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#33098751   2020/10/24 To Up

Prospective phase II study of children affected by bilateral intraocular retinoblastoma with macular involvement of both eyes or in the only preserved eye. Macular tumor control, eye preservation rate, and visual outcome.

Conservative treatments of intraocular retinoblastoma often consist of chemotherapy and focal treatments. The protocols vary and currently may combine two or three drugs, with different number of cycles, associated to the ocular treatments. In case of macular/paramacular involvement, tumor location and retinal scars induced by focal treatments often have a major negative impact on final visual outcome.
Ida Russo, Christine Levy-Gabriel, Axelle Dupont, Livia Lumbroso-Le Rouic, Nathalie Cassoux, Laurence Desjardins, Anne-Isabelle Bertozzi, Carole Coze, François Doz, Alexia Savignoni, Isabelle Aerts

2413 related Products with: Prospective phase II study of children affected by bilateral intraocular retinoblastoma with macular involvement of both eyes or in the only preserved eye. Macular tumor control, eye preservation rate, and visual outcome.



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#33098724   2020/10/24 To Up

Structural determinants for NF-Y subunit organization and NF-Y/DNA association in plants.

NF-Y transcription factor comprises three subunits; NF-YA, NF-YB, and NF-YC. NF-YB and NF-YC dimerize through their histone fold domain (HFD), which can bind DNA in a non-sequence-specific fashion while serving as a scaffold for NF-YA trimerization. Upon trimerization, NF-YA specifically recognizes the CCAAT box sequence on promoters and enhancers. In plants, each NF-Y subunit is encoded by several genes giving rise to hundreds of potential heterotrimeric combinations. In addition, plant NF-YBs and NF-YCs interact with other protein partners to recognize a plethora of genomic motifs, as the CCT protein family that binds CORE sites. The NF-Y subunit organization and its DNA-binding properties, together with the NF-Y HFD capacity to adapt different protein modules, represent plant-specific features that play a key role in development, growth and reproduction. Despite their relevance, these features are still poorly understood at the molecular level. Here, we present the structures of Arabidopsis and rice NF-YB/NF-YC dimers, and of an Arabidopsis NF-Y trimer in complex with the FT CCAAT box, together with biochemical data on NF-Y mutants. The dimeric structures identify the key residues for NF-Y HFD stabilization. The NF-Y/DNA structure and the mutation experiments shed light on HFD trimerization interface properties and the NF-YA sequence appetite for the bases flanking the CCAAT motif. These data explain the logic of plant NF-Y gene expansion: the trimerization adaptability and the flexible DNA-binding rules serve the scopes of accommodating the large number of NF-YAs, CCTs and possibly other NF-Y HFD binding partners and a diverse audience of genomic motifs.
Antonio Chaves-Sanjuan, Nerina Gnesutta, Andrea Gobbini, Damiano Martignago, Andrea Bernardini, Fabio Fornara, Roberto Mantovani, Marco Nardini

2540 related Products with: Structural determinants for NF-Y subunit organization and NF-Y/DNA association in plants.

20 100 μg2 mg 1 G0.1 mg1 mg100 100 ul100μg100 ug25 mg

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#33098722   2020/10/24 To Up

Vitamin D decreases Porphyromonas gingivalis internalized into macrophages by promoting autophagy.

This paper aims to study the effect of the active form of vitamin D (calcitriol) on the internalized P. gingivalis in macrophages and to assess the role of autophagy during this process.
Li Niu, Shuangshuang Chen, Xue Yang, Chunliang Ma, Chunling Pan, Hongyan Wang, Qian Li, Fengxue Geng, Xiaolin Tang

1534 related Products with: Vitamin D decreases Porphyromonas gingivalis internalized into macrophages by promoting autophagy.

100 250ul1 mg200 assays200ul2.5 g100ug Lyophilized100ug Lyophilized 25 G1L100ug1 g

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#33098721   2020/10/24 To Up

REGIONAL VARIABILITY OF INTEGRAL INTENSITY OF BIOLUMINESCENCE OF HYDROBIONTS IN THE WATERS OF THE BLACK SEA IN SUMMER PERIOD UNDER INFLUENCE OF HYDROPHYSICAL PROCESSE.

