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#33096561   // To Up

Scientists on the Spot: from the Scientists of Tomorrow to the scientist of today.


Mahmoud Abdellatif, Gemma Vilahur

2075 related Products with: Scientists on the Spot: from the Scientists of Tomorrow to the scientist of today.

11mg12000 IU100.00 ul500 Units

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#33096439   2020/10/15 To Up

Long-term bleeding risk vs. mortality risk in acute coronary syndrome patients according to the 2019 ARC-HBR definition.


Alberto Cordero, David Escribano, José Mª García-Acuña, Moisés Rodriguez-Mañero, Rosa Agra-Bermejo, Vicente Bertomeu-González, Belén Cid-Alvarez, Belén Alvarez-Alvarez, Pilar Zuazola, José R González-Juanatey

2025 related Products with: Long-term bleeding risk vs. mortality risk in acute coronary syndrome patients according to the 2019 ARC-HBR definition.

1 kit 0.1 mg 500 gm.100 μg100 ug25100 μg

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#33096420   2020/10/01 To Up

Impact of HER2 expression on EGFR-TKI treatment outcomes in lung tumors harboring EGFR mutations: A HER2-CS study subset analysis.

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are standard treatment for EGFR-mutated non-small-cell lung carcinoma (NSCLC); however, a biomarker to predict their efficacy has not been established. Although human epidermal growth factor receptor-2 (HER2) aberrations constitute a potential mechanism for acquired resistance to EGFR-TKIs, the impact of HER2 on EGFR-TKI treatment outcomes has not been systematically evaluated. In this post-hoc subgroup study, we examined the impact of HER2 on the effect of EGFR-TKIs in patients with NSCLC harboring EGFR mutations.
Kadoaki Ohashi, Kiichiro Ninomiya, Hiroshige Yoshioka, Akihiro Bessho, Takuo Shibayama, Keisuke Aoe, Nobuhisa Ishikawa, Toshiyuki Kozuki, Haruyuki Kawai, Shoichi Kuyama, Seigo Miyoshi, Kazunori Fujitaka, Hideto Obata, Yukari Tsubata, Yoshikazu Awaya, Masaaki Inoue, Koji Inoue, Naokatsu Horita, Hiroyuki Yanai, Katsuyuki Hotta, Katsuyuki Kiura

1512 related Products with: Impact of HER2 expression on EGFR-TKI treatment outcomes in lung tumors harboring EGFR mutations: A HER2-CS study subset analysis.

100 ul1 Set1 Set1 Set1 Set1 Set1 Set1 Set1 Set1 Set1 Set

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#33096349   2020/10/17 To Up

Microcirculation alterations in severe COVID-19 pneumonia.

To assess the presence of sublingual microcirculatory and skin perfusion alterations in COVID-19 pneumonia.
Vanina Siham Kanoore Edul, Juan Francisco Caminos Eguillor, Gonzalo Ferrara, Elisa Estenssoro, Daniel Shiovan Páez Siles, Cristián Emanuel Cesio, Arnaldo Dubin

1320 related Products with: Microcirculation alterations in severe COVID-19 pneumonia.

5 mg100ug Lyophilized200 50 ug100 µl (2 mM)100 μg5mg20 ul (10 mM)100 μg100μg

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#33096196   2020/10/20 To Up

Preventive effect of cocoa flavanols against glucotoxicity-induced vascular inflammation in the arteria of diabetic rats and on the inflammatory process in TNF-α-stimulated endothelial cells.

Hyperglycaemia induces a vascular inflammatory process that is a critical event in cardiovascular disease in type 2 diabetes. Cocoa and its flavanols have been widely investigated for its antioxidant and anti-inflammatory properties, and several clinical and pre-clinical studies support their vascular benefits. However, the effects of cocoa flavanols on vascular inflammation in diabetes remains to be elucidated. Herein, we evaluated the anti-inflammatory effect of a cocoa-rich diet on the aortas of Zucker diabetic fatty (ZDF) rats. Moreover, the potential role of flavanol-derived colonic metabolites to modulate the adhesion and inflammatory processes were also evaluated using TNF-α-stimulated endothelial cells. Results demonstrate that cocoa attenuates the levels of phospho-p65-nuclear factor-kappaB (NF-κB) and the expression of inflammatory factors including intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1) and inducible nitric oxide synthase in the aortas of ZDF rats. Experiments with endothelial cells further confirm that a mix of flavanol-derived colonic metabolites effectively down-regulate the levels of p-p65-NF-κB and the cell adhesion molecules ICAM-1 and VCAM-1, preventing thus the increase of monocyte-endothelial adhesion induced by TNF-α. These novel data provide the first evidence of the relevant role of cocoa and their flavanol-derived metabolites to avoid the development of endothelial inflammation and diabetic complications.
David Álvarez-Cilleros, María Elvira López-Oliva, Sonia Ramos, María Ángeles Martín

