Search results for: Novel
#34525483 2021/09/15 To Up
[Automatic detection of epileptiform potentials and seizures in the EEG].Automatic computer-based algorithms for the detection of epileptiform potentials and seizure patterns on EEG facilitate a time-saving, objective method of quantitative EEG interpretation which is available 7/24. For the automatic detection of interictal epileptiform potentials sensitivities range from 65 to 99% with false positive detections of 0,09 to 13,4 per minute. Recent studies documented equal or even better performance of automatic spike detection programs compared with experienced human EEG readers. The seizure detection problem-one of the major problems in clinical epileptology-consists of the fact that the majority of focal onset seizures with impaired awareness and of seizures arising out of sleep occur unnoticed by patients and their caregivers. Automatic seizure detection systems could facilitate objective seizure documentation and thus help to solve the seizure detection problem. Furthermore, seizure detection systems may help to prevent seizure-related injuries and sudden unexpected death in epilepsy (SUDEP), and could be an integral part of novel, seizure-triggered on-demand therapies in epilepsy. During long-term video-EEG monitoring seizure detection systems could improve patient safety, provide a time-saving objective and reproducible analysis of seizure patterns and facilitate automatic computer-based patient testing during seizures. Sensitivities of seizure detection systems range from 75 to 90% with extratemporal seizures being more difficult to detect than temporal seizures. The false positive alarm rate ranges from 0,1 to 5 per 24âhours. Finally, machine learning algorithms, especially deep learning approaches, open a new highly promising era in automatic spike and seizure detection.
Christoph Baumgartner, Sebastian Hafner, Johannes P Koren
1920 related Products with: [Automatic detection of epileptiform potentials and seizures in the EEG].1
#34525472 2021/09/15 To Up
Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland.Primary localized cutaneous amyloidosis (PLCA) is defined by the deposition of amyloid protein in the skin without systemic involvement. There are four subtypes of PLCA: lichen amyloidosis (LA), macular amyloidosis (MA), biphasic amyloidosis (BA), and nodular amyloidosis (NA). PLCA occurs most frequently in Latin Americans and Asians. Treatment is not standardized.
Carole Guillet, Simona Steinmann, Julia-Tatjana Maul, Isabel Kolm
2819 related Products with: Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland.1-99 mg/ml/ea price x 2500 tests100ug500 tests1-99 mg/ml/ea price x 2
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#34525426 2021/09/02 To Up
Detection and electrocatalytic mechanism of zearalenone using nanohybrid sensor based on copper-based metal-organic framework/magnetic FeO-graphene oxide modified electrode.A novel and simple strategy was proposed for the determination of ZEA in breakfast cereal, maize powder and rice flour using an electrochemical nanohybrid sensor based on copper-based metal-organic framework (Cu-MOF)/magnetic FeO-graphene oxide (FeO-GO) modified electrode fabricated by the layer-by-layer assembled technique. The synthesized Cu-MOF with high porosity favorably improved the effective surface area and the analytical performance of nanohybrid sensing electrode. The crafted sensor has large surface area, high electron transfer, and satisfactory efficiency. ZEA was electrochemically detected in a wide linear range from 159.2 to 2865.2Â ngÂ mL with LOD of 23.14Â ngÂ mL under the optimal conditions. Moreover, the electrocatalytic mechanism of ZEA oxidation was proposed by density functional theory (DFT). A favorable energetic interaction was presented when Cu-MOF adsorbed on FeO-GO, and a small new band appeared on the Fermi level energy (E) that facilitated the electron transfer between bands.
Yifang Zeng, MarÃa BelÃ©n Camarada, Xinyu Lu, Kaijie Tang, Weiqiang Li, Daoyang Qiu, Yangping Wen, Guoping Wu, Qiushui Luo, Ling Bai
1177 related Products with: Detection and electrocatalytic mechanism of zearalenone using nanohybrid sensor based on copper-based metal-organic framework/magnetic FeO-graphene oxide modified electrode.One 96-Well Microplate Ki100testsTwo 96-Well Microplate KiOne 96-Well Microplate Ki5mg50.00 ml500 testsOne 96-Well Microplate KiOne 96-Well Microplate Ki50.00 mlOne 96-Well Microplate Ki
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#34525388 2021/09/12 To Up
The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60-69 years (China BAPE Study).The exposome overhauls conventional environmental health impact research paradigms and provides a novel methodological framework that comprehensively addresses the complex, highly dynamic interplays of exogenous exposures, endogenous exposures, and modifiable factors in humans. Holistic assessments of the adverse health effects and systematic elucidation of the mechanisms underlying environmental exposures are major scientific challenges with widespread societal implications. However, to date, few studies have comprehensively and simultaneously measured airborne pollutant exposures and explored the associated biomarkers in susceptible healthy elderly subjects, potentially resulting in the suboptimal assessment and management of health risks. To demonstrate the exposome paradigm, we describe the rationale and design of a comprehensive biomarker and biomonitoring panel study to systematically explore the association between individual airborne exposure and adverse health outcomes. We used a combination of personal monitoring for airborne pollutants, extensive human biomonitoring, advanced omics analysis, confounding information, and statistical methods. We established an exploratory panel study of Biomarkers of Air Pollutant Exposure in Chinese people aged 60-69Â years (China BAPE), which included 76 healthy residents from a representative community in Jinan City, Shandong Province. During the period between September 2018 and January 2019, we conducted prospective longitudinal monitoring with a 3-day assessment every month. This project: (1) leveraged advanced tools for personal airborne exposure monitoring (external exposures); (2) comprehensively characterized biological samples for exogenous and endogenous compounds (e.g., targeted and untargeted monitoring) and multi-omics scale measurements to explore potential biomarkers and putative toxicity pathways; and (3) systematically evaluated the relationships between personal exposure to air pollutants, and novel biomarkers of exposures and effects using exposome-wide association study approaches. These findings will contribute to our understanding of the mechanisms underlying the adverse health impacts of air pollution exposures and identify potential adverse clinical outcomes that can facilitate the development of effective prevention and targeted intervention techniques.
