Only in Titles

Search results for: Opioid

paperclip

Error loading info... Pleas try again later.
paperclip

#35044740   // To Up

Significant factors associated with problematic use of opioid pain relief medications among the household population, Canada, 2018.

Reliance on the use of opioids to manage pain has increased over time, as have opioid-related morbidity and deaths. In 2018, 12.7% of Canadians reported having used opioid pain relief medications (OPRMs) in the previous year. Among these people, 9.6% had engaged in problematic use that could cause harm to their health. Though socioeconomic characteristics associated with opioid-related harms have previously been reported, population-level evidence based on administrative health data lacks important behavioural and psychosocial information. This analysis extends previous research by using modelling to report factors related to the problematic use of OPRMs for the household population aged 15 and older in Canada.
Gisèle Carrière, Rochelle Garner, Claudia Sanmartin

1358 related Products with: Significant factors associated with problematic use of opioid pain relief medications among the household population, Canada, 2018.

500 Units0.1mg96250ul1100ug 100ul0.1mg16 Arrays/Slide

Related Pathways

paperclip

#35044484   2022/01/19 To Up

Post-marketing surveillance of the safety and effectiveness of naldemedine in the management of opioid-induced constipation in patients with cancer pain in Japan.

This prospective post-marketing surveillance (PMS) was designed to collect data on the safety and effectiveness of naldemedine in routine clinical practice in patients with opioid-induced constipation (OIC) and cancer pain in Japan and explore the characteristics of patients prone to diarrhea.
Keiko Takata, Masami Nakazawa, Keiichi Honda, Sayo Hashimoto

2380 related Products with: Post-marketing surveillance of the safety and effectiveness of naldemedine in the management of opioid-induced constipation in patients with cancer pain in Japan.

1

Related Pathways

paperclip

#35044464   2022/01/13 To Up

Marketing Opioids to Veterans and Older Adults: A Content Analysis of Internal Industry Documents Released from State of Oklahoma v. Purdue Pharma, L.P. et al.

From 1999 to 2018 the opioid epidemic claimed over 500,000 lives in the United States. Military veterans and older adults were particularly affected; veterans' deaths attributed to opioid use increased by 65% from 2010 to 2016 while opioid prescriptions for older adults increased nine-fold between 1995 and 2010.
Hanna Yakubi, Brian Gac, Dorie Apollonio

2298 related Products with: Marketing Opioids to Veterans and Older Adults: A Content Analysis of Internal Industry Documents Released from State of Oklahoma v. Purdue Pharma, L.P. et al.

1 module1 module1 module1 module1 module1 module1 module1 module1 module1 module3 modules

Related Pathways

    No related Items
paperclip

#35044328   2022/01/17 To Up

Review of publications evaluating opioid use in patients with inflammatory rheumatic disease.

This article discusses publications assessing the prevalence, efficacy, and safety of opioid analgesics in patients with rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, ankylosing spondylitis, and systemic sclerosis.
Christine Anastasiou, Jinoos Yazdany

1762 related Products with: Review of publications evaluating opioid use in patients with inflammatory rheumatic disease.

2ug 50 UG1 mg2ug1-99 mg/ml/ea price x 2

Related Pathways

    No related Items
paperclip

#35043869   // To Up

Investigation of the effect of ultrasonography-guided bilateral erector spinae plane block on postoperative opioid consumption and pain scores in patients undergoing hepatectomy: a prospective, randomized, controlled study.

There is still a debate about what constitutes effective and safe postoperative analgesia in hepatectomy surgery. Erector spinae plane (ESP) block may be an important part of multimodal analgesia application in hepatectomy surgery.
Gülçin Hacıbeyoğlu, Ahmet Topal, Tevfik Küçükkartallar, Resul Yılmaz, Şule Arıcan, Sema Tuncer Uzun

1415 related Products with: Investigation of the effect of ultrasonography-guided bilateral erector spinae plane block on postoperative opioid consumption and pain scores in patients undergoing hepatectomy: a prospective, randomized, controlled study.

1100ug

Related Pathways

    No related Items
paperclip

#35043766   2022/01/19 To Up

Potential Therapeutic Application of Local Anesthetics in Cancer Treatment.

Local anesthetics are voltage-gated sodium channel blockers primarily administered locally or to the innervating nerves for anesthetic or analgesic purposes. In vitrol studies have found direct effects of local anesthetics on cancer cell, such as impacts on cancer cell proliferation, apoptosis, migration, invasion, and chemosensitivity, which involved multiple mechanisms. So far, in vivo evidence in the effect of local anesthetics on cancer cell lines is relatively lacking. Local and regional anesthesia administration has been reported to reduce postoperative pain and opioid use in cancer treatment. Additionally, regional anesthesia may reduce the perioperative stress response. However, the clinical therapeutic application of local anesthetics on cancer remains exploratory. In this review, we will discuss the direct and indirect effect of local anesthetics on cancer cells, and discuss the current evidence for the use of local anesthetics in the treatment of cancer.
Zhaosheng Jin, William Zhang, Hengrui Liu, Arianna Ding, Yongjian Lin, Shao-Xiong Wu, Jun Lin

1999 related Products with: Potential Therapeutic Application of Local Anesthetics in Cancer Treatment.