The analysis of the features of the vertical distribution the intensity of bioluminescence of the phytoplankton community, which characterizes the concentration of hydrobionts in the coastal and deep-water areas of the Black Sea in the summer, taking into account the thermohaline structure of the waters and the regional characteristics of eddy formations determined from satellite measurements of sea level anomalies, was carried out. For a comparative assessment of the variability of the total biomass and the number of hydrobionts in the considered regions, the integral intensity of bioluminescence of hydrobionts (IIBH) was used. It was found that the highest IIBH, averaging 37830 pW·cm ·l , was observed at stations located on the South-Western shelf of the Crimea, the layer with a high level of bioluminescence intensity of hydrobionts in this area was located at depths from 15 to 23 m. At the stations located in the Kerch pre-strait area, most of which were in the divergence zone, the average IIBH was quite high (30530 pW·cm ·l ), second only to the value on the shallow South-Western shelf.
Ye B Mel'nikova, A N Serebrennikov, A V Melnikov

1574 related Products with: REGIONAL VARIABILITY OF INTEGRAL INTENSITY OF BIOLUMINESCENCE OF HYDROBIONTS IN THE WATERS OF THE BLACK SEA IN SUMMER PERIOD UNDER INFLUENCE OF HYDROPHYSICAL PROCESSE.

5 G11 mg100μg

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#33098713   2020/10/24 To Up

Hospitalization for COVID-19 in patients treated with selected immunosuppressant and immunomodulating agents, compared to the general population - a Danish cohort study.

In the Danish population, we examined whether patients treated with thiopurines, methotrexate, systemic corticosteroids, anti-TNF-α agents, anti-interleukin therapeutic agents, selective immunosuppressive agents, and cyclosporine/tacrolimus had an increased risk of hospitalization for COVID- 19, compared to the background population.
Bente Mertz Nørgård, Jan Nielsen, Torben Knudsen, Rasmus Gaardskaer Nielsen, Michael Due Larsen, Line Riis Jølving, Jens Kjeldsen

1185 related Products with: Hospitalization for COVID-19 in patients treated with selected immunosuppressant and immunomodulating agents, compared to the general population - a Danish cohort study.

1 G100 μg1 kit100 100

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#33098699   2020/10/24 To Up

The significance of acute kidney injury in Clostridioides difficile infection.

Clostridioides difficile infection (CDI) may present as sepsis with acute kidney injury (AKI). Herein, we aimed to evaluate the clinical outcomes of patients with AKI complicating CDI.
T Avni, H Hammud, O Itzhaki, A Gafter-Gvili, B Rozen-Zvi, H Ben-Zvi, J Bishara, A Atamna

2356 related Products with: The significance of acute kidney injury in Clostridioides difficile infection.

96T

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#33098691   2020/10/24 To Up

Single-parent expression drives dynamic gene expression complementation in maize hybrids.

Single parent expression (SPE) is defined as gene expression in only one of the two parents. SPE can arise from differential expression between parental alleles (non-presence/absence (PAV) SPE) or the physical absence of a gene in one parent (PAV SPE). We used transcriptome data of diverse maize inbreds and hybrids including 401 samples from five different tissues to test for differences between these types of SPE genes. SPE, while commonly observed, is highly genotype- and tissue-specific. A positive correlation was observed between the genetic distance of the two inbred parents and the number of SPE genes identified. Regulatory analysis showed that PAV SPE and non-PAV SPE genes are mainly regulated by cis effects, with a small fraction under trans-regulation. Polymorphic transposable element insertions in promoter sequences contributed to the high level of cis-regulation for PAV SPE and non-PAV SPE genes. PAV SPE genes were more frequently expressed in hybrids than non-PAV SPE genes. The expression of parentally silent alleles in hybrids of non-PAV SPE genes was relatively rare, but occurred in most hybrids. Non-PAV SPE genes with expression of the silent allele in hybrids are more likely to exhibit above high-parent expression level than those that do not express the silent allele, leading to non-additive expression. This study provides a comprehensive understanding of the nature of non-PAV SPE and PAV SPE genes and their roles in gene expression complementation in maize hybrids. Supporting Information.
Zhi Li, Peng Zhou, Rafael Della Coletta, Tifu Zhang, Alex B Brohammer, Christine O'Connor, Brieanne Vaillancourt, Anna Lipzen, Chris Daum, Kerrie Barry, Natalia de Leon, Cory D Hirsch, C Robin Buell, Shawn M Kaeppler, Nathan M Springer, Candice N Hirsch

1396 related Products with: Single-parent expression drives dynamic gene expression complementation in maize hybrids.

