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#32746518   2020/07/31 To Up

Transforaminal Endoscopic Thoracic Discectomy: Technical Review to Prevent Complications.

For all the spine surgeons, thoracic disc herniations (TDHs) entrust a real challenge in terms of patient diagnosis, proper selection, surgical technique, and potential adverse events. TDHs are relatively uncommon compared to the lumbar and cervical levels. Literature reports a variable prevalence of TDHs around 6% to 40%, but less than 1% of all disk herniations are symptomatic TDHs, evidencing as a relatively unusual condition. Nowadays, transforaminal endoscopic thoracic discectomy (TETD) has been implemented as an alternative to classic open procedures with results that are as good as and, in some situations, better than those in traditional discectomy. However, the surgeon must be familiar with endoscopic lumbar spine surgery before opting to perform a TETD, considering that the learning curve is much harder. We describe all the steps and safety considerations during TETD based on the anatomic differences compared to lumbar endoscopic procedures. TETD is an effective and safe method that yields more benefits, provides a direct route to the lesion with less morbidity, and is performed in a minimally invasive way. Many severe complications related to the thoracic region could be avoided having the proper knowledge, adequate technique, and safety routes and considerations.
Gun Choi, Diego Munoz-Suarez

2597 related Products with: Transforaminal Endoscopic Thoracic Discectomy: Technical Review to Prevent Complications.

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#32746498   2020/08/03 To Up

Donor-Transmitted Cancers in Transplanted Livers: Analysis of Clinical Outcomes.

The risk of transmission of malignancy from donor to recipient is low; however, this occurrence has dramatic consequences. Many reports of donor derived cancers in liver transplant recipients have been published, but they have not been a systematically summarized into a lucid and unified analysis. The present study is an attempt to provide clarity to this unusual, but clinically important problem. We systematically reviewed all case reports, case series, and registries published on cancer transmission events through the end of December 2019. We identified a total of 67 publications with 92 transmission events. The most frequently transmitted cancers were lymphomas (30 [32.6%]), melanomas (8 [8.7%]), and neuroendocrine tumors (8 [8.7%]). Most of the melanomas were metastasizing, while most of the lymphomas were localized to the graft. The median time to cancer diagnosis after transplantation was 7 months, with 78% of diagnoses established in the first year. Melanoma carried the worst prognosis, with no recipients alive at 1 year after cancer diagnosis. Lymphoma recipients had a better outcome, with more than 75% surviving at 2 years. Conclusion: A metastatic cancer carries a worse prognosis for recipients, also because recipients with localized cancer can benefit from the chance to undergo transplantation again. The findings confirm the need to pay attention to donors with a history of melanoma but also suggest the need for a more careful evaluation of groups of donors, such as those dying from cerebral hemorrhage. Finally, recipients of organs from donors with cancer should be carefully followed to detect potential transmission.
Albino Eccher, Ilaria Girolami, Stefano Marletta, Matteo Brunelli, Amedeo Carraro, Umberto Montin, Ugo Boggi, Claudia Mescoli, Luca Novelli, Deborah Malvi, Letizia Lombardini, Massimo Cardillo, Desley Neil, Antonietta D'Errico

2993 related Products with: Donor-Transmitted Cancers in Transplanted Livers: Analysis of Clinical Outcomes.



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#32746430   // To Up

Comorbidity, Parental Psychopathology, and Accommodation in the Treatment of Pediatric Obsessive-Compulsive Disorder: A Case Study.

