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#33091938   2020/10/22 To Up

Proposal of a Multivariable Prediction Model for Graded Morbidity after Liver Resection for Colorectal Metastases.

Prognostic models to predict individual early postoperative morbidity after liver resection for colorectal liver metastases (CLM) are not available but could enable optimized preoperative patient selection and postoperative surveillance for patients at greater risk of complications. The aim of this study was to establish a prognostic model for the prediction of morbidity after liver resection graded according to Dindo.
Mara Sneidere, Harald Heinrich Schrem, Jan Christoph Mahlmann, Oliver Beetz, Sebastian Cammann, Felix Oldhafer, Moritz Kleine, Juergen Klempnauer, Alexander Kaltenborn, Ulrich Zwirner, Ulf Kulik

1466 related Products with: Proposal of a Multivariable Prediction Model for Graded Morbidity after Liver Resection for Colorectal Metastases.

100 assays10 mg25 g100μg100Tests1.0 mg 100ul10 mg20 ug0.2 mg

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#33091928   2020/10/22 To Up

Accuracy of Intraoperative Frozen Section in Detection of Acute Invasive Fungal Rhinosinusitis.

Acute invasive fungal rhinosinusitis (AIFRS) is an aggressive form of fungal sinusitis, which remains a significant cause of morbidity and mortality. Early diagnosis and intervention are keys to improving patient outcomes. Intraoperative consultation has shown promise in facilitating early surgical intervention, but the accuracy of frozen section has not been clarified in this setting.
Rahaf Alkhateb, Preethi Dileep Menon, Hamza Tariq, Sarah Hackman, Alia Nazarullah, Daniel D Mais

1234 related Products with: Accuracy of Intraoperative Frozen Section in Detection of Acute Invasive Fungal Rhinosinusitis.

1ml

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#33091922   2020/10/22 To Up

Development of a bio-inkjet printed LAMP test kit for detecting human African trypanosomiasis.

Human African trypanosomiasis (HAT) is one of the neglected tropical diseases in sub-Saharan Africa. Early diagnosis and treatment prior to disease progression are crucial for the survival of HAT patients. We had previously established a loop-mediated isothermal amplification (LAMP) method for HAT diagnosis in which the reagents were dried for field-use purposes. In this study, we used a semi-automated process to produce the test tubes using a bio-inkjet printer to achieve an accurate production. The performance of the inkjet printer-produced dried LAMP test (CZC-LAMP) was found to be stable after storage for up to 180 days at 30 °C. The diagnostic accuracy of CZC-LAMP HAT was evaluated using DNA samples that were extracted from 116 Trypanosoma brucei gambiense patients and 66 T. b. rhodesiense patients. The sensitivity was 72% for T. b. gambiense (95%CI: 63%-80%) and 80% for T. b. rhodesiense (95%CI: 69%-89%). The specificity determined using DNA from 116 endemic control DNA samples was 95% (95%CI: 89%-98%). The performance of the CZC-LAMP HAT and CZC-LAMP rHAT were also evaluated using 14 crude blood lysate samples obtained from T. b. rhodesiense patients and endemic control samples collected from Rumphi District in Malawi. The sensitivity and specificity were both 100% (95%CI: 77%-100%). As the developed CZC-LAMP test does not require a cold chain or a sophisticated laboratory, it holds promise for use as a routine simple molecular tool for point-of-care HAT diagnosis in endemic areas.
Kyoko Hayashida, Peter Nambala, Nick Van Reet, Philippe Büscher, Naoko Kawai, Mable Mwale Mutengo, Janelisa Musaya, Boniface Namangala, Chihiro Sugimoto, Junya Yamagishi

1039 related Products with: Development of a bio-inkjet printed LAMP test kit for detecting human African trypanosomiasis.

96 tests100 TESTS50 TESTS100 TESTS25 Tests 100ul25 Tests25 Tests100 Tests25 Tests25 TESTS

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#33091911   2020/10/22 To Up

Prognostic Impact of the Pulmonary Artery Pulsatility Index in Patients with Chronic Heart Failure and Severe Mitral Regurgitation Undergoing Percutaneous Edge-to-Edge Repair.

