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Lipid profiling of serum and lipoprotein fractions in response to pitavastatin using an animal model of familial hypercholesterolemia.Statins are widely used for the treatment of atherosclerotic cardiovascular diseases. They inhibit cholesterol biosynthesis in the liver and cause pleiotropic effects including anti-inflammatory and antioxidant effects. To develop novel therapeutic drugs, the effect of blood-borne lipid molecules on the pleiotropic effects of statins must be elucidated. Myocardial-infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbits, an animal model for hypercholesterolemia, are suitable for the determination of lipid molecules in blood in response to statins because their lipoprotein metabolism is similar to that of humans. Herein, lipid molecules were investigated by lipidome analysis in response to pitavastatin using WHHLMI rabbits. Various lipid molecules in the blood were measured using a supercritical fluid chromatography triple quadrupole mass spectrometry. Cholesterol and cholesterol ester blood levels decreased by reducing the secretion of very low density lipoproteins from the liver. Independent of the inhibition effects of cholesterol biosynthesis, the concentrations of some lipids with anti-inflammation and antioxidant effects (phospholipid molecules with -6 fatty acid side chains, lysophosphatidylcholines, phosphatidylethanolamine plasmalogens, and ceramide molecules) were significantly altered. These findings may lead to further investigation of the mechanism of statin action.
2212 related Products with: Lipid profiling of serum and lipoprotein fractions in response to pitavastatin using an animal model of familial hypercholesterolemia.FDA Standard Frozen Tissu CAR,CAR,Constitutive acti Mouse Anti-Lipoprotein Li Animal Biologicals Poole Proteins and Antibodies H Bovine Androstenedione,AS Animal Biologicals Poole FIV Core Ag, recombinant FDA Standard Frozen Tissu Anti beta3 AR Human, Poly Human interleukin 2(IL-2) FDA Standard Frozen Tissu
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Nonclinical safety assessment of repeated administration and biodistribution of ChAd3-EBO-Z Ebola candidate vaccine.ChAd3-EBO-Z is an investigational adenovirus-based vaccine for the prevention of Ebola virus disease. Two nonclinical studies were performed to evaluate the biodistribution, local tolerance and potential local and systemic toxic effects of this vaccine. In the biodistribution study, rats received a single intramuscular injection of either ChAd3-EBO-Z or saline. Enlargement of the draining lymph nodes, starting on day 2, was noticed in ChAd3-EBO-Z-treated rats, indicating that an immune response had taken place. Viral DNA was mainly found at the injection sites and in the draining lymph nodes, from where it progressively disappeared during the observation period, while it was found only transiently and occasionally in other organs. In the repeated-dose toxicity study, either ChAd3-EBO-Z or saline was administered intramuscularly to rabbits on two occasions with a 2-week interval. General health status, rectal temperature, local tolerance, ophthalmology, hematology, coagulation and blood chemistry parameters were monitored. Macroscopic and microscopic evaluations were performed. Treatment-related changes included a transient increase in neutrophil count, C-reactive protein and fibrinogen levels, and a transient decrease in platelet count. As expected, microscopic observations 3 days after the second injection were related to the elicited inflammatory reaction, and these inflammatory responses had almost completely disappeared 29 days after the second immunization. In conclusion, the vaccine was locally and systemically well-tolerated and the viral vector was partially or totally cleared from the organs where it disseminated, supporting the clinical development of the vaccine.
1249 related Products with: Nonclinical safety assessment of repeated administration and biodistribution of ChAd3-EBO-Z Ebola candidate vaccine.Ofloxacin CAS Number [824 Rabbit Anti-ZFAND5 Polycl Rabbit Anti-Rex1 Zinc fin ZNF101 Anti-Androgen Receptor pr Rabbit Anti-ZNF268 Polycl Rabbit Anti-ZDHHC16 Polyc Rabbit Anti-ZNRF3 Polyclo Rabbit Anti-RPS3 Polyclon Rabbit Anti-ZFAND5 Polycl Rabbit Anti-Rex1 Zinc fin ZNF165 antibody Source Ra
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An Oral Inoculation Infant Rabbit Model for Infection.species cause diarrheal disease globally. Shigellosis is typically characterized by bloody stools and colitis with mucosal damage and is the leading bacterial cause of diarrheal death worldwide. After the pathogen is orally ingested, it invades and replicates within the colonic epithelium through mechanisms that rely on its type III secretion system (T3SS). Currently, oral infection-based small animal models to study the pathogenesis of shigellosis are lacking. Here, we found that orogastric inoculation of infant rabbits with resulted in diarrhea and colonic pathology resembling that found in human shigellosis. Fasting animals prior to inoculation increased the frequency of disease. The pathogen colonized the colon, where both luminal and intraepithelial foci were observed. The intraepithelial foci likely arise through spreading from cell to cell. Robust intestinal colonization, invasion of the colonic epithelium, and epithelial sloughing all required the T3SS as well as IcsA, a factor required for bacterial spreading and adhesion Expression of the proinflammatory chemokine interleukin 8 (IL-8), detected with mRNA labeling, was higher in animals infected with wild-type versus mutant strains deficient in or T3SS, suggesting that epithelial invasion promotes expression of this chemokine. Collectively, our findings suggest that oral infection of infant rabbits offers a useful experimental model for studies of the pathogenesis of shigellosis and for testing of new therapeutics. species are the leading bacterial cause of diarrheal death globally. The pathogen causes bacillary dysentery, a bloody diarrheal disease characterized by damage to the colonic mucosa and is usually spread through the fecal-oral route. Small animal models of shigellosis that rely on the oral route of infection are lacking. Here, we found that orogastric inoculation of infant rabbits with led to a diarrheal disease and colonic pathology reminiscent of human shigellosis. Diarrhea, intestinal colonization, and pathology in this model were dependent on the type III secretion system and IcsA, canonical virulence factors. Thus, oral infection of infant rabbits offers a feasible model to study the pathogenesis of shigellosis and to develop and test new therapeutics.
