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#36485001   2022/12/09 To Up

Tumor-Infiltrating Lymphocyte Therapy in Melanoma: Facts to the Future.

Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) is gaining momentum and demonstrating durable responses in patients with advanced melanoma. Although increasingly considered as a treatment option for select patients with melanoma, TIL therapy is not yet approved by any regulatory agency. Pioneering studies with first-generation TIL therapy, undertaken before the advent of modern melanoma therapeutics, demonstrated clinical efficacy and remarkable long-term overall survival, reaching beyond 20 months for responding patients. TIL therapy is a multi-step process of harvesting patient-specific tumor-resident T cells from tumors, ex vivo T-cell expansion, and re-infusion into the same patient after a lymphodepleting preparative regimen, with subsequent supportive interleukin-2 administration. Objective response rates between 30% and 50% have consistently been observed in heavily pretreated metastatic melanoma patients, including those who have progressed after modern immune checkpoint inhibitors and BRAF targeted agents, a population with high unmet medical need. Although significant strides have been made in modern TIL therapeutics, refinement strategies to optimize patient selection, enhance TIL production, and improve efficacy are being explored. Here, we review past and present experience, current challenges, practical considerations, and future aspirations in the evolution of TIL therapy for the treatment of melanoma as well as other solid tumors.
Allison Betof Warner, Pippa G Corrie, Omid Hamid

1127 related Products with: Tumor-Infiltrating Lymphocyte Therapy in Melanoma: Facts to the Future.

10 1 mg100 mg

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#36484963   2022/12/09 To Up

A Pilot Study on the Effect of Peer Support on Quality of Life of Adolescents with Autism Spectrum Disorder and Gender Dysphoria.

Gender dysphoria (GD) and Autism Spectrum Disorder (ASD) co-occur relatively often, but there is no evidence-based treatment for this specific group. Therefore, we examined the effects of a group intervention for adolescents with ASD and GD in a pilot study with a pre-post-test design. The adolescents completed questionnaires on quality of life, self-esteem, gender dysphoric feelings, and social responsiveness. Results show that participating in this peer support group seems to increase aspects of quality of life, i.e., increased parent-reported psychological well-being and decreased psychological complaints. Even though more research is needed, these results indicate that peer support is an invaluable part of treatment for adolescents with ASD and GD.
T Brandsma, K Visser, J J G Volk, A Balleur van Rijn, L P Dekker

1600 related Products with: A Pilot Study on the Effect of Peer Support on Quality of Life of Adolescents with Autism Spectrum Disorder and Gender Dysphoria.

0.2 mg100.00 ug2.5 mg100ug0.2 mg100.00 ug 100ul 5 G1 mg100 mg

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#36484840   2022/12/09 To Up

Cedecea sulfonylureivorans sp. nov., a novel chlorimuron-ethyldegrading bacterium isolated from an herbicides-degrading consortium.

A Gram-stain-negative, motile, rod-shaped bacterium, designated strain LAM2020, was isolated from a sulfonylurea herbicides-degrading bacterial consortium. The optimal temperature and pH for the growth of strain LAM2020 were 30 °C and 7.0, respectively. Strain LAM2020 formed a distinct phylogenetic subclade within the genus Cedecea in the phylogenetic trees built with 16S rRNA gene sequences and shared the highest similarity with Cedecea davisae DSM 4568 (98.4%). The values of digital DNA-DNA hybridization and average nucleotide identity (ANI) based on the genome sequences between LAM2020 and C. davisae DSM 4568 were 22.7% and 80.0%, respectively. It contained 54.0 mol% of G + C in the genomic DNA. The major cellular fatty acids of strain LAM2020 were summed feature 3 (C ω6c and/or C ω7c), C and summed feature 8 (C ω7c/C ω6c). The major polar lipids present in strain LAM2020 were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine and aminophospholipid. The respiratory quinone of strain LAM2020 was ubiquinone-8 and ubiquinone-7. Based on the phenotypic characteristics, chemotaxonomic data and genotypic analyses, strain LAM2020 should be classified as a novel species of genus Cedecea, for which the name Cedecea sulfonylureivorans sp. nov. is proposed. The type strain is LAM2020 (= GDMCC 1.2363 = JCM 34640).
Qingqing Li, Jie Wang, Qingyun Ma, Xiaoyan Han, Wei Zhang, Zhiyong Ruan

1730 related Products with: Cedecea sulfonylureivorans sp. nov., a novel chlorimuron-ethyldegrading bacterium isolated from an herbicides-degrading consortium.

