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#32770828   2020/08/08 To Up

Circumstances of Human-Bat interactions and risk of lyssavirus transmission in metropolitan France.

Since the elimination of dog and terrestrial wild animal rabies, bat exposures remain the only source of autochthonous lyssavirus transmission to humans in Western Europe. European bats have already been found infected with several lyssaviruses, and human-bat interactions represent a risk of viral transmission and fatal encephalitis for humans. In this study, we aim to better characterize exposures to bats in metropolitan France from 2003 to 2016 and to identify circumstances associated with exposures to lyssavirus-positive bats. Two complementary sources of data were analysed: 1/ data associated with bats responsible for human exposure received for Lyssavirus testing by the French National Reference Centre for Rabies (NRCR); and 2/ data pertaining to individuals seeking medical care through the French Anti-Rabies Clinics network after contact with a bat. From 2003 to 2016, 425 bats originating from metropolitan France were submitted to the NRCR and 16 (4%) were found positive with a lyssavirus (EBLV-1b was diagnosed in 9 bats, EBLV-1a in 6 and BBLV in one specimen). The two factors associated with bat positivity in our study were the female sex and the bat belonging to the E. serotinus species. During the same study period, 1718 individuals sought care at an Anti-Rabies Clinic after exposure to a bat resulting in an estimated incidence of human-bat interactions of 1.96 per 10 person-years. The two most frequent circumstances of exposure were handling or bites. Interactions mostly involved one adult human being and one live and non-sick-looking bat. Our study provides new insights about circumstances of human-bat interactions and may be helpful to target prevention interventions to improve the awareness of the population of the risk of lyssavirus transmission.
Perrine Parize, Isabel Cristina Travecedo Robledo, Minerva Cervantes-Gonzalez, Lauriane Kergoat, Florence Larrous, Jordi Serra-Cobo, Laurent Dacheux, Hervé Bourhy

1104 related Products with: Circumstances of Human-Bat interactions and risk of lyssavirus transmission in metropolitan France.

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#32770752   2020/08/08 To Up

Forensic Identification of the Keratin Fibers of South American Camelids by Ambient Ionization Mass Spectrometry: Vicuña, Alpaca and Guanaco.

The keratin fleece of the endangered vicuña (Vicugna vicugna) commands a high value in international markets, and this trade has caused illegal poaching and a substantial decrease of vicuña populations. Morphological analysis of hairs does not have the resolution to determine the species of origin of camelid natural fibers. In addition, commerce in camelid fleece also includes the legal trade of alpaca (Vicugna pacos) and guanaco (Llama guanicoe) wool.
Erin Price, Dominique Marie Larrabure, Benito A Gonzales, Pamela J McClure, Edgard Espinoza

2884 related Products with: Forensic Identification of the Keratin Fibers of South American Camelids by Ambient Ionization Mass Spectrometry: Vicuña, Alpaca and Guanaco.

5 G100ul10 mg50 IU1000 TESTS/0.65ml100.00 ul 1 kit(s) 200ug200ul

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#32770702   2020/08/08 To Up

The role of alternative sugars on endurance capacity in balb/c mice.

Alternative sugars containing isomaltulose were investigated to confirm the hypothesis that isomaltulose ingestion affects endurance capacity due to slow rates of hydrolysis and absorption rate at the intestine. A swimming time of the control group tends to decrease, but the group administrated with low glycemic index (GI) sweeteners tend to increase gradually. Fructo-oligosaccharide (FOS) and inverted sugar (IS), contained isomaltulose, groups showed a significant difference of change in blood glucose and lactic acid level than control group (p < .05). Serum creatine phosphokinase (CPK) and serum lactate dehydrogenases (LDH) of PAL100 were significantly lower than that of the control group (p < .05). IS showed a significant difference in glutathione peroxidase (GSH-Px) compared to Con and PAL20 (20% isomaltulose) group (p < .05). Consuming FOS seems to increase an endurance capacity since fructose and FOS based in isomaltulose contained syrup showed low absorption rate and GI level. PRACTICAL APPLICATIONS: Sugar is a major energy source for exercise, but it causes excessive intake because of the short duration of sweetness, which causes diseases such as obesity, diabetes, and skin aging. An alternative sugar complex containing isomatulose was found to be a sugar substitute for athletic performance. Athletic performance is not just for athletes or active people. In general, elderly people with low muscle mass have low mobility. Alternative sugars can be a good source of supplements to help them perform smoothly with less intake. Therefore, an endurance test with alternative sugars is and important study for energy supplements industry.
Singeun Kim, Kyungae Jo, Nari Kim, Ki-Bae Hong, Hyung Joo Suh

