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Search results for: Pancreatic

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#33249718   2020/11/29 To Up

Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery.

Intraabdominal surgery is a known risk factor for splanchnic vein thrombosis (SVT). SVT incidence, management, and prognosis after hepatopancreatobiliary surgery are unknown.
Emmanuelle Duceppe, Jean-François Lauzon, Steven Galliger, Betty Zhang, Hannah Solomon, Pablo E Serrano

2834 related Products with: Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery.

100.00 ul200ug10 mg1000 tests100ug200ul25 mg100 mg200 10 mg100ug

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#33249641   2020/08/16 To Up

Editorial for: "Evaluation of Pancreatic Fibrosis With T1ρ Magnetic Resonance Imaging: A Preliminary Study".


Stefanie J Hectors, Bachir Taouli

1466 related Products with: Editorial for: "Evaluation of Pancreatic Fibrosis With T1ρ Magnetic Resonance Imaging: A Preliminary Study".

1 kit(s) 1001 kit1 mL1 mL at 10 mg/mL

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#33249525   2020/11/28 To Up

Tumor Necrosis Impacts Prognosis of Patients Undergoing Curative-Intent Hepatocellular Carcinoma.

The impact of tumor necrosis relative to prognosis among patients undergoing curative-intent resection for hepatocellular carcinoma (HCC) remains ill-defined.
Tao Wei, Xu-Feng Zhang, Fabio Bagante, Francesca Ratti, Hugo P Marques, Silvia Silva, Olivier Soubrane, Vincent Lam, George A Poultsides, Irinel Popescu, Razvan Grigorie, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Itaru Endo, Timothy M Pawlik

2931 related Products with: Tumor Necrosis Impacts Prognosis of Patients Undergoing Curative-Intent Hepatocellular Carcinoma.

96T/Kit 96T5ug1 mg1 kit(96 Wells)

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#33249524   2020/11/28 To Up

Editorial Comment on: MicroRNA-593-3p Expression in Peritoneal Lavage Fluid as a Prognostic Marker for Pancreatic Cancer Patients Undergoing Staging Laparoscopy.


Takehiko Yokobori

1117 related Products with: Editorial Comment on: MicroRNA-593-3p Expression in Peritoneal Lavage Fluid as a Prognostic Marker for Pancreatic Cancer Patients Undergoing Staging Laparoscopy.



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#33249514   2020/11/29 To Up

Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1).

To promote precision oncology in clinical practice, the Japanese Society of Medical Oncology, the Japanese Society of Clinical Oncology, and the Japanese Cancer Association, jointly published "Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment" in 2017. Since new information on cancer genomic medicine has emerged since the 1st edition of the guidance was released, including reimbursement for NGS-based multiplex gene panel tests in 2019, the guidance revision was made.
Yoichi Naito, Hiroyuki Aburatani, Toraji Amano, Eishi Baba, Toru Furukawa, Tetsu Hayashida, Eiso Hiyama, Sadakatsu Ikeda, Masashi Kanai, Motohiro Kato, Ichiro Kinoshita, Naomi Kiyota, Takashi Kohno, Shinji Kohsaka, Keigo Komine, Itaru Matsumura, Yuji Miura, Yoshiaki Nakamura, Atsushi Natsume, Kazuto Nishio, Katsutoshi Oda, Naoyuki Oda, Natsuko Okita, Kumiko Oseto, Kuniko Sunami, Hideaki Takahashi, Masayuki Takeda, Shimon Tashiro, Shinichi Toyooka, Hideki Ueno, Shinichi Yachida, Takayuki Yoshino, Katsuya Tsuchihara, , ,

2414 related Products with: Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1).



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#33249283   2020/11/26 To Up

Polydatin mitigates pancreatic β-cell damage through its antioxidant activity.

Several reports have been shown the pivotal role of oxidative stress in the progression of diabetes mellitus and its complications. Polydatin (PD), a natural phytochemical, has wide range of pharmacological actions, however, the underlying beneficial effects in pancreas was not clarified. In the current study, using in vivo and in vitro models, we investigated the possible protective effects of PD against oxidative damage in pancreatic β-cells. Diabetic rats were examined after oral administration with PD (50 mg/kg b.wt.) for 28 days. Results revealed that PD significantly enhanced glucose tolerance and insulin secretion in the bloodstream of diabetic rats as well as lipid metabolism. Interestingly, in vivo results indicated that PD decreased the lipid peroxidation, improved the antioxidant status, and inhibited the inflammation in pancreas. Alongside, we artificially induced oxidative stress by exposing the insulin-producing RINm5F cells to hydrogen peroxide in the presence or absence of PD. The co-treatment with PD preserved cell viability, reduced ROS accumulation, as well as enhanced the anti-oxidant, anti-apoptotic, and cell function markers. To conclude, PD exhibited potential action in preserving β-cell function and inhibiting oxidative damage probably through its antioxidant properties. Thus, PD could be a possible therapeutic agent for diabetic patients.
Ahmed I Yousef, Hossam H Shawki, Ahmed A El-Shahawy, Sanaa M Abd El-Twab, Adel Abdel-Moneim, Hisashi Oishi

2315 related Products with: Polydatin mitigates pancreatic β-cell damage through its antioxidant activity.

