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#34116428   2021/05/01 To Up

Interactions between cattle breed type and anabolic implant strategy impact circulating serum metabolites, feedlot performance, feeding behavior, carcass characteristics, and economic return in beef steers.

Introducing Bos indicus (BI) genetics into a beef herd has the potential to increase environmental sustainability. When introducing BI genetics, there are concerns regarding negative impacts on temperament, growth, and carcass characteristics. Implants are routinely used in the United States, with majority of cattle on feed receiving an anabolic implant to improve growth and efficiency, however research regarding the interaction between cattle breed type and anabolic implants is limited. This research compared the use of implants in BI influenced animals versus Bos taurus in a feedlot setting. Twenty steers were stratified by initial weight in a 2 × 2 factorial design examining two different breeds: Angus (AN; n = 10) or Santa Gertrudis influenced (SG; n = 10), and two implant strategies: no implant (CON; n = 10) or a combined implant containing 120 mg TBA and 24 mg E2 (IMP; n = 10; Revalor-S, Merck Animal Health). We hypothesized that anabolic implants would improve growth and feedlot performance of BI influenced animals. Steers were randomly placed into covered pens equipped with GrowSafe bunks and fed the same ration for 129 d. Steers were weighed every 28 d. Dry matter intake, feeding behavior, and carcass data of the steers was collected. Blood was collected and harvested as serum on d 0, 2, 10, 28 and every 28 d after that, and analyzed for serum urea nitrogen (SUN), haptoglobin, and 25HydroxyVitamin D. Angus steers tended to gain more (P = 0.06) weight than SG, while IMP tended to gain more (P = 0.10) weight than CON with no breed × treatment interaction observed (P > 0.10). A breed × treatment interaction was observed when analyzing SUN (P = 0.05) and haptoglobin (P = 0.02) concentrations. Serum 25HydroxyVitmain D concentrations tended to be increased (P = 0.09) in SG-IMP steers compared to SG-CON steers. Angus steers tended (P = 0.10) to have greater amounts of marbling compared to SG steers, while SG steers had improved (P = 0.04) yield grade. Economic return was decreased by $46 a head when introducing SG genetics, while implanting steers improved economic return by $46 a head. This research provides evidence suggesting that BI influenced animals may respond differently to anabolic implants when compared to BT animals. Economic analyses demonstrate that anabolic implants improve economic return to beef producers, while introducing SG genetics decreases economic return in animals raised in more temperate climates.
Caleb C Reichhardt, Ryan Feuz, Tevan J Brady, Laura A Motsinger, Reganne K Briggs, Brett R Bowman, Matthew D Garcia, Ryan Larsen, Kara J Thornton

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#34107618   // To Up

Serum TBA and GCA Levels Across Pregnancy and the Gestational Age-Specific Reference Intervals for Pregnant Chinese.

Reference intervals of clinical laboratory indexes are the basis of interpretation of test results. While intrahepatic cholestasis of pregnancy (ICP) could severely threaten maternal and fetal health, reference intervals of the biomarkers serum total bile acids (TBA) and glycocholic acid (GCA) are unsatisfactory. The purpose of this study was to derive gestational age-specific reference intervals for serum TBA and GCA in a Chinese population to promote early diagnosis of ICP.
Rong Wang, Hongmin Jiang, Yongjun Wang, Yuanqing Yang

2815 related Products with: Serum TBA and GCA Levels Across Pregnancy and the Gestational Age-Specific Reference Intervals for Pregnant Chinese.

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#34102134   2021/06/06 To Up

Changes in serum total bile acid concentrations are associated with the risk of developing adverse maternal and perinatal outcomes in pregnant Chinese women.

We aimed to investigate the association between total bile acid (TBA) concentrations changes during the second and third trimesters and the risk of developing adverse maternal and perinatal outcomes (AMPO).
Yao Liu, Ruifang Sun, Yan Li, Hengying Chen, Lanlan Wu, Siwen Shen, Yuanhuan Wei, Nuoya Wang, Zheqing Zhang, Zengyou Liu, Guifang Deng

2162 related Products with: Changes in serum total bile acid concentrations are associated with the risk of developing adverse maternal and perinatal outcomes in pregnant Chinese women.

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#34099459   2021/06/07 To Up

Antiplexin D1 Antibodies Relate to Small Fiber Neuropathy and Induce Neuropathic Pain in Animals.

To assess the prevalence of antiplexin D1 antibodies (plexin D1-immunoglobulin G [IgG]) in small fiber neuropathy (SFN) and the effects of these antibodies in vivo.
Takayuki Fujii, Eun-Jae Lee, Yukino Miyachi, Ryo Yamasaki, Young-Min Lim, Kyoko Iinuma, Ayako Sakoda, Kwang-Kuk Kim, Jun-Ichi Kira

1273 related Products with: Antiplexin D1 Antibodies Relate to Small Fiber Neuropathy and Induce Neuropathic Pain in Animals.

