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#34562979   2021/09/06 To Up

Argon Bioactivation of Implants Installed Simultaneously to Maxillary Sinus Lifting without Graft. An Experimental Study in Rabbits.

The treatment of the surface of titanium implants with argon plasma improved its hydrophilicity and cell adhesion, resulting in higher bone apposition on implant and graft surfaces. The spontaneous perforation over time of the sinus mucosa after sinus augmentation has been documented in experimental studies at both implants and graft particles. The aim of the present study was to evaluate the influence of plasma argon treatment of the implant surface on bone apposition and on the rate of sinus mucosa perforations.
Yuki Omori, Daniele Botticelli, Mauro Ferri, Rafael Delgado-Ruiz, Vitor Ferreira Balan, Samuel Porfirio Xavier

1902 related Products with: Argon Bioactivation of Implants Installed Simultaneously to Maxillary Sinus Lifting without Graft. An Experimental Study in Rabbits.

100 ul50 ul100 100 50 ul1 mg100 ul

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#34562975   2021/09/04 To Up

Mesenchymal Stromal Cells Enhance Vascularization and Epithelialization within 7 Days after Gingival Augmentation with Collagen Matrices in Rabbits.

Soft gingival tissue deficiency remains a severe problem leading to postoperative recession, peri-implantitis, and bone resorption. The use of collagen matrices does not always lead to complete rebuilding of the gingiva volume. The application of mesenchymal stromal cells (MSCs) simultaneously with collagen materials represents a promising approach for the restoration of soft gingival tissues. However, short-term effects of MSCs-enriched collagen grafts after gingival augmentation have not yet been studied properly. Mucograft and Mucoderm matrices were implanted in rabbits (n = 12) simultaneously with the intraoperative injection of rabbit bone marrow-derived mesenchymal stromal cells (BM-MSCs) or without cells. Collagen matrices were implanted under the flap or by the surface technique without intentional primary closure. The samples were harvested seven days after implantation, histological staining with hematoxylin and eosin, and immunohistochemical staining for VEGF, IGF1, and TGF were performed. The use of Mucoderm led to better augmentation outcomes on day 7 compared with Mucograft ( < 0.0001). Gingival augmentation in combination with the local administration of BM-MSCs led to better regeneration of the soft gingival tissues independently of the type of implanted collagen matrices ( < 0.0001). Furthermore, injection of BM-MSCs significantly enhanced gingival vascularization and epithelization with a clear positive correlation between vascular growth and epithelial response. Administration of BM-MSCs in combination with various collagen materials may potentially improve gingiva regeneration.
Anatoliy Kulakov, Evgenia Kogan, Tatiana Brailovskaya, Anna Vedyaeva, Nickolay Zharkov, Olga Krasilnikova, Mikhail Krasheninnikov, Denis Baranovskii, Timur Rasulov, Ilya Klabukov

2196 related Products with: Mesenchymal Stromal Cells Enhance Vascularization and Epithelialization within 7 Days after Gingival Augmentation with Collagen Matrices in Rabbits.

24 tests1x10e7 cells5mg96 tests10 mg50 ul1 mg1 vial1.00 flask4/120 Packing /sleeve/bo10mg

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#34562165   2021/09/25 To Up

Influence of dietary supplementation of clove and rosemary essential oils or their combination on growth performance, immunity status, and blood antioxidant of growing rabbits.

This study aimed to assess the dietary effects of rosemary and clove essential oils separately and in combination on the growth performance; immunological, hematological, and physiological responses; and antioxidant status of growing rabbits. One hundred forty-four of 42-day-old growing V-line rabbits (both sexes with initial live body weights of 765 ± 6 g) were randomly allocated into four treatment groups of 36 rabbits each. Each group was further sub-divided into 12 replicates of 3 rabbits in a completely randomized design. The 1 group was fed a basal diet free of additives and served as the control group, the 2 and 3 groups were fed basal diets supplemented with rosemary and clove essential oils, respectively, at doses of 400 mg/kg diet. The 4 group received a basal diet supplemented with a combination of clove and rosemary essential oils at doses of 200 mg/kg diet each. The results showed that the different supplementations did not influence rabbit performance or immunological traits. Opposite to performance or immunological traits, differences in red blood cells and hemoglobin value among all dietary treatments were improved (P < 0.05). Dietary essential oil supplementation with clove, rosemary oil, or a mixed of both increased (P < 0.05) blood concentrations of catalase, superoxide dismutase, and glutathione peroxidase by 47, 42, and 7%; 56, 35, and 36%; and 40, 39, and 37%, respectively, in supplemented rabbits versus control rabbits. In conclusion, clove and/or rosemary essential oils can potentially be used in rabbit diets to improve antioxidant status without change in rabbit's growth performance or immunological parameters.
Yassmine Moemen El-Gindy, Soliman Mohamed Zahran, Mohamed Abdel-Rahman Ahmed, Abdelfatah Z M Salem, Tahany Rahel Misbah

1239 related Products with: Influence of dietary supplementation of clove and rosemary essential oils or their combination on growth performance, immunity status, and blood antioxidant of growing rabbits.

