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#35044442   // To Up

Effects of Valproic Acid and Mitomycin C Combination Therapy in a Rabbit Model of Minimally Invasive Glaucoma Surgery.

This study aimed to compare the effectiveness of combination therapy consisting of low-dose mitomycin C (MMC) and valproic acid (VPA) against high-dose MMC for improving the scar phenotype in minimally invasive glaucoma surgery (MIGS).
Li-Fong Seet, Zhu Li Yap, Stephanie W L Chu, Li Zhen Toh, Farah Ilyana Ibrahim, Xiao Teng, Tina T Wong

1041 related Products with: Effects of Valproic Acid and Mitomycin C Combination Therapy in a Rabbit Model of Minimally Invasive Glaucoma Surgery.

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#35042006   2022/01/15 To Up

Extracellular vesicles delivered by injectable collagen promote bone-tendon interface healing and prevent fatty degeneration of rotator cuff muscle.

This study aimed 1) to confirm the maintenance of the extracellular vesicles (EV) delivered via injectable collagen at the application site, and 2) to evaluate the effect of EVs derived from the human umbilical cord-derived mesenchymal stem cells (Huc-MSCs) and loaded in an injectable collagen gel after rotator cuff repair (RCR).
Hyojune Kim, In Kyong Shim, Jae Hee Choi, Eui-Sup Lee, Yu Na Lee, In-Ho Jeon, Kyoung Hwan Koh

1654 related Products with: Extracellular vesicles delivered by injectable collagen promote bone-tendon interface healing and prevent fatty degeneration of rotator cuff muscle.

10ìg1 mg lyophilized0.1 mg100ug100ug100μg

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#35040841   2022/01/18 To Up

The solvent effect modulates the formation of homogeneous polyphenol composite hydrogels with improved transparency and mechanical strength for antibacterial delayed sternal closure films.

The usage of delayed sternal closure films after thoracotomy surgery helps doctors deal with emergency conveniently. There is a growing demand to develop suturable, antibacterial and transparent films for delayed sternal closure. Although polyphenol incorporated hydrogels provide good suture ability, they lose transparency because of the heterogeneous distribution of polyphenols during the post-immersion process. Here, a solvent exchange method is proposed to fabricate homogeneous polyphenol composite hydrogels in a bottom-up manner, which utilizes the distinct solvent effect of DMSO and HO to modulate the association and disassociation between polyphenols and the polymer backbones on demand. DMSO first provides a protective environment to turn off the intermolecular interactions and allows tannic acid (TA) to be dispersed into the polymer network PEG-lysozyme (PEG-LZM) homogeneously. The following water rehydration turns on the intermolecular interactions between titanic acid and PEG-lysozymes, and results in a homogeneous titanic acid toughened composite hydrogel (PEG-LZM-TA (DH)), which has an improved transparency and mechanical properties than those of the materials prepared by the post-immersion method. In addition, the TA integration provides antibacterial function to the hydrogels. We establish a rabbit delayed sternal closure model to demonstrate that PEG-LZM-TA (DH) films can be sutured to temporarily close the thoracic cavity of rabbits, provide a transparent window to inspect the wound at any time, and control the bacterial contamination efficiently. We further explore the solvent exchange method to other polyphenols and polymeric hydrogel composites. The results suggest that the solvent exchange method provides generic opportunities to fabricate homogeneous polyphenol strengthened hydrogel systems with high performance.
Jiahui Xie, Dawei Jin, Jiaqi Qiu, Jingyuan Cui, Meng Yin, Xue Qu

2121 related Products with: The solvent effect modulates the formation of homogeneous polyphenol composite hydrogels with improved transparency and mechanical strength for antibacterial delayed sternal closure films.

500IUmin 2 cartons100.00 ul 100 G1200 units1500 Units

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#35040258   2022/01/18 To Up

Fat-1 expression alleviates atherosclerosis in transgenic rabbits.

Atherosclerosis is the main cause of cardiovascular diseases. The Fat-1 gene can express the n-3 fatty acid desaturase, which converts n-6 polyunsaturated fatty acids (PUFA) to n-3 PUFAs. The role of n-3 PUFAs in atherosclerosis is widely debated. This study explored the effect of n-3 PUFAs on atherosclerosis in rabbits. In this study, atherosclerosis was induced in Fat-1 transgenic rabbits and their littermate (WT) rabbits by feeding a high-cholesterol diet containing 0.3% cholesterol and 3% soybean oil for 16 weeks. Plasma lipid, fatty acid and pathological analyses of atherosclerotic lesions were conducted. Fatty acid composition in the liver and muscle showed that n-3 PUFAs increased and n-6 PUFAs decreased in the Fat-1 group. Plasma high-density lipoprotein cholesterol (HDL-C) levels were significantly increased in the Fat-1 group, and the atherosclerotic lesion area of the aortic arch in Fat-1 transgenic rabbits was significantly reduced. Histological analysis showed that smooth muscle cells (SMCs) in atherosclerotic lesions decreased significantly. In conclusion, n-3 PUFAs improve atherosclerosis in Fat-1 transgenic rabbits, and this process may depend on the increase in plasma HDL-C and the decrease in the amount of SMCs in atherosclerotic plaques.
Chenyang Zhang, Xiaojing Wang, Suping Sun, Yu Fu, Yi Wu, Sihai Zhao, Xinzhong Fan, Enqi Liu

1016 related Products with: Fat-1 expression alleviates atherosclerosis in transgenic rabbits.

