Search results for: Pancreas
#32650341 2020/07/10 To Up
Defining EUS Features of Chronic Pancreatitis in Asians - A Multicentre Validation Study.INTRODUCTION Although EUS features and criteria have been described in chronic pancreatitis, challenges remain with inter-operator variability and ease of adoption. AIMS The aim of the study was to define and validate EUS features of chronic pancreatitis in a multi-center prospective study in Asia. METHOD The study was conducted in 2 phases. In phase I, expert endosonographers across Asia reviewed standardized EUS videos of the pancreas for features diagnostic for chronic pancreatitis. Features that had good overall interobserver agreement were selected to derive EUS features for the diagnosis of chronic pancreatitis in Asians in a multi-centre case-control phase II study. Prospectively-enrolled cases had standard internationally validated radiologic or histologic features of chronic pancreatitis, and controls were patients without chronic pancreatitis who underwent EUS examination. RESULTS The top 6 EUS features that had good interobserver agreement (mean kappa = 0.73; range 0.60-0.90) were selected to be further evaluated in phase II study. These included: hyper-echoic foci with shadowing, lobularity with honeycombing, cysts, dilated ducts, dilated side branches, and calculi in main pancreatic duct. 284 subjects (132 cases, 152 controls) were enrolled from 12 centres in Asia. All 6 features had high accuracy ranging from 63.3% to 89.1%. 2 or more of these 6 EUS features accurately defined chronic pancreatitis (sensitivity 94.7% specificity 98.0%), with an AUROC of 0.986. CONCLUSION This is a multicentre Asian study that characterizes and defines the EUS features of chronic pancreatitis. This provides a useful tool in clinical practice and further research in pancreatic cancer surveillance.
Calvin Koh, Sundeep Lakhtakia, Mitsuhiro Kida, Cosmas Rinaldi Lesmana, Tiing Ang, Charles K F Vu, Than Aye Than, Sun Hwa Park, Majid Almadi, Charing Chong, Raymond Tang, Xi Wu, Hilmi Ida, Vinay Dhir, Nonthalee Pausawasdi, Basha Jahangeer, Zhendong Jin, Ai-Ming Yang, Anthony Teoh, Dong Wan Seo, Hsiu-Po Wang, Khek-Yu Ho
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#32650064 2020/07/01 To Up
Anti-diabetic properties of genistein-chromium (III) complex in db/db diabetic mice and its sub-acute toxicity evaluation in normal mice.In this study, chromium (III) complex was synthesized from genistein (GEN) which had good hypoglycemic activity and inorganic chromium (III) element, and its hypoglycemic activity and sub-acute toxicity were studied.
Pengshou Li, Yujia Cao, Ge Song, Baosheng Zhao, Qixiang Ma, Ziyong Li, Chaojun He
2216 related Products with: Anti-diabetic properties of genistein-chromium (III) complex in db/db diabetic mice and its sub-acute toxicity evaluation in normal mice.50 ul
#32649791 2020/07/10 To Up
COVID-19 and Kidney Transplantation: Results from the TANGO International Transplant Consortium.Kidney transplant recipients may be at high risk of developing critical COVID-19 illness due to chronic immunosuppression and comorbidities. We identified hospitalized adult kidney transplant recipients at 12 transplant centers in the US, Italy and Spain who tested positive for COVID-19. Clinical presentation, laboratory values, immunosuppression and treatment strategies were reviewed and predictors of poor clinical outcomes were determined through multivariable analyses. Among 9,845 kidney transplant recipients across centers, 144 were hospitalized due to COVID-19 during the 9-week study period. 65% were male with a mean age of 60 (±12) years, 40% Hispanic and 25% African-American. Prevalent comorbidities included hypertension (95%), diabetes (52%), obesity (49%), heart (28%) and lung (19%) disease. Therapeutic management included antimetabolite withdrawal (68%), calcineurin inhibitor withdrawal (23%), hydroxychloroquine (71%), antibiotics (74%), tocilizumab (13%) and antivirals (14%). During a median follow-up period of 52 days (IQR: 16-66 days), acute kidney injury occurred in 52% cases, respiratory failure requiring intubation in 29%, and mortality was 32%. The 44 patients who died were older, had lower lymphocyte counts and eGFR, higher serum lactate dehydrogenase, procalcitonin and IL-6 levels. In sum, hospitalized kidney transplant recipients with COVID-19 have higher rates of acute kidney injury and mortality.
Paolo Cravedi, Sarvode Mothi Suraj, Yorg Azzi, Meredith Haverly, Samira Farouk, María José Pérez-Sáez, Maria Dolores Redondo-Pachón, Barbara Murphy, Sander Florman, Laura Goldfarb Cyrino, Monica Grafals, Sandheep Venkataraman, Xingxing Shelley Cheng, Aileen Xinqian Wang, Gianluigi Zaza, Andrea Ranghino, Lucrezia Furian, Joaquin Manrique, Umberto Maggiore, Ilaria Gandolfini, Nikhil Agrawal, Het Patel, Enver Akalin, Leonardo V Riella,
1238 related Products with: COVID-19 and Kidney Transplantation: Results from the TANGO International Transplant Consortium.100 mg5 mg100ul10 mg10 mg1 mg100 mg500 Units
#32649046 2020/07/10 To Up
Main duct intraductal papillary mucinous neoplasm of the pancreas with spontaneous fistula into stomach.
