Only in Titles

Search results for: Rat

paperclip

#36484982   2022/12/09 To Up

Stomatin-like Protein-2 Promotes Aggregation, Colonization and Migration of Endometriotic Cells.

Endometriosis is a chronic gynecological disease in women of childbearing age, which leads to infertility with risk of endometrial and ovarian cancer. The pathogenesis of endometriosis is poorly understood, and cure/treatment for it is not available, except for symptomatic treatment. The recurrence rate of endometriosis is high. SLP-2 is an inner mitochondrial membrane protein whose participation has been explained in cases of endometrial stromal cell growth, differentiation and migration, but its role in endometriosis is yet to be understood. Previous studies have found altered expression of stomatin-like protein 2 (SLP-2) in the serum of endometriotic patients. Therefore, we have studied the possible role of SLP-2 in the development of endometriosis. We found the ubiquitous and high expression of SLP-2 in the endometriotic tissue of both human endometriosis patients and rat endometriosis model. SLP-2 is seen in the glandular epithelial cells and stromal cells in the eutopic/normal or non-endometriosis group endometrium from human subjects. Finding high expression levels of SLP-2 in endometriotic tissue and ovarian cystic cells derived from endometriosis patients, we explored the possible role of SLP-2 in the cell aggregation, colonization, migration, and invasion in the human endometriotic cells associated with the progression of the endometriosis. Transient silencing of SLP-2 by its siRNA hinders endometriotic cells, aggregation, migration, and invasion into the extracellular matrix, which confirms SLP-2 involvement in endometriotic disease onset and progression. This study unravels the ubiquitous expression of SLP-2 in the human ectopic endometrial tissue and its role in the endometriotic cell migration, colonization, aggregation, and invasion leading to endometriosis progression.
Suparna Kumari, Pushplata Sankhwar, Rupal Tripathi, Ajay K Kawale, Satish Gupta, Rajesh Kumar Jha

1940 related Products with: Stomatin-like Protein-2 Promotes Aggregation, Colonization and Migration of Endometriotic Cells.

25UG250ul20000 U250ul1000 TESTS/0.65ml200ml25ml 5 x 200ul/Unit250ul25ml100ug Lyophilized

Related Pathways

paperclip

#36484960   2022/12/09 To Up

Obstructive sleep apnea-increased DEC1 regulates systemic inflammation and oxidative stress that promotes development of pulmonary arterial hypertension.

Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is a common risk factor for pulmonary arterial hypertension (PAH). As a hypoxia-induced transcription factor, differentially expressed in chondrocytes (DEC1) negatively regulates the transcription of peroxisome proliferative activated receptor-γ (PPARγ), a recognized protective factor of PAH. However, whether and how DEC1 is associated with PAH pathogenesis remains unclear. In the present study, we found that DEC1 was increased in lungs and pulmonary arterial smooth muscle cells (PASMCs) of rat models of OSA-associated PAH. Oxidative indicators and inflammatory cytokines were also elevated in the blood of the rats. Similarly, hypoxia-treated PASMCs displayed enhanced DEC1 expression and reduced PPARγ expression in vitro. Functionally, DEC1 overexpression exacerbated reactive oxygen species (ROS) production and the expression of pro-inflammatory cytokines (such as TNFα, IL-1β, IL-6, and MCP-1) in PASMCs. Conversely, shRNA knockdown of Dec1 increased PPARγ expression but attenuated hypoxia-induced oxidative stress and inflammatory responses in PASMCs. Additionally, DEC1 overexpression promoted PASMC proliferation, which was drastically attenuated by a PPARγ agonist rosiglitazone. Collectively, these results suggest that hypoxia-induced DEC1 inhibits PPARγ, and that this is a predominant mechanism underpinning oxidative stress and inflammatory responses in PASMCs during PAH. DEC1 could be used as a potential target to treat PAH.
Xiaoming Li, Xiang Zhang, Xiaozhi Hou, Xin Bing, Fangyuan Zhu, Xinhao Wu, Na Guo, Hui Zhao, Fenglei Xu, Ming Xia

1336 related Products with: Obstructive sleep apnea-increased DEC1 regulates systemic inflammation and oxidative stress that promotes development of pulmonary arterial hypertension.

164 Arrays/Slide200ug8 Sample Kit10 mg12100ug4 Membranes/Box

Related Pathways

paperclip

#36484951   2022/12/09 To Up

Retraction Note: Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-133a Restrains Myocardial Fibrosis and Epithelial-Mesenchymal Transition in Viral Myocarditis Rats Through Suppressing MAML1.


Qiming Li, Yunpeng Jin, Xiaoqi Ye, Wei Wang, Gang Deng, Xiaojian Zhang

1416 related Products with: Retraction Note: Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-133a Restrains Myocardial Fibrosis and Epithelial-Mesenchymal Transition in Viral Myocarditis Rats Through Suppressing MAML1.

24 wells24 wells24 wells3 inhibitors5 x 10A5 cells/vial25 ug10 ug100ug Lyophilized3 Modulators

Related Pathways

    No related Items
paperclip

Error loading info... Pleas try again later.
paperclip

Error loading info... Pleas try again later.
paperclip

#36484910   2022/12/09 To Up

Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.