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#35038306   2022/01/12 To Up

Pharmacokinetics of pimobendan following oral administration to New Zealand White rabbits (Oryctolagus cuniculus).

To determine the pharmacokinetics and potential adverse effects of pimobendan after oral administration in New Zealand White rabbits (Ocytolagus cuniculi).
Sarah M Ozawa, David Sanchez-Migallon Guzman, Michelle G Hawkins, Stephanie M Diao, Acacia E Masri, Catherine T Gunther-Harrington, Heather K Knych

2866 related Products with: Pharmacokinetics of pimobendan following oral administration to New Zealand White rabbits (Oryctolagus cuniculus).

10ml96T25ml50 mg5 mg 1 G1 kit(96 Wells)100 1 mg1mg

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#35038282   2022/01/17 To Up

High shear stress attenuated arterial neointimal hyperplasia accompanied by changes in yes-associated protein/jun N-terminal kinase/vascular cell adhesion protein 1 expression.

Abnormal neointimal hyperplasia (NIH) is known as the predominant mechanism in the pathogenesis of arterial restenosis after balloon angioplasty. Low shear stress (SS) is known to augment balloon injury-induced NIH. The aim of this study is to study the effect and mechanisms of an increase of shear stress caused by arteriovenous fistula could alleviate arterial NIH caused by balloon injury.
Feng Chen, Jun Fu Luo, Rong Wan

1290 related Products with: High shear stress attenuated arterial neointimal hyperplasia accompanied by changes in yes-associated protein/jun N-terminal kinase/vascular cell adhesion protein 1 expression.

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#35038172   2022/01/17 To Up

Effect of cooking methods on the edible, nutritive qualities and volatile flavor compounds of rabbit meat.

Rabbit meat is a good edible meat source with high nutritional values. Cooking has a significant impact on the edible properties, nutritional qualities and flavor characteristics of meat. Studying the effect of cooking methods on rabbit meat qualities could encourage more consumers understanding and accepting rabbit meat, and could also provide some reference for rabbit meat processing. Therefore, The effects of boiling (BRS), sous-vide cooking (SVRS), steaming (SRS), microwaving (MRS), roasting (RRS), frying (FRS) and pressure cooking (PRS) on the edible, nutritive and volatile qualities of rabbit meat were investigated.
Jia-Wei Rao, Fan-Bing Meng, Yun-Cheng Li, Wei-Jun Chen, Da-Yu Liu, Jia-Min Zhang

1747 related Products with: Effect of cooking methods on the edible, nutritive qualities and volatile flavor compounds of rabbit meat.

100ug50 ug 5 G100.00 ul1000 100.00 ul 100ul50 ug 100.00 ul1 ml100.00 ul100.00 ul

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#35038159   2022/01/17 To Up

Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes.

Type 2 diabetes is an independent risk factor for non-alcoholic steatohepatitis (NASH) progression and its mediators have not been resolved. In this study, a pathogenic role of cellular communication network factor 2 (CCN2) protein in NASH pathology, was investigated in an established preclinical NASH model. Male wild type C57BL/6 mice received either Chow or high fat diet (HFD) for 26 weeks, with some mice in each group randomly selected to receive low dose streptozotocin (STZ: 3 i.p. injections, 65 mg/kg) at 15 weeks to induce type 2 diabetes. In the final 10 of the 26 weeks mice from each group were administered i.p. either rabbit anti-CCN2 neutralizing antibody (CCN2Ab) or as control normal rabbit IgG, at a dose of 150 µg per mouse twice/week. NASH developed in the HFD plus diabetes (HFD+DM) group. Administration of CCN2Ab significantly downregulated collagen I and collagen III mRNA induction and prevented pro-inflammatory MCP-1 mRNA induction in HFD+DM mice. At the protein level, CCN2Ab significantly attenuated collagen accumulation by PSR stain and collagen I protein induction in HFD+DM. Phosphorylation of the pro-fibrotic ERK signalling pathway in liver in HFD+DM was attenuated by CCN2Ab treatment. Intrahepatic CCN1 mRNA was induced, whereas CCN3 was downregulated at both the mRNA and protein levels in HFD+DM. CCN3 down-regulation was prevented by CCN2Ab treatment. This in vivo study indicates that CCN2 is a molecular target in NASH with high fat diet and diabetes, and that regulation of ERK signalling is implicated in this process.
Jing Ren, Xiaoyu Wang, Sarah N Parry, Christine Yee, Mark D Gorrell, Susan V McLennan, Stephen M Twigg

2862 related Products with: Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes.

10 mg200ul200ul18 kgs250ul400Tests1200ul

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#35037903   // To Up

Transplantation of Preserved Human Amniotic Membrane for Surface Reconstruction in Severely Damaged Rabbit Corneas.


2285 related Products with: Transplantation of Preserved Human Amniotic Membrane for Surface Reconstruction in Severely Damaged Rabbit Corneas.

100ug Lyophilized 100ul4 Membranes/Box50ul50ul 100ul1 mg 100ul 100ul1 ml 100ul100

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