300 units5 μg

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#33098621   2020/10/24 To Up

Silver nanocolloid affects hindbrain vascular formation during medaka embryogenesis.

Angiogenesis is essential for the normal development of an embryo. Silver nanocolloid (SNC) is known to induce vascular malformation in the medaka embryo. We focused on the development of the central arteries (CtAs) in the hindbrain of Japanese medaka. The CtAs and the basilar artery from which they branch are essential for transporting the blood and nutrients necessary to support the hindbrain parenchyma and the development of the pons and cerebellum from the hindbrain. We exposed medaka embryos at developmental stage 21 (6 somite stage), to 0, 0.5, 5, or 10 mg/L SNC and evaluated hatching rate, number of thrombi per embryo, head size (length and width), body length, and angiogenesis. Although all SNC-exposed embryos hatched, their head size and body length were small in comparison to controls; in addition, the number of thrombi in the head increased and head size and body length decreased as the SNC concentration increased. To evaluate vasculogenic abnormalities, we performed whole-mount in situ hybridization using a vascular marker (eg, fl7) and visualized the CtAs in medaka embryos. In control embryos, CtAs started to sprout at stage 32 (somite completion stage) and their extension was complete by stage 35 (pectoral fin blood circulation stage). In contrast, CtAs failed to sprout in SNC-exposed embryos, and thrombi were present. Furthermore, qRT-PCR analysis showed that SNC significantly suppressed the egfl7 expression level at stage 35. Together, our findings suggest that SNC induced decreased developments of head and body in medaka embryos due to insufficient angiogenesis and hindbrain vascular formation.
Tomomi Matsukura, Chisato Kataoka, Yohei Kawana, Misato Fujita, Shosaku Kashiwada

2280 related Products with: Silver nanocolloid affects hindbrain vascular formation during medaka embryogenesis.

100ug 30 ml 2ug96 Tests 500 ml 100 μg 125 ml 2ug x 202ug2ug 125 ml 96tests

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#33098615   2020/10/24 To Up

The sodium-glucose cotransporter 2 inhibitor tofogliflozin prevents diabetic kidney disease progression in type 2 diabetic mice.

Trials on cardiovascular and renal outcomes in patients with type 2 diabetes have consistently demonstrated that sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of diabetic kidney disease (DKD) progression. However, their renal protective mechanisms have yet to be completely understood and the effect on albuminuria reduction in animal models is controversial. Here, we investigated these issues using KK and KK-A mice as a control (CTRL) and as a model for type 2 diabetes (DKD), respectively. KK-A mice were treated with 0.015% tofogliflozin, which is an SGLT2 inhibitor, starting at seven weeks of age for eight weeks. Compared with the CTRL mice, the DKD mice had higher HbA1c levels and albuminuria. Although tofogliflozin treatment significantly lowered HbA1c levels, it did not reverse albuminuria. Tofogliflozin treatment enhanced damage in both the glomerular (i.e., enlarged mesangial area, increased foot process effacement rate, and decreased number of WT-1-positive cells) and tubulointerstitial (increased protein levels of KIM-1 and MCP-1, increased number of macrophages, and abnormal mitochondrial morphology) areas. Our results suggest that tofogliflozin may prevent glomerular and tubulointerstitial damage, partly by ameliorating hyperglycemia, renal inflammation, and abnormal mitochondrial morphology.
Zi Li, Maki Murakoshi, Saki Ichikawa, Takeo Koshida, Eri Adachi, Chigure Suzuki, Seiji Ueda, Tomohito Gohda, Yusuke Suzuki

1143 related Products with: The sodium-glucose cotransporter 2 inhibitor tofogliflozin prevents diabetic kidney disease progression in type 2 diabetic mice.

10mg5mg200ul5mg10mg200ul20mg200ul5mg5mg

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