Ulcerative colitis (UC) and Crohn's disease (CD) are two major forms of inflammatory bowel disease (IBD). The disease has been linked with gut microbiota dysbiosis in which the balance of commensal communities is disrupted. Accumulating evidence demonstrates that treatment with biologically active compounds can modulate gut microbiota composition in animal models. Our previous work has also shown the beneficial effect of Luem Pua (LP) rice extract, which is rich in anthocyanins, on inflammation. However, its effect on gut microbiota is yet to be explored. In this study, we profiled fecal microbiota of acetic acid (AA)-induced UC and indomethacin (ID)-induced CD rat models with and without pretreatment with LP rice extract by 16S rRNA gene sequencing. The results showed that gut microbiota communities of rats were altered by both AA-induced UC and ID-induced CD. The relative abundances of beneficial bacteria, especially the Lachnospiraceae NK4A136 group and Lactobacillus, were decreased in the AA-induced UC model, while some opportunistic pathogens (Bacteroides, Escherichia/Shigella, Fusobacterium, and Veillonella) were raised by ID-induced CD. Interestingly, pretreatment with LP rice extract before AA-inducing UC in rats increased the proportion of the butyrate-producing bacteria (Lachnospiraceae NK4A136 group). The abundances of these beneficial bacteria and other SCFA-producing bacteria were unaffected by the indomethacin treatment with LP. Overall, our study revealed different impacts of AA-induced UC and ID-induced CD on changes in community composition and hinted at how LP may protect against UC by modifying the gut microbiota.
Kornsuda Thipart, Lucsame Gruneck, Kutcharin Phunikhom, Thomas J Sharpton, Jintana Sattayasai, Siam Popluechai

1257 related Products with: Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.

100ug Lyophilized400 ug100ug Lyophilized 100 G100ug Lyophilized100ug Lyophilized1 mg100ug100ug Lyophilized100ug Lyophilized1 mg100ug

Related Pathways

paperclip

#36484888   2022/12/09 To Up

BSA Capped gold Nanoclusters Modulated by Copper ion for Sensitive and Selective Detection of Histidine in Biological Fluid.

This research proposed a sample and environmentally sustainable technique for the synthesis of bovine serum albumin capped gold nanoclusters (BSA-AuNCs) with outstanding fluorescence. The synthesized BSA-AuNCs were investigated using various ways before being combined with Cu2+ to produce a fluorescent switch probe (BSA-AuNCs-Cu2+) for histidine determination. After adding Cu2+, the fluorescence of the BSA-AuNCs was quenched, the fluorescence intensity was enhanced after adding histidine due to good coordination between Cu2+ and histidine. The significant chelation of histidine with Cu2+ demonstrated the viability of developing a selective "switch on" probe for histidine detecting over other amino acids. Unlike existing fluorescent nanomaterial-based approaches for detecting histidine, this study promises good selectivity, high efficiency, and the avoiding of chemical solvents. The designed BSA-AuNCs-Cu2+ fluorescent probe demonstrated an acceptable linear detection range of 0 to 240 µM under optimum circumstances, with a detection limit of 0.9 µM. The BSA-AuNCs-Cu2+ system was investigated in rat serum and human urine, with recoveries ranging from 97.2 to 108.2%, demonstrating its potential applicability for histidine detection with favorable results.
Haitham Saad Al-Mashriqi, Muzi Cai, Shengda Qi, Honglin Zhai

1156 related Products with: BSA Capped gold Nanoclusters Modulated by Copper ion for Sensitive and Selective Detection of Histidine in Biological Fluid.

100 G100ug96 tests 1 G100ug Lyophilized250 mg100ug Lyophilized

Related Pathways

paperclip

#36484869   2022/12/09 To Up

Severe Infection of Nippostrongylus brasiliensis in Bandicota bengalensis Inhabiting Commensal Areas of Punjab, India: Prevalence, Risk Factor Analysis, Molecular Identification and Phylogenesis.

The present study aimed to record the prevalence, risk factors, molecular identification, and phylogeny of Nippostrongylus brasiliensis found in the small intestine of the lesser bandicoot rat, Bandicota bengalensis, a wild rodent species.
Shivani Rara, Neena Singla, Sukhmanpreet Kaur Brar, Dimple Mandla, Lachhman Das Singla

2252 related Products with: Severe Infection of Nippostrongylus brasiliensis in Bandicota bengalensis Inhabiting Commensal Areas of Punjab, India: Prevalence, Risk Factor Analysis, Molecular Identification and Phylogenesis.

100.00 ug100 μg50 ug0.5mg0.1 mg100 1 L.4 Membranes/Box100.00 ug100ul10ug100 units

Related Pathways

paperclip

#36484848   2022/12/09 To Up

Inhibition of tooth demineralization caused by Streptococcus mutans biofilm via antimicrobial treatment using hydrogen peroxide photolysis.

An antimicrobial technique utilizing hydroxyl radicals generated by the photolysis of 3% HO has been developed recently. The present study aimed to evaluate the effect of HO photolysis treatment on tooth demineralization caused by Streptococcus mutans biofilm.
Midori Shirato, Keisuke Nakamura, Taichi Tenkumo, Yoshimi Niwano, Taro Kanno, Keiichi Sasaki, Peter Lingström, Ulf Örtengren

2815 related Products with: Inhibition of tooth demineralization caused by Streptococcus mutans biofilm via antimicrobial treatment using hydrogen peroxide photolysis.

200 assays1 kit200 assays1 kit5x10 mL1 lt2 x 96 well plate25 Ct2 x 96 well plate1 mg1 kit100

Related Pathways

    No related Items
paperclip

#36484810   2022/12/09 To Up

Absorbable suture knots on the supraspinatus tendon prevent adverse effects of nonabsorbable suture knots in a rat model.

To compare the absorbable and nonabsorbable suture knots on the tendon on bone-to-tendon healing during the early phase in a rat rotator cuff tear (RCT) model.
Hui Ben, Chunbing Luo, Jiaqi Cheng, Chu Hui Zeng, Youlang Zhou, In-Ho Jeon, Yucheng Sun

1177 related Products with: Absorbable suture knots on the supraspinatus tendon prevent adverse effects of nonabsorbable suture knots in a rat model.

100ug118 kgs 100 UG250

Related Pathways