Helen Kandelaki, Blaithin Page, Simon Raimes
1230 related Products with: Main duct intraductal papillary mucinous neoplasm of the pancreas with spontaneous fistula into stomach.0.1 mg 100 G50 ul
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#32648986 2020/07/10 To Up
Pancreatic divisum with chronic pancreatitis of the ventral pancreas.
Souradeep Dutta, Sathyamangalam V Sowmiya, Uday K Chapa, Ankit Jain, Abhinaya Reddy, Vishnu Prasad Nelamangala Ramakrishnaiah 25UG96 tests100.00 ul100 100 Gmin 2 cartons100 mg1
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#32647955 2020/07/09 To Up
MicroRNA MiR-27a-5p Alleviates the Cerulein-Induced Cell Apoptosis and Inflammatory Injury of AR42J Cells by Targeting Traf3 in Acute Pancreatitis.Acute pancreatitis (AP), a sudden inflammatory process of pancreas, is painful and may contribute to death. The aberrant expression of miR-27a-5p has been reported in many types of cancers and diseases including AP. Thus, it is urgent to manifest the functions and mechanism of miR-27a-5p in AP. The levels of miR-27a-5p, tumor necrosis factor (TNF) receptor-associated factor 3 (Traf3) in serum of AP patient, or cerulein-treated AR42J cells were detected by qRT-PCR. Functionally, the apoptotic rate, the protein levels of Bcl-2 and Bax, the caspase-3 activity, and the levels of IL-1β, IL-6, and TNF-α in cerulein-treated AR42J cells were measured by flow cytometry, Western blot, caspase-3 activity assay, and qRT-PCR and ELISA assay, respectively. In addition, the putative target of miR-27a-5p was predicted by TargetScan online database, and the dual luciferase reporter assay and RNA immunoprecipitation (RIP) assay were conducted to verify this interaction. Cerulein-treated mouse AP model was established to explore the role of miR-27a-5p in AP in vivo. The level of miR-27a-5p was notably downregulated in AP patients and cerulein-treated AR42J cells. The functional experiments indicated that miR-27a-5p mimics attenuated the promotion effects on cell apoptosis and the inflammatory response in AR42J cells caused by cerulein. The interaction between miR-27a-5p and Traf3 was predicted by TargetScan online database and validated by dual luciferase reporter assay and RIP assay. Following qRT-PCR results exhibited that Traf3 was apparently enhanced in cerulein-treated AR42J cells. The further functional experiments disclosed that Traf3 overexpression relieved the inhibitory effects on cell apoptosis and the inflammatory response induced by miR-27a-5p mimics in cerulein-treated AR42J cells. Moreover, miR-27a-5p alleviated cerulein-induced injury in vivo. In this study, we established the cerulein-treated AR42J cells as AP model in vitro. We validated that miR-27a-5p was significantly downregulated, and Traf3 was strikingly upregulated in AP patient and/or cerulein-treated AR42J cells. The further mechanistical and functional experiments unraveled that miR-27a-5p regulated Traf3 to relieve the cerulein-induced cell apoptosis and inflammatory injury of AR42J cells. Therefore, this novel regulatory network may provide therapeutic target for AP patients.
Yi Zhu, Shuguang Liu, Feng Wang
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#32647920 2020/07/09 To Up
Chronic Pancreatitis: Epidemiology, Diagnosis, and Management Updates.Chronic pancreatitis is a clinical entity that results from the progressive inflammation and irreversible fibrosis of the pancreas resulting from the cumulative injury sustained by the pancreas over time. It is an illness with variable presentations that can severely impact quality of life, while its long-term complications such as exocrine pancreatic insufficiency (EPI), diabetes mellitus, and risk of pancreatic cancer can become life threatening. The diagnosis of chronic pancreatitis can be challenging as despite the recent advancements in imaging technology, the radiographic findings do not become prominent until late stages of disease. Thus, the physicians' clinical acumen in obtaining thorough history taking focusing on risk factors, clinical symptoms, in addition to high-quality imaging, often guide to the accurate diagnosis of chronic pancreatitis. Endoscopy also plays a pivotal role in the diagnosis and management of chronic pancreatitis. Endoscopic ultrasound (EUS) is believed to be the most sensitive modality for diagnosing chronic pancreatitis. Despite efforts, however, natural history studies have demonstrated that 61% of individuals with chronic pancreatitis will require at least one endoscopic intervention, while 31% will require a surgical procedure as part of their management strategy. Recent advancements in genomic studies have furthered our understanding of the genetic polymorphisms that are associated with the pathogenesis of chronic pancreatitis. Genetic testing offers the potential to reveal treatable pancreatitis-related disorders, and can inform decision making with regard to radical therapies for persistent or severe disease such as total pancreatectomy with islet autotransplantation (TPIAT). The management of patients suffering from chronic pancreatitis often requires a multi-disciplinary approach, addressing pertinent symptoms as well as the sequelae of chronic inflammation and fibrosis. Abdominal pain is the prevailing symptom and most common complication of chronic pancreatitis, and impairs quality of life. Although heavily dependent on a wide range of analgesia, endoscopic treatment such as endoscopic retrograde cholangiopancreatography (ERCP) and surgical intervention can offer long-lasting relief of symptoms. For EPI, treatment with pancreatic enzyme supplements offers marginal-to-moderate relief. The most feared complication of chronic pancreatitis-the development of pancreatic cancer-has no known prevention measure to date.
