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Search results for: Pancreatic

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#32272500   2020/04/09 To Up

Clinical Behavior and Treatment Response of Epstein-Barr Virus-Positive Metastatic Gastric Cancer: Implications for the Development of Future Trials.

Epstein-Barr virus (EBV)-positive gastric cancers (GCs) have been recently identified as a molecular subgroup showing excellent outcomes after surgery for early-stage disease and responsiveness to immune checkpoint inhibitors (ICIs) for metastatic stage. No data are available on the prevalence, clinical characteristics, and prognosis of this subgroup of GCs in the metastatic setting.
Salvatore Corallo, Giovanni Fucà, Federica Morano, Massimo Salati, Andrea Spallanzani, Annunziata Gloghini, Chiara Costanza Volpi, Desirè Viola Trupia, Riccardo Lobefaro, Vincenzo Guarini, Massimo Milione, Laura Cattaneo, Maria Antista, Michele Prisciandaro, Alessandra Raimondi, Carlo Sposito, Vincenzo Mazzaferro, Filippo de Braud, Filippo Pietrantonio, Maria Di Bartolomeo

1724 related Products with: Clinical Behavior and Treatment Response of Epstein-Barr Virus-Positive Metastatic Gastric Cancer: Implications for the Development of Future Trials.

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#32272472   2020/04/09 To Up

Surgical Indication for Advanced Gallbladder Cancer Considering the Optimal Preoperative Carbohydrate Antigen 19-9 Cutoff Value.

Selecting patients who will benefit from resection among those with advanced gallbladder cancer (GBCa) having poor prognostic factors is difficult.
Yusuke Yamamoto, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Ryo Ashida, Katsuhisa Ohgi, Katsuhiko Uesaka

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#32272193   2020/04/06 To Up

The GLP-1 analog exendin-4 modulates HSP72 expression and ERK1/2 activity in BTC6 mouse pancreatic cells.

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Dhanya Madhu, Abdelkrim Khadir, Maha Hammad, Sina Kavalakatt, Mohammed Dehbi, Fahd Al-Mulla, Jehad Abubaker, Ali Tiss

1416 related Products with: The GLP-1 analog exendin-4 modulates HSP72 expression and ERK1/2 activity in BTC6 mouse pancreatic cells.

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#32271733   // To Up

[Comparison of minimal invasive technologies for treatment of infected pancreatic necrosis].

the assessment of the role of minimally invasive interventional procedures in the treatment of patients with infected pancreatic necrosis and their safety, as well as comparison of the results of the most common modern minimally invasive techniques among themselves.
E A Gallyamov, M A Agapov, Yu B Busyrev, E E Gallyamov, V V Kakotkin, A R Allakhverdieva

2485 related Products with: [Comparison of minimal invasive technologies for treatment of infected pancreatic necrosis].

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#32271483   2020/04/09 To Up

Development of the digestive system of Argentine hake, Merluccius hubbsi, larvae.

The Argentine hake Merluccius hubbsi is an important fishery resource of the Southwestern Atlantic Ocean and it is also a potential species for cultivation. In this work, the digestive system development in field-caught hake larvae was studied using histological and histochemical approaches. The digestive tract of larvae was divided into: oropharyngeal cavity (OPC), esophagus, stomach (that develops in the preflexion stage), and intestine. The annexed digestive glands consisted of the liver and the exocrine pancreas. At the beginning of the preflexion stage, teeth were developed in the OPC. There were mucous cells in the esophagus secreting different glycoconjugates from hatching. The enterocytes in the posterior intestine exhibited supranuclear vesicles associated with protein absorption. Mucous cells were observed in the posterior intestine in the preflexion stage and, in the anterior region, ending the flexion stage. Each type of glycoconjugates has a specific role. Acidic mucins lubricate and protect from mechanical damage, sialomucines protect from bacterial infections and neutral mucins regulate the acidity of mucus secretion, protect against abrasion and participate in the formation of the chyme, indicating a pregastric digestion. The liver was present since hatching with pancreatic tissue inside and increased in size acquiring the typical structure with hepatocyte cords, sinusoids, vacuoles, and hepatic duct. The hepatocytes vacuolization increased with larval development. The pancreas became extra-hepatic, with basophilic acinar cells and acidophilic zymogen granules. Throughout the ontogeny, the increased structural and functional complexity of the digestive system reflected the transition to exogenous feeding and nutritional increasing needs.
Stefania Cohen, Marina V Diaz, Alcira O Díaz

1120 related Products with: Development of the digestive system of Argentine hake, Merluccius hubbsi, larvae.

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#32271451   // To Up

Calcium-calmodulin-dependent protein kinase type 2 induces apoptosis of hepatocytes after liver transplantation.

The warm ischemia-reperfusion injury confines the prevalence of allografts. To improve the success rate of allotransplantation, we designed experiments to study the mechanism of calcium-calmodulin-dependent protein kinase type 2 (CaMK II) in ischemia-reperfusion (I/R) injury.
W Li, X-B Zhang, R-C Wu, S-N Zhang, J Liu, Y Gao, K-P Zheng, J-H Ran

2280 related Products with: Calcium-calmodulin-dependent protein kinase type 2 induces apoptosis of hepatocytes after liver transplantation.

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#32271378   2020/04/09 To Up

Islet amyloid in patients with diabetes due to exocrine pancreatic disorders, type 2 diabetes and non-diabetic patients.

Amyloid deposits are a typical finding in in pancreatic islets from patients with type 2 diabetes. Whether this is linked to the pathogenesis of type 2 diabetes is currently unknown. Therefore, we compared the occurrence of islet amyloid in patients with type 2 diabetes, diabetes secondary to pancreatic disorders and non-diabetic individuals.
Sandra Ueberberg, Michael A Nauck, Waldemar Uhl, Chiara Montemurro, Andrea Tannapfel, Anne Clark, Juris J Meier

1914 related Products with: Islet amyloid in patients with diabetes due to exocrine pancreatic disorders, type 2 diabetes and non-diabetic patients.

