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#36938736 
2023/03/11
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Regulation of USP25 by SP1 Associates with Amyloidogenesis.
Trisomy 21, an extra copy of human chromosome 21 (HSA21), causes most Down's syndrome (DS) cases. Individuals with DS inevitably develop Alzheimer's disease (AD) neuropathological phenotypes after middle age including amyloid plaques and tau neurofibrillary tangles. Ubiquitin Specific Peptidase 25 (USP25), encoding by USP25 gene located on HSA21, is a deubiquitinating enzyme, which plays an important role in both DS and AD pathogenesis. However, the regulation of USP25 remains unclear.Ran Li, Beibei Song, Lu Xu, Jiali Zheng, Wenhao Pan, Fang Cai, Juelu Wang, Yili Wu, Weihong Song