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#34118669   2021/05/29 To Up

Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.

Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities. However, the complicated compositions make it difficult to explicit the specific roles of the individual components of biomass played in the co-HTC process. In this study, cellulose was used for co-HTC with swine manure to investigate the influence on the properties of the hydrochar. The yield of hydrochar obtained from co-HTC reduced gradually with the cellulose proportion increased, and the solid yield was lower than the theoretical value. This was because the cellulose-derived intermediates favored the stability of the fragments from hydrolysis of swine manure. The increased temperature resulted in the reduction of the hydrochar yield whereas the prolonged time enhanced the formation of solid product. The interaction of the co-HTC intermediates facilitated the formation of O-containing species, thus making the solid more oxygen- and hydrogen-rich with a higher volatility. In addition, the co-HTC affected the evolution of functionalities like -OH and CO during the thermal treatment of the hydrochar and altered its morphology by stuffing the pores from swine manure-derived solid with the microspheres from HTC of cellulose. The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.
Qingyin Li, Haisheng Lin, Shu Zhang, Xiangzhou Yuan, Mortaza Gholizadeh, Yi Wang, Jun Xiang, Song Hu, Xun Hu

2106 related Products with: Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.

5 G1 Set10 mg1 Set1 Set1 Set1 Set100ug1 Set1 Set1 Set

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#34118622   2021/06/05 To Up

Mixed biochar obtained by the co-pyrolysis of shrimp shell with corn straw: Co-pyrolysis characteristics and its adsorption capability.

The co-pyrolysis characteristics of shrimp shell (SS) with corn straw (CS) were investigated by comprehensive characterization to reveal the synergistic effects and further discuss the adsorption capability. TGA results showed that pyrolysis behavior and reactivity were improved with the increase of heating rate and doping ratio of CS. Flynn-Wall-Ozawa (FWO) and distributed activation energy model (DAEM) indicated that co-pyrolysis can effectively reduce energy consumption and promote the decomposition of CaCO. TG-FTIR and Py-GC/MS analysis indicated that the release of CH, CO, CO and NH at the doping ratio of 25% CS (75SS+25CS) was higher than that at other doping ratios, and the relative proportions of N-heterocyclics and oxygenates were lower, which was conducive to the development of pore structure for mixed biochar and effectively alleviated the pollution during co-pyrolysis process. The structure of mixed biochar was improved, confirmed by the characterizations of BET, SEM, FTIR and XRD. The mixed biochar prepared at 800 °C (75SS+25CS) exhibited optimal porosity, aromatization and the most thorough CaCO decomposition. Batch adsorption experiment showed that the removal rate of 50 mg/L Cu(II) by 75SS+25CS was close to 100% under the dosage of 1 g/L and pH = 3-6. The adsorption process was well described by Langmuir, pseudo-second-order and Webber-Morris model, illustrating diffusion monolayer chemisorption was the main adsorption mechanism of Cu(II) on 75SS+25CS. The maximum adsorption capacity of 75SS+25CS for Cu(II) was 79.77 mg/g at 35 °C. In short, this study provided a reference in optimizing the preparation process and improving the adsorption performance of mixed biochar.
Juan Liu, Xiaoyu Yang, Honghao Liu, Xuping Jia, Yongchao Bao

1149 related Products with: Mixed biochar obtained by the co-pyrolysis of shrimp shell with corn straw: Co-pyrolysis characteristics and its adsorption capability.

10 mg100ug1 g10 mg25 mg100 mg 100ul10ml1,000 tests

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#34118511   2021/04/20 To Up

The impact of a baked muffin matrix on the bioaccessibility and IgE reactivity of egg and peanut allergens.

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Hadeer Mattar, Phil Padfield, Angela Simpson, E N Clare Mills

2341 related Products with: The impact of a baked muffin matrix on the bioaccessibility and IgE reactivity of egg and peanut allergens.

10 mg 100ul100 mg100ug50 ug 200ul1 ml100 mg100.00 ul 25 MG200ug

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#34118402   2021/06/09 To Up

Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults.

