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Search results for: Pancreatic

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#32650346   2020/07/10 To Up

Contrast-enhanced harmonic versus standard endoscopic ultrasound-guided fine-needle aspiration in solid pancreatic lesions: a single-center prospective randomized trial.

 Contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) can visualize necrotic areas and vessels inside lesions. CH-EUS findings combined with EUS-guided fine-needle aspiration (EUS-FNA) improves diagnosis in pancreatic solid masses. CH-EUS can also guide EUS-FNA (CH-EUS-FNA), potentially improving the diagnostic rate of EUS-FNA, but such superiority has not been proved in prospective studies. We aimed to assess whether CH-EUS-FNA is superior to standard EUS-FNA for specific diagnosis of solid pancreatic masses and what factors affect the diagnostic rate.
Andrada Seicean, Andrada Samarghitan, Sorana D Bolboacă, Cristina Pojoga, Ioana Rusu, Daniel Rusu, Zeno Sparchez, Marcel Gheorghiu, Nadim Al Hajjar, Radu Seicean

2571 related Products with: Contrast-enhanced harmonic versus standard endoscopic ultrasound-guided fine-needle aspiration in solid pancreatic lesions: a single-center prospective randomized trial.

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#32650341   2020/07/10 To Up

Defining EUS Features of Chronic Pancreatitis in Asians - A Multicentre Validation Study.

INTRODUCTION Although EUS features and criteria have been described in chronic pancreatitis, challenges remain with inter-operator variability and ease of adoption. AIMS The aim of the study was to define and validate EUS features of chronic pancreatitis in a multi-center prospective study in Asia. METHOD The study was conducted in 2 phases. In phase I, expert endosonographers across Asia reviewed standardized EUS videos of the pancreas for features diagnostic for chronic pancreatitis. Features that had good overall interobserver agreement were selected to derive EUS features for the diagnosis of chronic pancreatitis in Asians in a multi-centre case-control phase II study. Prospectively-enrolled cases had standard internationally validated radiologic or histologic features of chronic pancreatitis, and controls were patients without chronic pancreatitis who underwent EUS examination. RESULTS The top 6 EUS features that had good interobserver agreement (mean kappa = 0.73; range 0.60-0.90) were selected to be further evaluated in phase II study. These included: hyper-echoic foci with shadowing, lobularity with honeycombing, cysts, dilated ducts, dilated side branches, and calculi in main pancreatic duct. 284 subjects (132 cases, 152 controls) were enrolled from 12 centres in Asia. All 6 features had high accuracy ranging from 63.3% to 89.1%. 2 or more of these 6 EUS features accurately defined chronic pancreatitis (sensitivity 94.7% specificity 98.0%), with an AUROC of 0.986. CONCLUSION This is a multicentre Asian study that characterizes and defines the EUS features of chronic pancreatitis. This provides a useful tool in clinical practice and further research in pancreatic cancer surveillance.
Calvin Koh, Sundeep Lakhtakia, Mitsuhiro Kida, Cosmas Rinaldi Lesmana, Tiing Ang, Charles K F Vu, Than Aye Than, Sun Hwa Park, Majid Almadi, Charing Chong, Raymond Tang, Xi Wu, Hilmi Ida, Vinay Dhir, Nonthalee Pausawasdi, Basha Jahangeer, Zhendong Jin, Ai-Ming Yang, Anthony Teoh, Dong Wan Seo, Hsiu-Po Wang, Khek-Yu Ho

2731 related Products with: Defining EUS Features of Chronic Pancreatitis in Asians - A Multicentre Validation Study.

50 UG1 Set1 Set

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#32650095   2020/07/07 To Up

Association of LINC00673 rs11655237 polymorphism with cancer susceptibility: A meta-analysis based on 23,478 subjects.