5 G1 ml1000 tests5mg100ug1 g10 mg100ul200ul10 mg

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#34561120   2021/09/13 To Up

Is induced membrane technique effective in reconstruction of mandibular segmental bone defects? An experimental study.

This study aimed to compare the effectiveness of different graft materials using induced membrane technique for reconstruction of mandibular segmental bone defects. New Zealand rabbits were used as the experimental animal. As first-stage surgical procedure, segmental bone defects were created at the lower border of the mandibula in all groups. Polymethylmethacrylate (PMMA) cement was inserted into the defects. After 6 weeks, PMMA cement was removed in all groups. In the Control group, defect areas were left empty. Defects were filled with autogenous graft in the Autograft group, xenograft in the Xenograft group, and a mixture of autogenous graft and xenograft in the Autograft + Xenograft group. Histopathological, stereological, and immunohistochemical analyses were performed. A total of 40 New Zealand rabbits were used. Rabbits were randomly divided into four subgroups as Control, Autograft, Xenograft and Autograft + Xenograft groups (n = 10). When the groups were compared in terms of newly formed bone tissue volumes, significant difference was found between the Control group and Autograft group, Xenograft group and Autograft + Xenograft group (p < 0.001, p < 0.001, p = 0.003). The results of immunohistochemical examination were consistent with this finding. Stereological and immunohistochemical results can be used as a justification to adopt the induced membrane technique on an experimental basis in humans when it comes to the reconstruction of small segmental mandibular defects.
Ezgi Yüceer-Çetiner, Nilüfer Özkan, Mehmet Emin Önger, Mustafa Yavuz Gülbahar, Metehan Keskin

2318 related Products with: Is induced membrane technique effective in reconstruction of mandibular segmental bone defects? An experimental study.

100 ul100 ul50 ul50 ul100ug Lyophilized0.1ml100ug Lyophilized100ug Lyophilized4 Membranes/Box100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#34560537   2021/09/21 To Up

Management of adrenoleukodystrophy: From pre-clinical studies to the development of new therapies.

X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder associated with mutations of the ABCD1 gene that encodes a peroxisomal transmembrane protein. It results in accumulation of very long chain fatty acids in tissues and body fluid. Along with other factors such as epigenetic and environmental involvement, ABCD1 mutation-provoked disorders can present different phenotypes including cerebral adrenoleukodystrophy (cALD), adrenomyeloneuropathy (AMN), and peripheral neuropathy. cALD is the most severe form that causes death in young childhood. Bone marrow transplantation and hematopoietic stem cell gene therapy are only effective when performed at an early stage of onsets in cALD. Nonetheless, current research and development of novel therapies are hampered by a lack of in-depth understanding disease pathophysiology and a lack of reliable cALD models. The Abcd1 and Abcd1/Abcd2 knock-out mouse models as well as the deficiency of Abcd1 rabbit models created in our lab, do not develop cALD phenotypes observed in human beings. In this review, we summarize the clinical and biochemical features of X-ALD, the progress of pre-clinical and clinical studies. Challenges and perspectives for future X-ALD studies are also discussed.
Chui Yan Ma, Cheng Li, Xiaoya Zhou, Zhao Zhang, Hua Jiang, Hongsheng Liu, Huanhuan Joyce Chen, Hung-Fat Tse, Can Liao, Qizhou Lian

1300 related Products with: Management of adrenoleukodystrophy: From pre-clinical studies to the development of new therapies.

5 G0.1ml (1mg/ml)

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#34559811   2021/09/24 To Up

Electroporation safety factor of 300 nanosecond and 10 millisecond defibrillation in Langendorff-perfused rabbit hearts.

Recently, a new defibrillation modality using nanosecond pulses was shown to be effective at much lower energies than conventional 10 millisecond monophasic shocks in ex vivo experiments. Here we compare the safety factors of 300 nanosecond and 10 millisecond shocks to assess the safety of nanosecond defibrillation.
Johanna U Neuber, Andrei G Pakhomov, Christian W Zemlin

2563 related Products with: Electroporation safety factor of 300 nanosecond and 10 millisecond defibrillation in Langendorff-perfused rabbit hearts.

100ul100ul100ul100ug Lyophilized100ug Lyophilized100ug Lyophilized 100ul100ug Lyophilized100ug100ug Lyophilized100ug 100ul

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#34559272   2021/09/24 To Up

Effects of hyaluronic acid on the bone healing after lateral osteotomy: an experimental animal model.

