Neuromedin U secreted by colorectal cancer cells promotes a tumour-supporting microenvironment. productsSearch results for: Neuromedin U secreted by colorectal cancer cells promotes a tumour-supporting microenvironment.
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2022/12/08
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Neuromedin U secreted by colorectal cancer cells promotes a tumour-supporting microenvironment.
Neuromedin U (NMU) was identified as one of the hub genes closely related to colorectal cancer (CRC) progression and was recently shown to be a motility inducer in CRC cells. Its autocrine signalling through specific receptors increases cancer cell migration and invasiveness. Because of insufficient knowledge concerning NMU accessibility and action in the tumour microenvironment, its role in CRC remains poorly understood and its potential as a therapeutic target is still difficult to define.Patrycja Przygodzka, Kamila Soboska, Ewelina Sochacka, Marcin Pacholczyk, Marcin Braun, Hassan Kassassir, Izabela Papiewska-Pająk, Michal Kielbik, Joanna Boncela