Primary antibody Caspase succinate-CoA ligase, ADP succinate-CoA ligase, GDP formin-like 1 antibody So RABBIT ANTI GSK3 BETA (pS Primary antibody FLIP An oral-facial-digital syndr Rabbit Anti-TSLP (human) Rabbit Anti-ATP7B Polyclo Rabbit Anti-Protamine 2 P Rabbit Anti-FLI1 Polyclon Rabbit Anti-phospho-LEF1(
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Genetic variability of functional longevity in five rabbit lines.The objectives of this study were to analyse the differences in the genetic determination of functional longevity in five Spanish lines of rabbits and to check how different systematic factors might affect this genetic determination. Four of the lines were maternal (lines A, V, H and LP), these lines were established selecting base generation animals according to different criteria, but in the subsequent generations all of them were selected for litter size at weaning. The other is the paternal line R, this line was constituted by selecting animals with an outstanding daily growth rate. The trait analysed, length of productive life, was the time in days between the date of the first positive pregnancy test and the date of culling or death of a doe. Four models extended from the Cox proportional hazard model were used to analyse data of each line separately and jointly. The complete model (Model 1) included the fixed effect of year-season (YS) combination, positive palpation order (OPP), that is, reproductive cycle, physiological status of the doe (PS) at service and number of kits born alive (NBA) in each kindling as time-dependent factors. The inbreeding coefficient was fitted as a continuous covariate and the animal's additive genetic effect was also fitted to the model (Model 1). The other models were identical to Model 1 but excluding OPP (Model 2) or PS (Model 3) or NBA (Model 4), which were explored to assess the consequence on additive variance estimates of not correcting for these animal-dependent factors. Estimated effective heritabilities of longevity were 0.07 ± 0.03, 0.03 ± 0.02, 0.14 ± 0.09, 0.05 ± 0.04, 0.02 ± 0.01 and 0.04 ± 0.01 for lines A, V, H, LP, R and for the merged data set, respectively. Removing the PS from the model led to an increase in the estimated additive genetic variance in all lines (0.17 ± 0.05, 0.05 ± 0.03, 0.29 ± 0.19, 0.29 ± 0.20, 0.07 ± 0.04 and 0.05 ± 0.02 for lines A, V, H, LP, R and the merged data set, respectively). The highest hazard of death and/or culling was observed during the first two parities and decreased as the order of parity progressed. Does non-pregnant-non-lactating had the highest risk of death or culling. The does that had zero kits born alive incurred the highest risk, and this risk decreased as the NBA increased. In conclusion, the consideration of longevity as selection criterion for the studied rabbit lines is not recommended.