1447 related Products with: The role of alternative sugars on endurance capacity in balb/c mice.

1mg1 100 UG100ug100 µl

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#32770699   2020/08/08 To Up

An alternative pentose phosphate pathway in human gut bacteria for the degradation of C5 sugars in dietary fibers.

The microbial degradation of pentoses in the human gut is a crucial factor for the utilization of plant-based dietary fibers. A vast majority of gut microbes are able to use these C5-sugars as a carbon and energy source. However, the underlying metabolic pathways are not fully understood. Bioinformatic analysis showed that a large number of abundant gut bacteria lack genes encoding a transaldolase as a key enzyme of the pentose phosphate pathway. Among them was the important human gut microbe Prevotella copri, which was able to grow in minimal media containing xylose or hemicelluloses as the sole carbon source. Therefore, we looked for an alternative pathway for pentose conversion in P. copri using bioinformatics, enzyme activity assays and the detection of intermediates of pentose metabolism. It became evident that the organism converted C5-sugars via the sedoheptulose-1,7-bisphosphate pathway (SBPP) to connect pentose metabolism with glycolysis. To circumvent the transaldolase reaction, P. copri uses the combined catalysis of a pyrophosphate-dependent phosphofructokinase and a fructose-bisphosphate aldolase. Furthermore, we present strong evidence that the SBPP is widely distributed in important gut bacteria, including members of the phyla Bacteroides, Firmicutes, Proteobacteria, Verrucomicrobia and Lentisphaerae.
Laura S Garschagen, Thomas Franke, Uwe Deppenmeier

1369 related Products with: An alternative pentose phosphate pathway in human gut bacteria for the degradation of C5 sugars in dietary fibers.

100 μg100 μg50ul100 μg100 μg1 mg100 4 Membranes/Box100μg100 μg100 μg100 μg

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#32770664   2020/08/08 To Up

The Un Oeuf study: Design, methods and baseline data from a cluster randomised controlled trial to increase child egg consumption in Burkina Faso.

In many low-income countries, such as Burkina Faso, rates of malnutrition are high among children. Research indicates that animal source foods may provide important elements to improve growth and development of young children, especially during periods of rapid development, such as the first 1,000 days of life. The Un Oeuf study is designed to test an innovative behaviour change communication strategy to increase egg consumption in children 6-24 months in Burkina Faso, thereby improving dietary diversity and nutritional outcomes. This 1-year cluster randomised controlled trial tests whether the gifting of chickens by a community champion directly to a child, combined with a behaviour change package of integrated poultry management and human nutrition trainings, can significantly increase egg consumption among children under 2 years in rural communities where egg consumption is very low. The nutrition-sensitive behaviour change package is designed to increase egg consumption through improving livestock production, women's empowerment and food security at the household level. This paper presents a detailed account of the study design and protocol for the Un Oeuf study, alongside a description of the study population. Baseline data show a study population with high rates of malnutrition (stunting 21.6%, wasting 10.8% and underweight 20.4%) and a very low rate of egg consumption-less than 10% among children. Although poultry production is quite common, egg consumption is low reportedly because of cultural norms, including widespread practice of allowing eggs to hatch and a lack of knowledge about the nutritional benefits of egg consumption.
Heather Stark, Anteneh Omer, Aïssata Wereme N'Diaye, Amanda C Sapp, Emily V Moore, Sarah L McKune

1483 related Products with: The Un Oeuf study: Design, methods and baseline data from a cluster randomised controlled trial to increase child egg consumption in Burkina Faso.