Pulmonary artery (PA) pulsatility index (PAPi), calculated as (PA systolic pressure - PA diastolic pressure)/right atrial pressure, emerged as a novel predictor of right ventricular failure in patients with acute inferior myocardial infarction, advanced heart failure, and severe pulmonary hypertension. However, the prognostic utility of PAPi in transcatheter mitral valve repair (TMVR) using the MitraClip® system has never been tested.
Rico Osteresch, Kathrin Diehl, Johannes Schmucker, Azza Ben Ammar, Oana Solyom, Patrick Dierks, Andreas Fach, Harm Wienbergen, Rainer Hambrecht

2803 related Products with: Prognostic Impact of the Pulmonary Artery Pulsatility Index in Patients with Chronic Heart Failure and Severe Mitral Regurgitation Undergoing Percutaneous Edge-to-Edge Repair.

1.00 flask 50 UG1.00 flask

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#33091826   2020/10/13 To Up

Representation based on ordinal patterns for seizure detection in EEG signals.

EEG signals carry rich information about brain activity and play an important role in the diagnosis and recognition of epilepsy. Numerous algorithms using EEG signals to detect seizures have been developed in recent decades. However, most of them require well-designed features that highly depend on domain-specific knowledge and algorithm expertise. In this study, we introduce the unigram ordinal pattern (UniOP) and bigram ordinal pattern (BiOP) representations to capture the different underlying dynamics of time series, which only assumes that time series derived from different dynamics can be characterized by repeated ordinal patterns. Specifically, we first transform each subsequence in a time series into the corresponding ordinal pattern in terms of the ranking of values and consider the distribution of ordinal patterns of all subsequences as the UniOP representation. Furthermore, we consider the distribution of the cooccurrence of ordinal patterns as the BiOP representation to characterize the contextual information for each ordinal pattern. We then combine the proposed representations with the nearest neighbor algorithm to evaluate its effectiveness on three publicly available seizure datasets. The results on the Bonn EEG dataset demonstrate that this method provides more than 90% accuracy, sensitivity, and specificity in most cases and outperforms several state-of-the-art methods, which proves its ability to capture the key information of the underlying dynamics of EEG time series at healthy, seizure-free, and seizure states. The results on the second dataset are comparable with the state-of-the-art method, showing the good generalization ability of the proposed method. All performance metrics on the third dataset are approximately 89%, which demonstrates that the proposed representations are suitable for large-scale datasets.
Yunxiao Liu, Youfang Lin, Ziyu Jia, Yan Ma, Jing Wang

1277 related Products with: Representation based on ordinal patterns for seizure detection in EEG signals.

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#33091745   2020/10/10 To Up

Specificity of trait anxiety in anxiety and depression: Meta-analysis of the State-Trait Anxiety Inventory.

The State-Trait Anxiety Inventory - Trait version (STAI-T) was developed to measure an individual's tendency to experience anxiety, but it may lack discriminant evidence of validity based on strong observed relationships with measures of depression. The present series of meta-analyses compares STAI-T scores among individuals with depressive disorders, anxiety disorders, and nonclinical comparison groups, as well as correlations with measures of anxiety and depressive symptom severity, in order to further examine discriminant and convergent validity. A total of 388 published studies (N = 31,021) were included in the analyses. Individuals with an anxiety disorder and those with a depressive disorder displayed significantly elevated scores on the STAI-T compared to nonclinical comparison groups. Furthermore, anxiety and depressive symptom severity were similarly strongly correlated with the STAI-T (mean r = .59 - .61). However, individuals with a depressive disorder had significantly higher STAI-T scores than individuals with an anxiety disorder (Hedges's g = 0.27). Given these findings, along with previous factor analyses that have observed a depression factor on the STAI-T, describing the scale as a measure of 'trait anxiety' may be a misnomer. It is proposed that the STAI-T be considered a non-specific measure of negative affectivity rather than trait anxiety per se.
Kelly A Knowles, Bunmi O Olatunji

1798 related Products with: Specificity of trait anxiety in anxiety and depression: Meta-analysis of the State-Trait Anxiety Inventory.