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#34098996   2021/06/07 To Up

Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy.

ICP pregnant women have a unique profile of serum bile acid metabolism, thus the early and accurate identification of ICP patients is beneficial to early appropriate treatment and improvement of pregnancy outcomes. In this study, ultra-high performance liquid chromatography-mass spectrometry/mass spectrometry (UPLC-MS/MS) was used to analyze the 15 types of serum bile acid profiles among patients with ICP in third trimester, patients with cholelithiasis, and patients with hepatitis B virus. The ICP diagnostic model established by partial least squares-discriminant analysis (PLS-DA) was used to screen the differential bile acids for clinical subtypes of ICP. 144 cases of ICP patients were involved in this study, and divided into four subgroups according to serum level of TBA, DBIL, and ALT.
Yong Shao, Siyu Chen, Huan Li, Qin Tang, Di Xu

2071 related Products with: Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy.

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#34095473   2020/12/28 To Up

Nelson Syndrome: A Case Report and Literature Review.

Nelson syndrome (NS) is a rare clinical disorder that can occur after total bilateral adrenalectomy (TBA), performed as a treatment for Cushing disease. NS is defined as the accelerated growth of an adrenocorticotropic hormone-producing pituitary adenoma. Our objective is to describe a case of NS and discuss it based on existing knowledge of this syndrome.
Felipe J Esparza-Salazar, Jhosue A Hernández-González, Alma R Lezama-Toledo, Diego Incontri-Abraham, Armando Corral, Javier I Armenta-Moreno, Valerie P Vargas-Abonce, Daniel Cuevas-Ramos, Francisco J Gómez-Pérez, Miguel A Gómez-Sámano

2907 related Products with: Nelson Syndrome: A Case Report and Literature Review.



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#34094182   2020/07/24 To Up

Capture and displacement-based release of the bicarbonate anion by calix[4]pyrroles with small rigid straps.

Two-phenoxy walled calix[4]pyrroles and strapped with small rigid linkers containing pyridine and benzene, respectively, have been synthesized. H NMR spectroscopic analyses carried out in CDCl revealed that both of receptors and recognize only F and HCO among various test anions with high preference for HCO (as the tetraethylammonium, TEA salt) relative to F (as the TBA salt). The bound HCO anion was completely released out of the receptors upon the addition of F (as the tetrabutylammonium, TBA salt) as a result of significantly enhanced affinities and selectivities of the receptors for F once converted to the TEAHCO complexes. Consequently, relatively stable TEAF complexes of receptors and were formed anion metathesis occurring within the receptor cavities. By contrast, the direct addition of TEAF to receptors and produces different complexation products initially, although eventually the same TEAF complexes are produced as sequential TEAHCO and TBAF addition. These findings are rationalized in terms of the formation of different ion pair complexes involving interactions both inside and outside of the core receptor framework.
Nam Jung Heo, Ju Ho Yang, Vincent M Lynch, Byoung Joon Ko, Jonathan L Sessler, Sung Kuk Kim

1937 related Products with: Capture and displacement-based release of the bicarbonate anion by calix[4]pyrroles with small rigid straps.

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#34085566   2021/06/04 To Up

Antihypoxic activity of the dry extract from .

The antihypoxic effect of the Nepeta multifida L. dry extract was studied in experiments on white Wistar rats. The life span of animals was determined against the background of acute hypoxias: hypercapnic, hemic, and histotoxic ones. Using the model of acute hypobaric hypoxia/reoxygenation there was evaluated the content of ATP, lactic and pyruvic acids, TBA-active products, reduced glutathione, catalase activity in brain tissue. On the model of acute hypobaric hypoxia/reoxygenation, the content of ATP, lactic and pyruvic acids, reduced glutathione and catalase activity in brain tissue The N. multifida dry extract demonstrated antihypoxic effect at the doses comprised between 100 and 300 mg/kg increasing lifespan of animals in hypercapnic, hemic and histotoxic hypoxias. decreases the manifestation of free-radical oxidation processes, increases the activity of the endogenic antioxidant system, and promotes the efficacy of tissue respiration and oxidative phosphorylation coupling in the brain of white rats in hypoxia/reoxygenation.
Yanina G Razuvaeva, Anyuta A Toropova, Daniil N Olennikov, Dmitrij V Kharzheev

2254 related Products with: Antihypoxic activity of the dry extract from .

2 x 96 well plate96-well plate X 21 mg100 assays500 assays1 kit101 ml100 assays

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