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#38035406 2023/11/25 To Up
Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression.Sleep deprivation (SD) weakens the immune system and leads to increased susceptibility to infectious or inflammatory diseases. However, it is still unclear how SD affects humoral immunity. In the present study, sleep disturbance was conducted using an sleep deprivation instrument, and the bacterial endotoxin lipopolysaccharide (LPS) was used to activate the immune response. It was found that SD-pretreatment reduced LPS-induced IgG2b B cells and IgG2b isotype antibody production in lymphocytes of spleen. And, SD-pretreatment decreased the proportion of CD4T cells, production of CD4T cells derived TGF-β1 and its contribution in helping IgG2b production. Additionally, BMAL1 and CLOCK were selectively up-regulated in lymphocytes after SD. Importantly, BMAL1 and CLOCK deficiency contributed to TGF-β1 expression and production of IgG2b B cells. Thus, our results provide a novel insight to explain the involvement of BMAL1 and CLOCK under SD stress condition, and their roles in inhibiting TGF-β1 expression and contributing to reduction of LPS induced IgG2b production.
Chen Xing, Bing Zhai, Yifan Zhang, Ying Fang, Min Zhang, Chongchong Zhang, Wei Wang, Mengnan Ding, Xin Huang, Beifen Shen, Renxi Wang, Lun Song
1002 related Products with: Sleep deprivation reduced LPS-induced IgG2b production by up-regulating BMAL1 and CLOCK expression.50ul (1mg/ml)1000 tests5 ml100ug250 ug100 ul5mg100ug400 ug
#38035365 2023/11/22 To Up
CSF 14-3-3β is associated with progressive cognitive decline in Alzheimer's disease.Alzheimer's disease is a neurodegenerative disorder characterized pathologically by amyloid-beta plaques, tau tangles and neuronal loss. In clinical practice, the 14-3-3 isoform beta (β) is a biomarker that aids in the diagnosis of sporadic Creutzfeldt-Jakob disease. Recently, a proteomics study found increased CSF 14-3-3β levels in Alzheimer's disease patients, suggesting a potential link between CSF 14-3-3β and Alzheimer's disease. Our present study aimed to further investigate the role of CSF 14-3-3β in Alzheimer's disease by analysing the data of 719 participants with available CSF 14-3-3β measurements from the Alzheimer's Disease Neuroimaging Initiative. Higher CSF 14-3-3β levels were observed in the mild cognitive impairment group compared to the cognitively normal group, with the highest CSF 14-3-3β levels in the Alzheimer's disease dementia group. This study also found significant associations between CSF 14-3-3β levels and CSF biomarkers of p-tau, t-tau, pTau/Aβ42 ratios and GAP-43, as well as other Alzheimer's disease biomarkers such as Aβ-PET. An early increase in CSF 14-3-3β levels was observed prior to Aβ-PET-positive status, and CSF 14-3-3β levels continued to rise after crossing the Aβ-PET positivity threshold before reaching a plateau. The diagnostic accuracy of CSF 14-3-3β (area under the receiver operating characteristic curve = 0.819) was moderate compared to other established Alzheimer's disease biomarkers in distinguishing cognitively normal Aβ pathology-negative individuals from Alzheimer's disease Aβ pathology-positive individuals. Higher baseline CSF 14-3-3β levels were associated with accelerated cognitive decline, reduced hippocampus volumes and declining fluorodeoxyglucose-PET values over a 4-year follow-up period. Patients with mild cognitive impairment and high CSF 14-3-3β levels at baseline had a significantly increased risk [hazard ratio = 2.894 (1.599-5.238), < 0.001] of progression to Alzheimer's disease dementia during follow-up. These findings indicate that CSF 14-3-3β may be a potential biomarker for Alzheimer's disease and could provide a more comprehensive understanding of the underlying pathological changes of Alzheimer's disease, as well as aid in the diagnosis and monitoring of disease progression.