This article discusses the treatment of a young person with obsessive-compulsive disorder (OCD) characterized primarily by symptoms of physical and mental contamination, as well as religious obsessions. The treatment was complicated by several factors that will be reviewed and addressed. First, this client had a comorbid diagnosis of attention-deficit/hyperactivity disorder. Second, the young client's mother was also diagnosed with OCD and had a significantly anxious presentation. This impacted treatment in two primary ways. One important way treatment was complicated was that the client frequently attempted to manage her mother's emotions by underreporting her own distress at times. The other implication of the mother's diagnosis was that it became difficult to involve her in the treatment of her daughter and reduce her accommodation of her daughter's symptoms. The manner in which these complicating factors were addressed in the successful treatment of this client by adapting evidence-based practice will be presented as a guide for clinicians facing similar challenges.
Melanie J Wadkins, Elizabeth Gordon

1120 related Products with: Comorbidity, Parental Psychopathology, and Accommodation in the Treatment of Pediatric Obsessive-Compulsive Disorder: A Case Study.



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#32746425   // To Up

Exposure and Response Prevention for Postpartum Obsessive-Compulsive Disorder.

Pregnancy and postpartum periods are associated with increased risk for onset and exacerbation of obsessive-compulsive disorder (OCD) symptoms. Common themes of the obsessive thoughts in this period are fears of accidently or intentionally harming the baby. Postpartum OCD may go underdiagnosed or misdiagnosed due to lack of standardized screening and potential shame associated with reporting these symptoms. Without treatment, OCD symptoms often persist and continue to impair mother's quality of life and interactions with the child. Literature on treatment specific to postpartum OCD is limited to case series and small studies. Exposure and response prevention (ERP), a gold-standard treatment for OCD, seems to be effective for this particular manifestation of OCD. This article presents a case history and ERP treatment course for a patient presenting with sudden onset of OCD following the birth of her child. Key differential diagnostic features, specific treatment strategies, and practice points are also explored.
Marina Gershkovich

1383 related Products with: Exposure and Response Prevention for Postpartum Obsessive-Compulsive Disorder.

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#32746371   2020/07/31 To Up

Secure and Robust Machine Learning for Healthcare: A Survey.

Recent years have witnessed widespread adoption of machine learning (ML)/deep learning (DL) techniques due to their superior performance for a variety of healthcare applications ranging from the prediction of cardiac arrest from one-dimensional heart signals to computer-aided diagnosis (CADx) using multi-dimensional medical images. Notwithstanding the impressive performance of ML/DL, there are still lingering doubts regarding the robustness of ML/DL in healthcare settings (which is traditionally considered quite challenging due to the myriad security and privacy issues involved), especially in light of recent results that have shown that ML/DL are vulnerable to adversarial attacks. In this paper, we present an overview of various application areas in healthcare that leverage such techniques from security and privacy point of view and present associated challenges. In addition, we present potential methods to ensure secure and privacy-preserving ML for healthcare applications. Finally, we provide insight into the current research challenges and promising directions for future research.
Adnan Qayyum, Junaid Qadir, Muhammad Bilal, Ala Al Fuqaha

1440 related Products with: Secure and Robust Machine Learning for Healthcare: A Survey.

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#32746370   2020/07/22 To Up

Simulation of blood as fluid: A review from rheological aspects.

Blood flow in the human vascular system is a complex to understand example of fluid dynamics in a closed conduit. Any irregularities in the hemodynamics may lead to lethal cardiovascular disease like heart attack, heart failure and ischemia. Numerical simulation of hemodynamics in the blood vessel can facilitate a thorough understanding of blood flow and its interaction with the adjacent vessel wall. A good simulation approach for blood flow can be helpful in early prediction and diagnosis of the mentioned disease. The simulation outcomes may also provide decision support for surgical planning and medical implants. This study reports an extensive review of various approaches adopted to analyze the influence of blood rheological characteristics in a different class of blood vessels. In particular, emphasis was given on the identification of best possible rheological model to effectively solve the hemodynamics inside different blood vessels. The performance capability of different rheological models was discussed for different classes and conditions of vessels and the best/poor performing models are listed out. The Carreau, Casson and generalized power-law models were appeared to be superior for solving the blood flow at all shear rates. In contrast, power law, Walburn-Scheck and Herchel-Bulkley model lacks behind in the purpose.
Vikas Kannojiya, Arup Das, Prasanta Kumar Das

1653 related Products with: Simulation of blood as fluid: A review from rheological aspects.