2134 related Products with: Preventive effect of cocoa flavanols against glucotoxicity-induced vascular inflammation in the arteria of diabetic rats and on the inflammatory process in TNF-α-stimulated endothelial cells.

96 wells1.00 flask1.00 flask11.00 flask

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#33096137   2020/10/20 To Up

Characteristics of contents of lower intestine in the 65-74 years of age range could impact the performance of safe and efficacious modified release products.

We characterized the contents of distal ileum and proximal colon of older people from a pharmaceutical product performance perspective, under two extreme situations, i.e. 5h after a glass of water to fasted volunteers (fasted state) and 5h after a high-calorie, high-fat meal to fasted volunteers (fed state). Five males and three females (65-70y) participated in a two-phase crossover study. Contents were collected via colonoscopy. In distal ileum, luminal pH was lower and buffer capacity was higher than in young adults; differences reached significance for pH in the fed state. In proximal colon, differences reached significance for pH/fasted state and for buffer capacity/both fasted and fed states. Aqueous fraction of contents contained more short chain fatty acids than previously observed in young adults. In distal ileum, osmolality was significantly higher than in young adults. In proximal colon, aqueous fraction in the fasted state was significantly lower and long chain fatty acids 5h after meal was significantly higher than in young adults. Characteristics of contents of lower intestine that are relevant to the performance of certain modified release products differ between individuals 65-74 years old and young adults, the typical age group employed in safety and efficacy studies of oral drug products.
Maria Vertzoni, Sarah Sulaiman, Konstantinos Goumas, Elisabeth Kersten, Johanna Anlahr, Uwe Muenster, Christos Reppas

2585 related Products with: Characteristics of contents of lower intestine in the 65-74 years of age range could impact the performance of safe and efficacious modified release products.

5 G 50 UG1 50 UG

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#33096120   2020/10/20 To Up

The impact of red grape juice (Vitis labrusca)consumption associated with physical training on oxidative stress, inflammatory and epigenetic modulation in healthy elderly women.

The imbalance of epigenetic, oxidative stress and inflammatory markers is associated with the aging physiopathology. Then, the influence of bioactive nutritional compounds and physical training on these biomarkers has been studied, although the combination of both strategies has been not investigated. Therefore, our aim was to verify the effect of the association of physical training with red grape juice (Vitis labrusca) consumption on global histone acetylation H3 and H4 levels, oxidative stress markers and interleukin 6 (IL-6) levels in peripheral blood of healthy elderly women. This double-blind randomized clinical study consisted of 29 volunteers, aged 59 years and over, divided into three groups: grape juice group (GJG, n = 9); placebo and exercise group (PLEG, n = 10) and grape juice and exercise group (GJEG, n = 10). During 1 month, GJG consumed 400 ml of grape juice per day (integral and conventional), while the PLEG and GJEG groups, besides consuming juice or placebo were submitted to a concurrent physical training protocol (two times per week, 60 minutes / session). The volunteers were submitted to blood collections before and after the intervention for the biomarkers analysis, e.g. IL-6, histone acetylation H3 and H4, lipid oxidative damage (TBARS), proteins (Carbonyl), non-enzymatic antioxidant defense (Sulfhydryl groups) and activity of antioxidant enzymes (superoxide dismutase and catalase). There were no statistically significant differences in the global levels of histone acetylation H3 and H4 post intervention compared to the basal period as well and between groups were found. However, PLEG and GJEG showed a remarkable reduction on IL-6 levels after intervention. We also observed an increase in Carbonyl levels, SOD activities and Sulfhydryl levels comparing before and after intervention. Considering the interaction of time and groups, a significant increase in Sulfhydryl levels only in GJG was found. The physical training protocol associated or not with grape juice consumption showed anti-inflammatory effects and an influence in the antioxidant defenses (non enzymatic and enzymatic) in elderly women. However in grape juice group, without exercise, we observed an increase in non enzymatic antioxidant defense, what could be attributed to the polyphenols content. These responses seem not to be involved with histone acetylation status.
Caroline Dani, Karen Moura Dias, Lucieli Trevizol, Luisa Bassôa, Iasmin Fraga, Isabel Cristina Teixeira Proença, Daniela Pochmann, Viviane Rostirola Elsner

