Search results for: Rabbit
#34118437 2021/06/09 To Up
One-step preparation of photoclick method for embolic microsphere synthesis and assessment for transcatheter arterial embolization.Vascular embolization is a well-known therapeutic treatment against hepatocellular carcinoma. However, existing embolic agents require complex synthesis, toxic organic solvents and sometimes produce only low yields. In this study, a novel photopolymerization technique, which addresses these issues, was used to prepare embolic microspheres successfully from the sucrose multi-allyl ether monomer in one step. Compared to the preparation of such microspheres always involved in multiple steps or complicated conditions, we obtained the microspheres used photoclick method in a soft template with simple, economic and feasible procedure. This work focuses on the synthesis of new materials by conducting a photopolymerzation in the presence of the sucrose monomer and the photoinitiator. Then, the embolic microspheres obtained were characterized by morphology assay, degradation, and swelling test. Cell experiments showed that the microspheres had good biocompatibility. Rabbit embolizations showed that the microspheres had long-term embolic effects. It is manifested that one-step preparation of photoclick method hold great potential and competitiveness of being used in preparation embolic microspheres in clinic.
Xiaotian Zhao, Wanqiu Huang, Xufeng Li, Runxing Lin, Qiuxia Li, Jingmiao Wu, Zongjun Yu, Yanfang Zhou, Hong Huang, Mingguang Yu, Yugang Huang, Guodong Ye
1311 related Products with: One-step preparation of photoclick method for embolic microsphere synthesis and assessment for transcatheter arterial embolization.100Tests 1 G1,000 tests 100 G1 mg1 g 500 G 25 G
#34117539 2021/06/12 To Up
595-nm pulsed dye laser combined with fractional CO laser reduces hypertrophic scar through down-regulating TGFÎ²1 and PCNA.595-nm pulsed dye laser and fractional CO laser have been demonstrated effective to treat hypertrophic scar. The underlying mechanism may involve transforming growth factor-beta1 (TGFÎ²1) and proliferating cell nuclear antigen (PCNA), but remains to be clarified. Our study was performed to investigate how 595-nm pulsed dye laser combined with fractional CO laser treats hypertrophic scars in a rabbit model through regulating the expression of TGFÎ²1 and PCNA. Twenty-four New Zealand white rabbits were randomly divided into control group, pulsed dye laser group, fractional CO laser group, and pulsed dye laser + fractional CO laser (combination) group. Surgical wounds were made and allowed to grow into hypertrophic scars at day 28. Next, 595-nm pulsed dye laser (fluence: 15Â J/cm; square: 7Â mm; pulse duration: 10Â ms) was used in pulsed dye laser and combination group, while fractional CO laser (combo mode, deep energy: 12.5Â mJ; super energy: 90Â mJ) in fractional CO laser and combination groups, once every 4Â weeks for 3 times. The appearance and thickness of hypertrophic scar samples were measured with hematoxylin-eosin and Van Gieson's straining. The expressions of TGFÎ²1 and PCNA were evaluated by immunohistochemical and western blot analysis. A significant improvement was noted in the thickness, size, hardness, and histopathology of hypertrophic scar samples after laser treatment, especially in combination group. Scar Elevation Index (SEI), fiber density (NA), and collagen fiber content (AA) decreased most significantly in combination group (2.10âÂ±â0.14; 2506âÂ±â383.00; 22.98âÂ±â2.80%) compared to 595-nm pulsed dye laser group (3.35âÂ±â0.28; 4857âÂ±â209.40; 42.83âÂ±â1.71%) and fractional CO laser group (2.60âÂ±â0.25; 3995âÂ±â224.20; 38.33âÂ±â3.01%) (PÂ <â0.001). Furthermore, TGFÎ²1 and PCNA expressions were more suppressed in combination group (8.78âÂ±â1.03; 7.81âÂ±â1.51) than in 595-nm pulsed dye laser (14.91âÂ±â1.68; 15.73âÂ±â2.53) and fractional CO laser alone group (15.96âÂ±â1.56; 16.13âÂ±â1.72) (PÂ <â0.001). The combination of 595-nm pulsed dye laser with fractional CO laser can improve the morphology and histology of hypertrophic scars in a rabbit model through inhibiting the expression of TGFÎ²1 and PCNA protein. Our findings can pave the way for new clinical treatment strategies for hypertrophic scars.
