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Effects of Melatonin and Flavonoid-Rich Fractions of on the Alteration of Proinflammatory Cytokines and Nitric Oxide Induced by Aflatoxin B1 in the Gastric Mucosa of Wistar Rats.

In this study, we investigated serum interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) after ingestion of aflatoxin B1 (AFB1) in rats. We also studied the effects of nitric oxide (NO) on the stomach after consumption of AFB1. Therefore, we hypothesized that a standard anti-inflammatory agent-melatonin (MEL), and the flavonoid-rich fractions from (FRFC) could counteract the deleterious effects of IL-1β, TNF-α, and NO after consumption of AFB1. Thirty-five Wistar rats (211.86 ± 27.23 g) were randomly selected into 5 groups, with 7 rats in each group. Group A (control); all rats in groups B, C, D, and E received 2.5 mg/kg AFB1 each orally on day 5, whereas those of groups C, D, and E received oral administration of 10 mg/kg MEL, 50 mg/kg FRFC, and 100 mg/kg FRFC, respectively, for 7 days. All of them were killed on the 8th day, 24 h after last treatment. Serum samples were analyzed for IL-1β and TNF-α, whereas stomach tissue was evaluated for NO level. Significant ( < 0.5) increase in serum IL-1β and TNF-α in rats given AFB1 only was recorded when compared with those in the control group. Conversely, we observed significant reduction in serum IL-1β and TNF-α in all the groups that received MEL, FRFC, and FRFC after pretreatment with AFB1 when compared with those that were given AFB1 only. In addition, there was a significant increase in NO in rats given AFB1 only when compared with control, whereas reduction in NO was significant in the groups C, D, and E that were given MEL, FRFC, and FRFC, respectively, when compared with AFB1 group. MEL and FRFC may be responsible for the prevention of increased gastric mucosal NO and inflammatory effects of proinflammatory cytokines induced by AFB1.

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Ofloxacin CAS Number [824 FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu Rat inducible nitric oxid Multiple organ tumor tiss MultiGene Gradient therm FDA Standard Frozen Tissu Thermal Shaker with cooli Rabbit Anti-Nitric Oxide FDA Standard Frozen Tissu FDA Standard Frozen Tissu

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Dangerous Liaison: Helicobacter pylori, Ganglionitis, and Myenteric Gastric Neurons: A Histopathological Study.

Chronic inflammation induced by () infection plays a major role in development of gastric cancer. However, recent findings suggested that progression of inflammation and neoplastic transformation in infection are more complex than previously believed and could involve different factors that modulate gastric microenvironment and influence host-pathogen interaction. Among these factors, gastric myenteric plexus and its potential adaptive changes in H. pylori infection received little attention. This study is aimed at identifying the impact of -associated gastritis on number and morphology of nerve cells in the stomach. The distribution of density, inflammation, and programmed cell death in neurons was immunohistochemically assessed in full-thickness archival tissue samples obtained from 40 patients with infection who underwent surgery for gastric cancer and were compared with findings on samples collected from 40 age- and sex-matched subjects without bacteria. Overall, significant differences were noted between -positive and -negative patients. The analysis of tissue specimens obtained from those with infection revealed higher density and larger surface of the myenteric nervous plexus, as well as a significant increase in the number of gastric neuronal cell bodies and glial cells compared to controls. A predominant CD3-immunoreactive T cell infiltrate confined to the myenteric plexus was observed in infected subjects. The presence of mature B lymphocytes, plasma cells, and eosinophils was also noted, but to a lesser extent, within the ganglia. Myenteric ganglionitis was associated with degeneration and neuronal loss. Our results represent the first histopathological evidence supporting the hypothesis that -induced gastric inflammation may induce morphological changes in myenteric gastric ganglia. These findings could help gain understanding of some still unclear aspects of pathogenesis of infection, with the possibility of having broader implications for gastric cancer progression.

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Helicobacter pylori antib Helicobacter pylori antib Human Helicobacter pylori Androgen Receptor (Ab-650 5α-N-Acetyl-2'H-androst- Androgen Receptor , Mouse 3β-O-Acetyl-androsta-5,1 5α-Androstan-3β-ol � Androgen Receptor (Phosph Androstane 3a, 17b diol 5 Helicobacter Pylori (H. P 19 Hydroxy 4 androstene 3

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: A Systematic Review of Evidence-Based Data in support of Its Medicinal Relevance.