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#32271170   2020/04/09 To Up

Pancreatic tropism of metastatic renal cell carcinoma.

Renal cell carcinoma (RCC) is characterized by a particularly broad metastatic swath, and, enigmatically, when the pancreas is a destination, the disease is associated with improved survival. Intrigued by this observation, we sought to characterize the clinical behavior, therapeutic implications, and underlying biology. While pancreatic metastases (PM) are infrequent, we identified 31 patients across 2 institutional cohorts and show that improved survival is independent of established prognostic variables, that these tumors are exquisitely sensitive to antiangiogenic agents and resistant to immune checkpoint inhibitors (ICIs), and that they are characterized by a distinctive biology. Primary tumors of patients with PM exhibited frequent PBRM1 mutations, 3p loss, and 5q amplification, along with a lower frequency of aggressive features such as BAP1 mutations and loss of 9p, 14q, and 4q. Gene expression analyses revealed constrained evolution with remarkable uniformity, reduced effector T cell gene signatures, and increased angiogenesis. Similar findings were observed histopathologically. Thus, RCC metastatic to the pancreas is characterized by indolent biology, heightened angiogenesis, and an uninflamed stroma, likely underlying its good prognosis, sensitivity to antiangiogenic therapies, and refractoriness to ICI. These data suggest that metastatic organotropism may be an indicator of a particular biology with prognostic and treatment implications for patients.
Nirmish Singla, Zhiqun Xie, Ze Zhang, Ming Gao, Qurratulain Yousuf, Oreoluwa Onabolu, Tiffani McKenzie, Vanina Toffessi Tcheuyap, Yuanqing Ma, Jacob Choi, Renee McKay, Alana Christie, Oscar Reig Torras, Isaac A Bowman, Vitaly Margulis, Ivan Pedrosa, Christopher Przybycin, Tao Wang, Payal Kapur, Brian Rini, James Brugarolas

1754 related Products with: Pancreatic tropism of metastatic renal cell carcinoma.

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#32270874   2020/04/09 To Up

Genome-wide association study identifies an early onset pancreatic cancer risk locus.

Early onset pancreatic cancer (EOPC) is a rare disease with a very high mortality rate. Almost nothing is known on the genetic susceptibility of EOPC, therefore we performed a genome-wide association study (GWAS) to identify novel genetic variants specific for patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) at younger ages. In the first phase, conducted on 821 cases with age of onset ≤60 years, of whom 198 with age of onset ≤50, and 3227 controls from PanScan I-II, we observed four SNPs (rs7155613, rs2328991, rs4891017 and rs12610094) showing an association with EOPC risk (P < 1x10 ). We replicated these SNPs in the PANcreatic Disease ReseArch (PANDoRA) consortium and used additional in silico data from PanScan III and PanC4. Among these four variants rs2328991 was significant in an independent set of 855 cases with age of onset ≤60 years, of whom 265 with age of onset≤50, and 4142 controls from the PANDoRA consortium while in the in silico data we observed no statistically significant association. However, the resulting meta-analysis supported the association (P = 1.15x10 ). In conclusion we propose a novel variant rs2328991 to be involved in EOPC risk. Even though it was not possible to find a mechanistic link between the variant and the function, the association is supported by a solid statistical significance obtained in the largest study on EOPC genetics present so far in the literature. This article is protected by copyright. All rights reserved.
Daniele Campa, Manuel Gentiluomo, Ofure Obazee, Alba Ballerini, Ludmila Vodickova, Péter Hegyi, Pavel Soucek, Hermann Brenner, Anna Caterina Milanetto, Stefano Landi, Xin Gao, Dania Bozzato, Gabriele Capurso, Francesca Tavano, Yogesh Vashist, Thilo Hackert, Franco Bambi, Simona Bursi, Martin Oliverius, Domenica Gioffreda, Ben Schöttker, Audrius Ivanauskas, Beatrice Mohelnikova-Duchonova, Erika Darvasi, Raffaele Pezzilli, Ewa Małecka-Panas, Oliver Strobel, Maria Gazouli, Verena Katzke, Andrea Szentesi, Giulia Martina Cavestro, Gyula Farkas, Jakob R Izbicki, Stefania Moz, Livia Archibugi, Viktor Hlavac, Áron Vincze, Renata Talar-Wojnarowska, Borislav Rusev, Juozas Kupcinskas, Bill Greenhalf, Frederike Dijk, Nathalia Giese, Ugo Boggi, Angelo Andriulli, Olivier R Busch, Giuseppe Vanella, Pavel Vodicka, Michael Nentwich, Rita T Lawlor, George E Theodoropoulos, Krzysztof Jamroziak, Raffaella Alessia Zuppardo, Lucia Moletta, Laura Ginocchi, Rudolf Kaaks, John P Neoptolemos, Maurizio Lucchesi, Federico Canzian

1484 related Products with: Genome-wide association study identifies an early onset pancreatic cancer risk locus.

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#32270773   2020/04/06 To Up

Serum mucin 3A as a potential biomarker for extrahepatic cholangiocarcinoma.

The aim of this study is to evaluate serum mucin 3A (MUC3A) as a candidate biomarker for extrahepatic cholangiocarcinoma (EHCC).
Jing Wang, Haibin Zhou, Yucheng Wang, Haitao Huang, Jing Yang, Weigang Gu, Xiaofeng Zhang, Jianfeng Yang

2179 related Products with: Serum mucin 3A as a potential biomarker for extrahepatic cholangiocarcinoma.

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