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#34525445   2021/08/14 To Up

Effects of dietary nicotinic acid supplementation on meat quality, carcass characteristics, lipid metabolism, and tibia parameters of Wulong geese.

The purpose of this study was to evaluate the effects of nicotinic acid (NA) supplementation on the meat quality, carcass characteristics, lipid metabolism, and tibia parameters in Wulong geese. A total of 360 twenty-nine-day-old Wulong geese were randomly divided into 6 treatments, and each treatment included 6 pens with 10 birds per pen. Birds were fed a basal diet supplemented with 0, 20, 40, 60, 80, or 100 mg/kg NA for 12 wk. Dietary NA supplementation linearly decreased L* value and increased pH and water-holding capacity in the breast muscle (P < 0.05). Increasing NA levels linearly and quadratically decreased shear force of breast muscle (P < 0.001). Dietary NA supplementation linearly reduced the thickness of subcutaneous fat plus the skin and percentage of abdominal fat, and enhanced the width of intermuscular fat band (P < 0.001). Dietary NA addition linearly and quadratically increased intramuscular fat (IMF) content (P ≤ 0.001). Increasing NA levels decreased serum total cholesterol and low-density lipoprotein cholesterol levels and increased serum lipase activity and hepatic mRNA expression of lipoprotein lipase in a linear manner (P < 0.05). There were linear and quadratic effects in serum triglycerides and high-density lipoprotein cholesterol (HDL-C) levels and malate dehydrogenase activity with the NA addition (P < 0.05). Feeding the NA-supplemented-diets linearly increased tibia length, circumference, fat-free dry weight, and ash content (P < 0.001). There were linear and quadratic increases in Ca and P contents with the NA supplementation (P < 0.05). According to the quadratic regression analyses fitted to shear force, IMF content, serum triglycerides and HDL-C levels, and tibial Ca and P contents, the optimal dietary NA supplementation was 80 to 90 mg/kg. In conclusion, NA addition enhanced meat quality and IMF content, regulated lipid metabolism, and increased tibia quality of Wulong geese. The dosage of 80 mg/kg NA in Wulong geese aged 5 to 16 wk was recommended.
Beibei Zhang, Jianzhong Hao, Hongji Yin, Chenlei Duan, Baowei Wang, Wenli Li

2362 related Products with: Effects of dietary nicotinic acid supplementation on meat quality, carcass characteristics, lipid metabolism, and tibia parameters of Wulong geese.

10 mg 100 G 100 G 10 UG1,000 tests1 g 5 G2.5 g25 mg 500 G 1 G

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#34525434   2021/09/04 To Up

Seroepidemiological study of severe fever with thrombocytopenia syndrome in animals and humans in Okinawa, Japan.

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Yumani Kuba, Hisako Kyan, Yasuhito Azama, Yoshimune Fukuchi, Eun-Sil Park, Tetsuya Kakita, Minori Oyama, Noriyuki Maeshiro, Masato Miyahira, Minoru Nidaira, Ken Maeda, Shigeru Morikawa, Kiyosu Taniguchi

1169 related Products with: Seroepidemiological study of severe fever with thrombocytopenia syndrome in animals and humans in Okinawa, Japan.

100 μg900 tests100 μg5 mg100 μg100ug Lyophilized100 μg 5 G

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#34525431   2021/08/31 To Up

No association between children's febrile seizures and S100B protein levels: A meta-analysis.

In recent years, studies have examined the relationship between febrile seizures in children and S100B protein with contradictory results. We systematically evaluated the relationship between children's febrile seizures and S100B protein levels.
Jiayu Huang, Jiao Li, Xiao Sun, Jinfeng Meng, Shangbin Li, Weichen Yan, Jie Wang, Changjun Ren, Ling Hao

2943 related Products with: No association between children's febrile seizures and S100B protein levels: A meta-analysis.

1 Set1 Set0.1 mg10 ml1 Set0.2 mg

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#34525397   2021/09/12 To Up

Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.

Humanin is an endogenous mitochondria-derived peptide that plays critical roles in oxidative stress, inflammation and CAD. In this study, we measured the levels of circulating humanin, markers of oxidative stress and inflammation in patients with unstable angina and MI and studied the relationship between these parameters and major adverse cardiac events (MACE).
He Cai, Pengyu Cao, Wanqing Sun, Wangshu Shao, Rongyu Li, Lin Wang, Lin Zou, Erick Forno, Radhika Muzumdar, Zhenwei Gong, Yang Zheng

2648 related Products with: Circulating humanin is lower in coronary artery disease and is a prognostic biomarker for major cardiac events in humans.