() is a plant commonly known as ginger lily, spiral ginger, or bush cane. It is reportedly used in traditional medicine practice (TMP) to treat and manage many ailments including diabetes mellitus, stomach ache, arthritis, inflammation, and gout. These purported ethnomedicinal uses have triggered many research studies on the plant to amass scientific evidence. However, these research reports are scattered, and thus, this systematic review seeks to provide a comprehensive update on it covering its traditional uses, phytochemical and nutritional constituents, pharmacological activities, and toxicological effects. An online search was done using search engines such as Google Scholar, PubMed, and ScienceDirect from the period 1970 to 2019. The online search included the use of keywords, " Ker-Gawl" or "." The search revealed that the stem and leaves of the plant contain substantial amounts of micronutrients and macronutrients. The leaves, stem, rhizomes, and roots of contain several steroidal sapogenins, aferosides, dioscin, and paryphyllin C and flavonoid glycoside kaempferol-3-O--L-rhamnopyranoside. Experimental studies on various parts of the plant showed bioactivities such as antihyperglycemic, hepatocellular protection, cardioprotection, nephroprotection, testicular protection, CNS depressant, analgesic, antiarthritis, antibacterial, and antioxidant. Based on these evident data, it is concluded that the plant could be used as an alternative and complementary therapy for many oxidative stress-related diseases, provided further scientific studies on the toxicological and pharmacological aspects are carried out.

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Advanced module Infinicyt High density larynx and p High density breast invas Small intestine disease s Prostate cancer, PIN (pro Goat Anti-Human TXNDC4, ( CCNB1 & PLK1 Protein Prot Anti AGO2 Human, Monoclon Cytoskeleton II Phospho-S PTK2 & RET Protein Protei Colon cancer tissue array Mouse Interleukin Array

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Endoscopic Ultrasound in Guiding Local Resection and Ampullary Preservation of a High-Risk Periampullary GIST.

Gastrointestinal stromal tumors (GISTs) typically develop in the stomach or small intestine and rarely involve the ampulla of Vater, with only 13 cases reported in the world literature since 2004. Most authors advocate performing pancreaticoduodenectomy for such lesions. However, this operation can carry higher rates of morbidity and mortality compared to local resection. We present a case of a high-risk, invasive periampullary GIST and the multidisciplinary management approach to local resection with the aid of endoscopic ultrasound. In addition, this case shows no local recurrence at 3 months and a favorable clinical outcome at 1 year.

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Stomach cancer high densi High density (188 cases 2 Colon cancer high density High density liver cancer High density stomach canc High density pancreatic c High density non small ce High density colon cancer High density cervical can High density multiple org High density ovarian canc High density breast cance

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Descriptive analysis of prevalence and medical expenses of cancer, cardio-cerebrovascular disease, psychiatric disease, and musculoskeletal disease in Korean firefighters.

Firefighters are exposed to many dangerous working conditions. Many studies have identified the risk of disease for firefighters, but only a few studies have addressed the medical expenses of firefighters, which represents a concrete scale of disease. Our purpose in this study was to determine the medical expenditures of firefighters to assess the overall scale of disease in Korea. We focused on cancer, mental disorders, cardio-cerebrovascular disease, and musculoskeletal disease, the prevalence of which was expected to be high in firefighters.

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Breast disease spectrum t Ovary disease spectrum (o Small intestine disease s Kidney disease spectrum ( Colon disease spectrum (c Ovarian disease spectrum Small intestine disease ( Male genitourinary system Tissue array of uterine c Rectum disease spectrum ( Brain disease spectrum (b Pancreatic disease spectr

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Esophageal Ulcer Due to Ectopic Pancreatic Tissue: A Case Report.

Heterotopic pancreatic tissue, known as pancreatic rest, is a pancreatic tissue that lacks anatomic and vascular continuity with the main body of the pancreas. Common locations for this tissue include the stomach, duodenum, jejunum, Meckel diverticulum, and ileum. In this report, we present a case of a patient whose pancreatic rest was diagnosed primarily during the investigation of dysphagia with solid foods and it was located in the mid esophagus as an unusual location.

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Esophageal tumor tissue a Oral cavity (tongue and p Mid advanced stage pancre Esophageal cancer and adj Multiple pancreatic cance Esophageal inflammation, Esophageal cancer tissue Pancreatic cancer and nor Tonsil disease spectrum ( High density esophageal c Multiple pancreatic cance High density pancreatic c

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PUMA-mediated epithelial cell apoptosis promotes Helicobacter pylori infection-mediated gastritis.

