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Search results for: TGF beta Receptor II Polyclonal100 ug[DISCONTINUED]

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#34826189   2021/11/26 To Up

Akt acts as a switch for GPCR transactivation of the TGF-β receptor type 1.

Transforming growth factor (TGF)-β signalling commences with the engagement of TGF-β ligand to cell surface TGF-β receptors (TGFBR) stimulating Smad2 carboxyl-terminal phosphorylation (phospho-Smad2C) and downstream biological responses. In several cell models, G protein-coupled receptors (GPCRs) transactivate the TGFBR1 leading to phospho-Smad2C, however, we have recently published that in keratinocytes thrombin did not transactivate the TGFBR1. The bulk of TGFBRs reside in the cytosol and in response to protein kinase B (Akt phosphorylation) can translocate to the cell surface increasing the cell's responsiveness to TGF-β. In this study we investigate the role of Akt in GPCR transactivation of the TGFBR1. We demonstrate that angiotensin II (AngII) and thrombin do not phosphorylate Smad2C in human vascular smooth muscle cells (VSMCs) and in keratinocytes, respectively. We used Akt agonist, SC79 to sensitize the cells to Akt and observed that Ang II and thrombin phosphorylate Smad2C via Akt/AS160 dependent pathways. We show that SC79 rapidly translocates TGFBRs to the cell surface thus increasing the cell's response to the GPCR agonist. These findings highlight novel mechanistic insight for the role of Akt in GPCR transactivation of the TGFBR1.
Raafat Mohamed, Aravindra Shajimoon, Rizwana Afroz, Mai Gabr, Wally Thomas, Peter J Little, Danielle Kamato

2038 related Products with: Akt acts as a switch for GPCR transactivation of the TGF-β receptor type 1.

100 ml100 μg

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#34825370   2021/11/25 To Up

SPHINGOSINE-1-PHOSPHATE/TGF- β AXIS DRIVES EPITHELIAL MESENCHYMAL TRANSITION IN ASTHMA-LIKE DISEASE.

Airway remodelling is a critical feature of chronic lung diseases. Epithelial-mesenchymal transition (EMT) represents an important source of myofibroblasts, contributing to airway remodelling. Here, we investigated the sphingosine-1-phosphate (S1P) role in EMT and its involvement in asthma-related airway dysfunction.
Maria A Riemma, Ida Cerqua, Barbara Romano, Elena Irollo, Antonio Bertolino, Rosa Camerlingo, Elisabetta Granato, Giuseppina Rea, Stefania Scala, Michela Terlizzi, Giuseppe Spaziano, Rosalinda Sorrentino, Bruno D'Agostino, Fiorentina Roviezzo, Giuseppe Cirino

2513 related Products with: SPHINGOSINE-1-PHOSPHATE/TGF- β AXIS DRIVES EPITHELIAL MESENCHYMAL TRANSITION IN ASTHMA-LIKE DISEASE.

96 tests 1 G

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#34819148   2021/11/25 To Up

The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis.

Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD), causing death in systemic sclerosis (SSc). The past decade has yielded many scientific insights into microRNA (miRNAs) in PAH and SSc. This growth of knowledge has well-illustrated the complexity of microRNA (miRNA)-based regulation of gene expression in PAH. However, few miRNA-related SSc-PAH were elucidated. This review firstly discusses the role of transforming growth factor-beta (TGF-β) signaling and bone morphogenetic protein receptor type II (BMPR2) in PAH and SSc. Secondly, the miRNAs relating to TGF-β and BMPR2 signaling pathways in PAH and SSc or merely PAH were subsequently summarized. Finally, future studies might develop early diagnostic biomarkers and target-oriented therapeutic strategies for SSc-PAH and PAH treatment.
Bei Xu, Guanhua Xu, Ye Yu, Jin Lin

2635 related Products with: The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis.