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Search results for: NAG

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#34130119   2021/05/26 To Up

The immunological response among COVID-19 patients with acute respiratory distress syndrome.

Coronavirus disease 2019 (COVID-19) often results in pneumonia and can lead to acute respiratory distress syndrome (ARDS). ARDS is one of the most significant causes of death in patients with COVID-19. The development of a "cytokine storm" in patients with COVID-19 causes progression to ARDS. In this scoping review, we investigated the effect of pro-inflammatory cytokines in inducing moderate and severe ARDS outcomes. A comprehensive search was performed using PubMed and Google Scholar to implement a broad query that captured all the relevant studies published between December 2019 and September 2020.We identified seven studies that evaluated the immune response in COVID-19 patients with ARDS. The white blood cell counts (WBCs), CRP, and IL-6 were higher in the moderately presenting ARDS patients, critically ill patients, and those with more severe ARDS. This study may contribute to better patient management and outcomes if tailored immune marker interventions are implemented in the near future.
Abdulaziz S Almutairi, Hassan Abunurah, Abdulkarim Hadi Alanazi, Faraj Alenazi, Hassan Nag, Nafea Saad Almutairi, Michael Wells, Abdullah Alawam, Mohammed M Alqahtani

2336 related Products with: The immunological response among COVID-19 patients with acute respiratory distress syndrome.

1100 MG 25 G100ug96T200 units 100 G1 g25 mg11 ml 1 G

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#34124886   2021/06/14 To Up

Selective Discrimination of VOCs Applying Gas Sensing Kinetic Analysis over a Metal Oxide-Based Chemiresistive Gas Sensor.

Semiconducting metal oxide-based gas sensors have inadequate selectivity as they are responsive toward a variety of gases. Here, we report the implementation of gas sensing kinetic analysis of the sensor to identify the tested volatile organic compounds (VOCs) (2-propanol, formaldehyde, methanol, and toluene) precisely. A single chemiresistive sensor was employed having tin oxide-based hollow spheres as the sensing material, which were obtained by chemical synthesis. The gas sensing measurements were conducted in a dynamic manner where the sensor displayed excellent response with high sensitivity. Eley-Rideal model was adopted to obtain the kinetic properties of the gas sensing phenomenon through theoretical fitting of response transient curves and their corresponding kinetic parameters. The calculated characteristic kinetic properties were further examined to discriminate among different VOCs. The approach of using gas sensing kinetic analysis for multiple gas discrimination is an attractive solution to mitigate the problem of cross-sensitivity for resistive gas sensors.
Snehanjan Acharyya, Sudip Nag, Sanjay Kimbahune, Avik Ghose, Arpan Pal, Prasanta Kumar Guha

2651 related Products with: Selective Discrimination of VOCs Applying Gas Sensing Kinetic Analysis over a Metal Oxide-Based Chemiresistive Gas Sensor.

250 TESTS 100ul100ug100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug100ug100ug

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#34123890   2021/04/29 To Up

Rational use of PPE and preventing PPE related skin damage.

On 31 December, 2019, an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared in Wuhan, China. On 24 March 2020, there was a nationwide lockdown for 21 days, followed by Janata curfew on 22 March. As the pandemic has developed and spread across continents, everyone including policy makers have realized shortage of personal protective equipment (PPE) such as N95 respirators, coverall, and face shields. This is one of the major factors putting healthcare workers not only at risk of infection but also to various side effects of prolonged use of PPE. Based on international experiences, new ideas in procuring and mass manufacturing, rational use of PPE equipment is the need of hour, especially for developing nations which lack adequate resources and infrastructure for manufacturing PPEs.
Binit Sureka, Vijaya Lakshmi Nag, Mahendra Kumar Garg, Vibhor Tak, Mithu Banerjee, Ashok Bishnoi, Sanjeev Misra

2633 related Products with: Rational use of PPE and preventing PPE related skin damage.

100ul100ug100.00 ul1000 96T100ug2000ml/pouch50 mg1000 TESTS/0.65ml 6 ml Ready-to-use

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#34123883   2021/04/29 To Up

Suraksha Chakra: A new scoring system to protect the healthcare workers from COVID.

