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#33091967   2020/10/22 To Up

Nationwide Comparison of Surgical and Oncologic Outcomes in Endometrial Cancer Patients Undergoing Robotic, Laparoscopic, and Open Surgery: A Population-Based Cohort Study.

Population-based comparisons between minimally invasive surgery (MIS) (robotic surgery [RS] and laparoscopic surgery [LS]) and open surgery (OS) for managing endometrial cancer are lacking. This study aimed to compare surgical and oncologic outcomes between endometrial cancer patients who underwent surgical staging via MIS or OS.
Kyung-Jin Eoh, Eun-Ji Nam, Sang-Wun Kim, Minkyung Shin, Stella J-H Kim, Jung-Ae Kim, Yong-Tae Kim

1180 related Products with: Nationwide Comparison of Surgical and Oncologic Outcomes in Endometrial Cancer Patients Undergoing Robotic, Laparoscopic, and Open Surgery: A Population-Based Cohort Study.



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#33091964   2020/10/22 To Up

The utility of a monocyte monolayer assay in the assessment of intravenous immunoglobulin-associated hemolysis.

Hemolysis following the administration of intravenous immunoglobulin (IVIG) is an important adverse event (AE). While the monocyte monolayer assay (MMA) has been used to predict in vivo hemolysis when serologically incompatible blood may be transfused, it has also been shown to correlate with IVIG-associated hemolysis. In this study, the MMA was examined for its utility in assessing the risk of hemolysis after IVIG.
Tik Nga Tong, Megan Blacquiere, Darinka Sakac, Emeralda Burke-Murphy, Qilong Yi, Jeannie Callum, Christine Cserti-Gazdewich, Nagina Parmar, Nadine Shehata, Katerina Pavenski, Wendy Lau, Yulia Lin, Lani Lieberman, Donald R Branch, Jacob Pendergrast

1152 related Products with: The utility of a monocyte monolayer assay in the assessment of intravenous immunoglobulin-associated hemolysis.

1100 assays48 assays 96 assays

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#33091960   2020/10/22 To Up

Epithelial-to-mesenchymal transition in Oral Squamous Cell Carcinoma: challenges and opportunities.

Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90% of all forms of oral cancer worldwide. Although great efforts have been made in the past decades, the five-year survival rate of OSCC patients is no more than 60% due to tumor metastasis and subsequent recurrence. The metastasis from the primary site is due to a complex process known as epithelial-to-mesenchymal transition (EMT). During the EMT, epithelial cells gradually acquire the structural and functional characteristics of mesenchymal cells, leading to the upregulation of cell migration and the promotion of tumor cell dissemination. Therefore, EMT attracted broad attention due to its close relationship with cancer invasion and metastasis. Therefore, in the present review, an extensive description of the current research on OSCC and the role of EMT in this cancer type is provided, including diverse EMT markers, regulatory networks and crucial EMT-inducing transcription factors in OSCC. Moreover, a brief summary was made regarding the current application of EMT-correlated indexes in the prognostic analysis of OSCC patients, and the potential therapeutic approaches against OSCC and difficulties in the development of an effective anti-EMT treatment are discussed. Our aim is to provide novel insights to develop new strategies to combat OSCC by targeting EMT.
Zihang Ling, Bin Cheng, Xiaoan Tao

2508 related Products with: Epithelial-to-mesenchymal transition in Oral Squamous Cell Carcinoma: challenges and opportunities.



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#33091959   2020/10/22 To Up

Identification of A Methylation Panel Aid in Risk Stratification in Node-positive Penile Squamous Cell Carcinoma.

Molecular prognostic factors for individualized treatment of Squamous Cell Carcinoma (SCC) are poorly defined. This study developed and validated a novel molecular tools aid in pre- and post- inguinal lymphadenectomy risk stratification in node-positive penile SCC. Patients with node-positive penile SCC who underwent inguinal or ilioinguinal lymphadenectomy were divided into three cohorts: a discovery set, a development set and a validation set. The local ethics committee approved the study. The primary endpoint was cancer-specific survival (CSS). At the discovery stage, 17 CpG sites were significantly associated with CSS. In the development set, we constructed a 3-CpG-based prognostic score for survival prediction. The hazard ratio (HR) of the panel (dichotomized using the optimal cutoff) was 5.8 in the multivariate analyses (p<0.001). The addition of the methylation score significantly improved the pN-stage C-index from 0.70 to 0.79 (incremental C=0.09, p<0.001). In the validation set, the methylation panel showed a HR of 9.9 in the multivariate analyses. The addition of the molecular marker improved the pN-stage C-index from 0.69 to 0.78 (incremental C=0.09, p<0.001). The methylation score remarkably separated survival curves in different pN stages, which indicate the tool can be applied to tailor the treatment in both pre- and post- inguinal lymphadenectomy settings. We developed and validated a prognostic methylation panel for node-positive penile SCC. The tool may aid in the risk stratification of the population with heterogeneous outcomes and needs prospective validation. Patients in high risk group may benefit from more aggressive therapy or clinical trials.
Weijie Gu, Fangning Wan, Jun Chen, Hualei Gan, Beihe Wang, Yu Wei, Guiming Zhang, Jiaquan Zhou, Xuefei Ding, Peipei Zhang, Shengming Jin, Qinghua Xu, Dingwei Ye, Yao Zhu

2432 related Products with: Identification of A Methylation Panel Aid in Risk Stratification in Node-positive Penile Squamous Cell Carcinoma.