Postoperative comfort of the patients undergoing rhinoplasty might be poor because of edema and ecchymosis caused by lateral osteotomy. In this animal experiment, we aimed at performing a quantitative assessment of effects of hyaluronic acid usage on healing process of lateral osteotomy.
Guven Yildirim, Kursat Murat Ozcan, Zuleyha Erisgin, Omer Hizli, Cengiz Sivrikaya

2092 related Products with: Effects of hyaluronic acid on the bone healing after lateral osteotomy: an experimental animal model.

1 ml900 tests50 ug 1 mg100ug100ug Lyophilized100 μg100ug1mg1mg50 mg100ug Lyophilized

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#34559047   // To Up

Monitoring the therapeutic efficacy of CA4P in the rabbit VX2 liver tumor using dynamic contrast-enhanced MRI.

The present work aims to evaluate whether dynamic contrast-enhanced magnetic resonance Imaging (DCE-MRI) can monitor non-invasively the blocking effect on microvessels of the Combretastatin-A4-phosphate (CA4P) and assess the therapeutic efficacy.
Tianzhuang Han, Qingqing Duan, Rong Yang, Yuzhe Wang, Huabin Yin, Fanhua Meng, Yongjuan Liu, Ting Qian

2478 related Products with: Monitoring the therapeutic efficacy of CA4P in the rabbit VX2 liver tumor using dynamic contrast-enhanced MRI.

1 ml1

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#34556711   2021/09/23 To Up

The prevailing O serogroups among the serologically differentiated clinical Proteus spp. strains in central Poland.

In the years 2006-2011, 617 Proteus spp. strains isolated mostly from urine and wounds or other clinical sources were collected in Łódź, Poland, to determine the offensive O serotypes frequently occurring among patients. P. mirabilis exhibited the most intensive swarming growth and was dominating species (86.9%), followed by P. genomospecies, P. vulgaris, and P. penneri. Ninety four per cent strains were recognized as S (smooth) forms. Serological studies (involving ELISA-enzyme-linked immunosorbent assay and Western blotting using native and adsorbed rabbit antisera) enabled classification of 80% S isolates into respective Proteus O serogroups among the 83 ones, described so far. The remaining strains seemed to be serologically unique. Despite the observed big serological variety of Proteus spp. isolates, we found the O78 serogroup recently described in Poland as dominating and identified other widespread serotypes: O3, O6, O10, O11, O27, O28, and O30 reported earlier as predominating also in other countries; O77 and O79 detected lately in Poland; O16, O18, O20, and O50. No unique structural feature of the prevalent O serotypes has been indicated. However, the prevalence of some O serogroups indicates that particular serotypes may be in some ways beneficial to the strains producing these kinds of O antigen.
Dominika Drzewiecka, Agata Palusiak, Małgorzata Siwińska, Agnieszka Zabłotni

2608 related Products with: The prevailing O serogroups among the serologically differentiated clinical Proteus spp. strains in central Poland.

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#34556674   2021/09/23 To Up

Hunting dogs bark differently when they encounter different animal species.

Previous studies have shown that vocalizations of dogs can provide information to human companions. While acoustic signals of dogs have been intensively studied during the last decade, barking during hunting activities remains unstudied. The experiences of hunters indicate that owners can recognize what animal species has been found based on the bark of their dog. Such a phenomenon has never been tested before. We tested such an ability by comparing barks that were produced when dogs encountered four different animal species: wild boar, red fox, rabbit and fowl. Classification results of a discrimination analysis showed, that based on barks of dachshunds and terriers, it is possible to categorize towards which animal species barks were produced. The most distinctive barks were produced during encounters with the most dangerous of these animals, the wild boar. On the contrary, barks evoked by red fox encounters were classified similarly as those towards other smaller and non-dangerous animals like rabbits and fowl. Although the red fox represents a potentially dangerous species, the barking provoked was not classified with a much higher result than barking at animals that pose no threat. This might indicate that the key parameter could be the body size of the animal the dog meets. We further tested whether the degree of threat from the species of animal the dog encounters is reflected in the structure of the acoustic parameters based on the valence-arousal model. We found that barks produced in contact with a wild boar showed significantly lower frequency parameters and longest duration compared to other barks. According to these results, it seems that the variability of barking depending on the species of animal a dog encounters is an expression of the dog's inner state rather than functionally reference information.
Richard Policht, Ondřej Matějka, Kateřina Benediktová, Jana Adámková, Vlastimil Hart

1147 related Products with: Hunting dogs bark differently when they encounter different animal species.

2 x 96 tests96 tests0.2 mg 100ul50 ug 96 tests5 g20 ug50 ug 50ul 100ul 100ul

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