RAGE is the receptor of AGEs, advanced glycation end products with 35,000 molecular weight and was cloned from bovine lung in 1992 ( David Stern et al.). RAGE has been found in several tissues such as monocytes, macrophages, endothelial cells, astocytes. The ligand of RAGE is demonstrated not only AGEs but also anfoterin, EN-RAGE, N-carboxymethyllysine(CML), beta-amyloid and so on. The accumulation of AGEs-proteins in vivo has been demonstrated in several disease, it is not clear whether AGEs-proteins accumulated in vivo is a direct cause of the disease or rather reflects its effect. Regarding this issue, AGEs-modified proteins are known to interact with several cells by the AGEs-receptors and induce several cellular phenomena. Recently, it has been discovered that RAGE is involved in pathophysiological function of diabetes and Alzheimer’s disease. This antibody is affinity purified rabbit polyclonal antibody raised against partial peptide of human RAGE and should be used for western blotting or immunohistochmistry.