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#32791513   2020/08/13 To Up

Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.

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Wenqiang Li, Xin Cai, Hui-Juan Li, Meng Song, Chu-Yi Zhang, Yongfeng Yang, Luwen Zhang, Lijuan Zhao, Weipeng Liu, Lu Wang, Minglong Shao, Yan Zhang, Chen Zhang, Jun Cai, Dong-Sheng Zhou, Xingxing Li, Li Hui, Qiu-Fang Jia, Na Qu, Bao-Liang Zhong, Shu-Fang Zhang, Jing Chen, Bin Xia, Yi Li, Xueqin Song, Weixing Fan, Wei Tang, Wenxin Tang, Jinsong Tang, Xiaogang Chen, Weihua Yue, Dai Zhang, Yiru Fang, Xiao Xiao, Ming Li, Luxian Lv, Hong Chang

2595 related Products with: Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.

100 tests100 plates1,000 tests50 assays10 plates1 kit96 assays 10 plates

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#32791475   2020/07/27 To Up

Synthesis and characterization of [I]TZ6544, a promising radioligand for investigating sphingosine-1-phosphate receptor 2.

Sphingosine-1-phosphate receptor 2 (S1PR2) activation exerts a critical role in biological abnormalities and diseases. A suitable radiotracer will advance our understanding of S1PR2 pathophysiology of diseases. The objective of this study is to evaluate the potential of iodine-125 labeled [I]TZ6544 to be used for screening new compounds binding toward S1PR2, and assessing the changes of S1PR2 expression in the kidney of streptozotocin-induced diabetic rats.
Zonghua Luo, Qianwa Liang, Hui Liu, Joshi Sumit, Hao Jiang, Robyn S Klein, Zhude Tu

1982 related Products with: Synthesis and characterization of [I]TZ6544, a promising radioligand for investigating sphingosine-1-phosphate receptor 2.

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#32791354   2020/07/31 To Up

Low magnitude high frequency vibration promotes chondrogenic differentiation of bone marrow stem cells with involvement of β-catenin signaling pathway.

Mesenchymal stem cells (MSCs) are well known to have the capability to form bone and cartilage, and chondrogenesis derived from MSCs is reported to be affected by mechanical stimuli. This research aimed to study the effects of low magnitude high frequency (LMHF) vibration on the chondrogenic differentiation of bone marrow-derived MSCs (BMSCs) which were cultured with chondrogenic medium, and to investigate the role of β-catenin cascade in this process.
Weiwei Hou, Denghui Zhang, Xiaoxia Feng, Yi Zhou

1661 related Products with: Low magnitude high frequency vibration promotes chondrogenic differentiation of bone marrow stem cells with involvement of β-catenin signaling pathway.

2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box1.5x10(6) cells2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box1.5 x 10^6 cells

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#32791334   2020/08/10 To Up

Moderate treadmill exercise improves spatial learning and memory deficits possibly via changing PDE-5, IL-1 β and pCREB expression.

Alzheimer's is a progressive disorder of the nervous system. Prior studies suggested that physical activity contributes to the improvement of cognitive impairment and slows down pathogenesis of AD; however, the exact mechanisms for this have not been fully understood. Therefore, in this study, we examined the effect of aerobic training before and after induction of Alzheimer's on spatial learning and memory, expression of interleukin-1 beta (IL-1β), cAMP-responsive element-binding protein (pCREB), and Phosphodiesterase-5 (PDE-5) in the hippocampus of male rats Wistar. Aβ was microinjected into the CA1 area of the hippocampus animals. The moderate treadmill exercise protocols for pre and post induction of Alzheimer's were the same (5 days/week, for 4 weeks with a customized regime). The Morris Water Maze (MWM) method has been to assess spatial learning and memory. The real time-PCR method was used to measure gene expression. Our results showed that intra-hippocampal injection of Aβ1-42 impaired spatial learning and memory which was accompanied by reduced pCREB activity and elevated IL-1β and PDE-5 in the hippocampus of rats. In contrast, moderate treadmill exercise ameliorated the Aβ1-42-induced spatial learning and memory deficit, which was accompanied by restored pCREB activity and decreasing IL-1β and PDE-5 levels. In conclusion, our finding suggests that exercise before and after Alzheimer's induction leads to an increase in pCREB and an alleviation of inflammation which likely involved in ameliorating spatial learning and memory deficits in an animal model of AD.
Mostafa Sabouri, Mohammadreza Kordi, Fatemeh Shabkhiz, Pejman Taghibeikzadehbadr, Zeinabosadat Geramian

1488 related Products with: Moderate treadmill exercise improves spatial learning and memory deficits possibly via changing PDE-5, IL-1 β and pCREB expression.