Jinxia Zhang, Shuanglin Zhou, Zhikuan Xia, Zhuoying Peng, Xiaoxian Cheng, Xin Yang, Wanting Luo, Rongya Yang
1158 related Products with: 595-nm pulsed dye laser combined with fractional CO laser reduces hypertrophic scar through down-regulating TGFÎ²1 and PCNA.100ug100ug10.00 nmol100ug Lyophilized100 100ug
#34116263 2021/06/08 To Up
Creating Clinically Relevant Aneurysm Sizes in the Rabbit Surgical Elastase Model.Creating aneurysm sizes in animal models that resemble human aneurysms is essential to study and test neuroendovascular devices. The commonly used rabbit surgical elastase model, however, produces saccular aneurysms that are smaller than those typically treated in humans. The goal of this study was to determine whether an increased vessel stump length and the addition of calcium chloride to the incubation solution has an effect on the resulting aneurysm size.
Brooke L Belanger, Michael B Avery, Arindom Sen, Muneer Eesa, Alim P Mitha
2041 related Products with: Creating Clinically Relevant Aneurysm Sizes in the Rabbit Surgical Elastase Model.100ul100ug Lyophilized100ug Lyophilized5 mg100ug100ug100 100ug100ug100ug
#34115781 2021/06/11 To Up
Development of the Bristol Rabbit Pain Scale (BRPS): A multidimensional composite pain scale specific to rabbits (Oryctolagus cuniculus).A species-specific composite pain scale is a prerequisite for adequate pain assessment. The aim of this study was to develop a multidimensional pain scale specific to rabbits (Oryctolagus cuniculus) called the Bristol Rabbit Pain Scale (BRPS). The scale was developed over five phases using a unique combination of methods: focus groups and behavioural observation. The first two phases aimed at identifying descriptors to describe a rabbit in pain, and then reducing their number, both using focus groups. A total of 72 pain descriptors were grouped under six categories (Demeanour, Posture, Facial expression, Attention to the painful area, Audible and Other) and 'No pain' descriptors were added. The third phase aimed to confirm, through video observation of rabbits, the categories and descriptors previously described, to reject those terms that were ambiguous, and identify any new descriptors that had not been included in the previous list of descriptors. This led to the rejection of the categories Audible and Attention to the painful area and of 34 descriptors. Seven new descriptors were identified. The last two phases constructed the final format of the BRPS by refining the categories, ranking the descriptors on an ordinal scale and testing the internal reliability of the scale using Cronbach's alpha test. This led to a composite pain scale of six categories (Demeanour, Posture, Locomotion, Ears, Eyes and Grooming) with four intensities of pain (0, 1, 2, and 3), a total score of 0-18, and a high Cronbach's alpha coefficient (alpha = 0.843). This BRPS fills an important gap in the field of rabbit medicine and has the potential to improve the assessment and management of pain in rabbits providing veterinary professionals with a novel multidimensional pain assessment tool. Further studies will investigate the clinical utility, validity and reliability of the BRPS.
Livia Benato, Joanna Murrell, Toby G Knowles, Nicola J Rooney
2859 related Products with: Development of the Bristol Rabbit Pain Scale (BRPS): A multidimensional composite pain scale specific to rabbits (Oryctolagus cuniculus).1 mL100ug Lyophilized100 1 kit100ug100ug Lyophilized 100ul100ug Lyophilized100.00 ul 100ul0.1ml (1.3mg/ml)
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#34114406 // To Up
Icariin contributes to healing skull defects in rabbit model.To investigate the efficacy of icariin for healing skull defects in rabbit models.
Fu-Liang Hao, Shuang Mei, Xiao Liu, Yang Liu, Xu-Dong Zhang, Fu-Sheng Dong100 100ug Lyophilized100ug Lyophilized100ug1 mL100ug Lyophilized100ug100ug100ug0.1 ml
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#34114193 2021/06/10 To Up
Enterocins as Novel Feed Additives in Rabbit Diet: Enterocin Ent M and Durancin Ent ED26E/7, Their Combination, and Effects on Microbiota, Caecal Fermentation, and Enzymatic Activity.The present study investigates the effects of enterocin Ent M and durancin Ent ED26E/7 applied separately and in combination on the intestinal microbiota, caecal enzymatic activity, and fermentaion of rabbits. Eighty rabbits (M91 meatline, aged 5Â weeks, both sexes) were divided into groups E (Ent M; 50 ÂµL/animal/day), D (Ent ED26E/7; 50 ÂµL/animal/day), Eâ+âD (Ent Mâ+âEnt ED26E/7), and control (C). The additives were administered in drinking water for 21Â days. Antimicrobial activity of Ent M and Ent ED26E/7 on coliforms (E, Eâ+âD: Pâ<â0.001) and pseudomonads (D: Pâ<â0.05) in feces was noted, compared to C. Ent M and Ent ED26E/7 application stimulated caecal enzymatic activity in rabbits. Pectinolytic (E vs. D, Eâ+âD: Pâ<â0.01), inulolytic (E vs. Eâ+âD: Pâ<â0.01; E vs. C: Pâ<â0.05), and amylolytic (E vs. D, Eâ+âD. Pâ<â0.001; E vs. C: Pâ<â0.01) activities were influenced by Ent M, while cellulolytic (D vs. Eâ+âD: Pâ<â0.01) and inulolytic (D vs. Eâ+âD, C: Pâ<â0.01) activities by Ent ED26E/7 treatment. The cellulolytic and pectinolytic acitivities changed with time. TreatmentâÃâtime interaction was detected for cellulose and xylan degradation. During Ent M and Ent ED26E/7 treatment, increased ammonia, lactic, butyric and iso-valeric acid, and lower acetic, propionic, iso-butyric, valeric, and caproic acid concentrations were noted. It can be concluded that Ent M and Ent ED26E/7 application can improve rabbit health due to reduced spoilage microbiota and enhanced caecal enzymatic activity.
