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#35751869   2022/06/25 To Up

Non-linear shrinkage of Batson's #17 resin during vascular corrosion casting.

Many studies of cardiovascular function require a realistic representation of vascular geometry. Corrosion casting has been used to acquire such geometries for many decades. However, the fidelity with which this method reproduces vascular anatomy has not been completely determined. Here we report on the non-linear shrinkage characteristics and exothermic properties of Batson's #17, a widely used casting resin, in model systems and in aortas of rats and rabbits. The setting process was captured using high-resolution photography. Shrinkage ranged from 3.4 ± 1.5% of the diameter in 1 ml plastic syringes (inner diameter 4.8 mm) to 19.6 ± 5.6% in the aorta of rats (diameter 1.5-2.6 mm). In addition, aortic curvature and branching angles changed during setting. These effects should be determined and corrected in studies of vascular geometry where high accuracy is required.
Kang-Chi Julia Shih, Véronique Peiffer, Ethan M Rowland, Peter Sowinski, Peter D Weinberg

2749 related Products with: Non-linear shrinkage of Batson's #17 resin during vascular corrosion casting.

110 mg100 MG10 mg96tests96T5 mg 100ul

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#35751560   // To Up

Skin involvement in Francisella tularensis infection: a case report of two clinical cases.

Tularemia, or rabbit fever, is a zoonotic infection caused by Francisella tularensis, a Gram-negative coccobacillus. F. tularensis subsp. holarctica (type B) is the predominant form in Slovenia. Humans become infected through arthropod bites, direct contact with an infected animal, ingestion of contaminated water or food, and inhalation of contaminated aerosol. The most common form is ulceroglandular tularemia (> 80%), which is characterized by a skin ulcer and regional lymphadenopathy. Below we present two cases of tularemia with skin involvement.
Maja Prah, Ana Kenk, Jana Rejc Marko

1494 related Products with: Skin involvement in Francisella tularensis infection: a case report of two clinical cases.



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#35751538   // To Up

Skin involvement in Francisella tularensis infection: a case report of two clinical cases.

Tularemia, or rabbit fever, is a zoonotic infection caused by Francisella tularensis, a Gram-negative coccobacillus. F. tularensis subsp. holarctica (type B) is the predominant form in Slovenia. Humans become infected through arthropod bites, direct contact with an infected animal, ingestion of contaminated water or food, and inhalation of contaminated aerosol. The most common form is ulceroglandular tularemia (> 80%), which is characterized by a skin ulcer and regional lymphadenopathy. Below we present two cases of tularemia with skin involvement.
Maja Prah, Ana Kenk, Jana Rejc Marko

1931 related Products with: Skin involvement in Francisella tularensis infection: a case report of two clinical cases.



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#35750538   2022/06/21 To Up

A typhoid fever protein capsular matrix vaccine candidate formulated with Advax-CpG adjuvant induces a robust and durable anti-typhoid Vi polysaccharide antibody response in mice, rabbits and nonhuman primates.

Typhax is an investigational typhoid fever vaccine candidate that is comprised of Vi polysaccharide from Salmonella enterica serovar typhi (S. Typhi) non-covalently entrapped in a glutaraldehyde catalyzed, cross-linked α-poly-L-lysine and CRM protein matrix. A previous Phase 1 trial of an aluminum phosphate adjuvanted Typhax formulation showed it induced Vi IgG after a single dose but that subsequent doses failed to further boost Vi IgG levels. The current study asked whether Advax-CpG adjuvant might instead be able to overcome polysaccharide-induced immune inhibition and improve Typhax immunogenicity. Advax-CpG adjuvanted Typhax elicited high and sustained Vi IgG responses in mice, rabbits and non-human primates (NHP) with levels being boosted by repeated immunization. High Vi antibody responses were lost in CD4 + T cell depleted mice confirming that despite the lack of conjugation of the polysaccharide to the carrier protein, Typhax nevertheless acts in a T cell dependent manner, explaining its ability to induce long-term B cell memory responses to Vi capable of being boosted. In NHP, Advax-CpG adjuvanted Typhax induced up to 100-fold higher Vi IgG levels than the commercial Typhim Vi polysaccharide vaccine. Typhax induced high and sustained serum bactericidal activity against S. Typhi and stimulated robust Vi IgG responses even in animals previously primed with a pure polysaccharide vaccine. Hence Advax-CpG adjuvanted Typhax vaccine is a highly promising candidate to provide robust and durable protection against typhoid fever.
Yoshikazu Honda-Okubo, Robert T Cartee, Ann Thanawastien, Jae Seung Yang, Kevin P Killeen, Nikolai Petrovsky

2217 related Products with: A typhoid fever protein capsular matrix vaccine candidate formulated with Advax-CpG adjuvant induces a robust and durable anti-typhoid Vi polysaccharide antibody response in mice, rabbits and nonhuman primates.

1 mL100200 100100100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#35749970   2022/06/24 To Up

Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of both Cartilage and Subchondral Bone.