100ug Lyophilized100ug Lyophilized100ug Lyophilized1mg0.1ml100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#34525389   2021/09/12 To Up

A mouse model of the regression of alcoholic hepatitis: Monitoring the regression of hepatic steatosis, inflammation, oxidative stress, and NAD metabolism upon alcohol withdrawal.

This study aimed to develop a well-characterized mouse model of alcoholic hepatitis (AH) regression. Male C57BL/6J mice were fed a Lieber-DeCarli (LD) control diet or LD containing 5% ethanol for ten days followed by one binge, which is the chronic-binge model of AH developed by the National Institute on Alcohol Abuse and Alcoholism. To determine AH regression, mice previously exposed to ethanol were put on LD control diet and metabolic and inflammatory features were monitored weekly for three weeks. Serum alcohol, total cholesterol, and alanine transaminase levels were increased in ethanol-fed mice, which declined to those of no ethanol controls within one and three weeks after ethanol withdrawal, respectively. Serum malondialdehyde was increased with ethanol feeding, but it was restored to no ethanol control levels within one week. Ethanol-induced changes in the hepatic expression of genes involved in lipogenesis, fatty acid oxidation, ethanol metabolism, and antioxidant response were restored to those of no ethanol controls after 3 weeks of ethanol withdrawal. Also, ethanol-induced hepatic inflammation was gradually decreased during the 3 weeks of ethanol withdrawal. Hepatic nicotinamide adenine dinucleotide (NAD) levels and the expression of enzymes involved in the NAD salvage pathway were decreased by ethanol feeding, which was mitigated after ethanol withdrawal. Ethanol significantly lowered hepatic sirtuin 1 expression, but its levels were restored with ethanol cessation. This study established a mouse model of AH regression, which can be used as a preclinical model to study the potential of dietary bioactives or therapeutic agents on AH regression.
Hyunju Kang, Mi-Bo Kim, Young-Ki Park, Ji-Young Lee

2632 related Products with: A mouse model of the regression of alcoholic hepatitis: Monitoring the regression of hepatic steatosis, inflammation, oxidative stress, and NAD metabolism upon alcohol withdrawal.

100 4 Arrays/Slide4 Sample Kit100.00 ul100 ug100ug61-8 Sample Kit

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#34525305   2021/09/15 To Up

Implications of the Coffee-Ring Effect on Virus Infectivity.

The factors contributing to the survival of enveloped viruses (e.g., influenza and SARS-CoV-2) on fomite surfaces are of societal interest. The bacteriophage Phi6 is an enveloped viral surrogate commonly used to study viability. To investigate how viability changes during the evaporation of droplets on polypropylene, we conducted experiments using a fixed initial Phi6 concentration while systematically varying the culture concentration and composition (by amendment with 2% fetal bovine serum (FBS), 0.08 wt % BSA, or 0.5 wt % SDS). The results were consistent with the well-founded relative humidity (RH) effect on virus viability; however, the measured viability change was greater than that previously reported for droplets containing either inorganic salts or proteins alone, and the protein effects diverged in 1× Dulbecco's modified Eagle's medium (DMEM). We attribute this discrepancy to changes in virus distribution during droplet evaporation that arise due to the variable solute drying patterns (i.e., the "coffee-ring" effect) that are a function of the droplet biochemical composition. To test this hypothesis, we used surface-enhanced Raman spectroscopy (SERS) imaging and three types of gold nanoparticles (pH nanoprobe, positively charged (AuNPs(+)), and negatively charged (AuNPs(-))) as physical surrogates for Phi6 and determined that lower DMEM concentrations, as well as lower protein concentrations, suppressed the coffee-ring effect. This result was observed irrespective of particle surface charge. The trends in the coffee-ring effect correlate well with the measured changes in virus infectivity. The correlation suggests that conditions resulting in more concentrated coffee rings provide protective effects against inactivation when viruses and proteins aggregate.
Qishen Huang, Wei Wang, Peter J Vikesland

1524 related Products with: Implications of the Coffee-Ring Effect on Virus Infectivity.

100100ug Lyophilized200 6 ml Ready-to-use 96/kit100 96 Tests 100 96 Tests/kit500 100ug Lyophilized

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#34525286   // To Up

Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine.