Qiang Qiang, Loren Skudder-Hill, Tomoko Toyota, Zhe Huang, Wenshi Wei, Hiroaki Adachi,
1083 related Products with: CSF 14-3-3β is associated with progressive cognitive decline in Alzheimer's disease.96 tests96 tests96 tests96 tests100ug Lyophilized0.1ml100100ug Lyophilized
#38035344 2023/11/15 To Up
Undernutrition-induced substance metabolism and energy production disorders affected the structure and function of the pituitary gland in a pregnant sheep model.Undernutrition spontaneously occurs in ewes during late gestation and the pituitary is an important hinge in the neurohumoral regulatory system. However, little is known about the effect of undernutrition on pituitary metabolism.
Shuai Liu, Huizhen Lu, Shengyong Mao, Zijun Zhang, Wen Zhu, Jianbo Cheng, Yanfeng Xue
2596 related Products with: Undernutrition-induced substance metabolism and energy production disorders affected the structure and function of the pituitary gland in a pregnant sheep model.11 ml500 mg25 mg
#38035337 2023/11/15 To Up
A new candidate epitope-based vaccine against PspA PhtD of : a computational experimental approach.Pneumococcus is an important respiratory pathogen that is associated with high rates of death in newborn children and the elderly. Given the disadvantages of current polysaccharide-based vaccines, the most promising alternative for developing improved vaccines may be to use protein antigens with different roles in pneumococcus virulence. PspA and PhtD, highly immunogenic surface proteins expressed by almost all pneumococcal strains, are capable of eliciting protective immunity against lethal infections.
Mona Shafaghi, Zohreh Bahadori, Seyed Mahmoud Barzi, Elnaz Afshari, Hamid Madanchi, Seyed Fazlollah Mousavi, Ali Akbar Shabani
1122 related Products with: A new candidate epitope-based vaccine against PspA PhtD of : a computational experimental approach.100tests1 mg0.5 mg100 ug/vial1 mg0.5 mg200ul0.5 mg100 µg200 0.5 mg
#38035334 2023/11/15 To Up
Extracellular vesicle storm during the course of Ebola virus infection in primates.Ebola virus (EBOV) is an RNA virus of the Filoviridae family that is responsible for outbreaks of hemorrhagic fevers in primates with a lethality rate as high as 90%. EBOV primarily targets host macrophages leading to cell activation and systemic cytokine storm, and fatal infection is associated with an inhibited interferon response, and lymphopenia. The EBOV surface glycoprotein (GP) has been shown to directly induce T cell depletion and can be secreted outside the virion via extracellular vesicles (EVs), though most studies are limited to epithelial cells and underlying mechanisms remain poorly elucidated.
Andrea Vucetic, Andrea Lafleur, Marceline Côté, Darwyn Kobasa, Mable Chan, Fernando Alvarez, Ciriaco Piccirillo, George Dong, Martin Olivier
1684 related Products with: Extracellular vesicle storm during the course of Ebola virus infection in primates.1 mL10 1 mg100 96 tests1 mg200 100 96 tests1mg50 25
#38035330 2023/11/14 To Up
Human HLA prolongs the host inflammatory response in serotype 2 infection compared to mouse H2 molecules.() is widely acknowledged as a significant zoonotic pathogen in Southeast Asia and China, which has led to a substantial number of fatalities in both swine and humans. Despite the prevalent use of mice as the primary animal model to study pathogenesis, the substantial differences in the major histocompatibility complex (MHC) between humans and mice underscore the ongoing exploration for a more suitable and effective animal model. In this study, humanized transgenic HLA-A11/DR1 genotypes mice were used to evaluate the differences between humanized HLA and murine H2 in infection. Following intravenous administration of suspensions, we investigated bacterial load, cytokine profiles, pathological alterations, and immune cell recruitment in both Wild-type (WT) and humanized mice across different post-infection time points. Relative to WT mice, humanized mice exhibited heightened pro-inflammatory cytokines, exacerbated tissue damage, increased granulocyte recruitment with impaired resolution, notably more pronounced during the late infection stage. Additionally, our examination of bacterial clearance rates suggests that HLA-A11/DR1 primarily influences cell recruitment and mitochondrial reactive oxygen species (ROS) production, which affects the bacterial killing capacity of macrophages in the late stage of infection. The reduced IL-10 production and lower levels of regulatory T cells in humanized mice could underlie their compromised resolution ability. Intervention with IL-10 promotes bacterial clearance and inflammatory regression in the late stages of infection in transgenic mice. Our findings underscore the heightened sensitivity of HLA-A11/DR1 mice with impaired resolution to infection, effectively mirroring the immune response seen in humans during infection. The humanized HLA-A11/DR1 mice could serve as an optimal animal model for investigating the pathogenic and therapeutic mechanisms associated with sepsis and other infectious diseases.