The molecular mechanism responsible for Helicobacter pylori infection-mediated gastritis and carcinogenesis is not yet clear. Increased evidence suggests that chronic gastritis and elevated gastric epithelial cell (GEC) apoptosis are crucial events during stomach carcinoma transformation. PUMA is a potent proapoptotic Bcl-2 protein and mediates acute tissue injury. In this study, we aimed to investigate the role of PUMA in GEC apoptosis and inflammation induced by H. pylori infection. As a result, we found that PUMA expression was elevated in gastritis tissues compared with uninvolved tissues, and it was correlated with the severity of apoptosis and gastritis. In mice, PUMA mRNA and protein were markedly induced in GECs upon induction of gastritis by H. pylori. PUMA-deficient mice were highly resistant to apoptosis and gastritis induced by H. pylori. Furthermore, the transcription factor NF-κB p65 binds to PUMA promoter to activate PUMA transcription after H. pylori infection. In addition, NF-κB inhibitor could rescue H. pylori-induced apoptosis and gastritis. Finally, H. pylori-induced activation of p-p65 and PUMA was mediated via Toll-like receptor 2 (TLR2) and blocked in TLR2 knockout mice. Taken together, these results verified the pro-inflammatory effect of PUMA in H. pylori-infected gastric tissue. Moreover, TLR2/NF-κB-mediated transcriptional regulation of PUMA contributes to the pathogenesis of H. pylori-infected gastritis.

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Infection diseases: Heli Infection diseases: Heli Cell Meter™ Phosphatidy Cell Meter™ Caspase 8 A Human Helicobacter pylori Cell Meter™ Annexin V B Cell Meter™ Caspase 3 7 Cell Meter™ Caspase 9 A Cell Meter™ Annexin V B Mouse Anti-Human Fibrobla Cell Meter™ Phosphatidy TUNEL Apoptosis Detection

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Successful combination of endoscopic and laparoscopic removal of multiple ingested needles: A case report.

Foreign body (FB) ingestion is a relatively common clinical situation in the emergency department. However, multiple sharply pointed foreign bodies located in different organs are rare conditions and no definite treatment guidelines has been established.

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Multiple organ, diseased Multiple organ cancer and Multiple organ diseased t FDA standard normal rat m Multiple types of cancer Esophagus squamous cell c High density, multiple co Multiple organ gastrointe High density (69 cases 20 Rectum carcinoma (combina Multiple cervix cancer te Multiple head and neck tu

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Addition of an Alginate Hydrogel to a Carbohydrate Beverage Enhances Gastric Emptying.

To examine the effect of altering osmolality or adding sodium alginate and pectin to a concentrated carbohydrate (CHO) beverage on gastric emptying (GE) rate.

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Low-cost bio-based sustainable removal of lead and cadmium using a polyphenolic bioactive Indian curry leaf (Murraya koengii) powder.

There is an increasing trend of developing various low-cost biogenic sorbents for the efficient and economical removal of noxious metals . Curry leaf powder (CLP), a promising non-toxic biosorbent containing several bioactive compounds was prepared by the pulverization of the dried leaves for the effective removal of Lead (Pb) and Cadmium (Cd). Various batch sorption experiments were carried out under constant temperature (25 °C), different pH (4.5-10.5), initial concentrations (50-200 mg L), adsorbent dosages (0.10-0.40 g) and contact times (0-60 min) to understand the optimum experimental conditions and simultaneously evaluate the adsorption isotherms and removal kinetics of CLP. Adsorption equilibrium was established in less than an hour interval (50 min). The pseudo-equilibrium process was best described by the pseudo-second-order kinetic (R ≥ 0.99), Freundlich and Langmuir isotherm model (R ≥ 0.94). The removal rate of Pb and Cd gradually increased (15.7 and 12.7 mg g for Pb and Cd) at 100 mg L of initial concentration till 60 min of contact period in a single contaminant system, the effect was non-significant for multiple adsorbent dosage systems (p > 0.05; t-test) though. The regeneration potential of the exhausted biosorbent was excellent upto 5 cycles with the better efficiency observed for Pb. The obtained results explicitly validated the probable utilization of CLP as a promising green adsorbent for metal removal . Future study may highlight the decontamination aspects of emerging contaminants with such green bio sorbents in large scale as well as mimicing the stomach conditions.

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Cal-520™ Medium Removal Mouse serum albumin lyoph Androgen Receptor (Ab-650 (5α,16β)-N-Acetyl-16-[2 Canine serum albumin lyop Androgen Receptor Ab-1 An (5α)-Androst-2-en-17-one AZD-3514 Mechanisms: Andr 1,4 Androstadiene 3,17 di ELISA 5α-Androstane-3α, Fatty acid free heat sho Goat Anti-Human Androgen

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