Although Zika virus (ZIKV) infection is typically self-limiting, other associated complications such as congenital birth defects and the Guillain-Barré syndrome are well described. There are no approved vaccines against ZIKV infection.
Pablo Tebas, Christine C Roberts, Kar Muthumani, Emma L Reuschel, Sagar B Kudchodkar, Faraz I Zaidi, Scott White, Amir S Khan, Trina Racine, Hyeree Choi, Jean Boyer, Young K Park, Sylvie Trottier, Celine Remigio, Diane Krieger, Susan E Spruill, Mark Bagarazzi, Gary P Kobinger, David B Weiner, Joel N Maslow

1563 related Products with: Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine.

100ug Lyophilized1 mg0.2 mg100ug Lyophilized100ug0.1 mg100 100 μg96T1 mL100ug Lyophilized1 mL

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#34525272   2021/09/16 To Up

Does serum TSH level act as a surrogate marker for psychological stress and cardio-metabolic risk among adolescent and young people?

The incidence of metabolic syndrome is increasing even at younger ages. Metabolic syndrome constitutes a group of cardiovascular risk factors that include high cholesterol, triacylglycerol, hyperglycemia, central obesity, etc., which increases the risk of cardiovascular disease, diabetes mellitus, may be even cancer. Indian students enter colleges just after crossing their adolescent age and will be exposed to greater academic stress. Psychological stress or depression is associated with transient change in thyroid hormones level or dysfunction. To explore an association among serum Thyroid Stimulating Hormone (TSH) levels, fT3:fT4 ratio, psychological stress scores, and selected known cardio-metabolic risk markers.
Niranjan Gopal, Akash Shivaji Pune, Roshan Takhelmayum, Ashok Kumar Ahirwar

1306 related Products with: Does serum TSH level act as a surrogate marker for psychological stress and cardio-metabolic risk among adolescent and young people?

96T1 kit100ug

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#34525075   // To Up

Refractive index modulation in magnetophoresis of bioreaction induced self-assembled magnetic fluid.

We explore the refractive index (RI) modulation of bioreaction induced self-assembled magnetic fluid (SAMF) so as to facilitate the design of sensitive biosensors. Bovine serum albumin (BSA) is taken as a model protein to induce self-assembly of carboxylated magnetic nanoparticles (MNPs). A bidirectional magnetophoresis (BDMP) system is designed to generate uniform and large RI modulation to SAMF. A robust Mach-Zehnder interferometer compatible to the BDMP system is used for the RI detection. It is found that BDMP has greater ability in modulating the RI of magnetic fluid than the alignment of MNPs in a uniform magnetic field. The modulation depth of the RI increases with the increase of BSA concentration when applying a certain external magnetic field for a period of time. A larger magnetic field has greater ability to modulate the RI of SAMF. However, it may generate an over-modulation.
Rende Ma, Xiaoping Li, Hongzhong Cao, Wendi Wu, Zhongxiao Man, Yunjie Xia

2733 related Products with: Refractive index modulation in magnetophoresis of bioreaction induced self-assembled magnetic fluid.

2ug50 ul5ug100ug400 ug100 ul100ug400 ug96T100 ul1 mg 100ul

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#34524978   2021/09/01 To Up

Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine.

Treatment with radioactive iodine (RAI) in women with differentiated thyroid cancer is associated with decreased serum concentrations of anti-Müllerian hormone (AMH); however, other markers have not been investigated. Therefore, this study aimed to evaluate the effect of RAI on antral follicle count (AFC) and the serum concentration of inhibin B, follicle-stimulating hormone (FSH), and AMH in women with papillary thyroid cancer (PTC) treated with RAI. We examined 25 women at a median age of 33 years treated with a single dose of RAI. We divided the participants into women over (n = 11) and under 35 years of age (n = 14). Serum concentrations of inhibin B, FSH, AMH, and AFC were assessed at baseline and one year after RAI treatment. We found decreased AFC (p = 0.03), serum levels of AMH (p < 0.01), inhibin B (p = 0.03), but not FSH (p = 0.23), one year after RAI treatment in comparison to baseline in the whole group. When we compared serum levels of AMH in younger vs. older women separately, we observed a significant reduction of this hormone's serum level after RAI treatment in both groups (p < 0.01; p = 0.04, respectively). We concluded that RAI treatment significantly impacts the functional ovarian reserve in premenopausal women with PTC.
Agnieszka Adamska, Paulina Tomczuk-Bobik, Anna Beata Poplawska-Kita, Katarzyna Siewko, Angelika Buczyńska, Piotr Szumowski, Łukasz Żukowski, Janusz Myśliwiec, Monika Zbucka-Krętowska, Marcin Adamski, Adam Jacek Krętowski

2799 related Products with: Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine.



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