Chengpei Ni, Yi Han, Yajing Wang, Ting Ma, Dan Sha, Yanan Xu, Wenting Cao, Song Gao
2188 related Products with: Human HLA prolongs the host inflammatory response in serotype 2 infection compared to mouse H2 molecules.100ug Lyophilized200ug0.1ml0.1ml100 ul100 ul100ug Lyophilized200ug0.1ml100ug Lyophilized200ug100ug Lyophilized
#38035328 2023/11/16 To Up
Biological effects of -farnesol in .Farnesol, derived from farnesyl pyrophosphate in the sterols biosynthetic pathway, is a molecule with three unsaturations and four possible isomers. predominantly secretes the , -farnesol (, -FOH) isomer, known for its role in regulating the virulence of various fungi species and modulating morphological transition processes. Notably, the evolutionary divergence in sterol biosynthesis between fungi, including , and trypanosomatids resulted in the synthesis of sterols with the ergostane skeleton, distinct from cholesterol. This study aims to assess the impact of exogenously added , -farnesol on the proliferative ability of and to identify its presence in the lipid secretome of the parasite.
Liliane Sena Pinheiro, Valter Viana Andrade-Neto, Marcio Mantuano-Barradas, Elisa Cavalcante Pereira, Rodrigo Cesar Fernandes Barbosa, Marcia Cristina Campos de Oliveira, Rubem Figueiredo Sadok Menna-Barreto, Edézio Ferreira Cunha-Júnior, Eduardo Caio Torres-Santos100 μg2 100 μg1 g1 ml2.5 mg1 mL
#38035304 2023/11/14 To Up
Association between dietary protein intake, diet quality and diversity, and obesity among women of reproductive age in Kersa, Ethiopia.In Ethiopia, there is limited evidence on the effect of dietary protein intake on women's body mass index. Therefore, this study investigated the association between dietary protein intake, diet quality, and overweight and obesity.
Aklilu Abrham Roba, Nega Assefa, Kedir Teji Roba, Yadeta Dessie, Elena Hamler, Wafaie Fawzi
1885 related Products with: Association between dietary protein intake, diet quality and diversity, and obesity among women of reproductive age in Kersa, Ethiopia.1000 TESTS/0.65ml100ul1 Set50210501 Set1 Set1 Set1 Set100.00 ul
#38035278 2023/11/14 To Up
Impact of food insecurity and food environment on the diet quality of older African Americans during the COVID-19 pandemic.A high quality diet is vital in promoting wellbeing and ensuring good health, particularly for those living with chronic conditions. Older African Americans, already burdened with a higher prevalence of chronic conditions, also face a higher risk for suboptimal diets. The COVID-19 pandemic had lasting effects on access to healthy food for all Americans, but some demographic groups were disproportionately affected. Older African Americans, who already experienced reduced access to healthy food pre-pandemic, were particularly afflicted, but the full extent of the pandemic's impact on their food insecurity and food environment remains unclear.
Lucy W Kibe, Katrina Schrode, Mohsen Bazargan, Magda Shaheen
2040 related Products with: Impact of food insecurity and food environment on the diet quality of older African Americans during the COVID-19 pandemic.1200 units96 wells100 100 G500IUmin 2 cartons100.00 ul1200 units
#38035269 2023/11/15 To Up
Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults.We explored the interaction of optical coherence tomography (OCT) parameters and white matter hyperintensities with cognitive measures in our older adult cohort.
Ruilin Wang, Xinmao Wu, Zengyi Zhang, Le Cao, William Robert Kwapong, Hang Wang, Wendan Tao, Chen Ye, Junfeng Liu, Bo Wu
1939 related Products with: Retinal ganglion cell-inner plexiform layer, white matter hyperintensities, and their interaction with cognition in older adults.2 Pieces/Box1 Set1 Set1 Set1 Set24 tests1 Set1 Set1 Set1 Set1 Set1 Set
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