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#34550262   // To Up

The levels of inflammatory biomarkers in hemodialysis and peritoneal dialysis patients.

In this study, we aimed to determine fibroblast growth factor 23, soluble alpha klotho, osteocalcin, indoxyl sulphate, sclerostin, Procollagen 1 N Terminal Propeptide, and beta-CrossLaps levels in hemodialysis and peritoneal dialysis patients, and to compare the levels of these markers among hemodialysis and peritoneal dialysis patients, as well as healthy individuals.
Mehmet Yildirim, Seyyid Bilal Acikgoz, Ahmed Bilal Genc, Selçuk Yaylaci, Hamad Dheir, Sava S Sipahi

2814 related Products with: The levels of inflammatory biomarkers in hemodialysis and peritoneal dialysis patients.

2ug2ug5ug5ug15ug0.1 mg

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#34544545   // To Up

Development of a Sandwich Chemiluminescence Immunoassay for the Detection of Intact Procollagen Type I N Propeptide with Magnetic Nanosphere Carrier Technology.

The metabolic product of type I collagen synthesis, intact procollagen type I N propeptide (intact PINP), is a potential marker of bone formation and osteoporosis, which is not affected by kidney function. We sought to establish a chemiluminescent immunoassay method for the detection of serum intact PINP with previously prepared paired monoclonal antibodies and to evaluate the diagnostic value of the assay in osteoporosis. Using the capture molecule and monoclonal antibody as detection molecule, a diagnostic reagent was developed to detect intact PINP in serum with magnetic nanosphere carriers by the chemiluminescence method, and its analytical performance in the laboratory was evaluated. Serum intact PINP was measured in 142 healthy people and 115 osteoporosis patients. Results were matched with results of a similar test kit, Roche total PINP Elecsys Chemiluminescent Immunoassay Assay. Compared with the performance of the Roche PINP assay product, our method had higher sensitivity (0.02 ng/mL), wider linear range (0.02-1500 ng/mL), and anti-interference. Serum intact PINP values in osteoporosis patients were significantly higher than in healthy subjects (p < 0.001). Our method had good consistency compared with the Roche PINP assay ( = 0.9794). This chemiluminescence method for detecting serum intact PINP (CLIA-intact PINP) with magnetic nanosphere carrier technology meets the requirements of a clinical testing reagent and is expected to have clinical application after further evaluation and can compete with expensive imported kits on the market.
Li Song, Chunmei Xie, Xueke Liu, Zhen Huo, Yinhai Xie, Jiafeng Gao, Shuping Zhou, Jing Shen, Xiaolong Tang, Xinkuang Liu

2628 related Products with: Development of a Sandwich Chemiluminescence Immunoassay for the Detection of Intact Procollagen Type I N Propeptide with Magnetic Nanosphere Carrier Technology.

0.1 mg0.1 mg100ug Lyophilized100ug Lyophilized25 µg0.25 mg100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#34535967   2021/09/17 To Up

The Effect of Discontinuing Denosumab in Patients With Rheumatoid Arthritis Treated With Glucocorticoids.

To evaluate changes in bone turnover and bone mineral density (BMD) in subjects with rheumatoid arthritis (RA) on glucocorticoid (GC) after discontinuing denosumab for 12 months.
Kenneth G Saag, Michele T McDermott, Jonathan Adachi, Willem Lems, Nancy E Lane, Piet Geusens, Robert Kees Stad, Li Chen, Shuang Huang, Robin Dore, Stanley Cohen

1279 related Products with: The Effect of Discontinuing Denosumab in Patients With Rheumatoid Arthritis Treated With Glucocorticoids.

11 ml

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#34515769   2021/09/13 To Up

Effects of silver nanoparticles-polysaccharide on bleomycin-induced pulmonary fibrosis in rats.

The first goal of this study was to synthesize the silver nanoparticles Alcaligenes xylosoxidans exopolysaccharide (Ag-AXEPS). The second objective was to analyse the role of Ag-AXEPS nanoparticles (NPS) in treating bleomycin (BLM)-induced lung fibrosis.
Amal I Hassan, Amer Samir, Hanan F Youssef, Sahar S Mohamed, Mohsen S Asker, Manal G Mahmoud

1190 related Products with: Effects of silver nanoparticles-polysaccharide on bleomycin-induced pulmonary fibrosis in rats.

5ug2ug100ug96T100 ul400 ug100ug100ug100 ul400 ug50 ul1 mg

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#34514857   2021/09/13 To Up

Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma: a longitudinal follow-up study.