Song Tang, Tiantian Li, Jianlong Fang, Renjie Chen, Yu'e Cha, Yanwen Wang, Mu Zhu, Yi Zhang, Yuanyuan Chen, Yanjun Du, Tianwei Yu, David C Thompson, Krystal J Godri Pollitt, Vasilis Vasiliou, John S Ji, Haidong Kan, Junfeng Jim Zhang, Xiaoming Shi
2202 related Products with: The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60-69 years (China BAPE Study).100ug100ug1 mL100 μg4 Arrays/Slide
#34525348 2021/09/08 To Up
Visualization of individual cell division history in complex tissues using iCOUNT.T
Annina Denoth-Lippuner, Baptiste N Jaeger, Tong Liang, Lars N Royall, Stefanie E Chie, Kilian Buthey, Diana Machado, Vladislav I Korobeynyk, Merit Kruse, Clara M Munz, Alexander Gerbaulet, Benjamin D Simons, Sebastian Jessberger
1584 related Products with: Visualization of individual cell division history in complex tissues using iCOUNT.1.00 flask100ug Lyophilized96 samples50 ul100 μg1x10e7 cells
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#34525330 2021/09/08 To Up
Increased fidelity of protein synthesis extends lifespan.Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the accuracy of translation, yet the physiological consequence of having fewer protein synthesis errors during multi-cellular organismal aging is poorly understood. Our phylogenetic analysis of RPS23, a key protein in the ribosomal decoding center, uncovered a lysine residue almost universally conserved across all domains of life, which is replaced by an arginine in a small number of hyperthermophilic archaea. When introduced into eukaryotic RPS23 homologs, this mutation leads to accurate translation, as well as heat shock resistance and longer life, in yeast, worms, and flies. Furthermore, we show that anti-aging drugs such as rapamycin, Torin1, and trametinib reduce translation errors, and that rapamycin extends further organismal longevity in RPS23 hyperaccuracy mutants. This implies a unified mode of action for diverse pharmacological anti-aging therapies. These findings pave the way for identifying novel translation accuracy interventions to improve aging.
Victoria Eugenia Martinez-Miguel, Celia Lujan, Tristan Espie-Caullet, Daniel Martinez-Martinez, Saul Moore, Cassandra Backes, Suam Gonzalez, Evgeniy R Galimov, AndrÃ© E X Brown, Mario Halic, Kazunori Tomita, Charalampos Rallis, Tobias von der Haar, Filipe Cabreiro, Ivana Bjedov50100ug10001mg100ug Lyophilized101 Set1mg100ug Lyophilized
#34525329 2021/09/12 To Up
Application of carbon monoxide in kidney and heart transplantation: A novel pharmacological strategy for a broader use of suboptimal renal and cardiac grafts.Carbon monoxide (CO) was historically regarded solely as a poisonous gas that binds to hemoglobin and reduces oxygen-carrying capacity of blood at high concentrations. However, recent findings show that it is endogenously produced in mammalian cells as a by-product of heme degradation by heme oxygenase, and has received a significant attention as a medical gas that influences a myriad of physiological and pathological processes. At low physiological concentrations, CO exhibits several therapeutic properties including antioxidant, anti-inflammatory, anti-apoptotic, anti-fibrotic, anti-thrombotic, anti-proliferative and vasodilatory properties, making it a candidate molecule that could protect organs in various pathological conditions including cold ischemia-reperfusion injury (IRI) in kidney and heart transplantation. Cold IRI is a well-recognized and complicated cascade of interconnected pathological pathways that poses a significant barrier to successful outcomes after kidney and heart transplantation. A substantial body of preclinical evidence demonstrates that CO gas and CO-releasing molecules (CO-RMs) prevent cold IRI in renal and cardiac grafts through several molecular and cellular mechanisms. In this review, we discuss recent advances in research involving the use of CO as a novel pharmacological strategy to attenuate cold IRI in preclinical models of kidney and heart transplantation through its administration to the organ donor prior to organ procurement or delivery into organ preservation solution during cold storage and to the organ recipient during reperfusion and after transplantation. We also discuss the underlying molecular mechanisms of cyto- and organ protection by CO during transplantation, and suggest its clinical use in the near future to improve long-term transplantation outcomes.
George J Dugbartey, Karl K Alornyo, Patrick P W Luke, Alp Sener
2245 related Products with: Application of carbon monoxide in kidney and heart transplantation: A novel pharmacological strategy for a broader use of suboptimal renal and cardiac grafts.100ul100 ml50ul1 ml 25 MG 100ul200ug25 mg100ug Lyophilized
#34525300 // To Up
Using an implementation science approach to build leader facilitation capability in healthcare: a novel approach for enhancing action learning set facilitation.The study describes the implementation of a novel strategy, entitled the Action Learning Set Facilitation Model, to develop internal facilitation capability to lead change. The Model incorporated the Novice-Experienced-Expert pathway, a facilitation development approach underpinning the integrated-Promoting Action on Research Implementation in Health Services Implementation Framework, with action learning methodology.
Jodie Shoobridge, Tim Schultz, Gill Harvey, Neil Kirby
2912 related Products with: Using an implementation science approach to build leader facilitation capability in healthcare: a novel approach for enhancing action learning set facilitation.100 100 1 mg100 μg 100ul200 16 Arrays/Slide
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