Osteochondral defects are characterized by injuries to both cartilage and subchondral bone, which is a result of trauma, inflammation, or inappropriate loading. Due to the unique biological properties of subchondral bone and cartilage, developing a tissue engineering scaffold that can promote dual-lineage regeneration of cartilage and bone simultaneously remains a great challenge. In this study, we fabricated a microporous nanosilicate-reinforced enzymatically-crosslinked silk fibroin (SF) hydrogel by introducing two-dimensional montmorillonite (MMT) nanoparticles via intercalation chemistry. In vitro studies showed that SF-MMT nanocomposite hydrogel had improved mechanical properties and hydrophilicity, as well as the bioactivities to promote the osteogenic differentiation of bone marrow stem cells (BMSCs) with an increased ALP activity and calcium deposition and maintain chondrocyte phenotype with a higher aggrecan expression and a lower matrix-degrading enzyme expression (MMP3/13, ADAMTS4/5) compared with SF hydrogel. Global proteomic analysis verified the dual-lineage bioactivities of SF-MMT nanocomposite hydrogel, which were probably regulated by multiple signaling pathways. Besides, it was observed that the biophysical interaction of cells and SF-MMT nanocomposite hydrogel was partially mediated by clathrin-mediated endocytosis and its downstream processes. In vivo, SF-MMT nanocomposite hydrogel effectively promoted subchondral bone and cartilage regeneration in rabbit osteochondral defect model as evidenced by macroscopic, micro-CT, and histological evaluation. In conclusion, we developed a functionalized SF-MMT nanocomposite hydrogel with dual-lineage bioactivity for osteochondral regeneration, indicating its potential in osteochondral tissue engineering. Statement of significance Osteochondral defects involve the injuries of both articular cartilage and subchondral bone. Due to the distinct properties of these two tissues, it remains a great challenge to induce the dual-lineage regeneration of cartilage and bone simultaneously. This study developed an SF-MMT nanocomposite hydrogel by enzymatic crosslinking and intercalation chemistry, which effectively enhanced the osteogenic differentiation of BMSCs and the maintenance of chondrocyte phenotype, thereby promoting the dual-lineage regeneration of articular cartilage and subchondral bone in osteochondral defects. Therefore, SF-MMT nanocomposite hydrogel with dual-lineage bioactivity is a promising scaffold for osteochondral tissue engineering. This article is protected by copyright. All rights reserved.
Renwang Sheng, Jialin Chen, Hongmei Wang, Yifan Luo, Jia Liu, Zhixuan Chen, Qingyun Mo, Jiayu Chi, Chen Ling, Xin Tan, Qingqiang Yao, Wei Zhang

2784 related Products with: Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of both Cartilage and Subchondral Bone.

100μg10ìg50.00 ml10 mg5 ug200ug

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#35749706   // To Up

Effect of Photobiomodulation Therapy on Peri-Implant Bone Healing in Extra-Short Implants in a Rabbit Model: A Pilot Study.

To evaluate the effects of photobiomodulation therapy (PBMT) at distinct energy levels on peri-implant bone healing in extra-short implants in a experimental rabbit model. The effect of PBMT on peri-implant bone healing in short implants remains unclear. This explored the effect of PBMT on extra-short implants in terms of bone-implant contact (BIC) length and rate, and implant stability quotient (ISQ). Fifteen white New Zealand rabbits were randomly divided into five groups. In all groups, extra-short implants (3.5 × 4 mm; Nucleoss T6, İzmir/Turkey) were placed in both tibias of the rabbits. PBMT was performed in four groups (group 1, 5 J/cm; group 2, 10 J/cm; group 3, 20 J/cm; and group 4, 25 J/cm); no PBMT was performed in the control group. On the 30th day, the rabbits were sacrificed and peri-implant tissue samples were obtained to determine the BIC length and BIC rate. Implant stability levels were measured by resonance frequency analysis using the Osstell penguin device and were determined as ISQ values on the 1st and 30th days of the study. PBMT significantly increased the BIC length and BIC rate in groups 3 and 4 ( < 0.001). For the ISQ values, there were significant differences between the 1st and 30th day ( < 0.001). On the 30th day, the ISQ values were significantly higher in groups 3 and 4 compared with the remaining groups ( < 0.001). In this study, PBMT improved peri-implant bone healing through increase in BIC length, BIC rate, and ISQ parameter values in extra-short implants.
Turan Emre Kuzu, Kübra Öztürk, Cem A Gürgan, Aslihan Üşümez, Arzu Yay, Özge Göktepe

2872 related Products with: Effect of Photobiomodulation Therapy on Peri-Implant Bone Healing in Extra-Short Implants in a Rabbit Model: A Pilot Study.

100ug100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#35748851   2022/06/24 To Up

Histologic and Immunohistochemical Evaluation of Radiosurgery in Strabismus Surgery in a Rabbit Model.

The aim of this study was to evaluate the use of monopolar radiosurgery (MRS) assisted strabismus surgery and to compare its histologic and immunohistochemical wound healing outcomes with conventional surgery.
Demet Yolcu, Ahmet Murad Hondur, Nalan Akyürek, Kamil Bilgihan

1376 related Products with: Histologic and Immunohistochemical Evaluation of Radiosurgery in Strabismus Surgery in a Rabbit Model.

100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug5µg100ug100ug Lyophilized100ug Lyophilized100ug100 100ug100ug Lyophilized

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