Only in Titles

Search results for: TNM

paperclip

#33249210   2020/11/21 To Up

The prognostic value of the tumor-stroma ratio in squamous cell lung cancer, a cohort study.

The tumor-stroma ratio (TSR) is based on the relative amount of stroma in the primary tumor and has proven to be an independent prognostic factor in various solid tumors. The prognosis of patients and adjuvant treatment decision making in lung squamous cell carcinomas (SqCC) is based on the TNM classification. Currently, no other prognostic biomarkers are available. In this study we evaluated the prognostic value of the TSR in lung SqCC.
Marloes A Smit, Mark Wh Philipsen, Pieter E Postmus, Hein Putter, Rob Aem Tollenaar, Danielle Cohen, Wilma E Mesker

2170 related Products with: The prognostic value of the tumor-stroma ratio in squamous cell lung cancer, a cohort study.



Related Pathways

paperclip

#33248991   2020/11/26 To Up

Is There a Prognostic Difference Between Stage IIIA Subgroups in Lung Cancer?

Treatment of stage IIIA lung cancer remains controversial because it includes a very heterogeneous group of patients. The purpose of our study was to compare survival between stage IIIA-subsets, and to externally validate our results with another center's database.
Necati Citak, Laura Guglielmetti, Yunus Aksoy, Ozgür Isgörücü, Muzaffer Metin, Adnan Sayar, Isabelle Opitz, Didier Schneiter, Walter Weder, Ilhan Inci

1067 related Products with: Is There a Prognostic Difference Between Stage IIIA Subgroups in Lung Cancer?



Related Pathways

paperclip

#33248414   2020/11/25 To Up

A label-free microfluidic chip for the highly selective isolation of single and cluster CTCs from breast cancer patients.

Circulating tumor cells (CTCs) existing in peripheral blood can be used to predict the prognosis and survival of cancer patients. The study was designed to detect circulating tumor cells and circulating tumor single cell genes by applying microfluidic chip technology. It was used to explore the clinical application value in breast cancer.
Xiaofen Zhang, Xu Lu, Wanlei Gao, Yanmin Wang, Chunping Jia, Hui Cong

2608 related Products with: A label-free microfluidic chip for the highly selective isolation of single and cluster CTCs from breast cancer patients.



Related Pathways

paperclip

Error loading info... Pleas try again later.
paperclip

Error loading info... Pleas try again later.
paperclip

#33244139   2020/11/26 To Up

UBC9 coordinates inflammation affecting development of bladder cancer.

Dysregulation of SUMO modification is linked to carcinogenesis. UBC9 is the sole conjugating enzyme in sumoylation and plays a pivotal role in maintaining homeostasis and restraining stress reactions. However, the clinical significance and function of UBC9 in bladder cancer remain unclear. In this study, immunohistochemistry was used to determine the expression of UBC9. UBC9 knock-down and SUMO inhibition were conducted followed by proliferation, migration, and cell cycle assays. RNA sequencing and bioinformatic analysis were used to identify potential mechanisms of UBC9. Cytokine membrane antibody array was used to detect the expression of cytokine. The mass cytometry TOF (CyTOF) was used to explore the association between bladder cancer stem cell-like population and UBC9 expression. Our results showed that UBC9 played a dual role in bladder cancer. UBC9 was up-regulated in bladder cancer, but was negatively correlated with TNM stage and grade. Knocking-down of UBC9 resulted in dramatic activation of inflammatory gene expression, which might cause inhibition of cell proliferation and inducing cell apoptosis. IL6 was the hub gene in UBC9 regulatory network. Markedly up-regulated IL6 after knocking-down of UBC9 activated the expression of CD44, which was a prominent marker of cancer stem cells. Thus, our results revealed an important and previously undescribed role for UBC9 in modulation of inflammatory signaling of bladder cancer. UBC9 in bladder cancer cells is required to maintain high sumoylation levels and alleviate stress-related inflammation threats to cell survival. Lacking UBC9 contributes to inflammation activation, epithelial-mesenchymal transition and stem cell-like population formation, leading to cancer progression.
Xiaoliang Huang, Yuting Tao, Jiamin Gao, Xianguo Zhou, Shaomei Tang, Caiwang Deng, Zhiyong Lai, Xinggu Lin, Qiuyan Wang, Tianyu Li

2557 related Products with: UBC9 coordinates inflammation affecting development of bladder cancer.



Related Pathways

paperclip

Error loading info... Pleas try again later.
paperclip

#33243732   // To Up

[Association of JMJD3, MMP-2 and VEGF expressions with clinicopathological features of invasive ductal breast carcinoma].

To examine the expressions of JMJD3, matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in invasive ductal breast carcinoma, their association with the clinicopathological features of the patients and the effect of JMJD3 overexpression on proliferation and MMP-2 and VEGF expressions in breast cancer cells.
Xiaoyan Xu, Jianjun Wang, Chen Yan, Yingli Men, Huang Jiang, Huijuan Fang, Xianwei Xu, Jinhua Yang

2018 related Products with: [Association of JMJD3, MMP-2 and VEGF expressions with clinicopathological features of invasive ductal breast carcinoma].



Related Pathways

paperclip

#33243621   2020/11/05 To Up

Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis.

We evaluated the long-term prognosis of synchronous multiple primary lung cancer (SMPLC) patients after surgical treatment and explored prognostic factors for overall survival (OS).
Yuntao Nie, Xun Wang, Fan Yang, Zuli Zhou, Jun Wang, Kezhong Chen

1823 related Products with: Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis.



Related Pathways

paperclip

#33243205   2020/11/26 To Up

Long non-coding RNA SNHG15 in various cancers: a meta and bioinformatic analysis.

The snoRNA host gene SNHG15 produces a long non-coding RNA (lncRNA) with a short half-life and has been reported to be dysregulated in multiple cancers and has recently been found to be correlated with tumour progression. Therefore, this meta-analysis was performed to evaluate the generalised prognostic role of small nucleolar RNA host gene 15 (SNHG15) in malignancies, based on variable data from different studies.
Caizhi Chen, Yeqian Feng, Jingjing Wang, Ye Liang, Wen Zou

1996 related Products with: Long non-coding RNA SNHG15 in various cancers: a meta and bioinformatic analysis.

100μg100μg200ul100 μg

Related Pathways