Adam Kichler, Sunguk Jang10 mg100ug500 MG25 mg 50 UG200 96T100ul50 mg25 mg1000 tests1000 TESTS/0.65ml
#32647648 // To Up
Chemopreventive and Chemotherapeutic Effect of Propolis and Its Constituents: A Mini-review.Propolis is a bee wax rich in various phytocomponents and traditionally used to treat various ailments. Propolis is reported to possess an array of biological properties including anti-inflammatory, antioxidant, anti-cancer, and anti-diabetic as well as cardioprotective, hepatoprotective, renoprotective, and derma protective activities. A plethora of studies confirmed that propolis is effective against various types of cancer including head and neck, lung, liver, brain (glioma), pancreas, kidney, prostate, skin (melanoma), breast, oral, esophagus, gastric, colorectal, and bladder cancers. However, many researchers have demonstrated that propolis displays potent chemoprotective/chemopreventive or anti-cancer activity against only a few types of cancers like oral, gastrointestinal, dermal (melanoma), breast, and prostate cancers. Therefore, this mini-review only summarizes the chemopreventive/chemotherapeutic activities of propolis and its updated underlying mechanisms. Taken together, propolis displays potent chemoprotective or anti-cancer effect due to the presence of various phytocomponents which contribute to pro-apoptotic, cytotoxic, anti-proliferative (cell cycle arrest), anti-metastatic, anti-invasive, anti-angiogenic and anti-genotoxic or anti-mutagenic properties along with antioxidant, immunomodulatory, and anti-inflammatory functions. Hence, propolis could be used as an adjuvant for treating various cancers along with standard chemotherapeutic drugs. However, many large-scale clinical studies are needed to justify such applications.
Hui-Fang Chiu, Yi-Chun Han, You-Cheng Shen, Oksana Golovinskaia, Kamesh Venkatakrishnan, Chin-Kun Wang
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#32647576 2020/06/30 To Up
Significance of prediction of the dorsal landmark using three-dimensional computed tomography during laparoscopic lymph node dissection along the proximal splenic artery in gastric cancer.Dissection of the No. 11p lymph nodes is technically challenging because of variations in anatomical landmarks. This study aimed to determine the accuracy and efficacy of predicting the dorsal landmark of No. 11p lymph node using three-dimensional computed tomography simulation.
Taro Ikeda, Shingo Kanaji, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
2700 related Products with: Significance of prediction of the dorsal landmark using three-dimensional computed tomography during laparoscopic lymph node dissection along the proximal splenic artery in gastric cancer.
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#32647222 2020/07/09 To Up
Adult pancreatoblastoma: clinical features and Imaging findings.The objective of this study was to illustrate the clinical, CT, MRI, and F-FDG PET/CT features of adult pancreatoblastoma, an extremely rare disease. In this study, the clinical and imaging features of seven adult patients with pathologically confirmed pancreatoblastoma were retrospectively analyzed. The following parameters were evaluated: size, location, shape, margination, solid-cystic ratio, CT attenuation values or signal intensity and contrast enhancement pattern. We also analyzed whether abnormal FDG uptake occurred during F-FDG PET/CT imaging. All seven patients were male (mean age 45 years; range 22-65 years). Six tumors were irregular in shape, exogenous, and grew outward from the pancreatic parenchyma, similar to branches growing from a tree trunk (85.7%). The tumor margins were clear in five patients (71.4%), and three tumors (42.9%) were encapsulated. Six tumors (71.4%) were solid, with homogeneous enhancement observed on contrast-enhanced CT and MRI. Dynamic-enhanced CT and MRI showed progressive enhancement for all tumors. On F-FDG PET/CT, one tumor exhibited abnormal FDG uptake, and two tumors exhibited no abnormal uptake (66.7%). In conclusion, adult pancreatoblastoma most commonly occurs in male patients, and it usually appears as an exophytic, irregular, and hypovascular mass with well-defined margins and progressive enhancement on CT and MRI. This type of tumor always grows out of the parenchyma of the pancreas, similar to branches growing outward from a tree trunk.
Xi Zhang, Shu-Juan Ni, Xiao-Hong Wang, Dan Huang, Wei Tang100ug5mg
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