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Downregulation of nicotinamide nucleotide transhydrogenase and its naturally occurring antisense RNA in gastric cancer.
Nicotinamide Nucleotide Transhydrogenase (NNT) gene encodes a protein, which is an important antioxidative enzyme that converts NADH to NADPH. This enzyme provides a significant proportion of the entire NADPH resourceĀ in the mitochondria. Previous reports have shown possible contribution of this gene in the carcinogenesis process.Farbod Esfandi, Mohammad Taheri, Mir Salar Kahaei, Mir Davood Omrani, Vahid Kholghi Oskooei, Soudeh Ghafouri-Fard