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Search results for: Nuclear

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#35045554   2022/01/17 To Up

Can nuclear imaging accurately detect scar in ischemic cardiac resynchronization therapy candidates?

Accurate scar assessment is crucial in cardiac resynchronization therapy (CRT) candidates, since its presence is a negative predictor for CRT response. Therefore, we assessed the performance of different PET parameters to detect scar in CRT candidates.
Ganna Degtiarova, Piet Claus, Jürgen Duchenne, Georg Schramm, Johan Nuyts, Jan Bogaert, Gabor Vöros, Rik Willems, Hein J Verberne, Jens-Uwe Voigt, Olivier Gheysens

1134 related Products with: Can nuclear imaging accurately detect scar in ischemic cardiac resynchronization therapy candidates?



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#35045553   2022/01/17 To Up

Predicting pathological response and overall survival in locally advanced gastric cancer patients undergoing neoadjuvant chemotherapy: the role of PET/computed tomography.

Gastric cancer is the second leading cause of cancer-related deaths, with a 5-year survival rate of about 20-25%. The ability to predict pathological response (PR) to neoadjuvant chemotherapy (NACT); hence, overall survival (OS) probability of patients can allow the clinician to individualize treatment strategies. We investigated the role of F-18 fluorodeoxyglucose PET-computed tomography (F-18 FDG PET/CT) in predicting histopathologic response and prognosis in locally advanced gastric cancer (LAGC) patients undergoing NACT.
Zeynep Gülsüm Güç, Bülent Turgut, Arzu Avci, Fevzi Cengiz, Mehmet Eren Kalender, Ahmet Alacacioğlu

2627 related Products with: Predicting pathological response and overall survival in locally advanced gastric cancer patients undergoing neoadjuvant chemotherapy: the role of PET/computed tomography.

100 UG

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#35045552   2022/01/17 To Up

Prediction of early biochemical response after 177Lu-PSMA radioligand therapy with 68Ga-PSMA PET, a different perspective with quantitative parameters.

In this study, our aim was to evaluate the relationship of the quantitative data obtained from pretreatment 68Ga prostate-specific membrane antigen (PSMA) PET-computerized tomography (PET/CT) with treatment response of the patients with the diagnosis of metastatic castrationresistant prostate cancer (mCRPC) who received 177Lu-PSMA radioligand therapy (RLT).
Ayşegül Aksu, Özge Vural Topuz, Burçak Yilmaz, Nazli Pinar Karahan Şen, Emine Acar, Gamze Çapa Kaya

2255 related Products with: Prediction of early biochemical response after 177Lu-PSMA radioligand therapy with 68Ga-PSMA PET, a different perspective with quantitative parameters.

100tests16 Arrays/Slide100ug Lyophilized16 Arrays/Slide1mg100ug8 Sample Kit16 Arrays/Slide100ug Lyophilized100Tests16 Arrays/Slide100ug Lyophilized

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#35045551   2022/01/17 To Up

Dosimetry in Lu-177-PSMA-617 prostate-specific membrane antigen targeted radioligand therapy: a systematic review.

177Lu-prostate-specific membrane antigen (PSMA) gained popularity as a choice of agent in the treatment of patients with advanced prostate cancer or metastatic castration-resistant stage of prostate carcinoma (mCRPC) diseases. However, this treatment may cause fatal effects, probably due to unintended irradiation of normal organs. We performed an extensive systematic review to assess the organs at risk and the absorbed dose received by tumor lesions in 177Lu-PSMA therapy.
Amit Nautiyal, Ashish K Jha, Sneha Mithun, Venkatesh Rangarajan

1825 related Products with: Dosimetry in Lu-177-PSMA-617 prostate-specific membrane antigen targeted radioligand therapy: a systematic review.

100 4 Membranes/Box4 Membranes/Box4 Membranes/Box 25 ml Ready-to-use 4 Membranes/Box4 Membranes/Box4 Membranes/Box1 kit(96 Wells)4 Membranes/Box 25 ml Ready-to-use

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#35045550   2022/01/17 To Up

Comparison of 99mTc-methyl diphosphonate bone scintigraphy and 68Ga-DOTANOC PET/computed tomography in articular manifestation of rheumatoid arthritis.

Tc-99m methyl diphosphonate (MDP) bone scintigraphy is used to assess disease activity in rheumatoid arthritis (RA). Somatostatin receptor (SSTR) expression in RA has been reported previously. SSTR-based PET/computed tomography (CT) may be superior to bone scintigraphy to know disease extent and in locating inflammatory joints that can be further targeted with peptide receptor radionuclide therapy thereby opening up new theranostic avenues. Based on these facts, the present study was designed to compare Tc-99m MDP bone scintigraphy and Ga-68 DOTANOC PET/CT in patients with RA.
Shamim Ahmed Shamim, Geetanjali Arora, Naresh Kumar, Abhishek Behera, Jhangir Hussain, Ranjan Gupta, Rakesh Kumar, Chandrasekhar Bal

1000 related Products with: Comparison of 99mTc-methyl diphosphonate bone scintigraphy and 68Ga-DOTANOC PET/computed tomography in articular manifestation of rheumatoid arthritis.

