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#32472474   2020/05/29 To Up

The comparison of the anatomic stage and pathological prognostic stage according to the AJCC 8th edition for the prognosis in Japanese breast cancer patients: data from a single institution.

The TNM system, which reflects the anatomical extent of disease, was used for stage definition. In the recently published AJCC 8th edition, the new staging system of the clinical and pathological prognostic stage, which incorporates biological factors, is introduced.
Eriko Tokunaga, Hideki Ijichi, Wakako Tajiri, Takanobu Masuda, Katsumi Takizawa, Hiroki Ueo, Chinami Koga, Junko Tanaka, Yoshiaki Nakamura, Shinji Ohno, Kenichi Taguchi, Masahiro Okamoto

1530 related Products with: The comparison of the anatomic stage and pathological prognostic stage according to the AJCC 8th edition for the prognosis in Japanese breast cancer patients: data from a single institution.



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#32463532   2020/05/28 To Up

Circular RNA_0001742 has potential to predict advanced tumor stage and poor survival profiles in tongue squamous cell carcinoma management.

Circular RNA_0001742 (circ_0001742) has been reported to be upregulated in tongue squamous cell carcinoma (TSCC) tissues/cells and regulate TSCC cell proliferation, migration, and invasion. This study aimed to further investigate the clinical significance of circ_0001742 in TSCC management.
Yuan Yao, Lei Bi, Chunguang Zhang

1784 related Products with: Circular RNA_0001742 has potential to predict advanced tumor stage and poor survival profiles in tongue squamous cell carcinoma management.



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#32462756   2020/05/28 To Up

How should colorectal surgeons practice during the COVID-19 epidemic? A retrospective single-center analysis based on real-world data from China.

The coronavirus disease 2019 is currently of global concern. Cancer patients are advised to stay at home in case of potential infection, which may cause delays of routine diagnosis and necessary treatment. How colorectal surgeons should manage this during the epidemic remains a big challenge.
He Changzheng, Li Yuxuan, Liu Yichen, Hu Shidong, Yan Yang, Teng Da, Zhao Pengyue, Lin Haiguan, Xu Xiaolei, Wang Yufeng, Huang Xiaohui, Du Xiaohui

1385 related Products with: How should colorectal surgeons practice during the COVID-19 epidemic? A retrospective single-center analysis based on real-world data from China.

10 mg1 moduleOne 96-Well Microplate Ki100 mg100 ul 15 ml 1mg10 g1 module1 module

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#32462718   2020/05/27 To Up

LncRNAs GACAT3 and LINC00152 regulate each other through miR-103 and are associated with clinicopathological characteristics in colorectal cancer.

Long non-coding RNAs (lncRNAs) perform pivotal regulatory roles in tumor development. Our previous work revealed that the lncRNA gastric cancer-associated transcript 3 (GACAT3) was significantly overexpressed and associated with tumor size and metastasis in gastric cancer.
Shazhou Ye, Yicong Lu, Yuqing Ru, Xiaoyue Wu, Ming Zhao, Jiayi Chen, Mingjun Xu, Qin Huang, Yibo Wang, Shanping Shi, Shizhong Bu, Yang Xi

2891 related Products with: LncRNAs GACAT3 and LINC00152 regulate each other through miR-103 and are associated with clinicopathological characteristics in colorectal cancer.

25 mg100 μg10 mg

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#32462420   2020/05/27 To Up

Loss of Interleukin-17RA Expression is Associated with Tumour Progression in Colorectal Carcinoma.

Interleukin-17 (IL-17) is a pro-inflammatory cytokine found in various cancers. Current evidence indicates that IL-17 plays a vital role in tumour initiation and progression in colorectal carcinoma (CRC) via binding with its receptor, IL-17RA. However, the association between clinicopathological features and presence of IL-17 and IL-17RA protein in primary CRC tissues remains unclear. This study also investigates the difference between the presence of IL-17 and IL-17RA in the paired tumour tissues versus adjacent normal tissues. The presence of IL-17RA and IL-17 protein in primary CRC tissues was determined by immunohistochemistry. Associations between clinicopathological features and IL-17RA and IL-17 immunoreactivity, were analyzed by χ2 tests. We found that both IL-17RA (p = 0.001) and IL-17 (p = 0.025) in tumour cells of primary CRC tissues was significantly lower as compared to adjacent normal tissue. Positive immunoreactivity for IL-17RA and IL-17 were detected in 51.0% and 16.8% of tumour tissues, respectively. Furthermore, negative immunoreactivity of IL-17R was significantly associated with advanced stage according to TNM classifier (p = 0.027), high grade of tumour (p = 0.019), increased depth of tumour invasion (p = 0.023) and vascular invasion (p = 0.039). Positive IL-17 immunoreactivity was associated with advanced stage (p = 0.008) and lymph node metastasis (p = 0.008). Thus, this study suggests that the loss of IL-17RA expression occurs as tumour progresses and this may predict the aggressiveness of tumour whilst expression of IL-17 promotes tumour progression and lymph node metastasis. Thus, loss of IL-17RA could be a useful prognostic biomarker for tumour progression in CRC patients.
Boon Yean Chai, Wai Kien Yip, Noraini Dusa, Norhafizah Mohtarrudin, Heng Fong Seow

1906 related Products with: Loss of Interleukin-17RA Expression is Associated with Tumour Progression in Colorectal Carcinoma.