Endemic human coronaviruses (hCoVs) are common causative agents of respiratory tract infections, affecting especially children. However, in the ongoing SARS-CoV-2 pandemic, children are the least affected age-group. The objective of this study was to investigate the magnitude of endemic hCoVs antibodies in Finnish children and adults, and pre-pandemic antibody cross-reactivity with SARS-CoV-2. Antibody levels against endemic hCoVs start to rise at a very early age, reaching to overall 100% seroprevalence. No difference in the antibody levels was detected for OC43 but the magnitude of 229E-specific antibodies was significantly higher in the sera of children. OC43 and 229E hCoV antibody levels of children correlated significantly with each other and with the level of cross-reactive SARS-CoV-2 antibodies, whereas these correlations completely lacked in adults. Although none of the sera showed SARS-CoV-2 neutralization, the higher overall hCoV cross-reactivity observed in children might, at least partially, contribute in controlling SARS-CoV-2 infection in this population.
Kirsi Tamminen, Marjo Salminen, Vesna Blazevic

1943 related Products with: Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults.

200ug200ug0.1 mg200ul1 ml10 mg200ul1000 TESTS/0.65ml100ug Lyophilized1,000 tests100ug1 mg

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#34118095   2021/06/12 To Up

Versatile Reaction Pathways of 1,1,3,3,3-pentafluoropropene at Rh(I) complexes [Rh(E)(PEt3)3] (E = H, GePh3, Si(OEt)3, F, Cl): C-F versus C-H Bond Activation Steps.

The reaction of the rhodium(I) complexes [Rh(E)(PEt 3 ) 3 ] (E = GePh 3 ( 1 ), H ( 6 ), F ( 7 )) with 1,1,3,3,3-pentafluoropropene afforded the defluorinative germylation products Z/E -2-(triphenylgermyl)-1,3,3,3-tetrafluoropropene and the fluorido complex [Rh(F)(CF 3 CHCF 2 )(PEt 3 ) 2 ] ( 2 ) together with the fluorophosphorane E -(CF 3 )CH=CF(PFEt 3 ). For [Rh(Si(OEt) 3 )(PEt 3 ) 3 ] ( 4 ) the coordination of the fluoroolefin was found  to give [Rh{Si(OEt) 3 }(CF 3 CHCF 2 )(PEt 3 ) 2 ] ( 5 ). Two equivalents of complex 2 reacted further by C-F bond oxidative addition to yield [Rh(CF=CHCF 3 )(PEt 3 ) 2 ( µ -F) 3 Rh(CF 3 CHCF 2 )(PEt 3 )] ( 9 ). The role of the fluorido ligand on the reactivity of complex 2 was assessed by comparison with the analogous chlorido complex. The use of complexes 1 , 4 and 6 as catalysts for the derivatization of 1,1,3,3,3-pentafluoropropene provided products, which were generated by hydrodefluorination, hydrometallation and germylation reactions.
Thomas Braun, Maria Talavera

1261 related Products with: Versatile Reaction Pathways of 1,1,3,3,3-pentafluoropropene at Rh(I) complexes [Rh(E)(PEt3)3] (E = H, GePh3, Si(OEt)3, F, Cl): C-F versus C-H Bond Activation Steps.

30 Reactions96 tests96 tests25 0.1 mg Protein A96 wells (1 kit)1.00 flask200 72 tests1 kit(96 Wells)1.00 flask

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#34117818   2021/06/12 To Up

Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology.

Inhibition of the protein phosphatase calcineurin (CN) ameliorates pathophysiologic and cognitive changes in aging rodents and mice with aging-related Alzheimer's disease (AD)-like pathology. However, concerns over adverse effects have slowed the transition of common CN-inhibiting drugs to the clinic for the treatment of AD and AD-related disorders. Targeting substrates of CN, like the nuclear factor of activated T cells (NFATs), has been suggested as an alternative, safer approach to CN inhibitors. However, small chemical inhibitors of NFATs have only rarely been described. Here, we investigate a newly developed neuroprotective hydroxyquinoline derivative (Q134R) that suppresses NFAT signaling, without inhibiting CN activity. Q134R partially inhibited NFAT activity in primary rat astrocytes, but did not prevent CN-mediated dephosphorylation of a non-NFAT target, either in vivo, or in vitro. Acute (≤1 week) oral delivery of Q134R to APP/PS1 (12 months old) or wild-type mice (3-4 months old) infused with oligomeric Aβ peptides led to improved Y maze performance. Chronic (≥3 months) oral delivery of Q134R appeared to be safe, and, in fact, promoted survival in wild-type (WT) mice when given for many months beyond middle age. Finally, chronic delivery of Q134R to APP/PS1 mice during the early stages of amyloid pathology (i.e., between 6 and 9 months) tended to reduce signs of glial reactivity, prevented the upregulation of astrocytic NFAT4, and ameliorated deficits in synaptic strength and plasticity, without noticeably altering parenchymal Aβ plaque pathology. The results suggest that Q134R is a promising drug for treating AD and aging-related disorders.
Pradoldej Sompol, Jenna L Gollihue, Susan D Kraner, Irina A Artiushin, Ryan A Cloyd, Emad A Chishti, Shon A Koren, Grant K Nation, Jose F Abisambra, Orsolya Huzian, Lajos I Nagy, Miklos Santha, Laszlo Hackler, Laszlo G Puskas, Christopher M Norris

2724 related Products with: Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology.