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#33091956   2020/10/22 To Up

Circulating Liver Function Markers and Colorectal Cancer Risk: A Prospective Cohort Study in the UK Biobank.

Evidence links the liver to development of colorectal cancer (CRC). However, it remains unknown how liver function may influence CRC risk in the general population. We conducted a prospective cohort study in the UK Biobank of 375,693 participants who provided blood samples in 2006-2010. Circulating levels of liver function markers [alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBIL), gamma glutamyltransferase (GGT), alkaline phosphatase (ALP), total protein (TP), and albumin (ALB)] were measured. Incident cancer cases were identified through linkage to the national cancer registry up to 2019. Repeated biomarker measurements were available from a subset of 11,320 participants who were re-assessed in 2012-2013. After a median follow-up of 10.0 years, we documented 2,662 cases of CRC. Circulating levels of ALT, AST, TBIL, GGT, TP, and ALB at baseline were inversely associated with CRC risk (P<.01), with multivariable hazard ratio (95% confidence interval) comparing decile 10 versus 1 of 0.62 (0.51-0.75), 0.63 (0.53-0.75), 0.85 (0.72-1.02), 0.74 (0.61-0.89), 0.70 (0.59-0.84), and 0.66 (0.55-0.79), respectively. Strengthened associations were found after recalibration for repeated measurements. The associations appeared stronger for proximal colon cancer than distal colon cancer and rectal cancer, but consistent for early-, mid-, and late-onset CRC. In a large cohort of general population, the UK Biobank, higher circulating levels of ALT, AST, TBIL, GGT, TP, and ALB, largely within the normal range, were associated with a lower risk of CRC. The findings support a link between liver function and CRC, and may spur future research on the gut-microbiota-liver axis. This article is protected by copyright. All rights reserved.
Ming-Ming He, Zhe Fang, Dong Hang, Feng Wang, Georgios Polychronidis, Liang Wang, Chun-Han Lo, Kai Wang, Rong Zhong, Markus D Knudsen, Scott G Smith, Rui-Hua Xu, Mingyang Song

2285 related Products with: Circulating Liver Function Markers and Colorectal Cancer Risk: A Prospective Cohort Study in the UK Biobank.



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#33091955   2020/10/22 To Up

Prognostic value of qAnti-HBc in hepatitis B virus related acute-on-chronic liver failure.

It has been reported that serum quantification of anti-HBc (qAnti-HBc) could predict antiviral response in chronic hepatitis B (CHB) patients, while its role in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) remains unclear. Its implication in HBV-ACLF was evaluated in this study.
Jing Li, Qi-Ming Gong, Pei-Lin Xie, Jun-Yu Lin, Jia Chen, Dong Wei, De-Min Yu, Yue Han, Xin-Xin Zhang

1611 related Products with: Prognostic value of qAnti-HBc in hepatitis B virus related acute-on-chronic liver failure.

100ug Lyophilized100ug50 ug2ug 2 ml Ready-to-use 50 UG96T100ug Lyophilized

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#33091944   2020/10/22 To Up

Antibiotic Timing in Previable Prelabor Rupture of Membranes Less Than 24 Weeks of Gestation.

 This study aimed to compare neonatal and maternal outcomes between immediate and delayed prophylactic antibiotic administration after previable prelabor premature rupture of membranes (PROM) less than 24 weeks of gestation.
Rubymel J Knupp, Sarah Pederson, Christina Blanchard, Jeff Szychowski, Deepa Etikala, Rachel Sinkey, Luisa Wetta, Lorie M Harper

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#33091941   2020/10/22 To Up

Risk Factors for Mortality among Newborns with Neonatal Seizures.

 The aim of the study is to examine the incidence and risk factors for death among neonates who developed neonatal seizures (NS) in an ethnically distinctive community with high consanguinity rate in Israel.
Osama Tanous, Mohamad Watad, Clari Felszer-Fisch, Marina Peniakov, Dan Miron, Raed Salim

1269 related Products with: Risk Factors for Mortality among Newborns with Neonatal Seizures.

1 G100 ml250ul500 100ug100μg96T10 mg 1000 ml 1000 units1mg

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