0.1 mg 100ul 0.1 mg 96 wells (1 kit)5 100ug Lyophilized100ug Lyophilized10 1 kit(96 Wells)100ug Lyophilized

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#32462387   2020/05/27 To Up

Survival prediction and treatment strategies for patients with advanced laryngeal carcinoma: a population-based study.

This study aimed at exploring high-risk factors associated with survival outcomes in patients with advanced primary laryngeal carcinoma and at developing and validating a survival-predicting model to help to select the appropriate treatment for each patient.
Xiaoke Zhu, Yu Heng, Liang Zhou, Ming Zhang, Wenping Li, Lei Tao

2965 related Products with: Survival prediction and treatment strategies for patients with advanced laryngeal carcinoma: a population-based study.



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#32462010   2020/05/13 To Up

Is a Potential Prognostic Biomarker in Gastric Cancer and Function as a Tumor Suppressor by Modulating EMT-Related Pathways.

The AT-hook transcription factor, AKNA, is a nuclear protein that affects a few physiological and pathological processes including cancer. Here, we investigated the role of in gastric cancer (GC). By using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, was found deregulated in both GC cell lines and 32 paired GC tissues. Subsequently, Kaplan-Meier analysis and clinicopathological analysis were conducted using both 32 GC cases' data above and RNA-Seq data of in 354 GC patients and the corresponding clinical-pathological data obtained from The Cancer Genome Atlas (TCGA), and expression was found closely related to location, metastasis, and TNM staging of GC. Then, the potential molecular mechanisms of in GC were explored by gene set enrichment analysis (GSEA), qRT-PCR, and Western blot assays. was found to be a hub gene related to homotypic cell to cell adhesion, regulation of cell to cell adhesion, leukocyte cell to cell adhesion, and regulation of T cell proliferation in GC. GO analysis revealed that involved in the regulation of epithelial-mesenchymal transition (EMT)-related pathways including chemokine signaling pathway, cytokine to cytokine receptor interaction, cell adhesion molecules, and jak-stat signaling pathway in GC. To explore the regulation of expression, and were used to predict the possible miRNA which targeted and found the expression of was negatively correlated to miR-762 which could be sponged by circTRNC18. In conclusion, could function as a tumor suppressor by modulating EMT-related pathways in GC. The expression of might be regulated by circTRNC18/miR-762 axis. could serve as a potential biomarker and an effective target for GC diagnosis and therapy.
Gang Wang, Dan Sun, Wenhui Li, Yan Xin

1988 related Products with: Is a Potential Prognostic Biomarker in Gastric Cancer and Function as a Tumor Suppressor by Modulating EMT-Related Pathways.

0.1ml (1mg/ml)1 kit1 kit(96 Wells)50 ul

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#32461933   // To Up

Expressions of CD23, IL-17 and MMP-9 in Patients with Colorectal Cancer.

We aimed to detect IL-17, MMP-9 and CD23 in serum of patients with colorectal cancer to provide some proper references for diagnosis and treatment of this disease.
Xueguang Guo, Gang Liu, Xiaoping Xie, Jing Li, Zehui Hou, Yanhong Gu, Lijiang Yu

1524 related Products with: Expressions of CD23, IL-17 and MMP-9 in Patients with Colorectal Cancer.

96tests

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#32461790   // To Up

Perineural invasion as a prognostic factor in patients with stage I-III rectal cancer - 5-year follow up.

Rectal cancer (RC) is one of the most common diagnosed cancers, and one of the major causes of cancer-related death nowadays. Majority of the current guidelines rely on TNM classification regarding therapy regiments, however recent studies suggest that additional histopathological findings could affect the disease course.
Milica Stojkovic Lalosevic, Tamara Milovanovic, Marjan Micev, Mirjana Stojkovic, Sanja Dragasevic, Milos Stulic, Ivan Rankovic, Vladimir Dugalic, Zoran Krivokapic, Aleksandra Pavlovic Markovic

2031 related Products with: Perineural invasion as a prognostic factor in patients with stage I-III rectal cancer - 5-year follow up.



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#32461015   2020/05/23 To Up

Comparison of short-term efficacy of transanal total mesorectal excision and laparoscopic total mesorectal excision in low rectal cancer.

The transanal total mesorectal excision(TaTME) of rectal malignancies is largely referred to as treatment of mid to low, especially low rectal cancer. This study was to compare the short-term efficacy of TaTME and laparoscopic total mesorectal excision (LaTME) for low rectal cancer.
Jingqing Ren, Shaojie Liu, Huixing Luo, Bailin Wang, Fan Wu

2423 related Products with: Comparison of short-term efficacy of transanal total mesorectal excision and laparoscopic total mesorectal excision in low rectal cancer.

1 kit96 wells (1 kit)1 kit10

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