100uL1mg1mg1mg10mg100.00 ug

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#34117695   2021/06/11 To Up

Nucleophilic Neutralization of Organophosphates: Lack of Selectivity or Plenty of Versatility?

Neutralization of organophosphates is an issue of public health and safety, involving agrochemicals and chemical warfare. A promising approach is the nucleophilic neutralization, scope of this review, which focuses on the molecular nucleophiles: hydroxide, imidazole derivatives, alpha nucleophiles, amines and other nucleophiles. A reactivity mapping is given correlating the pathways and reaction efficiency with structural dependence of the nucleophile (basicity) and the organophosphate (electrophilic centers, P=O/P=S shift, leaving and non-leaving group). Reactions extremely unfavorable (>20 years) can be reduced to seconds with various nucleophiles, some which are catalytic. Although there is no universal nucleophile, a lack of selectivity in some cases accounts for plenty of versatility in other reactions. The ideal neutralization requires a solid mechanistic understanding, together with balancing factors such as milder conditions, fast process, selectivity and less toxic products.
Valmir B Silva, Renan B Campos, Paulina Pavez, Michelle Medeiros, Elisa S Orth

1731 related Products with: Nucleophilic Neutralization of Organophosphates: Lack of Selectivity or Plenty of Versatility?

5 G100110 ml (10X)96T1 mg100ug

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#34117181   2021/05/31 To Up

Impact of comorbidities and antiplatelet regimen on platelet reactivity levels in patients undergoing transcatheter aortic valve implantation.

The aim of our study is to assess the impact of anemia, chronic kidney disease (CKD) and diabetes mellitus on platelet reactivity (PR) in patients with severe aortic stenosis, both at baseline and after transcatheter aortic valve implantation (TAVI). This study is a pre-specified subanalysis of the REAC-TAVI prospective, multicentre trial that included patients pre-treated with aspirin+clopidogrel before TAVI. PR was measured at baseline and at 5 different time points after TAVI with the VerifyNow assay (Accriva Diagnostics, San Diego, CA), over a 3-month follow-up period. Patients with high PR (HPR) at baseline, before TAVI, (n=48) were randomized to aspirin+clopidogrel or aspirin+ticagrelor for 3 months, while those with normal PR (NPR) (n=20) were continued on aspirin+clopidogrel. A "Raiser-response" in PR was defined as an increase in PR units >20% of baseline after TAVI. Patients with HPR before TAVI presented concomitant anemia and CKD more frequently than their counterparts with NPR. Anemia and higher body mass index were independently associated to HPR to clopidogrel at baseline. Moreover, anemic patients with baseline HPR that were continued on clopidogrel presented higher PR after TAVI than HPR patients switched to ticagrelor. All patients with baseline NPR presented a "Raiser-response" after TAVI, which was non-existent among HPR patients managed with ticagrelor. In summary, anemia appears as a relevant factor associated to baseline HPR and higher PR after TAVI in patients with baseline HPR randomized to clopidogrel, while ticagrelor proved more effective than clopidogrel at attaining sustained reductions in PR during follow-up, regardless of baseline comorbidities.
Blanca Trejo-Velasco, Antonio Tello-Montoliu, Ignacio Cruz-González, Raul Moreno, Jose Antonio Baz-Alonso, Pablo Juan Salvadores, Rafael Romaguera, Eduardo Molina-Navarro, Emilio Paredes-Galán, Saleta Fernández-Barbeira, Alberto Ortiz-Saez, Guillermo Bastos-Fernandez, Antonio De Miguel-Castro, Adolfo Figueiras-Guzman, Andres Iñiguez-Romo, Victor Alfonso Jimenez-Diaz

2775 related Products with: Impact of comorbidities and antiplatelet regimen on platelet reactivity levels in patients undergoing transcatheter aortic valve implantation.

100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized100ug Lyophilized1 Product tipe: Instrumen50ul100ug100ug Lyophilized100ug Lyophilized100ug100ug Lyophilized

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