Survivors of pediatric differentiated thyroid carcinoma (DTC) receive thyrotropin (TSH) suppressive therapy to minimize disease recurrence. However, knowledge about long-term effects of subclinical hyperthyroidism on bone mineral density (BMD) in pediatric DTC survivors is scarce, as is the information regarding long-term consequences of permanent hypoparathyroidism on BMD. We evaluated BMD in pediatric DTC survivors and investigated if BMD was affected by subclinical hyperthyroidism and/or permanent hypoparathyroidism during long-term follow-up.
Bernadette L Dekker, Anneke C Muller Kobold, Adrienne H Brouwers, Graham R R Williams, Marloes Nies, Mariëlle Sanne Klein Hesselink, Anouk N A van der Horst-Schrivers, Bas Havekes, Marry M van den Heuvel-Eibrink, Heleen J H van der Pal, John Th M Plukker, Cecile M Ronckers, Hanneke M van Santen, Johannes G M Burgerhof, Eleonora P M Corssmit, Romana Netea-Maier, Robin P Peeters, Eveline W C M van Dam, Annemieke Boot, Wim J E Tissing, Gianni Bocca, Thera P Links

1809 related Products with: Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma: a longitudinal follow-up study.



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#34508879   2021/09/08 To Up

Deletion of the sodium/hydrogen exchanger 6 causes low bone volume in adult mice.

The sodium/hydrogen exchanger 6 (NHE6) localizes to recycling endosomes, where it mediates endosomal alkalinization through K/H exchange. Mutations in the SLC9A6 gene encoding NHE6 cause severe X-linked mental retardation, epilepsy, autism and corticobasal degeneration in humans. Patients with SLC9A6 mutations exhibit skeletal malformations, and a previous study suggested a key role of NHE6 in osteoblast-mediated mineralization. The goal of this study was to explore the role of NHE6 in bone homeostasis. To this end, we studied the bone phenotype of NHE6 knock-out mice by microcomputed tomography, quantitative histomorphometry and complementary ex vivo and in vitro studies. We detected NHE6 transcript and protein in both differentiated osteoclasts and mineralizing osteoblasts. In vitro studies with osteoclasts and osteoblasts derived from NHE6 knock-out mice demonstrated normal osteoclast differentiation and osteoblast proliferation without an impairment in mineralization capacity. Microcomputed tomography and bone histomorphometry studies showed a significantly reduced bone volume and trabecular number as well as an increased trabecular space at lumbar vertebrae of 6 months old NHE6 knock-out mice. The bone degradation marker c-terminal telopeptides of type I collagen was unaltered in NHE6 knock-out mice. However, we observed a reduction of the bone formation marker procollagen type 1 N-terminal propeptide, and increased circulating sclerostin levels in NHE6 knock-out mice. Subsequent studies revealed a significant upregulation of sclerostin transcript expression in both primary calvarial cultures and femora derived from NHE6 knock-out mice. Thus, loss of NHE6 in mice causes an increase of sclerostin expression associated with reduced bone formation and low bone volume.
Daniela Schnyder, Giuseppe Albano, Patrycja Kucharczyk, Silvia Dolder, Mark Siegrist, Manuel Anderegg, Ganesh Pathare, Willy Hofstetter, Roland Baron, Daniel G Fuster

2741 related Products with: Deletion of the sodium/hydrogen exchanger 6 causes low bone volume in adult mice.

25 G10 mg1 g1 g118 kgs100 g 100 G1 g

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#34504945   2021/09/01 To Up

Biomarkers of inflammation and fibrosis in young adults with history of Kawasaki disease.

Myocardial histology from autopsies of young adults with giant coronary artery aneurysms following Kawasaki disease (KD) shows bridging fibrosis beyond the territories supplied by the aneurysmal arteries. The etiology of this fibrosis is unknown, but persistent, low-level myocardial inflammation and microcirculatory ischemia are both possible contributing factors. To investigate the possibility of subclinical myocardial inflammation or fibrosis, we measured validated biomarkers in young adults with a remote history of KD.
Shinsuke Hoshino, Sonia Jain, Chisato Shimizu, Samantha Roberts, Feng He, Lori B Daniels, Andrew M Kahn, Adriana H Tremoulet, John B Gordon, Jane C Burns

1412 related Products with: Biomarkers of inflammation and fibrosis in young adults with history of Kawasaki disease.

96 tests4 Membranes/Box4 Sample Kit1-99 mg/ml/ea price x 216-22 Sample Kit16 Arrays/Slide

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#34497820   2021/08/23 To Up

Changes in Intestinal Flora Structure and Metabolites Are Associated With Myocardial Fibrosis in Patients With Persistent Atrial Fibrillation.