10 mg48 assays 25 mg50 mg1 mg900 tests96 assays 100 mg10 mg

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#35045548   2022/01/17 To Up

Development of neutron-activated samarium-153-loaded polystyrene microspheres as a potential theranostic agent for hepatic radioembolization.

Hepatic radioembolization is an effective minimally invasive treatment for primary and metastatic liver cancers. Yttrium-90 [90Y]-labelled resin or glass beads are typically used as the radioembolic agent for this treatment; however, these are not readily available in many countries. In this study, novel samarium-153 oxide-loaded polystyrene ([153Sm]Sm2O3-PS) microspheres were developed as a potential alternative to 90Y microspheres for hepatic radioembolization.
Hun Yee Tan, Yin How Wong, Azahari Kasbollah, Mohammad Nazri Md Shah, Basri Johan Jeet Abdullah, Alan Christopher Perkins, Chai Hong Yeong

2479 related Products with: Development of neutron-activated samarium-153-loaded polystyrene microspheres as a potential theranostic agent for hepatic radioembolization.

10 plates96 Tests1 kit50 assays100 assays0.1ml (1mg/ml)1 kit100 plates1 kit

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#35045547   2022/01/17 To Up

F-18 DOPA PET/CT in pediatric patients with hyperinsulinemic hypoglycemia: A correlation with genetic analysis.

Persistent hyperinsulinemic hypoglycemia is a rare but life-threatening disease of infancy and childhood. 18F-DOPA PET/CT has been shown to be a useful modality in the localization of focal pancreatic lesions in these patients. We aimed to assess the role of 18F-DOPA PET/CT in such patients at our institution.
Sambit Sagar, Geetanjali Arora, Nishikant Damle, Rajni Sharma, Vandana Jain, Manisha Jana, Madhavi Tripathi, Chandrasekhar Bal, Prabudh Goel

2762 related Products with: F-18 DOPA PET/CT in pediatric patients with hyperinsulinemic hypoglycemia: A correlation with genetic analysis.

1 Set1 Set1 Set1 Set1 Set1 Set1 Set1 Set1 Set200ul1 Set1 Set

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#35045546   2022/01/17 To Up

Evaluation of fluorine-18-fluorodeoxyglucose PET/computed tomography and human epithelial growth factor receptor 2 expression in treatment-naive patients with lung adenocarcinoma.

Human epithelial growth factor receptor 2 (HER2) is overexpressed in several types of cancers. The correlation between tumor glucose activity and HER2 expression can vary. This study is a retrospective investigation of fluorine-18-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) and HER2 expression status in patients with lung adenocarcinoma.
Yuan Li, Xiaodong Wu, Juanjuan Fang, Qingping Zhao, Yan Huang, Lei Jiang

1248 related Products with: Evaluation of fluorine-18-fluorodeoxyglucose PET/computed tomography and human epithelial growth factor receptor 2 expression in treatment-naive patients with lung adenocarcinoma.

20ug2 Pieces/Box10ug1 kit(96 Wells)4 Membranes/Box100 μg2ug100ug Lyophilized96tests2 50 ug1 ml

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#35045368   2022/01/13 To Up

Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway.

Inhibition of oxidized low-density lipoprotein (oxLDL)-induced vascular endothelial cell (VEC) injury is one of the effective strategies for treating atherosclerosis. In the present study, a series of novel marine phidianidine-inspired indole-1,2,4-oxadiazoles was designed, synthesized, and evaluated for their effects against oxLDL-induced injury in VECs. Among them, compound D-6, displaying the most effective protective activity, was found to inhibit oxLDL-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Mechanistic studies showed that D-6 could trigger Nrf2 nuclear translocation, subsequently resulting in increased expression of Nrf2 target gene HO-1. Meanwhile, D-6 suppressed the increase of ROS level and nuclear translocation of NF-κB induced by oxLDL. Importantly, Nrf2 knockdown attenuated the inhibition effects of D-6 on oxLDL-induced apoptosis, ROS production and NF-κB nuclear translocation. Collectively, our studies demonstrated that compound D-6 protected against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway.
Hong-Xu Xie, Yan-Hong Wang, Jin-He Zhang, Juan Zhang, Ying-Nan Zhong, Yong-Xi Ge, Zhi-Qiang Cheng, Cheng-Shi Jiang, Ning Meng

1804 related Products with: Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway.

100 0.5 ml100ug Lyophilized200 100ug Lyophilized0.2 mL100ug Lyophilized20 100ul100ug Lyophilized50 ul0.5 ml

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