50 ul100 ug100 ul100 ul50 ul0.25 mg50ul100ug100.00 ug100ug1.00 mg1 Set

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#36484822   2022/12/09 To Up

Possible transfer of lncRNA H19-derived miRNA miR-675-3p to adjacent H19-non-expressing trophoblast cells in near-term mouse placenta.

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Banyar Than Naing, Takami Takizawa, Takanobu Sakurai, Chaw Kyi-Tha-Thu, Toshihiro Takizawa

2991 related Products with: Possible transfer of lncRNA H19-derived miRNA miR-675-3p to adjacent H19-non-expressing trophoblast cells in near-term mouse placenta.

100 μg1.00 flask100 μg2 ml96 wells (1 kit)0.2 mg100 μg1.00 flask100 μg100 μg100 μg

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#36484803   2022/12/09 To Up

Pharmacokinetics and bioequivalence evaluation of 2 oral formulations of methotrexate tablets in healthy Chinese volunteers under fasting and fed conditions.

Methotrexate is an anti-metabolite drug that is frequently used for rheumatoid arthritis treatment. This study is aimed at evaluating the bioequivalence of 2 methotrexate tablets (2.5 mg) under fasting and fed conditions in healthy Chinese volunteers. A single-center, randomized, open-label, two-drug, two-period, crossover, single-dose trial protocol was designed. Fifty-two healthy Chinese participants were enrolled and randomly classified into fasting (n = 26) and fed (n = 26) group. Fifty of them participated in the whole trial course. Blood samples for pharmacokinetic (PK) analysis were collected 1 h before and up to 24 h after drug administration. To evaluate the bioequivalence of test and reference tablets, PK parameters including maximum plasma drug concentration (C), time to reach maximum concentration (T), area under the plasma concentration-time curve from time 0 to the last measurable concentration (AUC), and area under the plasma concentration-time curve from time 0 to infinity (AUC) were calculated. Our data revealed that 90% CIs of geometric mean ratio of the test or reference drugs for C, AUC, and AUC fell within the acceptance range for bioequivalence (80-125%). Besides, it is worthwhile to mention that C and T in the fed group were lower than those in the fasting group. Interestingly, the absorption, measured by AUC, did not have significant difference in both groups. There were no suspected serious adverse reactions or serious adverse events over the entire trial. Our results demonstrated that the test and reference tablets were bioequivalent under fasting and fed conditions.
Xu Zuo, Xin Zhao, Tiandong Zhang

2244 related Products with: Pharmacokinetics and bioequivalence evaluation of 2 oral formulations of methotrexate tablets in healthy Chinese volunteers under fasting and fed conditions.

200ul10 mg200ul200ug200ug10mg1000 tests1mg100 mg25 mg100ug

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#36484779   2022/12/09 To Up

VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis.

Leptomeningeal metastasis is associated with dismal prognosis and has few treatment options. However, very little is known about the immune response to leptomeningeal metastasis. Here, by establishing an immunocompetent mouse model of breast cancer leptomeningeal metastasis, we found that tumor-specific CD8 T cells were generated in deep cervical lymph nodes (dCLNs) and played an important role in controlling leptomeningeal metastasis. Mechanistically, T cells in dCLNs displayed a senescence phenotype and their recruitment was impaired in mice bearing cancer cells that preferentially colonized in leptomeningeal space. Upregulation of p53 suppressed the transcription of VLA-4 in senescent dCLN T cells and consequently inhibited their migration to the leptomeningeal compartment. Clinically, CD8 T cells from cerebrospinal fluid of patients with leptomeningeal metastasis exhibited senescence and VLA-4 downregulation. Collectively, our findings demonstrated that CD8 T cell immunosenescence drives leptomeningeal metastasis.
Jiaqian Li, Di Huang, Bingxi Lei, Jingying Huang, Linbing Yang, Man Nie, Shicheng Su, Qiyi Zhao, Ying Wang

1744 related Products with: VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis.