The occurrence of atrial fibrillation is often accompanied by myocardial fibrosis. An increasing number of studies have shown that intestinal flora is involved in the occurrence and development of a variety of cardiovascular diseases. This study explores the relationship between changes in the structure and function of intestinal flora and the progression of myocardial fibrosis in patients with persistent atrial fibrillation. Serum and stool samples were collected from 10 healthy people and 10 patients with persistent atrial fibrillation (PeAF), and statistical analyses were performed on the subjects' clinical baseline conditions. ELISA was used to measure the levels of carboxy-terminal telopeptide of type I collagen (CTX-I), propeptide of type I procollagen (PICP), procollagen III N-terminal propeptide (PIIINP), fibroblast growth factor-23 (FGF-23), and transforming growth factor-beta 1 (TGF-β1) in serum. Through 16S rRNA sequencing technology, the structural composition of the intestinal flora was detected and analyzed. In addition, metabolomics data were analyzed to determine the differences in the metabolites produced by the intestinal flora of the subjects. By comparing the baseline data of the subjects, it was found that compared with those of the control group, the levels of creatinine (CRE) and serum uric acid (SUA) in the serum of PeAF patients were significantly increased. In addition, we found that the levels of CTX-I, PICP, PIIINP, and TGF-β1 in the serum of PeAF patients were significantly higher than those of the control group subjects. Although the control and PeAF groups exhibited no significant differences in the α diversity index, there were significant differences in the β diversity indexes (Bray-Curtis, weighted UniFrac and Anosim). At the phylum, family and species levels, the community structure and composition of the intestinal flora of the control group and those of the PeAF group showed significant differences. In addition, the compositions of the intestinal metabolites in the two different groups of people were significantly different. They were correlated considerably with PIIINP and specific communities in the intestinal flora. Pathologically, PeAF patients may have a higher risk of myocardial fibrosis. Systematically, abnormal changes in the structure and composition of the intestinal flora in PeAF patients may lead to differences in intestinal metabolites, which are involved in the process of myocardial fibrosis through metabolite pathways.
Langsha Liu, Juan Su, Rui Li, Fanyan Luo

1933 related Products with: Changes in Intestinal Flora Structure and Metabolites Are Associated With Myocardial Fibrosis in Patients With Persistent Atrial Fibrillation.

100ul20 100ug Lyophilized1 L.100ug100ug100ug Lyophilized96tests100ug100ug

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#34491615   2021/09/07 To Up

The mechanism of Epimedin B in treating osteoporosis as revealed by RNA sequencing-based analysis.

With the ageing of populations, the management of osteoporosis is a priority of society in general. Epimedin B, a major ingredient of Herba Epimedii, which has the advantages of high content and hypotoxicity has been proved to be effective in preventing osteoporosis in vitro. However, the efficacy and mechanism of Epimedin B on osteoporosis in vivo have not been well elucidated yet. This study aimed to investigate the effects and the potential mechanisms of 8-week repeated oral administration of Epimedin B (10 and 20 mg/kg/day) on a mouse osteoporosis model. Effects of Epimedin B were evaluated by examinations of serum bone turnover markers, bone mineral density, bone microstructure parameters and histopathological section. Epimedin B significantly rose N-terminal propeptide of type I procollagen (P1NP) and dropped C-telopeptide of type I collagen (CTX1). Connectivity density (Conn.D) increased significantly while structure model index (DA) decreased significantly after treated by Epimedin B. Meanwhile, Epimedin B administration significantly increased the number of trabecular bones while significantly decreased the gap between them. Overall, Epimedin B showed beneficial effects on osteoporosis. Furthermore, RNA sequencing-based analysis revealed 5 significantly down-regulated transcripts and 107 significantly up-regulated transcripts between the Epimedin B administration group and the model group. These transcripts were mapped to 15 pathways by KEGG enrichment analysis, of which PI3K-Akt signalling pathway, MAPK signalling pathway and PPAR signalling pathway were most connected to osteoporosis. To conclude, Epimedin B is effective in treating osteoporosis in mice via regulating PI3K-Akt, MAPK and PPAR signalling pathway.
Xinyue Diao, Liwen Wang, Yating Zhou, Yanan Bi, Kun Zhou, Lei Song

2091 related Products with: The mechanism of Epimedin B in treating osteoporosis as revealed by RNA sequencing-based analysis.

900 tests5mg500 tests10mg48 assays5mg1

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