2 Pieces/Box50ul

Related Pathways

paperclip

#35043681   2022/01/19 To Up

Inhibition of POMC neurons in mice undergoing activity-based anorexia selectively blunts food anticipatory activity without affecting bodyweight or food intake.

Anorexia nervosa (AN) is a debilitating eating disorder characterized by severely restricted eating and significant bodyweight loss. Additionally, many individuals also report engaging in excessive exercise. Previous research using the activity-based anorexia (ABA) model has implicated the hypothalamic proopiomelanocortin (POMC) system. Using the ABA model, Pomc mRNA has been shown to be transiently elevated in both male and female rodents undergoing ABA. Additionally, the POMC peptide β-endorphin appears to contribute to food anticipatory activity (FAA), a characteristic of ABA, as both deletion and antagonism of the mu opioid receptor (MOR) which β-endorphin targets, results in decreased FAA. The role of β-endorphin in reduced food intake in ABA is unknown and POMC neurons release multiple transmitters in addition to β-endorphin. In the current study, we set out to determine whether targeted inhibition of POMC neurons themselves rather than their peptide products would lessen the severity of ABA. Inhibition of POMC neurons during ABA via chemogenetic Designer Receptors Exclusively Activated by Designer Drugs (DREADD) technology resulted in reduced FAA in both male and female mice with no significant changes in bodyweight or food intake. The selective reduction in FAA persisted even in the face of concurrent chemogenetic inhibition of additional cell types in the hypothalamic arcuate nucleus. The results suggest that POMC neurons could be contributing preferentially to excessive exercise habits in patients with AN. Furthermore, the results also suggest that metabolic control during ABA appears to take place via a POMC neuron-independent mechanism.
Caitlin M Daimon, Shane T Hentges

1935 related Products with: Inhibition of POMC neurons in mice undergoing activity-based anorexia selectively blunts food anticipatory activity without affecting bodyweight or food intake.

48 assays0.1ml (1mg/ml)48 assays 96 assays 1 kit48 assays 96 assays 48 assays 96 wells

Related Pathways

paperclip

#35043597   2022/01/18 To Up

6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects.

Current common analgesics are mediated through the mu or kappa opioid receptor agonism. Unfortunately, selective mu or kappa receptor agonists often cause harmful side effects. However, ligands exhibiting dual agonism to the opioid receptors, such as to mu and kappa, or to mu and delta, have been suggested to temper undesirable adverse effects while retaining analgesic activity. Herein we report an introduction of various 6,5-fused rings to C2 of the salvinorin scaffold via an ester linker. In vitro studies showed that many of these compounds have dual agonism on kappa and mu opioid receptors. In vivo studies on the lead dual kappa and mu opioid receptor agonist demonstrated supraspinal thermal analgesic activity while avoiding anxiogenic effects in male mice, thus providing further strong evidence in support of the therapeutic advantages of dual opioid receptor agonists over selective opioid receptor agonists.
Nicholas Akins, Nisha Mishra, Hannah Harris, Narendar Dudhipala, Seong Jong Kim, Adam Keasling, Soumyajit Majumdar, Jordan Zjawiony, Jason Paris, Nicole Ashpole, Hoang Le

2377 related Products with: 6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects.

100ug100ug100ug100ug Lyophilized100ug100ug Lyophilized100ug100ug100ug100ug100ug Lyophilized100ug

Related Pathways

paperclip

#35043434   2022/01/18 To Up

Stability evaluation of morphine, hydromorphone, metamizole and esketamine containing analgesic mixtures applied for patient-controlled analgesia in hospice and palliative care.

In this study, different injection solutions containing opioid and non-opioid compounds used for patient-controlled analgesia in hospice and palliative care were evaluated in terms of analyte stability. Investigated injection solutions contained different combinations of morphine, hydromorphone, metamizole and esketamine. For the practical implementation, samples from infusion pumps were daily drawn over a period of seven days at 22°C and 37°C. Quantitative measurements were performed on a high-performance liquid chromatography system with ultraviolet detection applying a validated analytical method. All compounds apart from morphine showed no evident changes in concentration. However, a significant loss of morphine was observed for injection mixtures containing both morphine and metamizole at 37°C. After seven days, only 72% of the initially measured morphine concentration was measured in the binary and 77% in the ternary mixture. Furthermore, an additional compound was detected that could represent the morphine-metamizole-adduct, "metamorphine". Based on these results, a significantly reduced morphine concentration must be expected after only three days if an injection solution mixture containing both morphine and metamizole is administered to a patient at 37°C. Since the analgesic effects of morphine-metamizole-adducts have not yet been thoroughly investigated, further clinical studies are necessary before accurate conclusions can be drawn in this regard.
Matthias Harder, Anna Fiegl-Lechner, Herbert Oberacher, Ulrike E I Horvath, Andreas Schlager, Martina Jeske, Sylvia Kerndler, Falko Schüllner, Günther K Bonn, Matthias Rainer

1963 related Products with: Stability evaluation of morphine, hydromorphone, metamizole and esketamine containing analgesic mixtures applied for patient-controlled analgesia in hospice and palliative care.

10 mg10 mg0.1 mg100 mg100.00 ul1,000 tests200ug2.5 mg1 mg

Related Pathways