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#33652371   2021/02/12 To Up

Paradoxical sensory reactivity induced by functional disconnection in a robot model of neurodevelopmental disorder.

Neurodevelopmental disorders are characterized by heterogeneous and non-specific nature of their clinical symptoms. In particular, hyper- and hypo-reactivity to sensory stimuli are diagnostic features of autism spectrum disorder and are reported across many neurodevelopmental disorders. However, computational mechanisms underlying the unusual paradoxical behaviors remain unclear. In this study, using a robot controlled by a hierarchical recurrent neural network model with predictive processing and learning mechanism, we simulated how functional disconnection altered the learning process and subsequent behavioral reactivity to environmental change. The results show that, through the learning process, long-range functional disconnection between distinct network levels could simultaneously lower the precision of sensory information and higher-level prediction. The alteration caused a robot to exhibit sensory-dominated and sensory-ignoring behaviors ascribed to sensory hyper- and hypo-reactivity, respectively. As long-range functional disconnection became more severe, a frequency shift from hyporeactivity to hyperreactivity was observed, paralleling an early sign of autism spectrum disorder. Furthermore, local functional disconnection at the level of sensory processing similarly induced hyporeactivity due to low sensory precision. These findings suggest a computational explanation for paradoxical sensory behaviors in neurodevelopmental disorders, such as coexisting hyper- and hypo-reactivity to sensory stimulus. A neurorobotics approach may be useful for bridging various levels of understanding in neurodevelopmental disorders and providing insights into mechanisms underlying complex clinical symptoms.
Hayato Idei, Shingo Murata, Yuichi Yamashita, Tetsuya Ogata

2553 related Products with: Paradoxical sensory reactivity induced by functional disconnection in a robot model of neurodevelopmental disorder.

1 Product tipe: Instrumen100ug100ug Lyophilized100ug Lyophilized50ul100ug100ug Lyophilized96 assays100ug Lyophilized100 ul100ug100ug Lyophilized

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#33652370   2021/02/17 To Up

Self-augmentation: Generalizing deep networks to unseen classes for few-shot learning.

Few-shot learning aims to classify unseen classes with a few training examples. While recent works have shown that standard mini-batch training with carefully designed training strategies can improve generalization ability for unseen classes, well-known problems in deep networks such as memorizing training statistics have been less explored for few-shot learning. To tackle this issue, we propose self-augmentation that consolidates self-mix and self-distillation. Specifically, we propose a regional dropout technique called self-mix, in which a patch of an image is substituted into other values in the same image. With this dropout effect, we show that the generalization ability of deep networks can be improved as it prevents us from learning specific structures of a dataset. Then, we employ a backbone network that has auxiliary branches with its own classifier to enforce knowledge sharing. This sharing of knowledge forces each branch to learn diverse optimal points during training. Additionally, we present a local representation learner to further exploit a few training examples of unseen classes by generating fake queries and novel weights. Experimental results show that the proposed method outperforms the state-of-the-art methods for prevalent few-shot benchmarks and improves the generalization ability.
Jin-Woo Seo, Hong-Gyu Jung, Seong-Whan Lee

1249 related Products with: Self-augmentation: Generalizing deep networks to unseen classes for few-shot learning.

1 mg1.00 flask1 mg480/kit 1 G1 module96/kit 50 UG

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#33652356   2021/02/23 To Up

Alzheimer's disease and its treatment by different approaches: A review.

Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability development and interrupts neurocognitive function. This neuropathological condition is depicted by neurodegeneration, neural loss, and development of neurofibrillary tangles and Aβ plaques. There is also a greater risk of developing AD at a later age for people with cardiovascular diseases, hypertension and diabetes. In the biomedical sciences, effective treatment for Alzheimer's disease is a severe obstacle. There is no such treatment to cure Alzheimer's disease. The drug present in the market show only symptomatic relief. The cause of Alzheimer's disease is not fully understood and the blood-brain barrier restricts drug efficacy are two main factors that hamper research. Stem cell-based therapy has been seen as an effective, secure, and creative therapeutic solution to overcoming AD because of AD's multifactorial nature and inadequate care. Current developments in nanotechnology often offer possibilities for the delivery of active drug candidates to address certain limitations. The key nanoformulations being tested against AD include polymeric nanoparticles (NP), inorganic NPs and lipid-based NPs. Nano drug delivery systems are promising vehicles for targeting several therapeutic moieties by easing drug molecules' penetration across the CNS and improving their bioavailability. In this review, we focus on the causes of the AD and their treatment by different approaches.
Sukriti Srivastava, Razi Ahmad, Sunil Kumar Khare

2318 related Products with: Alzheimer's disease and its treatment by different approaches: A review.

96 tests96 tests96 tests96 tests100ug 500 ml

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#33652348   2021/02/27 To Up

Regulatory T cells in autoimmune hepatitis: Un updated overview.

Regulatory T-cells (Tregs) are key players in the maintenance of immune homeostasis by preventing immune responses to self-antigens. Defects in Treg frequency and/or function result in overwhelming CD4 and CD8 T cell immune responses participating in the autoimmune attack. Perpetuation of autoimmune damage is also favored by Treg predisposition to acquire effector cell features upon exposure to a proinflammatory challenge. Treg impairment plays a permissive role in the initiation and perpetuation of autoimmune liver diseases, namely autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. In this Review, we outline studies reporting the role of Treg impairment in the pathogenesis of these conditions and discuss methods to restore Treg number and function either by generation/expansion in the test tube or through in vivo expansion upon administration of low dose IL-2. Challenges and caveats of these potential therapeutic strategies are also reviewed and discussed.
Maria Serena Longhi, Giorgina Mieli-Vergani, Diego Vergani

2696 related Products with: Regulatory T cells in autoimmune hepatitis: Un updated overview.

50000 Units110 Inserts of 96 Tips/Uni96 tests96 tests

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#33652345   2021/02/27 To Up

Serum Albumin, Body Mass Index, and Preceding Xa and P2Y12 Inhibitors Predict Prognosis of Recurrent Ischemic Stroke.

A third to half of recurrent stroke occur while on antiplatelet therapy, but no study has explored factors relating to prognosis of recurrent ischemic stroke. This study aimed to clarify the risk factors to determine the clinical outcome of recurrent ischemic stroke.
Ryusei Kiboshi, Sousuke Satoh, Kasumi Mikami, Maiko Kitajima, Mayumi Urushizaka, Norifumi Metoki, Tomohiro Osanai

1098 related Products with: Serum Albumin, Body Mass Index, and Preceding Xa and P2Y12 Inhibitors Predict Prognosis of Recurrent Ischemic Stroke.

96T50mg10 mg50ul10gm200ul100 mg50 mg200ul200ug10gm

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#33652343   2021/02/08 To Up

Synthesis, characterization, reaction mechanism prediction and biological study of mono, bis and tetrakis pyrazole derivatives against Fusarium oxysporum f. sp. Albedinis with conceptual DFT and ligand-protein docking studies.

