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#34118791   2021/06/11 To Up

Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway.

Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR injury in nondiabetic animal models. However, its effects on diabetic CIR injury and the underlying mechanisms remain unclarified. Herein, we found that melatonin administration improved neurological deficit, cerebral infarct volume, brain edema, and cell viability, reduced mitochondrial swelling, reactive oxygen species generation, and cytoplasmic cytochrome C release, and increased mitochondrial antioxidant enzymes activities, adenosine triphosphate production, and mitochondrial membrane potential in both streptozotocin-induced diabetic mice and high glucose-treated HT22 cells. Importantly, melatonin also activated protein kinase B (Akt) and sirtuin 3 (SIRT3)/superoxide dismutase 2 (SOD2) signaling and upregulated mitochondrial biogenesis-related transcription factors. However, these effects were largely attenuated by LY294002 (a specific Akt signaling blocker) administration. Additionally, 3-TYP (a selective SIRT3 inhibitor) and SIRT3 siRNA inhibited the above protective effects of melatonin as well as the upregulation of SIRT3 and the decrease of SOD2 acetylation but did not affect the p-Akt/Akt ratio. Overall, we demonstrate that melatonin can alleviate CIR injury in diabetic mice by activating Akt-SIRT3-SOD2 signaling and subsequently improving mitochondrial damage.
Lian Liu, Quan Cao, Wenwei Gao, Bingyu Li, Zhongyuan Xia, Bo Zhao

1481 related Products with: Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway.

2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/BoxInhibitors2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box11 inhibitors

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#34118767   2021/06/09 To Up

The scope of flavin-dependent reactions and processes in the model plant Arabidopsis thaliana.

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Reinmar Eggers, Alexandra Jammer, Shalinee Jha, Bianca Kerschbaumer, Majd Lahham, Emilia Strandback, Marina Toplak, Silvia Wallner, Andreas Winkler, Peter Macheroux

1880 related Products with: The scope of flavin-dependent reactions and processes in the model plant Arabidopsis thaliana.

1500 Units96tests

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#34118754   2021/05/24 To Up

Meliponinae and Apis mellifera honey in southern Brazil: Physicochemical characterization and determination of pesticides.

This study evaluated the physicochemical parameters and the occurrence of pesticides in multi-flower honey produced by six species of Meliponinae and Apis mellifera and collected in different seasons, floral species and sites in southern Brazil. Meliponinae honey were found to exhibit higher moisture, free acidity and sucrose concentration and lower concentration of reducing sugars than the standard of Apis mellifera honey in Brazil. Regarding Apis mellifera honey, reducing sugars and sucrose did not comply with the legislation. The Principal Component Analysis (PCA) showed that most of the composition variability was defined by free acidity, moisture, soluble solids, fructose, glucose, and reducing sugars. Determination of pesticides was carried out by the citrate QuEChERS method and gas chromatography tandem mass spectrometry (GC-MS/MS). However, no pesticide residues at concentrations above the limit of quantification were found in the twenty honey samples. Results show that this region has the potential to produce honey.
Lucas Cavagnoli Marcolin, Luanne Ramos Lima, Jean Lucas de Oliveira Arias, Andrea Carolina Begambre Berrio, Larine Kupski, Sergiane Caldas Barbosa, Ednei Gilberto Primel

2389 related Products with: Meliponinae and Apis mellifera honey in southern Brazil: Physicochemical characterization and determination of pesticides.

100ul100ul25 mg1000 tests100.00 ul100ug100ug400Tests10 mg 5 G50 ug 2.5 mg

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#34118747   2021/06/09 To Up

Zinc oxide nanoparticles alleviates the adverse effects of cadmium stress on Oryza sativa via modulation of the photosynthesis and antioxidant defense system.