100ug100ug100 100 μg100 μg

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#32770634   2020/08/07 To Up

A Serum Protein Signature is associated with Rheumatoid Arthritis development.

The pathophysiologic events that precede the onset of Rheumatoid Arthritis (RA) remain incompletely understood. We aimed to identify changes in the serum proteome that precede RA and provide new insights into the pathogenic mechanisms that lead to its development.
Liam J O'Neil, Victor Spicer, Irene Smolik, Xiaobo Meng, Rishi R Goel, Vidyanand Anaparti, John Wilkins, Hani S El-Gabalawy

2913 related Products with: A Serum Protein Signature is associated with Rheumatoid Arthritis development.

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#32770590   2020/08/07 To Up

Fractionation of stable oxygen and clumped isotope during acid digestion of calcite in the presence of an external DC electric field.

Phosphoric acid digestion of carbonate generates CO for stable oxygen and clumped isotope analysis using a gas source isotope ratio mass spectrometer. The initial step of digestion reaction is protonation of calcite while the product CO equilibrates with the system allowing further exchange of isotopes to various extents depending on the nature of acid digestion methods. An external electric field is introduced in the break seal method to demonstrate the role of the protonation reaction and the post-digestion isotopic exchanges in the final isotopic composition of product CO .
Sanchita Banerjee, Prosenjit Ghosh, Chirantan Pramanik, Subba Reddy B

1765 related Products with: Fractionation of stable oxygen and clumped isotope during acid digestion of calcite in the presence of an external DC electric field.

100ug Lyophilized100 μg100ug Lyophilized100ug Lyophilized100 μg100ug100ug100ug Lyophilized

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#32770468   2020/08/08 To Up

New insights into toxic effects of arsenate on four Microcystis species under different phosphorus regimes.

Very little information is available on the stressed growth of Microcystis imposed by arsenate (As(V)) under different phosphorus (P) regimes. In this study, we examined the growth characteristics and arsenic transformation of four Microcystis species exposed under As(V) with two P sources involving dissolved inorganic phosphorus (IP) and organophosphate (D-glucose-6-phosphate disodium salt, GP). Results showed that all the four chosen Microcystis species could grow and reproduce with GP as the only P source, and the difference was insignificant when compared with IP. From optical density (OD), chlorophyll a (Chla), and actual quantum yield (Yield), the tolerance to As(V) of the chosen species was following as FACHB 905 > FACHB 1028 > FACHB 1334 > FACHB 912. Specifically, the 96 h EC of As(V) for FACHB 905 in IP was approx. 4 orders of magnitude higher than that in GP, but for other three algal species, the 96 h EC values were similar under the two given different P conditions. Furthermore, all antioxidant enzyme activities of superoxide dismutase (SOD), peroxide dismutase (POD), glutathione S-transferases (GSTs), and metalloproteinase (MTs) in algal cells were significantly increased in GP conditions. Moreover, the enzyme activities of AKP, GSTs, and MTs were inhibited with increasing As(V) levels under both IP and GP conditions. In addition, arsenite (As(III)) and methylated As of monomethylarsonic acid (MMA) and dimethylthioarsinic acid (DMA) were found in FACHB 912 and FACHB 1334 media, indicating that these Microcystis could detoxify As(V) by As biotransformation under IP and GP conditions. Specifically, As(V) reduction was elevated in media of FACHB 1334 and FACHB 905, but was decreased in media of FACHB 912 under GP conditions. Our results highlight the different P sources that impact the toxic effects of arsenate exposure on Microcystis and subsequent As biotransformation.
Zhuanxi Luo, Zhenhong Wang, Aifen Liu, Yu Yan, Yaqing Wu, Xiaoyong Zhang

2331 related Products with: New insights into toxic effects of arsenate on four Microcystis species under different phosphorus regimes.

100ul 100ul50 ug 100ul96T 100ul 100ul 100ul 100ul 100ul50 ug

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