Twelve heterocyclic compounds were prepared using the condensation of hydroxymethanol pyrazole derivatives with different primary aminesas example 2-aminothiazole and 1-aminobenzotriazole to have a diverse productin good yield up to 97%. Those ligands were tested against Fusarium oxysporum f. sp. Albedinis fungi (BAYOUD Disease) with IC = 25.6-33.2 µg/ml. After experiments, theoretical investigations were done as DFT study to know the ligands molecular reactivity and the-ligandprotein- docking study to know the possible binding between the prepared ligands with two biological targets: FGB1 (Fusarium oxysporum Guanine nucleotide-binding protein beta subunitprimary amino acid sequence) and Fophy (Fusarium oxysporum phytase domain enzyme). Of all the obtained results, the experimental ones were well correlated with the theoretical with the most common thing between those compounds is (N-N) which is the antifungal pharmacophore as proposed pincers for Foa inhibition. From docking studies over FGB1 and Fophy, the ligand 9 has the best binding energy of -6.4872 kcal/mol in FGB1 active site and -5.5282 kcal/mol in Fophy active site, but better correlation with Fophy than FGB1 which is followed by PLIF graph to get that Arg116, Arg120 and Lys336 are the vital amino acids of fophy protein based the study over the chosen active site.
Yassine Kaddouri, Farid Abrigach, Sabir Ouahhoud, Redouane Benabbes, Mohamed El Kodadi, Ali Alsalme, Nabil Al-Zaqri, Ismail Warad, Rachid Touzani

2000 related Products with: Synthesis, characterization, reaction mechanism prediction and biological study of mono, bis and tetrakis pyrazole derivatives against Fusarium oxysporum f. sp. Albedinis with conceptual DFT and ligand-protein docking studies.

100ul1000 TESTS/0.65ml5mg200ug25 mg100ul1000 tests100ug200ul100 mg10 mg1 ml

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#33652328   2021/02/24 To Up

Venous thromboembolism in Asia and worldwide: Emerging insights from GARFIELD-VTE.

Although epidemiological studies report a lower risk of venous thromboembolism (VTE) than in the Western world, VTE rates in Asia may be underestimated. Furthermore, it is uncertain whether VTE outcomes differ in Asia and the rest of the world (ROW).
Pantep Angchaisuksiri, Shinya Goto, Alfredo E Farjat, Henrik Fryk, Soo-Mee Bang, Chern-En Chiang, Zhi-Cheng Jing, Katsuhiro Kondo, Jameela Sathar, Eric Tse, Sithakom Phusanti, Gloria Kayani, Jeffrey I Weitz, Walter Ageno, Samuel Z Goldhaber, Ajay K Kakkar

2198 related Products with: Venous thromboembolism in Asia and worldwide: Emerging insights from GARFIELD-VTE.

5mg100μg100.00 ug100ug500 MG0.1 mg100 μg1 Set100 μg

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#33652323   2021/02/20 To Up

Risk assessment of potential thaw settlement hazard in the permafrost regions of Qinghai-Tibet Plateau.

Climate warming could exacerbate the occurrence of thaw settlement hazard in the permafrost regions of the Qinghai-Tibet Plateau (QTP), which would threaten the stability of engineering infrastructure in cold regions. The risk associated with permafrost settlement, valuable for the regional sustainable development, remains poorly assessed or understood on the QTP. In this study, three common Geo-hazard indices were used to assess the settlement risks in the permafrost regions of the QTP, including the settlement index, the risk zonation index, and the allowable bearing capacity index. However, large spatial differences existed in simulating the risk maps by using the abovementioned Geo-hazard indices. Hence, we developed a combined index (I) by integrating the three indices to reduce the uncertainty of the simulations. The results indicated that the ground ice is a critical factor for assessing the settlement risk in permafrost regions. We also applied the I to assess the settlement risk along the Qinghai-Tibet Railway (QTR). The proportion of low-risk area along the QTR would be the highest (45.38%) for the future periods 2061-2080 under Representative Concentration Pathway 4.5. The medium-risk area combined with the high-risk area would be accounted for more than 40%, which were located at the boundary of the present permafrost regions. Therefore, the corresponding adaptation measures should be taken to reduce the potential economic losses caused by the high-risk regions to the infrastructure. Overall, the results would present valuable references for engineering design, construction and maintenance, and provide insights for early warning and prevention of permafrost thaw settlement hazard on the QTP.
Jie Ni, Tonghua Wu, Xiaofan Zhu, Xiaodong Wu, Qiangqiang Pang, Defu Zou, Jie Chen, Ren Li, Guojie Hu, Yizhen Du, Junming Hao, Xiangfei Li, Yongping Qiao

1965 related Products with: Risk assessment of potential thaw settlement hazard in the permafrost regions of Qinghai-Tibet Plateau.