1 kit100 Tests100 Tests1.00 flask1 kit100 Tests96 assays

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#33249202   2020/11/26 To Up

LDL, HDL and endocrine-related cancer: from pathogenic mechanisms to therapies.

Cholesterol is essential for a variety of functions in endocrine-related cells, including hormone and steroid production. We have reviewed the progress to date in research on the role of the main lipoprotein transporters; low-density lipoprotein (LDL) and high-density lipoprotein (HDL), and their impact on intracellular cholesterol homeostasis and carcinogenic pathways in endocrine-related cancers. Neither LDL-cholesterol (LDL-C) nor HDL-cholesterol (HDL-C) was consistently associated with endocrine-related cancer risk. However, preclinical studies showed that LDL receptor plays a critical role in endocrine-related tumor cells, mainly by enhancing circulating LDL-C uptake and modulating tumorigenic signaling pathways. Although scavenger receptor type BI-mediated uptake of HDL could enhance cell proliferation in breast, prostate, and ovarian cancer, these effects may be counteracted by the antioxidant and anti-inflammatory properties of HDL. Moreover, 27-hydroxycholesterol a metabolite of cholesterol promotes tumorigenic processes in breast and epithelial thyroid cancer. Furthermore, statins have been reported to reduce the incidence of breast, prostate, pancreatic, and ovarian cancer in large clinical trials, in part because of their ability to lower cholesterol synthesis. Overall, cholesterol homeostasis deregulation in endocrine-related cancers offers new therapeutic opportunities, but more mechanistic studies are needed to translate the preclinical findings into clinical therapies.
Giovanna Revilla, Lídia Cedó, Mireia Tondo, Antonio Moral, José Ignacio Pérez, Rosa Corcoy, Enrique Lerma, Victoria Fuste, Srivinasa T Reddy, Francisco Blanco-Vaca, Eugènia Mato, Joan Carles Escolà-Gil

1805 related Products with: LDL, HDL and endocrine-related cancer: from pathogenic mechanisms to therapies.

255mg1 module1 mg

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#33249137   2020/11/26 To Up

Transient NADPH oxidase 2-dependent HO production drives early palmitate-induced lipotoxicity in pancreatic islets.

Modern lifestyles, including lack of physical activity and poor nutritional habits, are driving the rapidly increasing prevalence of obesity and type 2 diabetes. Increased levels of free fatty acids (FFAs), particularly saturated FFAs, in obese individuals have been linked to pancreatic β-cell failure. This process, termed lipotoxicity, involves activation of several stress responses, including ER stress and oxidative stress. However, the molecular underpinnings and causal relationships between the disparate stress responses remain unclear. Here we employed transgenic mice, expressing a genetically-encoded cytosolic HO sensor, roGFP2-Orp1, to monitor dynamic changes in HO levels in pancreatic islets in response to chronic palmitate exposure. We identified a transient increase in HO levels from 4-8 hours after palmitate addition, which was mirrored by a concomitant decrease in cellular NAD(P)H levels. Intriguingly, islets isolated from NOX2 knock-out mice displayed no HO transient upon chronic palmitate treatment. Furthermore, NOX2 knockout rescued palmitate-dependent impairment of insulin secretion, calcium homeostasis and viability. Chemical inhibition of NOX activity protected islets from palmitate-induced impairment in insulin secretion, however had no detectable impact upon the induction of ER stress. In summary, our results reveal that transient NOX2-dependent HO production is a likely cause of early palmitate-dependent lipotoxic effects.
Eloisa Aparecida Vilas-Boas, Lisa Nalbach, Emmanuel Ampofo, Camila Ferraz Lucena, Léa Naudet, Fernanda Ortis, Angelo Rafael Carpinelli, Bruce Morgan, Leticia Prates Roma

1862 related Products with: Transient NADPH oxidase 2-dependent HO production drives early palmitate-induced lipotoxicity in pancreatic islets.

96 tests1000 Units100 ug 50 ug 96T50 ul0.1mg

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#33249079   2020/11/26 To Up

FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity.

Glucose production and the consumption of high levels of carbohydrate increase the chance of insulin resistance, especially in cases of obesity. Therefore, maintaining a balanced glucose homeostasis might form a strategy to prevent or cure diabetes and obesity. The activation and inhibition of glucose production is complicated due to the presence of many interfering pathways. These pathways can be viewed at the downstream level because they activate certain transcription factors, which include the Forkhead-O1 (FoxO1). This has been identified as a significant agent in the pancreas, liver, and adipose tissue, which is significant in the regulation of lipids and glucose. The objective of this review is to discuss the intersecting portrayal of FoxO1 and its parallel cross-talk which highlights obesity-induced insulin susceptibility in the discovery of a targeted remedy. The review also analyses current progress and provides a blueprint on therapeutics, small molecules, and extracts/phytochemicals which are explored at the pre-clinical level.
Khaled Benchoula, Aditya Arya, Ishwar S Parhar, Wong Eng Hwa

2627 related Products with: FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity.

250 ml0.2 mg1 LITRE0.1 ml25 µg100 ml0.2 mg25 µg0.25 mg1 ml0.1 mg

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#33249030   2020/08/10 To Up

Diabetes Mellitus and Pancreatic Cancer: A Risk Assessment.


Tomoyuki Kawada

2523 related Products with: Diabetes Mellitus and Pancreatic Cancer: A Risk Assessment.



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