1694 related Products with: The impact of red grape juice (Vitis labrusca)consumption associated with physical training on oxidative stress, inflammatory and epigenetic modulation in healthy elderly women.

2ug10.1 mg100 ml.2ug5ug25 ml.

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#33096079   2020/10/20 To Up

A combined experimental-computational approach to quantify patient-specific blood rheology predicts altered systemic blood flow in sickle cell disease.

In sickle cell disease, aberrant blood flow due to oxygen-dependent changes in red cell biomechanics is a key driver of pathology. Most studies to date have focused on the potential role of altered red cell deformability and blood rheology in precipitating vaso-occlusive crises. Numerous studies, however, have shown that sickle blood flow is affected even at high oxygen tensions, suggesting a potentially systemic role for altered blood flow in driving pathologies, including endothelial dysfunction, ischemia, and stroke. In this study, we applied a combined experimental-computation approach that leveraged an experimental platform that quantifies sickle blood velocity fields under a range of oxygen tensions and shear rates. We computationally fit a continuum model to our experimental data to generate physics-based parameters that capture patient-specific rheological alterations. Our results suggest that sickle blood flow is altered systemically, from the arterial to the venous circulation. We also demonstrated the application of this approach as a tool to design patient-specific transfusion regimens. Finally, we demonstrated that patient-specific rheological parameters can be combined with patient-derived vascular models to identify patients who are at higher risk for cerebrovascular complications such as aneurysm and stroke. Overall, this study highlights that sickle blood flow is altered systemically, which can drive numerous pathologies, and this study demonstrates the potential utility of an experimentally parameterized continuum model as a predictive tool for patient-specific care.
M S Bazzi, J M Valdez, V H Barocas, D K Wood

1291 related Products with: A combined experimental-computational approach to quantify patient-specific blood rheology predicts altered systemic blood flow in sickle cell disease.

100 extractions1 kit1 kit 100 UG1 kit2 Pieces/Box2 Pieces/Box100ug Lyophilized2 Pieces/Box50 mg

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#33095951   2020/10/23 To Up

Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach.

The severity of facial telangiectasia or red veins is associated with many lifestyle factors. However, the genetic predisposition remains unclear.
S Mekić, C Wigmann, D A Gunn, L C Jacobs, M Kayser, T Schikowski, T Nijsten, L M Pardo

1840 related Products with: Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach.

1300 units100 μg96 assays

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#33095930   2020/10/23 To Up

Heterozygous APOE Christchurch in familial Alzheimer's disease without mutations in other Mendelian genes.

A rare APOE variant, named APOE3 Christchurch (APOEch) [1], yielding a missense mutation from Arginine to Serine at amino acid 136 (corresponding to codon 154), has been recently found in some members of a large Colombian kindred with autosomal dominant Alzheimer's disease (ADAD) due to an E280A mutation in PSEN1 [2]. The authors described a woman homozygous for the APOEch, who did not develop mild cognitive impairment (MCI) until her seventies, almost 30 years after the typical age of onset related to the PSEN1 mutation [3].
Isabel Hernandez, Ellen Gelpi, Laura Molina-Porcel, Sara Bernal, Benjamín Rodríguez-Santiago, Oriol Dols-Icardo, Agustín Ruiz, Daniel Alcolea, Mercè Boada, Alberto Lleó, Jordi Clarimón

1503 related Products with: Heterozygous APOE Christchurch in familial Alzheimer's disease without mutations in other Mendelian genes.

96 tests96 tests96 tests96 tests500 tests

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