1 5 G1 mg

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#33652322   2021/02/19 To Up

Long-term response of marine benthic fauna to thin-layer capping with powdered activated carbon in the Grenland fjords, Norway.

The Grenland fjords in Norway have a long history of contamination by large emissions of dioxins and mercury. As a possible sediment remediation method in situ, thin-layer capping with powdered activated carbon (AC) mixed with clay was applied at two test sites at 30 m and 95 m depth in the Grenland fjords. This study presents long-term effects of the AC treatment on the benthic community structure, i.e. nine years after capping. Capping with AC significantly reduced the number of species, their abundance and biomass at the two test sites, compared to uncapped reference sites. At the more shallow site, the dominant brittle star species Amphiura filiformis disappeared shortly after capping and did not re-establish nine years after capping. At the deeper site, the AC treatment also caused long-lasting negative effects on the benthic community, but some recovery was observed after nine years. Ecological indices used to assess environmental status did not capture the impaired benthic communities caused by the capping. The present study is the first documentation of negative effects of powdered AC on marine benthic communities on a decadal scale. Our results show that the benefits of reduced contaminant bioavailability from capping with AC should be carefully weighed against the cost of long-term detrimental effects on the benthic community. More research is needed to develop a thin-layer capping material that is efficient at sequestering contaminants without being harmful to benthic species.
Hilde C Trannum, Caroline Raymond, Rita Næss, Gunhild Borgersen, Jonas S Gunnarsson, Morten T Schaanning

1101 related Products with: Long-term response of marine benthic fauna to thin-layer capping with powdered activated carbon in the Grenland fjords, Norway.

1 mg 0.1 mg 100 μg100 μg100 μg100 μg

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#33652318   2021/02/16 To Up

Temporal variability in the impacts of particulate matter on crop yields on the North China Plain.

The North China Plain (NCP) is a major agricultural region, producing 45% of China's maize. It is also vital to the Chinese economy, encompassing the Beijing-Tianjin-Hebei megacity region. Anthropogenic factors increasingly impact crop yields on the NCP, and globally. Particulate matter (PM) pollution is a significant problem in this region, where annual average PM concentrations over three times the Chinese national air quality standard were recorded for the Beijing-Tianjin-Hebei megacity region between 2013 and 18. PM absorbs light, reducing total shortwave radiation (SW), thereby limiting plant productivity. However, PM also scatters incoming SW, increasing the diffuse fraction, which has been shown to increase growth and biomass assimilation. The Joint UK Land Environment Simulator (JULES) crop model was used to assess the net impact of these competing changes in light on NCP maize yields. In contrast to some previous analyses, we find that PM-associated decreases in SW outweigh any positive impact on yield from an increasing proportion of diffuse radiation. Furthermore, carbon allocation to different portions of the growing cropchanges during the development cycle. We find significant differences between the effect on final yield of identical changes to diffuse fraction and total SW occurring during different development stages. The greatest simulated yield gains from increased SW and reduced diffuse fraction, consistent with reductions in PM, are observed during the early reproductive stage of development (July-August), when the simulated gain of yield is as much as 12.9% more than in other periods. To further assess the impact of PM-linked changes in SW and diffuse fraction on NCP crop yields, radiation profiles from different city regions were then applied across the NCP. The changes in SW associated with these city regions could increase maize yields across China by ~8 Mt. This would completely offset China's annual maize imports, increasing both national and global food security.
Michael C Wolffe, Oliver Wild, Stephen P Long, Kirsti Ashworth

2728 related Products with: Temporal variability in the impacts of particulate matter on crop yields on the North China Plain.

1100ug200 units 2 ml

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