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#22439867   2012/03/23 To Up

New immunosuppressive cyclomyrsinol diterpenes from Euphorbia kopetdaghi Prokh.

Aceton: chloroform (1:2) extracts of the aerial parts of Euphorbia kopetdaghi Prokh. (Euphorbiaceae) were investigated for its diterpenoids and afforded three new five-membered ring, pentacyclic myrisinane polyester comprised of 3,5,10-O-triacetyl-8-O-isobutanoyl-14-O-benzoylcyclomyrsinol (1), 3,5,10,14-O-tetraacetyl-8-O-(2'-methyl butanoyl)-cyclomyrsinol (2) and 3,5,10,14-O-tetracetyl-8-O-isobutanoylcyclomyrsinol (3). The structures were elucidated based on (13)C- and (1)H-NMR as well as 2D-NMR, IR and different MS spectra and the immunomodulation activity for compound 1 was evaluated through lymphocyte proliferation assay, IL-2 assay, oxidative burst of phagocytic leukocytes and through their cytotoxicity on two cell lines. Compound 1 showed significant suppressive activity against phytohemagglutinin-activated T-cell proliferation with an IC(50) of 1.83 µg mL(-1), IL-2 suppressive activity with an IC(50) of 19.0 µg mL(-1) and oxidative burst suppressive activity with an IC(50) of 1.6 µg mL(-1) and ignorable cytotoxic effect on the CC-1 rat hepatocyte and 3T3-L1 mouse fibroblast cell-lines.
Syed Mustafa Ghanadian, Abdul Majid Ayatollahi, M Ahmed Mesaik, Omer Mohamed Abdalla

1000 related Products with: New immunosuppressive cyclomyrsinol diterpenes from Euphorbia kopetdaghi Prokh.

100 ml200 25500 ml100 ml500 ml1 mg

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#18245915   // To Up

Effect of chemical surface treatments and repair material on transverse strength of repaired acrylic denture resin.

This study was performed to evaluate the transverse strength of a denture base resin (H), repaired with an autopolymerizing acrylic resin (A) or a visible light-curing (VLC) resin (T) following the use of three chemical solvents: methyl methacrylate monomer, aceton or chloroform.
Mahroo Vojdani, Sakineh Rezaei, Lila Zareeian

1182 related Products with: Effect of chemical surface treatments and repair material on transverse strength of repaired acrylic denture resin.

5 G100ug 6 ml Ready-to-use 100 µg10 mg10 μg50 ug 100ug0.1 mg0.25200ul

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#16022439   // To Up

Effects of visible light irradiation on eugenol-treated oral mucosa.

The purpose of this study was to evaluate the histopathological effects of eugenol (EUG) and iso-eugenol (IsoEUG)--with or without visible light (VL) irradiation--on oral mucous membranes. Oral mucous membranes of mice were applied with three agents, EUG, IsoEUG, and aceton (as the control) in the absence or presence of VL irradiation. VL irradiation resulted in more tissue damage for EUG- or IsoEUG-treated mucosa compared to corresponding compounds without VL irradiation, and that damage under IsoEUG treatment was greater than that under EUG treatment. Necrosis, but not apoptosis, was preferentially expressed in EUG- or IsoEUG-treated mucous membranes in the presence of VL irradiation.
Seiichiro Fujisawa, Eitoku Muraoka, Yoshihiro Nakazato, Norihisa Okada

2608 related Products with: Effects of visible light irradiation on eugenol-treated oral mucosa.

1.5 mL100ug 6 ml Ready-to-use 2 ml Ready-to-use 1 mg1 mg2.5 mg1 mg100 ug100ug100 Tests

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