Some studies on the relationship between LINC00673 polymorphism and cancer susceptibility have been inconsistent. To perform a more comprehensively quantitative assessment of LINC00673 rs11655237 and risk of overall cancer, we operated this meta-analysis for the first time.
Na Li, Zhigang Cui, Dayang Huang, Min Gao, Sixuan Li, Mingyang Song, Ying Wang, Lianwei Tong, Zhihua Yin

1356 related Products with: Association of LINC00673 rs11655237 polymorphism with cancer susceptibility: A meta-analysis based on 23,478 subjects.

1 module1 module

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#32650064   2020/07/01 To Up

Anti-diabetic properties of genistein-chromium (III) complex in db/db diabetic mice and its sub-acute toxicity evaluation in normal mice.

In this study, chromium (III) complex was synthesized from genistein (GEN) which had good hypoglycemic activity and inorganic chromium (III) element, and its hypoglycemic activity and sub-acute toxicity were studied.
Pengshou Li, Yujia Cao, Ge Song, Baosheng Zhao, Qixiang Ma, Ziyong Li, Chaojun He

2743 related Products with: Anti-diabetic properties of genistein-chromium (III) complex in db/db diabetic mice and its sub-acute toxicity evaluation in normal mice.

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#32650031   2020/07/07 To Up

Enolase inhibition alters metabolic hormones and inflammatory factors to promote neuroprotection in spinal cord injury.

Enolase inhibition is a potential therapeutic strategy currently being investigated for treatment of spinal cord injury (SCI) as it reduces pro-inflammatory cytokines and chemokines, alters metabolic factors, and reduces gliosis in acute SCI. Herein, the role of enolase in SCI has been examined to better understand the effects of this enzyme on inflammation, metabolic hormones, glial cell activation, and neuroprotection under these shorter injury conditions. Immunohistochemical analyses of inflammatory markers vimentin, Cox-2, and caspase-1 indicated that enolase inhibition attenuated the elevated levels of inflammation seen following SCI. Iba1, GFAP, NFP, and CSPG staining indicated that enolase inhibition with prolonged administration of ENOblock reduced microglia/astrocyte activation and lead to enhanced neuroprotection in SCI. An analysis of metabolic hormones revealed that ENOblock treatment significantly upregulated plasma concentrations of peptide YY, glucagon-like peptide 1, glucose-dependent insulinotropic peptide, glucagon, and insulin hormones as compared to vehicle-treated controls (Mann-Whitney, p≤ 0.05). ENOblock did not have a significant effect on plasma concentrations of pancreatic polypeptide. Interestingly, ENOblock treatment inhibited chondroitin sulfate proteoglycan (CSPG), which is produced by activated glia and serves to block regrowth of axons across the lesion site following injury. An increased level of NeuN and MBP with reduced caspase-1 was detected in SCI tissues after ENOblock treatment, suggesting preservation of myelin and induction of neuroprotection. ENOblock also induced improved motor function in SCI rats, indicating a role for enolase in modulating inflammatory and metabolic factors in SCI with important implications for clinical consideration.
Rachel Polcyn, Mollie Capone, Denise Matzelle, Azim Hossain, Raghavendar Chandran, Naren L Banik, Azizul Haque

1322 related Products with: Enolase inhibition alters metabolic hormones and inflammatory factors to promote neuroprotection in spinal cord injury.

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#32649800   2020/07/10 To Up

Analysis of clinical characteristics of tigecycline-induced acute pancreatitis.

The purpose of this study is to explore the clinical characteristics of tigecycline-induced acute pancreatitis.
Weijin Fang, Dan Yi, Linli Sun, Chunjiang Wang

2418 related Products with: Analysis of clinical characteristics of tigecycline-induced acute pancreatitis.

5 G1 module100 mg 15 ml 2 modules

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#32649791   2020/07/10 To Up

COVID-19 and Kidney Transplantation: Results from the TANGO International Transplant Consortium.