100 mg2.5 mg10 mg 500 G100 mg 5 G48001 mg (4000 assays)100 25 G 25 G100ug

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#36484774   2022/11/23 To Up

Scientific Advances and Technical Innovations in Musculoskeletal Radiology.

Decades of technical innovations have propelled musculoskeletal radiology through an astonishing evolution. New artificial intelligence and deep learning methods capitalize on many past innovations in magnetic resonance imaging (MRI) to reach unprecedented speed, image quality, and new contrasts. Similarly exciting developments in computed tomography (CT) include clinically applicable molecular specificity and substantially improved spatial resolution of musculoskeletal structures and diseases. This special issue of Investigative Radiology comprises a collection of expert summaries and reviews on the most impactful innovations and cutting-edge topics in musculoskeletal radiology, including radiomics and deep learning methods for musculoskeletal disease detection, high-resolution MR neurography, deep learning-driven ultra-fast musculoskeletal MRI, MRI-based synthetic CT, quantitative MRI, modern low-field MRI, 7.0 T MRI, dual-energy CT, cone beam CT, kinematic CT, and synthetic contrast generation in musculoskeletal MRI.
Jan Fritz, Val M Runge

1538 related Products with: Scientific Advances and Technical Innovations in Musculoskeletal Radiology.

100 μg10 5mg100 μg5 mg100μg100ug100ug Lyophilized50 ml 100ul1 Set

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#36484760   2022/12/09 To Up

Comparing Equilibrium Concentrations of PCBs based on Passive Sampling and Bioaccumulation in Water Column Deployments.

Biomonitoring at contaminated sites undergoing clean-up, including Superfund sites, often use bioaccumulation of anthropogenic contaminants by field-deployed organisms as a metric of remedial effectiveness. Bioaccumulation studies are unable to assess the equilibrium status of the organisms relative to the contaminants to which they are exposed. Establishing equilibrium provides a reproducible benchmark upon which scientific and management decisions can be based (e.g., comparison to human dietary consumption criteria). Unlike bioaccumulating organisms, passive samplers can be assessed for their equilibrium status. In this investigation, over a three-year period, we compared the bioaccumulation of selected polychlorinated biphenyls (PCBs) by mussels in water column deployments at the New Bedford Harbor Superfund site (New Bedford, MA, USA) to co-deployed passive samplers. Based on comparisons to the calculated passive sampler equilibrium concentrations, the mussels were not at equilibrium, and the subsequent analysis focused on evaluating approaches for estimating equilibrium bioaccumulation. In addition, a limited evaluation of metal bioaccumulation by the exposed mussels and a metal passive sampler was performed. In general, mussel and passive sampler accumulation of PCBs was significantly correlated; however, surprisingly, agreement on the magnitude of accumulation was optimal when bioaccumulation and passive sampler uptake were not corrected for non-equilibrium conditions. A subsequent comparison of four approaches for estimating equilibrium mussel bioaccumulation using octanol-water and triolein-water partition coefficients (K and K , respectively), and two types of polymer-lipid partition coefficients demonstrated field deployed mussels were not at equilibrium with many PCBs. A range of estimated equilibrium mussel bioaccumulation concentrations were calculated with the magnitude of the K -based values the smallest and polymer-lipid partition coefficient-based values the largest. These analyses are intended to assist environmental scientists and managers to interpret field deployment data when transitioning from biomonitoring to passive sampling. This article is protected by copyright. All rights reserved. Environ Toxicol Chem 2022;00:0-0. © 2022 SETAC.
Robert M Burgess, Mark G Cantwell, Zhao Dong, James S Grundy, Abigail S Joyce

1536 related Products with: Comparing Equilibrium Concentrations of PCBs based on Passive Sampling and Bioaccumulation in Water Column Deployments.

100ug50μl100 μg20 100 μg10mg100 μg10 Two 96-Well Microplate Ki

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