Rabbit Anti-G protein alp Rabbit Anti-Phospho-INPPL Rabbit Anti-IAA (Indole-3 Rabbit Anti-Cell death in Rabbit Anti-Integrin β2 Rabbit Anti-NOS-2 iNOS Po Rabbit Anti-Integrin beta Rabbit Anti-Insulin Polyc Rabbit Anti-Cell death in Rabbit Anti-NOS-2 iNOS Po Rabbit Anti-Integrin beta Rabbit Anti-Insulin Polyc
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Causes of Mortality and Disease in Rabbits and Hares: A Retrospective Study.In this study we determined the causes of mortality and disease in a total of 325 lagomorphs (rabbits and hares) in northern Spain between 2000 and 2018. Risk factors such as the species, age, sex, time of year and origin were also considered. Clinical signs, gross and histopathological findings and ancillary test results were the basis for the final diagnoses that were reviewed to classify and identify the different disorders. A total of 26 different conditions were identified. A single cause of death or illness was detected in 267 animals. They were grouped into parasitic conditions (= 65; 24.34%) represented by encephalitozoonosis, hepatic coccidiosis, hepatoperitoneal cysticercosis, intestinal coccidiosis, parasitic gastritis and cutaneous ectoparasitosis; bacterial diseases ( = 56; 20.97%) including pseudotuberculosis, blue breast, skin abscesses, tularemia, pneumonic pasteurellosis and staphylococcal infections; nutritional and metabolic diseases ( = 48; 17.97%) with epizootic rabbit enteropathy, hepatic steatosis and pregnancy toxemia as prominent diseases; viral infections (= 31; 11.61%) comprising rabbit hemorrhagic disease and myxomatosis and miscellaneous causes ( = 31; 11.61%) where rabbit enteritis complex, renal conditions (nephrosis), heat stroke, and arterial bone metaplasia were included; neoplasms ( = 12; 4.49%) represented by uterine adenocarcinoma, mammary adenocarcinoma, cutaneous fibroma, intestinal lymphoma and hepatic cholangiocarcinoma; toxicoses ( = 11; 4.11%); trauma-related injuries ( = 9; 3.37%) and finally congenital diseases ( = 4; 1.49%). In 58 animals of the study, some of these conditions were presented jointly. We discuss the detection frequency, possible causes or associated factors of the different pathologies as well as the importance of the different variables considered.
2148 related Products with: Causes of Mortality and Disease in Rabbits and Hares: A Retrospective Study.∆1-Androstene-3β,17β- FIV Core Ag, recombinant Rabbit Anti-Rat Androgen Beta Amyloid (1 40) ELISA Androgen Receptor (Phosph (5α,16β)-N-Acetyl-16-ac Androgen Receptor Ab 1 Androst-4-ene-3,17-dion-1 Androgen Receptor (Ab 650 Androstadienone C19H26O C Liver disease spectrum ti Androstane-3a, 17b-diol 5
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Comparison of the effects of omecamtiv mercabil on excitation contraction coupling between isolated rabbit ventricular myocytes and human iPSC-derived cardiomyocytes.
1187 related Products with: Comparison of the effects of omecamtiv mercabil on excitation contraction coupling between isolated rabbit ventricular myocytes and human iPSC-derived cardiomyocytes.RAP2C, member of RAS onco Rabbit Anti-Human Androge Rabbit Anti-Human Androge Rabbit Anti-Human Androge TCP-1 theta antibody Sour thymic dendritic cell-der Rabbit Anti-Human HSP90 a Epoxide hydrolase 1 antib Antibodies, Rabbit: Rabb Sec61 alpha-1 antibody So LIM kinase 2 antibody Sou Rabbit Anti-Human MSLN An
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Characterization of a conscious, restrained, rabbit CV telemetry model for assessing hemodynamic and ECG risk liabilities in early drug research and development.
2246 related Products with: Characterization of a conscious, restrained, rabbit CV telemetry model for assessing hemodynamic and ECG risk liabilities in early drug research and development.Anti-Androgen Receptor pr Rabbit Anti-Human Androge Androgen Receptor (Ab 650 Androgen Receptor (Phosph Rabbit Anti-Human Androge Rabbit anti Androgen Rece Rabbit Anti-Human Androge Anti Androgen Receptor pr Androgen Receptor (Phosph Rabbit Anti-Rat Androgen Caspase 4 Inhibitor Drug Rabbit Anti-intestinal FA
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A translational analysis: Cardiac ion channels and isolated rabbit left ventricular wedge in predicting CV safety risk.
2289 related Products with: A translational analysis: Cardiac ion channels and isolated rabbit left ventricular wedge in predicting CV safety risk.Rabbit Anti-Trypsin Inhib Rabbit Anti-Integrin alph Rabbit Anti-HSPβ7 cvHSP Rabbit Anti-Insulin Recep Rabbit Anti-Human Inhibin Integrin alphaX antibody Rabbit Anti-Integrin alph Rabbit Anti-Integrin alph Rabbit Anti-HSPβ7 cvHSP Rabbit Anti-CD11b Integri Rabbit Anti-APIP Apaf1 In Rabbit Anti-Human Androge
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Evaluation of cardiac function after cardioplegic treatment in isolated rabbit hearts.
2377 related Products with: Evaluation of cardiac function after cardioplegic treatment in isolated rabbit hearts.Rabbit Anti-Insulin Recep Rabbit Anti-intestinal FA Rabbit Anti-phospho-cardi Rabbit Anti-Insulin Recep Rabbit Anti-G protein alp Rabbit Anti-TNIP2 ABIN2 T Polyclonal Rabbit Anti In Rabbit Anti-Integrin alph Rabbit Anti-ING1 p33 Poly Rabbit Anti-Insulin Recep Integrin â3 (Phospho Tyr Rabbit Anti-G protein alp
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