Cadmium (Cd) is a trace element causing severe toxicity symptoms in plants, besides posing hazardous fitness issue due to its buildup in the human body through food chain. Nanoparticles (NPs) are recently employed as a novel strategy to directly ameliorate the Cd stress and acted as nano-fertilizers. The intend of the current study was to explore the effects of zinc oxide nanoparticles (ZnO-NPs; 50 mg/L) on plant growth, photosynthetic activity, elemental status and antioxidant activity in Oryza sativa (rice) under Cd (0.8 mM) stress. To this end, the rice plants are treated by Cd stress at 15 days after sowing (DAS), and the treatment was given directly into the soil. Supply of ZnO-NPs as foliar spray was given for five consecutive days from 30 to 35 DAS, and sampling was done at 45 DAS. However, rice plants supplemented with ZnO-NPs under the Cd toxicity revealed significantly increased shoot length (SL; 34.0%), root fresh weight (RFW; 30.0%), shoot dry weight (SDW; 23.07%), and root dry weight (RDW; 12.24%). Moreover, the ZnO-NPs supplement has also positive effects on photosynthesis related parameters, SPAD value (40%), chloroplast structure, and qualitatively high fluorescence observed by confocal microscopy even under Cd stress. ZnO-NPs also substantially prevented the increases of hydrogen peroxide (HO) and malondialdehyde (MDA) triggered by Cd. Physiological and biochemical analysis showed that ZnO-NPs increased enzymatic activities of superoxide dismutase (SOD; 59%), catalase (CAT; 52%), and proline (17%) that metabolize reactive oxygen species (ROS); these increases coincided with the changes observed in the HO and MDA accumulation after ZnO-NPs application. In conclusion, ZnO-NPs application to foliage has great efficiency to improve biomass, photosynthesis, protein, antioxidant enzymes activity, mineral nutrient contents and reducing Cd levels in rice. This can be attributed mainly from reduced oxidative damage resulted due to the ZnO-NPs application.
Mohammad Faizan, Javaid Akhter Bhat, Kamel Hessini, Fangyuan Yu, Parvaiz Ahmad

1316 related Products with: Zinc oxide nanoparticles alleviates the adverse effects of cadmium stress on Oryza sativa via modulation of the photosynthesis and antioxidant defense system.

500 Units1mg111 ml100.00 ul12000 IU500 Units

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#34118721   2021/06/02 To Up

Discovery and preliminary mechanism of 1-carbamoyl β-carbolines as new antifungal candidates.

Natural β-carboline alkaloids are ideal models for the discovery of pharmaceutically important entities. Various 1-substituted β-carbolines were synthesized from commercially inexpensive tryptophan and demonstrated significant in vitro antifungal activity against G. graminis. Significantly, compound 4m (EC = 0.45 μM) with carboxamide at 1-position displayed the best efficacy and nearly 20 folds enhancement in antifungal potential compared to Silthiopham (EC = 8.95 μM). Moreover, compounds 6, 7, and 4i exhibited excellent in vitro antifungal activities and in vivo protective and curative activities against B. cinerea and F. graminearum. Preliminary mechanism studies revealed that compound 4m caused reactive oxygen species accumulation, cell membrane destruction, and deregulation of histone acetylation. These findings indicated that 1-carbamoyl β-carboline can be selected as a promising model for the discovery of novel and broad-spectrum fungicide candidates.
Tao Sheng, Mengmeng Kong, Yujie Wang, HuiJun Wu, Qin Gu, Anita Shyying Chuang, Shengkun Li, Xuewen Gao

1137 related Products with: Discovery and preliminary mechanism of 1-carbamoyl β-carbolines as new antifungal candidates.

5mgEA96 Samples100100 assays1000 assays25 assays250.5 mg

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#34118680   2021/06/01 To Up

Nanoplastics adsorption and removal efficiency by granular activated carbon used in drinking water treatment process.