Kidney transplant recipients may be at high risk of developing critical COVID-19 illness due to chronic immunosuppression and comorbidities. We identified hospitalized adult kidney transplant recipients at 12 transplant centers in the US, Italy and Spain who tested positive for COVID-19. Clinical presentation, laboratory values, immunosuppression and treatment strategies were reviewed and predictors of poor clinical outcomes were determined through multivariable analyses. Among 9,845 kidney transplant recipients across centers, 144 were hospitalized due to COVID-19 during the 9-week study period. 65% were male with a mean age of 60 (±12) years, 40% Hispanic and 25% African-American. Prevalent comorbidities included hypertension (95%), diabetes (52%), obesity (49%), heart (28%) and lung (19%) disease. Therapeutic management included antimetabolite withdrawal (68%), calcineurin inhibitor withdrawal (23%), hydroxychloroquine (71%), antibiotics (74%), tocilizumab (13%) and antivirals (14%). During a median follow-up period of 52 days (IQR: 16-66 days), acute kidney injury occurred in 52% cases, respiratory failure requiring intubation in 29%, and mortality was 32%. The 44 patients who died were older, had lower lymphocyte counts and eGFR, higher serum lactate dehydrogenase, procalcitonin and IL-6 levels. In sum, hospitalized kidney transplant recipients with COVID-19 have higher rates of acute kidney injury and mortality.
Paolo Cravedi, Sarvode Mothi Suraj, Yorg Azzi, Meredith Haverly, Samira Farouk, María José Pérez-Sáez, Maria Dolores Redondo-Pachón, Barbara Murphy, Sander Florman, Laura Goldfarb Cyrino, Monica Grafals, Sandheep Venkataraman, Xingxing Shelley Cheng, Aileen Xinqian Wang, Gianluigi Zaza, Andrea Ranghino, Lucrezia Furian, Joaquin Manrique, Umberto Maggiore, Ilaria Gandolfini, Nikhil Agrawal, Het Patel, Enver Akalin, Leonardo V Riella,

2788 related Products with: COVID-19 and Kidney Transplantation: Results from the TANGO International Transplant Consortium.

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#32649614   2020/07/08 To Up

Surgical management of blunt pancreatic transection.


Shokei Matsumoto, Masayuki Shimizu, Natsuho Maekawa, Motoyasu Yamazaki, Mitsuhide Kitano

2805 related Products with: Surgical management of blunt pancreatic transection.

100ul10010 μg1 mL1.00 flask1100

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#32649469   2020/07/07 To Up

Actual Five-year Survival After Upfront Resection for Pancreatic Ductal Adenocarcinoma: Who Beats the Odds?

To determine actual five-year survival (5YS) rates associated with a strategy of upfront surgery and adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC).
Oliver Strobel, Philipp Lorenz, Ulf Hinz, Matthias Gaida, Anna-Katharina König, Thomas Hank, Willem Niesen, Jörg Kaiser, Mohammed Al-Saeedi, Frank Bergmann, Christoph Springfeld, Christoph Berchtold, Markus K Diener, Martin Schneider, Arianeb Mehrabi, Beat P Müller-Stich, Thilo Hackert, Dirk Jäger, Markus W Büchler

2980 related Products with: Actual Five-year Survival After Upfront Resection for Pancreatic Ductal Adenocarcinoma: Who Beats the Odds?

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#32649457   2020/07/07 To Up

Noninvasive Discrimination of Low and High-risk Pancreatic Intraductal Papillary Mucinous Neoplasms.

To propose a noninvasive diagnostic approach, which allows reliable distinction between low- and high-risk pancreatic intraductal papillary mucinous neoplasms (IPMNs).
Susanne Roth, Promita Bose, Mohamed S S Alhamdani, Shakhawan A Mustafa, Christine Tjaden, Katharina Zamzow, Ulf Hinz, Christoph W Michalski, John P Neoptolemos, Jörg D Hoheisel, Markus W Büchler, Thilo Hackert

2508 related Products with: Noninvasive Discrimination of Low and High-risk Pancreatic Intraductal Papillary Mucinous Neoplasms.

25100 mg50 ug 6 ml Ready-to-use

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