5 G1 15 ml

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#33091601   2020/10/19 To Up

Automated rhythm-based control of radiofrequency ablation close to the atrioventricular node: pre-clinical, animal and first-in-human testing.

Risk of heart block during radiofrequency ablation of AVNRT and septal accessory pathways is minimized by rapidly ceasing ablation in response to markers of risk, such as atrio-ventricular dissociation, fast junctional rhythm, PR interval prolongation, or two consecutive atrial or ventricular depolarisations. Currently this is done manually.
Darren A Hooks, Remi Dubois, Valentine Meillet, John Nicot, Benjamin Berte, Seigo Yamashita, Saagar Mahida, Jean-Marc Sellal, Antonio Frontera, Arnaud Denis, Frederic Sacher, Nicolas Derval, Ian Crozier, Iain Melton, Michel Haissaguerre, Pierre Jais

2612 related Products with: Automated rhythm-based control of radiofrequency ablation close to the atrioventricular node: pre-clinical, animal and first-in-human testing.

1ml1mg1mg100 μg100 1mg1mg

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#33091531   2020/10/19 To Up

Perdurable PD-1 blockage awakes anti-tumor immunity suppressed by precise chemotherapy.

The application of nanocarriers as drug delivery system for chemotherapeutic drugs has become a research hotspot in cancer treatment. Chemotherapy with high tumor-targeting accuracy and drug release specificity is the key to improve the efficacy of tumor chemotherapy and reduce the side effects caused by repeated doses drugs. Here, we synthesized a redox-sensitive nano-micelle formed by hyaluronic acid (HA) conjugated with d-α-tocopherol succinate (TOS) using a disulfide bond as the linker (HA-SS-TOS, HSST), which could actively accumulate to the tumor sites and metastasis cancer cells with high expression of CD44. The micelles could dissociate under the high GSH level in cancer cells, triggering a release of paclitaxel (PTX). Surprisingly, the precise chemotherapy instead induced a suppressive tendency of immune system, manifested by a significant increase in TGF-β, which weakened the therapeutic effect of micelles. Moreover, the high levels of TGF-β might be related to the increased drug-resistance of cancer cells. Research has shown that PD-1 pathway blockade can result in reduction in TGF-β expression, thus, a PLGA microsphere encapsulating PD-1 antagonist peptides A12 ([email protected]) was further prepared to activate the host immune response. Our data indicated that PTX-loaded HSST could accurately "find" the tumors as well as metastasis cancer cells, and efficiently kill most of them. The joining of a durable PD-1 blockage significantly boosted the efficacy of [email protected] on multiple tumor models, including lung metastatic tumors and even multidrug-resistant tumors. Thus, our work presented an optimal chemo-immunotherapy combined system, which shows profound significance for future cancer therapy in clinic.
Mengshi Jiang, Wei Li, Chunqi Zhu, Xiang Li, Junlei Zhang, Zhenyu Luo, Bing Qin, Yongzhong Du, Lihua Luo, Jian You

1173 related Products with: Perdurable PD-1 blockage awakes anti-tumor immunity suppressed by precise chemotherapy.

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#33091515   2020/10/19 To Up

Dynamic Carotid Plaque Imaging Using Ultrasound.

Dynamic image analysis of carotid plaques has demonstrated that during systole and early diastole all plaque components move in the same direction (concordant motion) in some plaques, while in others, different parts of the plaque move in different directions (discordant motion). The aim of our study was (a) to determine the prevalence of discordant motion in symptomatic and asymptomatic plaques, (b) to develop a measurement of the severity of discordant motion and (c) to determine the correlation between the severity of discordant motion and prevalence of symptoms.
Argyrios A Giannopoulos, Efthyvoulos Kyriacou, Maura Griffin, Constantinos S Pattichis, Joanna Michael, Toby Richards, George Geroulakos, Andrew N Nicolaides

1696 related Products with: Dynamic Carotid Plaque Imaging Using Ultrasound.

1 kit(s) 96 tests1 kit10 ug1 kit96 tests1 mg96 tests 70 Slides 96 tests

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