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#36183236   2022/10/02 To Up

Longitudinal development of well-being among Finnish employees during 2019-2021: Relationships with personality trait profiles.

We examined well-being profiles among Finnish employees before and during the COVID-19 pandemic and their links with personality trait profiles. Longitudinal survey data were collected in 2019-2021, and 733 respondents participated in all five surveys. The data were analyzed with a person-centered approach using latent profile analysis (LPA). Measures included burnout, work engagement, psychological distress; and Big Five personality traits. Six well-being profiles: Disengaged, Declined, Engaged, Fluctuated, Stable, and Burned-out, and four personality profiles: Ordinary, Reserved, Resilient, and Overcontrolled were identified. Resilient participants typically belonged to the Engaged well-being profile and Reserved to Burned-out and Fluctuated well-being profiles. Although some separation in developmental well-being profiles existed, overall, well-being was rather stable. Personality trait profiles played a crucial role in maintaining well-being.
Reetta Oksa, Anne Mäkikangas, Nina Savela, Rita Latikka, Atte Oksanen

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#36183192   2022/10/02 To Up

A candidate multi-epitope vaccine against Lumpy Skin Disease.

Lumpy skin disease (LSD) is a fulminant infectious disease that mostly affects cattle and causes considerable economic loss throughout the globe. This study was conducted to develop a new multi-epitope-based vaccine against LSD that can elicit immunological responses using an in silico reverse vaccinology approach. Initially, three antigenic proteins, protein E5, E3 ubiquitin-protein ligase LAP, and 62 kDa protein, were manipulated to recognize potential T-cell and B-cell epitopes. To identify superior epitopes, a variety of bioinformatic techniques including antigenicity testing, transmembrane topology screening, allergenicity assessment, conservancy analysis, and toxicity evaluation were used. Finally, three new subunit vaccines were developed employing the most effective epitopes, suitable adjuvants, pan HLA DR-binding epitope (PADRE), and linkers. Furthermore, based on the validation score of the 3D structures of the initially constructed vaccines, one of the best vaccine candidates (V2) was chosen for revealing the superiority of the vaccine. The results of the molecular dynamic simulation and disulfide engineering indicated that the vaccine was stable. Additionally, the immunological simulation findings supported the vaccine candidate's ability to trigger humoral and cellular immune responses. Further validation of the proposed vaccine candidate may necessitate additional in vitro and in vivo investigations. This article is protected by copyright. All rights reserved.
Md Bashir Uddin, Fatema Yeasmin Tanni, Syeda Farjana Hoque, Emran Hossain Sajib, Md Atik Faysal, Md Anisur Rahman, Asaduzzaman Galib, Ahsan Al Emon, Md Mukter Hossain, Mahmudul Hasan, Syed Sayeem Uddin Ahmed

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