Doctors, nurses, house cleaning staff and hospital ward attendants are at increased risk of acquiring coronavirus disease 2019 (COVID-19) if there is a breach in the personal protection equipment. A new simple, easy to implement scoring system has been developed by our Suraksha Chakra team which can be used by the policy makers and hospital administrators. The scoring system is not to discourage anyone but constantly reinforce the healthcare workers for safe practices during patient care.
Binit Sureka, Vibhor Tak, Vijaya Lakshmi Nag, Raj Rani, Mahendra Kumar Garg, Sanjeev Misra

2706 related Products with: Suraksha Chakra: A new scoring system to protect the healthcare workers from COVID.

2 modules100 ugOne 96-Well Strip Micropl1 100 G 500 Slides

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#34121218   2021/06/14 To Up

Structure-based investigation of MARK4 inhibitory potential of Naringenin for therapeutic management of cancer and neurodegenerative diseases.

MAP/microtubule affinity-regulating kinase 4 (MARK4) is a member of serine/threonine kinase family and considered an attractive drug target for many diseases. Screening of Indian Medicinal Plants, Phytochemistry, and Therapeutics (IMPPAT) using virtual high-throughput screening coupled with enzyme assay suggested that Naringenin (NAG) could be a potent inhibitor of MARK4. Structure-based molecular docking analysis showed that NAG binds to the critical residues found in the active site pocket of MARK4. Furthermore, molecular dynamics (MD) simulation studies for 100 ns have delineated the binding mechanism of NAG to MARK4. Results of MD simulation suggested that binding of NAG further stabilizes the structure of MARK4 by forming a stable complex. In addition, no significant conformational change in the MARK4 structure was observed. Fluorescence binding and isothermal titration calorimetric measurements revealed an excellent binding affinity of NAG to MARK4 with a binding constant (K) = 0.13 × 10 M obtained from fluorescence binding studies. Further, enzyme inhibition studies showed that NAG has an admirable IC value of 4.11 µM for MARK4. Together, these findings suggest that NAG could be an effective MARK4 inhibitor that can potentially be used to treat cancer and neurodegenerative diseases.
Saleha Anwar, Shama Khan, Anas Shamsi, Farah Anjum, Alaa Shafie, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassan

1172 related Products with: Structure-based investigation of MARK4 inhibitory potential of Naringenin for therapeutic management of cancer and neurodegenerative diseases.

5 G96 tests100 mg100preparations100ug

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#34119787   2021/06/10 To Up

Risk assessment of Escherichia coli in bioaerosols generated following land application of farmyard slurry.

Transfer of Escherichia coli in bioaerosols to humans during and shortly after the land application of farmyard slurry may pose human health hazards, but it has not been extensively explored to date. The present study developed a quantitative risk assessment model for E. coli through the air exposure route. The probabilistic model assessed the predicted number of microorganisms in the air (PN) to which humans may be exposed. A Gaussian air dispersion model was used to calculate the concentration of E. coli transmitted through aerosols. Human exposure (HE) to E. coli was estimated using a Monte Carlo simulation approach. This research predicted the mean HE as 26 CFU day (95th percentile 263 CFU day) and suggests the importance of keeping a distance of at least 100 m for the residential population from land spreading activities. However, the simulated mean daily or annual (once a year application) risk of 2.65 × 10 person year due to land application of slurry indicates very low occupational risk for farmworkers not equipped with the personal protective equipment (PPE), who are potentially exposed to E. coli indirectly. The model found that the decay constant of E. coli in air, duration of decay, and bio-aerosolisation efficiency factor (top three) could influence HE to airborne E. coli. Furthermore, this research recommends an average time lag of at least 2.5 h following the application of farmyard slurry to the field before humans access the field again without PPE, allowing the airborne pathogen to decay, thereby ensuring occupational safety. The model suggested that the bio-aerosolisation efficiency factor (E) for other pathogens requires further investigation. The information generated from this model can help to assess likely exposure from bioaerosols triggered by land application of farmyard slurry.
Rajat Nag, Ciaran Monahan, Paul Whyte, Bryan K Markey, Vincent O'Flaherty, Declan Bolton, Owen Fenton, Karl G Richards, Enda Cummins

2845 related Products with: Risk assessment of Escherichia coli in bioaerosols generated following land application of farmyard slurry.

1 mL0.1ml (1mg/ml) 100ul 100ul100ug Lyophilized10 1mg0.1ml100ug Lyophilized 100ul0.1ml 100ul

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#34117368   2021/06/11 To Up

Oroxylin A inhibits the migration of hepatocellular carcinoma cells by inducing NAG-1 expression.

