GABA A Receptor alpha 5

Rat

Rat and mouse.

N.B. Antibody reactivity and working conditions may vary between species., Mouse

This product detects a band of approximately 55kDa in rat brain membrane fractions.

This product is specific for the alpha 5 subunit of gamma-aminobutyric acid A (GABA_A ) receptor. 

GABA_A receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABA_A site results in increased intracellular chloride concentration and hyperpolarization of the cell. 

GABA_A receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression.

GABA_A receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).

Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 12 months after receipt.

Purified IgG prepared by affinity chromatography