1000 tests1000 TESTS/0.65ml100ug100ul1000 tests100ug100ug10 mg100ul100 mg100ug100ug

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#32791331   2020/08/10 To Up

Lentivirus-delivered ACE siRNA rescues the impaired peak bone mass accumulation caused by prenatal dexamethasone exposure in male offspring rats.

Angiotensin I converting enzyme (ACE) is a major component of the renin-angiotensin system (RAS). Our previous study demonstrated that activated bone RAS was associated with low peak bone mass induced by prenatal dexamethasone exposure (PDE) in male offspring rats. However, we did not determine whether the inhibition of ACE expression could rescue PDE-induced low peak bone mass. In the present study, we treated pregnant Wistar rats with dexamethasone (0.2 mg/kg.d) on gestational days 9-20 and obtained eight weeks old male offspring rats. Some of the offspring rats from the PDE group were injected lentivirus delivered-ACE siRNA (LV-ACE siRNA) through the intra-bone marrow for 4 weeks. We found that the intra-bone marrow injection of LV-ACE siRNA rescued the impaired peak bone mass accumulation caused by PDE in male offspring rats. Moreover, LV-ACE siRNA ameliorated PDE-induced inhibition of osteogenesis and alleviated PDE-induced RAS activation in the bone tissues in vivo. Our in vitro findings further confirmed that LV-ACE siRNA reversed the suppressed osteogenic differentiation caused by dexamethasone, which can be attributed to alleviated RAS activation. In conclusion, LV-ACE siRNA rescued impaired peak bone mass accumulation caused by PDE through alleviation of local bone RAS activation in male offspring rats.
Hao Xiao, Yinxian Wen, Zhixin Wu, Haitao Chen, Jacques Magdalou, Hui Wang, Liaobin Chen

2196 related Products with: Lentivirus-delivered ACE siRNA rescues the impaired peak bone mass accumulation caused by prenatal dexamethasone exposure in male offspring rats.

100 mg250 mg 1 G1100ug2.50 nmol25 mg100ug Lyophilized10 mg

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#32791294   2020/08/10 To Up

The cold-soaking extract of Chinese yam (Dioscorea opposita Thunb.) protects against erectile dysfunction by ameliorating testicular function in hydrocortisone-induced KDS-Yang rats and in oxidatively damaged TM3 cells.

Clinical applications and pharmacological research suggest that Dioscorea opposita Thunb. (Chinese yam), a well-known traditional Chinese medicine which has been used for more than 2000 years to nourish kidney-yang and protect the male reproductive system, might be efficacious for the treatment of erectile dysfunction (ED).
Shiting Yu, Bing Han, Xueyuan Bai, Shichao Liu, Xin Xing, Daqing Zhao, Meichen Liu, Siming Wang

2178 related Products with: The cold-soaking extract of Chinese yam (Dioscorea opposita Thunb.) protects against erectile dysfunction by ameliorating testicular function in hydrocortisone-induced KDS-Yang rats and in oxidatively damaged TM3 cells.

400 ug1 mg1 mg10 rxns400 ug-1.00 flask1x10e7 cells96 assays100ug50 ul100 µg

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#32791285   2020/08/06 To Up

Sigma-1 antagonism inhibits binge ethanol drinking at adolescence.

Ethanol use during adolescence is a significant health problem, yet the pharmacological treatments to reduce adolescent binge drinking are scarce. The present study assessed, in male and female adolescent Wistar rats, if the sigma-1 receptor (S1-R) antagonists S1RA or BD-1063 disrupted ethanol drinking.
Leandro Ruiz-Leyva, Agustín Salguero, Ignacio Morón, Enrique Portillo-Salido, Cruz Miguel Cendán, Ricardo Marcos Pautassi

2174 related Products with: Sigma-1 antagonism inhibits binge ethanol drinking at adolescence.