Hepatocellular carcinoma (HCC), the most prevalent liver cancer, is considered one of the most lethal malignancies with a dismal outcome mainly due to frequent intrahepatic and distant metastasis. In the present study, we demonstrated that oroxylin A, a natural product extracted from Scutellaria radix, significantly inhibits transforming growth factor-beta1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) and metastasis in HCC. Oroxylin A blocked the TGF-β1/Smad signaling via upregulating the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) expression. Oroxylin A promoted NAG-1 transcription by regulating the acetylation of CCAAT/enhancer binding protein β (C/EBPβ), a transcription factor that binds to the NAG-1 promoter. In terms of the underlying mechanism, oroxylin A may interact with histone deacetylase 1 (HDAC1) by forming hydrogen bonds with GLY149 residue and induce proteasome-mediated degradation of HDAC1 subsequently impairing HDAC1-mediated deacetylation of C/EBPβ and promoting the expression of NAG-1. Taken together, our findings revealed a previously unknown tumor-suppressive mechanism of oroxylin A. Oroxylin A should be further investigated as a potential clinical candidate for inhibiting HCC metastasis.
Tong-Xin Huo, Xiao-Ping Wang, Zhou Yu, Bo Kong, Yuan He, Qing-Long Guo, Xiao-Bo Zhang, Lei Qiang

1797 related Products with: Oroxylin A inhibits the migration of hepatocellular carcinoma cells by inducing NAG-1 expression.

100ul100ug Lyophilized100ug Lyophilized100ul100ug Lyophilized 100ul100ug Lyophilized100ul100ug Lyophilized100ug Lyophilized

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#34114530   // To Up

Correlation of medial longitudinal arch morphology with body characteristics and locomotive function in community-dwelling older women: A cross-sectional study.

This cross-sectional study aimed to investigate the effects of foot arch deformities on physical characteristics, muscular strength, and motor function in older women depending on the presence or absence of pain.
Hidetoshi Nakao, Masakazu Imaoka, Mitsumasa Hida, Ryota Imai, Fumie Tazaki, Takeshi Morifuji, Masashi Hashimoto, Misa Nakamura

1514 related Products with: Correlation of medial longitudinal arch morphology with body characteristics and locomotive function in community-dwelling older women: A cross-sectional study.

100ug Lyophilized100 μg100ug100 μg25 mg100ug Lyophilized100 μg100ug Lyophilized1 Set100 μg1 Set200.00 ug

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#34114323   2021/06/10 To Up

Urinary biomarkers of early renal injury in antiretroviral-naïve HIV-positive persons in Shanghai, China: comparison with the general population.

People living with HIV (PLWH) have a high risk of kidney injury. Measurement of serum creatinine, along with proteinuria, is not sensitive to detect early kidney injury. Here, we investigated novel urinary biomarkers of early renal injury in PLWH.
X Q Le, D P Liu, J Chen, Z Y Gong, J N Xun, J R Wang, J J Sun, C Steinhart, L Liu, Y Z Shen, T K Qi, Z Y Wang, X Zhang, Y Tang, W Song, H Z Lu, R F Zhang

2038 related Products with: Urinary biomarkers of early renal injury in antiretroviral-naïve HIV-positive persons in Shanghai, China: comparison with the general population.

5 mg5mg100 ul10 rxns1 Set4/120 Packing /sleeve/bo96T100 μg2.5 mg

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#34110585   2021/06/10 To Up

Kidney injury molecule-1: potential biomarker of acute kidney injury and disease severity in patients with COVID-19.

The aim of the current study was to evaluate whether tubular markers kidney injury molecule-1 (KIM-1) and N-acetyl-ß-glucosaminidase (NAG) are related to acute kidney injury (AKI) and severe disease in patients with COVID-19.
Manuel J Vogel, Julian Mustroph, Stephan T Staudner, Simon B Leininger, Ute Hubauer, Stefan Wallner, Christine Meindl, Frank Hanses, Markus Zimmermann, Lars S Maier, Carsten G Jungbauer, Julian Hupf

1912 related Products with: Kidney injury molecule-1: potential biomarker of acute kidney injury and disease severity in patients with COVID-19.

96T540 tests

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