In this study Granular Activated Carbon (GAC) used in drinking water treatment processes is evaluated for its capacity to adsorb and remove polystyrene (PS) nanoplastics. Batch experiments are conducted in ultrapure and surface water from Lake Geneva, currently used as drinking water resources. Equilibrium and kinetic studies are conducted to understand adsorption mechanisms and limiting factors. Our results show that in ultrapure water the adsorption and removal of PS nanoplastics are mainly due to electrostatic interactions between the positively charged nanoplastics and negatively charged GAC. It is found that the adsorption capacity increases with nanoplastic concentration with a maximum adsorption capacity of 2.20 mg/g. The adsorption kinetics follows a pseudo-second-order model and indicates that the intra-particle diffusion is not the only rate-controlling step. The Langmuir isotherm indicates that nanoplastics are adsorbed as a homogeneous monolayer onto the GAC surface with a maximum monolayer adsorption capacity of 2.15 mg/g in agreement with the experimental value. In Lake Geneva water the adsorption capacity and removal efficiency of PS nanoplastics are found three times higher than in ultrapure water and increase significantly with increasing PS nanoplastics concentration with a maximum adsorption capacity of 6.33 mg/g. This improvement in adsorption capacity is due to the presence of Dissolved Organic Matter (DOM), resulting in PS surface charge modification, presence of divalent ions making possible the adsorption of PS-DOM complexes, and, aggregation of PS nanoplastics. The kinetic pseudo-second-order and intra-particle diffusion provide a good correlation with the experimental data. In contrast, neither Langmuir nor Freundlich isotherms describe in a satisfactory way the adsorption of nanoplastics by GAC. This study reveals that GAC produced from renewable sources can be considered as a moderate adsorbent for the removal of PS nanoplastics in water treatment plants and that the presence of DOM and cationic species play a major role.
Lina Ramirez Arenas, Stéphan Ramseier Gentile, Stéphane Zimmermann, Serge Stoll

2880 related Products with: Nanoplastics adsorption and removal efficiency by granular activated carbon used in drinking water treatment process.

50μl5 mg0.1mg 25 G5mg100 μg100ul100 μg

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#34118674   2021/06/06 To Up

Trophic interactions of reef-associated predatory fishes (Hexagrammos otakii and Sebastes schlegelii) in natural and artificial reefs along the coast of North Yellow Sea, China.

Large reef-associated predatory fishes play important roles in aquatic ecosystem along coast because of their ecological functions and economic values to recreational and commercial fisheries. This study was carried out to assess the function of artificial reefs as alternative habitats for two common reef-associated predatory fishes in the north of Yellow Sea, China, Fat Greenling Hexagrammos otakii and Korean rockfish Sebastes schlegelii. According to the catch per unit effort (CPUE), the biomass of predatory fishes at the artificial reef was comparable (H. otakii) to or higher (S. schlegelii) than the natural reef, highlighting the environmental fitness of the artificial reef. Gut content analysis (GCA) showed that H. otakii preyed primarily on Decapod and Amphipoda, while S. schlegelii exhibited higher dependence on fish (Blinniidae and Gobiidae) and Decapod. Collectively, prey richness and diversity were greater at the natural reef relative to the artificial reef, and prey availability may be different between the two reef types. Stable isotopic analysis (SIA) in conjunction with the Bayesian mixing model (MixSIAR) revealed spatial and interspecific difference on the diet composition of H. otakii and S. schlegelii as well. Based on GCA and MixSIAR result, the habitat-specific effect on the prey availability was confirmed. Additionally, comparisons on trophic niche breadth and niche overlap indicated higher trophic diversity but relatively lower food resources partitioning degree for both species at the natural reef than at the artificial reef. Our results suggest that artificial reefs may harbor a different prey assemblage comparing to natural reef but can support large populations of predatory reef-associated fishes and accommodate their coexistence.
Rongliang Zhang, Hui Liu, Qianqian Zhang, Hua Zhang, Jianmin Zhao

1538 related Products with: Trophic interactions of reef-associated predatory fishes (Hexagrammos otakii and Sebastes schlegelii) in natural and artificial reefs along the coast of North Yellow Sea, China.

10 mg100ul200 200ug25 mg1000 tests100ug200ul100 mg10 mg100ug

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#34118669   2021/05/29 To Up

Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.

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Qingyin Li, Haisheng Lin, Shu Zhang, Xiangzhou Yuan, Mortaza Gholizadeh, Yi Wang, Jun Xiang, Song Hu, Xun Hu

2905 related Products with: Co-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products.

5 G1 Set1 Set25 mg1 Set1 Set1 Set1 Set500 Units1 Set1 Set

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