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#32746365   2020/06/24 To Up

Segmentation of White Blood Cell, Nucleus and Cytoplasm in Digital Haematology Microscope Images: A Review-Challenges, Current and Future Potential Techniques.

Segmentation of white blood cells in digital haematology microscope images represents one of the major tools in the diagnosis and evaluation of blood disorders. Pathological examinations are being the gold standard in many haematology and histophathology, and also play a key role in the diagnosis of diseases. In clinical diagnosis, white blood cells are analysed by pathologists from peripheral blood smears samples of patients. This analysis is mainly based on morphological features and characteristics of the white blood cells and their nuclei and cytoplasm, including, shapes, sizes, colours, textures, maturity stages and staining processes. Recently, Computer Aided Diagnosis techniques have been rapidly growing in the digital haematology area related to white blood cells, and their nuclei and cytoplasm detection, as well as their segmentation and classification techniques. In digital haematology image analysis, these techniques have played and will continue to play, a vital role for providing traceable clinical information, consolidating pertinent second opinions, and minimizing human intervention. This study outlines, discusses, and introduces the major trends from a particular review of detection and segmentation methods for white blood cells and their nuclei and cytoplasm from digital haematology microscope images.
Khamael Al-Dulaimi, Jasmine Banks, Kien Nguyen, Aiman Al-Sabaawi, Inmaculada Tomeo-Reyes, Vinod Chandran

2470 related Products with: Segmentation of White Blood Cell, Nucleus and Cytoplasm in Digital Haematology Microscope Images: A Review-Challenges, Current and Future Potential Techniques.

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#32746350   2020/06/30 To Up

Towards a portable platform integrated with multi-spectral non-contact probes for delineating normal and breast cancer tissue based on near-infrared spectroscopy.

Currently, the confirmation of diagnosis of breast cancer is made by microscopic examination of an ultra-thin slice of a needle biopsy specimen. This slice is conventionally formalin-fixed and stained with hematoxylin-eosin and visually examined under a light microscope. This process is labor-intensive and requires highly skilled doctors (pathologists). In this paper, we report a novel tool based on near-infrared spectroscopy (Spectral-IRDx) which is a portable, non-contact, and cost-effective system and could provide a rapid and accurate diagnosis of cancer. The Spectral-IRDx tool performs absorption spectroscopy at near-infrared (NIR) wavelengths of 850 nm, 935 nm, and 1060 nm. We measure normalized detected voltage (Vdn) with the tool in 10 deparaffinized breast biopsy tissue samples, 5 of which were cancer (C) and 5 were normal (N) tissues. The difference in Vdn at 935 nm and 1060 nm between cancer and normal tissues is statistically significant with p-values of 0.0038 and 0.0022 respectively. Absorption contrast factor (N/C) of 1.303, 1.551, and 1.45 are observed for 850 nm, 935 nm, and 1060 nm respectively. The volume fraction contrast (N/C) of lipids and collagens are reported as 1.28 and 1.10 respectively. Higher absorption contrast factor (N/C) and volume fraction contrast (N/C) signifies higher concentration of lipids in normal tissues as compared to cancerous tissues, a basis for delineation. These preliminary results support the envisioned concept for non-invasive and non-carcinogenic NIR-based breast cancer diagnostic platform, which will be tested using a larger number of samples.
Uttam Mrinal Pal, Anil Vishnu Gk, Gayatri Gogoi, Saeed Rila, Saahil Shroff, Gokul Am, Manoj Varma, Vishnu Kurpad, Deb Baruah, Pronami Borah, Jayant S Vaidya, Hardik Jeetendra Pandya

2898 related Products with: Towards a portable platform integrated with multi-spectral non-contact probes for delineating normal and breast cancer tissue based on near-infrared spectroscopy.



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