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#36737772   2023/02/04 To Up

Effects of a locally administered risedronate/autogenous bone graft combination on bone healing in a critical-size rabbit defect model.

Risedronate is a bisphosphonate with poor oral absorption. An extremely hydrophilic molecule that has a high affinity for bone, risedronate also inhibits the farnesyl diphosphate synthase enzyme, inhibiting osteoclastic activity and reducing bone turnover and resorption. Autogenous bone grafts contain osteogenic cells and osteoinductive factors that are essential for bone regeneration and are therefore considered the gold standard. Thus, this study aimed to investigate the impact of local risedronate administered with autogenous bone grafts on the healing of defects in rabbit skulls using histological, histomorphometric, immunohistochemical, and three-dimensional radiological methods.
Taha Özer, Vusala Guliyeva, Alper Aktaş, Emre Barış, Mert Ocak

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