0032 16 50 90 45
[email protected]
France
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50 Fax 01 43 25 01 60
[email protected]
Germany
GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Tel 0241 40 08 90 86 Fax 0241 55 91 05 36
[email protected]
United Kingdom
GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
[email protected]
Also in
Luxembourg +35220880274
Schweiz Züri +41435006251
Danmark +4569918806
Österreich +43720880899
Česká republika Praha +420246019719
Ireland Dublin +35316526556
Norge Oslo +4721031366
Finland Helsset +358942419041
Sverige Stockholm +46852503438
Ελλάς Αθήνα +302111768494
Magyarország Budapest +3619980547
Poland
GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
Tel 058 710 33 44
Fax 058 710 33 48
[email protected]
skype gentaurpoland
Nederland
GENTAUR Nederland BV
Kuiper 1
5521 DG Eersel Nederland
Tel 0208-080893 Fax 0497-517897
[email protected]
Italy
GENTAUR SRL
IVA IT03841300167
Piazza Giacomo Matteotti, 6, 24122 Bergamo
Tel 02 36 00 65 93 Fax 02 36 00 65 94
[email protected]
Spain
GENTAUR Spain
Tel 0911876558
[email protected]
Bulgaria
GENTAUR Bulgaria
53 Iskar Str. 1191 Kokalyane, Sofia
Sofia 1000
Tel 0035924682280
Fax 0035929830072
[email protected]