100ul100μl100ug 50 MG100ul100ug Lyophilized100ug Lyophilized100ul100ug100ul100ug Lyophilized10reactions

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#32791256   2020/08/10 To Up

Accounting for cardiac t-tubule increase with age and myocyte volume to improve measurements of its membrane area and ionic current densities.

In-silico models of cardiac myocytes allow simulating experiments in numbers on series of myocytes as well as on large populations of myocytes assembled in 3D structures. The simulated myocyte populations should have realistic values and statistical dispersions of biophysical parameters such as myocyte dimensions and volume and areas of the peripheral membrane and transverse-axial tubular system (TATS). Dependencies among these variables also have to be taken into account. In this work, we propose a quantitative representation of the changes in the fraction of membrane area in the TATS that integrates published dependencies with body weight (age) and size of rat ventricular cardiac myocytes while respecting the above constraints. Imposing a constant total membrane area-to-volume ratio appears to account for the increase of this fraction with myocyte size (i.e.: volume) within a given age group. The agreement of our results with published data was discussed and reasons for discrepancies were analysed. On the basis of our framework, strategies are proposed for minimizing the influence of non-random dispersion related to myocyte volume on measurements of the area of TATS and surface membrane compartments and of ionic current densities. The next step will be to quantitatively compare these strategies by evaluating the impact of myocyte morphological parameters and their dependencies, sample size, biases and errors, on the output of experiments.
Georges Christé, Robert Bonvallet, Christophe Chouabe

1452 related Products with: Accounting for cardiac t-tubule increase with age and myocyte volume to improve measurements of its membrane area and ionic current densities.

100ug500 mg100.00 ul100ul25 mg1 ml1000 10 mg25 mg 5 G 5 G100ug

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#32791212   2020/08/10 To Up

Spinal interleukin-6 contributes to central sensitisation and persistent pain hypersensitivity in a model of juvenile idiopathic arthritis.

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Charlie Ht Kwok, Annastazia E Learoyd, Julia Canet-Pons, Tuan Trang, Maria Fitzgerald

1570 related Products with: Spinal interleukin-6 contributes to central sensitisation and persistent pain hypersensitivity in a model of juvenile idiopathic arthritis.

500 100 UG100.00 ug1 mg 0.1 mg 32-50 Sample Kit100.00 ug100.00 ug10 mg500 96 wells (1 kit)

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#32791190   2020/08/10 To Up

Melatonin stimulates VEGF expression in human granulosa-lutein cells: A potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome.

Melatonin can be synthesized and secreted not only by the pineal gland but also by many extra-pineal tissues. It has been shown that many ovarian functions are regulated by melatonin locally. Ovarian hyperstimulation syndrome (OHSS) is a serious complication during ovulation induction of the in vitro fertilization treatment. To date, the etiology of OHSS is not fully understood. However, vascular endothelial growth factor (VEGF) is recognized as a critical mediator for the pathogenesis of OHSS. High expression of melatonin has been detected in the follicular fluid of OHSS patients. However, whether VEGF expression can be regulated by melatonin in human granulosa cells and further contributes to the pathogenesis of OHSS remain unknown. In this study, we show that melatonin stimulates VEGF expression in human granulosa-lutein (hGL) cells. Our results reveal that the MT2 receptor and activation of AKT are involved in melatonin-induced VEGF expression. Using a rat OHSS model, we report that the VEGF levels are up-regulated in the ovaries of OHSS rats. Blocking the melatonin system by administrating MT2 receptor antagonist, 4-P-PDOT, alleviates OHSS symptoms by decreasing the expression of VEGF. In addition, the expression levels of melatonin and VEGF in the follicular fluid of OHSS patients are up-regulated and positively correlated. This study demonstrates an important role for melatonin in regulating the pathogenesis of OHSS.
Yiran Li, Lanlan Fang, Ruizhe Zhang, Sijia Wang, Yuxi Li, Yang Yan, Yiping Yu, Jung-Chien Cheng, Ying-Pu Sun

1202 related Products with: Melatonin stimulates VEGF expression in human granulosa-lutein cells: A potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome.

1.00 flask0.1ml (1mg/ml)1.00 flask100 μg100 μg100.00 ug4 Membranes/Box100 μg100 μg100 μg100 µg

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