M PogÃ¡ny SimonovÃ¡, A LaukovÃ¡, Ä½ ChrastinovÃ¡, A KandriÄÃ¡kovÃ¡, J Å ÄerbovÃ¡, V StrompfovÃ¡, R Miltko, G Belzecki
1672 related Products with: Enterocins as Novel Feed Additives in Rabbit Diet: Enterocin Ent M and Durancin Ent ED26E/7, Their Combination, and Effects on Microbiota, Caecal Fermentation, and Enzymatic Activity.48 assays100ug48 assays 200 1000 TESTS/0.65ml96 assays 50 ug 5mg1000
#34113182 2021/05/31 To Up
Pharmacokinetics and Safety of an Intravitreal Humanized Anti-VEGF-A Monoclonal Antibody (PRO-169), a Biosimilar Candidate to Bevacizumab.PRO-169 is a biosimilar candidate to bevacizumab (BEV), a monoclonal antibody (mAb) that inhibits vascular endothelial growth factor-A (VEGF-A) developed for intravitreal use. The current study demonstrates the intraocular pharmacokinetics (PK) of PRO-169 and its safety using New Zealand white (NZW) rabbits.
Patricia MuÃ±oz-Villegas, Alejandra Sanchez-Rios, Mayra G Quinonez-Alvarado, Oscar Olvera-MontaÃ±o, Juan D Quintana-Hau, Leopoldo Baiza-Duran
2176 related Products with: Pharmacokinetics and Safety of an Intravitreal Humanized Anti-VEGF-A Monoclonal Antibody (PRO-169), a Biosimilar Candidate to Bevacizumab.100ug Lyophilized1 mg100ul100ul100ug100ug100100ul100ul100ug Lyophilized100ug100ul
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#34112059 2021/06/10 To Up
Relevant essential oil components: a minireview on increasing applications and potential toxicity.Phenolic compounds carvacrol, thymol, eugenol and vanillin are four of the most thoroughly investigated essential oil components given their relevant biological properties. These compounds are generally considered safe for consumption and have been used in a wide range of food and non-food applications. Significant biological properties, including antimicrobial, antioxidant, analgesic, anti-inflammatory, anti-mutagenic or anti-carcinogenic activity, have been described for these components. They are versatile molecules with wide-ranging potential applications whose use may substantially increase in forthcoming years. However, some and studies, and several case reports, have indicated that carvacrol, thymol and eugenol may have potential toxicological effects. Oxidative stress has been described as a main mechanism underlying their cytotoxic behavior, and mutagenic and genotoxic effects have been occasionally observed. studies show adverse effects after acute and prolonged carvacrol and thymol exposure in mice, rats and rabbits, and eugenol has caused pulmonary and renal damage in exposed frogs. In humans, exposure to these three compounds may cause different adverse reactions, including skin irritation, inflammation, ulcer formation, dermatitis or slow healing. Toxicological vanillin effects have been less reported, although reduced cell viability after exposure to high concentrations has been described. In this context, the possible risks deriving from increased exposure to these components for human health and the environment should be thoroughly revised.
Cristina Fuentes, Ana Fuentes, JosÃ© Manuel Barat, MarÃa JosÃ© Ruiz
2404 related Products with: Relevant essential oil components: a minireview on increasing applications and potential toxicity.25 mg1 mg10 mg 50 UG100ul0.25 mg1 kit500 mg0.2 mg50 ug 5 G100 TESTS
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