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Search results for: Porcine

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#34524698   2021/09/15 To Up

Intracranial Pressure and Cerebral Hemodynamic Monitoring After Cardiac Arrest in Pediatric Pigs Using Contrast Ultrasound-Derived Parameters.

We explore the correlation of contrast-enhanced ultrasound (CEUS) parameters to intracranial pressure (ICP) in a porcine experimental model of pediatric cardiac arrest.
Samuel S Shin, Anush Sridharan, Kristina Khaw, Thomas Hallowell, Ryan W Morgan, Todd J Kilbaugh, Misun Hwang

1987 related Products with: Intracranial Pressure and Cerebral Hemodynamic Monitoring After Cardiac Arrest in Pediatric Pigs Using Contrast Ultrasound-Derived Parameters.

96 tests100 μg100 μg100ug Lyophilized1x10e7 cells100 μg50 ul1mg100 μg

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#34524535   2021/09/15 To Up

Porcine deltacoronavirus and its prevalence in China: a review of epidemiology, evolution, and vaccine development.

Porcine deltacoronavirus (PDCoV) is one of the most important enteropathogenic pathogens, and it causes enormous economic losses to the global commercial pork industry. PDCoV was initially reported in Hong Kong (China) in 2012 and subsequently emerged in swine herds with diarrhea in Ohio (USA) in 2014. Since then, it has spread to Canada, South Korea, mainland China, and several Southeast Asian countries. Information about the epidemiology, evolution, prevention, and control of PDCoV and its prevalence in China has not been comprehensively reported, especially in the last five years. This review is an update of current information on the general characteristics, epidemiology, geographical distribution, and evolutionary relationships, and the status of PDCoV vaccine development, focusing on the prevalence of PDCoV in China and vaccine research in particular. Together, this information will provide us with a greater understanding of PDCoV infection and will be helpful for establishing new strategies for controlling this virus worldwide.
Pan Tang, Enhui Cui, Yihong Song, Ruoqian Yan, Jingyu Wang

2730 related Products with: Porcine deltacoronavirus and its prevalence in China: a review of epidemiology, evolution, and vaccine development.

100ug25 mg 5 G 5 G50 ug 1 g96 wells (1 kit)100ug100ul200ul10 mg100 mg

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#34523557   2021/09/08 To Up

Process design and techno-economic analysis of 2'-fucosyllactose enriched distiller's dried grains with solubles production in dry grind ethanol process using genetically engineered Saccharomyces cerevisiae.

2'-fucosyllactose (2'-FL) has been linked positively with piglet gut health. Genetically engineered Saccharomyces cerevisiae strains producing 2'-FL can be used in the dry grind process to enrich Distiller's dried grains with solubles (DDGS) with 2'-FL and supplement swine diets with 2'-FL. The objectives of our study were to modify dry grind ethanol process for 2'-FL enriched DDGS production and evaluate the techno-economic feasibility of the process. Concentrations of 19.8 g 2'-FL/kg dry DDGS were achieved in the dry grind process using engineered strain without negatively affecting the ethanol yield. Process models for conventional and modified dry grind processes producing 2'-FL enriched DDGS (1150 MT corn/day capacity) were developed using SuperPro Designer. Capital and ethanol production costs for modified dry grind processes were higher than the conventional process. The internal rate of return for the modified processes was higher than the conventional process for $300/MT 2'-FL enriched DDGS selling price.
Chinmay Kurambhatti, Jae Won Lee, Yong-Su Jin, Ankita Juneja, Deepak Kumar, Kent D Rausch, M E Tumbleson, Sadia Bekal, Vijay Singh

1592 related Products with: Process design and techno-economic analysis of 2'-fucosyllactose enriched distiller's dried grains with solubles production in dry grind ethanol process using genetically engineered Saccharomyces cerevisiae.

96tests10ml96 tests 25 G5ml96 wells10 96 rxns1 Set

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#34523051   2021/09/15 To Up

Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity.

DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age, epigenetic clocks, for many species. Using a custom methylation array, we generated DNA methylation data from n = 238 porcine tissues including blood, bladder, frontal cortex, kidney, liver, and lung, from domestic pigs (Sus scrofa domesticus) and minipigs (Wisconsin Miniature Swine™). Samples used in this study originated from Large White X Landrace crossbred pigs, Large White X Minnesota minipig crossbred pigs, and Wisconsin Miniature Swine™. We present 4 epigenetic clocks for pigs that are distinguished by their compatibility with tissue type (pan-tissue and blood clock) and species (pig and human). Two dual-species human-pig pan-tissue clocks accurately measure chronological age and relative age, respectively. We also characterized CpGs that differ between minipigs and domestic pigs. Strikingly, several genes implicated by our epigenetic studies of minipig status overlap with genes (ADCY3, TFAP2B, SKOR1, and GPR61) implicated by genetic studies of body mass index in humans. In addition, CpGs with different levels of methylation between the two pig breeds were identified proximal to genes involved in blood LDL levels and cholesterol synthesis, of particular interest given the minipig's increased susceptibility to cardiovascular disease compared to domestic pigs. Thus, breed-specific differences of domestic and minipigs may potentially help to identify biological mechanisms underlying weight gain and aging-associated diseases. Our porcine clocks are expected to be useful for elucidating the role of epigenetics in aging and obesity, and the testing of anti-aging interventions.
Kyle M Schachtschneider, Lawrence B Schook, Jennifer J Meudt, Dhanansayan Shanmuganayagam, Joseph A Zoller, Amin Haghani, Caesar Z Li, Joshua Zhang, Andrew Yang, Ken Raj, Steve Horvath

2668 related Products with: Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity.

10 mg50 ug 100ug10 mg100 mg1,000 tests5mg200ug1 mg0.1 mg100ug

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#34522940   2021/09/15 To Up

-Adventitial delivery of smooth muscle cells in porous collagen scaffolds for treatment of experimental abdominal aortic aneurysm.

Abdominal aortic aneurysm (AAA) is associated with the loss of vascular smooth muscle cells (SMCs) within the vessel wall. Direct delivery of therapeutic cells is challenging due to impaired mechanical integrity of the vessel wall. We hypothesized that porous collagen scaffolds can be an effective vehicle for the delivery of human-derived SMCs to the site of AAA. The purpose was to evaluate if the delivery of cell-seeded scaffolds can abrogate progressive expansion in a mouse model of AAA. Collagen scaffolds seeded with either primary human aortic SMCs or induced pluripotent stem cell derived-smooth muscle progenitor cells (iPSC-SMPs) had >80% cell viability and >75% cell penetrance through the scaffold's depth, while preserving smooth muscle phenotype. The cell-seeded scaffolds were successfully transplanted onto the murine aneurysm -adventitia on day 7 following AAA induction using pancreatic porcine elastase infusion. Ultrasound imaging revealed that SMC-seeded scaffolds significantly reduced the aortic diameter by 28 days, compared to scaffolds seeded with iPSC-SMPs or without cells (acellular scaffold), respectively. Bioluminescence imaging demonstrated that both cell-seeded scaffold groups had cellular localization to the aneurysm but a decline in survival with time. Histological analysis revealed that both cell-seeded scaffold groups had more SMC retention and less macrophage invasion into the medial layer of AAA lesions, when compared to the acellular scaffold treatment group. Our data suggest that scaffold-based SMC delivery is feasible and may constitute a platform for cell-based AAA therapy.
Joscha Mulorz, Mahdis Shayan, Caroline Hu, Cynthia Alcazar, Alex H P Chan, Mason Briggs, Yan Wen, Ankita P Walvekar, Anand K Ramasubramanian, Joshua M Spin, Bertha Chen, Philip S Tsao, Ngan F Huang

2370 related Products with: -Adventitial delivery of smooth muscle cells in porous collagen scaffolds for treatment of experimental abdominal aortic aneurysm.

100ul 5 G96T100ul1x10e7 cells 100ul 2 ml Ready-to-use 200ul100 μg96 samples100ul

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#34521351   2021/09/14 To Up

The 3D nuclear conformation of the major histocompatibility complex changes upon cell activation both in porcine and human macrophages.

The crucial role of the major histocompatibility complex (MHC) for the immune response to infectious diseases is well-known, but no information is available on the 3D nuclear organization of this gene-dense region in immune cells, whereas nuclear architecture is known to play an essential role on genome function regulation. We analyzed the spatial arrangement of the three MHC regions (class I, III and II) in macrophages using 3D-FISH. Since this complex presents major differences in humans and pigs with, notably, the presence of the centromere between class III and class II regions in pigs, the analysis was implemented in both species to determine the impact of this organization on the 3D conformation of the MHC. The expression level of the three genes selected to represent each MHC region was assessed by quantitative real-time PCR. Resting and lipopolysaccharide (LPS)-activated states were investigated to ascertain whether a response to a pathogen modifies their expression level and their 3D organization.
Florence Mompart, Alain Kamgoué, Yvette Lahbib-Mansais, David Robelin, Agnès Bonnet, Claire Rogel-Gaillard, Silvia Kocanova, Martine Yerle-Bouissou

1617 related Products with: The 3D nuclear conformation of the major histocompatibility complex changes upon cell activation both in porcine and human macrophages.

1.00 flask10 ug100ug Lyophilized1mg 100ul100ug Lyophilized1050 ul100 1.00 flask

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