Only in Titles

           Search results for: Target    

paperclip

#32084663   // Save this To Up

Outcomes of a primary care mental health implementation program in rural Rwanda: A quasi-experimental implementation-effectiveness study.

To address the know-do gap in the integration of mental health care into primary care in resource-limited settings, a multi-faceted implementation program initially designed to integrate HIV/AIDS care into primary care was adapted for severe mental disorders and epilepsy in Burera District, Rwanda. The Mentoring and Enhanced Supervision at Health Centers (MESH MH) program supported primary care-delivered mental health service delivery scale-up from 6 to 19 government-run health centers over two years. This quasi-experimental study assessed implementation reach, fidelity, and clinical outcomes at health centers supported by MESH MH during the scale up period.

1356 related Products with: Outcomes of a primary care mental health implementation program in rural Rwanda: A quasi-experimental implementation-effectiveness study.



Related Pathways

  •  
  • No related Items
paperclip

#32084660   // Save this To Up

A simple strategy for enhanced production of nanoparticles by laser ablation in liquids.

Upgrading the productivity of nanoparticles (NPs), generated by pulsed laser ablation in liquid (PLAL), still remains challenging. Here a novel variant of PLAL was developed, where a doubled frequency Nd:YAG laser beam (532 nm, ~ 5 ns, 10 Hz) at different fluences and for different times was directed into a sealed vessel, toward the interface of the meniscus of ethanol with a tilted bulk metal target. Palladium, copper and silver NPs, synthesized in the performed proof of concept experiments, were mass quantified, by an inductively coupled plasma optical emission spectrometry, and characterized by ultraviolet-visible extinction spectroscopy, transmission electron microscopy and X-ray diffraction. The NPs consist of crystalline metals of a few nm size and their ablation rates and agglomeration levels depend on the employed laser fluences. The ensuing laser power-specific productivity curves for each metal, peaked at specific laser fluences, were fitted to the results of a simple model accounting for plasma absorption and heat transfer. The resulting peaked yields and concentrations were more than an order of magnitude higher than those obtained for totally immersed targets. Besides, the measured productivities showed nearly linear dependencies during time intervals up to 30 min of ablation, but became saturated at 1 h, due to accumulation of a significant number of NPs along the laser beam path, reducing the laser intensity reaching the target. The suggested approach that led to enhanced productivities and to generation of high concentrations of NPs in a single vessel could inspire future studies that will contribute to further developments of efficient generation of NPs with controlled characteristics.

1748 related Products with: A simple strategy for enhanced production of nanoparticles by laser ablation in liquids.



Related Pathways

paperclip

#32084633   // Save this To Up

The true penalty of the waiting room: the role of wait time in patient satisfaction in a busy spine practice.

Most clinics collect routine data on performance metrics on physicians for outpatient visits. However, the relationship of these metrics with patient experience is unclear. The goal of this study was to investigate the relationships between the Consumer Assessment of Healthcare Providers and Systems Clinician and Group Survey (CG-CAHPS), the standard patient experience survey, and clinic performance metrics to understand the determinants of patient satisfaction and identify targets for improving patient experience.

1839 related Products with: The true penalty of the waiting room: the role of wait time in patient satisfaction in a busy spine practice.

Multiple organ tumor tiss FDA Standard Frozen Tissu Thermal Shaker with cooli FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu MultiGene Gradient therm Avian Influenza virus H5N FDA Standard Frozen Tissu Rat Anti-CCT theta Antibo

Related Pathways

  •  
  • No related Items
paperclip

#32084582   // Save this To Up

The knockdown of MALAT1 inhibits the proliferation, invasion and migration of hemangioma endothelial cells by regulating MiR-206 / VEGFA axis.

LncRNA MALAT1 is involved in regulation of angiogenesis, however, its expression and mechanism in infantile hemangioma (IH) are less reported. The study aimed to investigate MALAT1 in IH and to reveal the potential mechanism of MALAT1 acting on IH.

1727 related Products with: The knockdown of MALAT1 inhibits the proliferation, invasion and migration of hemangioma endothelial cells by regulating MiR-206 / VEGFA axis.



Related Pathways

paperclip

#32084566   // Save this To Up

How many streamlines are required for reliable probabilistic tractography? Solutions for microstructural measurements and neurosurgical planning.

Diffusion MRI tractography is commonly used to delineate white matter tracts. These delineations can be used for planning neurosurgery or for identifying regions of interest from which microstructural measurements can be taken. Probabilistic tractography produces different delineations each time it is run, potentially leading to microstructural measurements or anatomical delineations that are not reproducible. Generating a sufficiently large number of streamlines is required to avoid this scenario, but what constitutes "sufficient" is difficult to assess and so streamline counts are typically chosen in an arbitrary or qualitative manner. This work explores several factors influencing tractography reliability and details two methods for estimating this reliability. The first method automatically estimates the number of streamlines required to achieve reliable microstructural measurements, whilst the second estimates the number of streamlines required to achieve a reliable binarised trackmap than can be used clinically. Using these methods, we calculated the number of streamlines required to achieve a range of quantitative reproducibility criteria for three anatomical tracts in 40 Human Connectome Project datasets. Actual reproducibility was checked by repeatedly generating the tractograms with the calculated numbers of streamlines. We found that the required number of streamlines varied strongly by anatomical tract, image resolution, number of diffusion directions, the degree of reliability desired, the microstructural measurement of interest, and/or the specifics on how the tractogram was converted to a binary volume. The proposed methods consistently predicted streamline counts that achieved the target reproducibility. Implementations are made available to enable the scientific community to more-easily achieve reproducible tractography.

2575 related Products with: How many streamlines are required for reliable probabilistic tractography? Solutions for microstructural measurements and neurosurgical planning.

Cellufine Formyl Media (3R,4S,5R,6S)-1-Aza-4-hyd Anti-ADAMTS-13 (A Disinti Amplite™ Fluorimetric F 4-Amino-5-formylamino-3-i Formalin Solution (20%) Indole 7 carboxaldehyde ( N-(2-Amino-4,6-dichloro-5 2 Fluoro 5 formylphenylbo Bone Morphogenetic Protei MOUSE ANTI BOVINE ROTAVIR Protein A (Liquid form)

Related Pathways

paperclip

#32084560   // Save this To Up

TRAIL in oncology: From recombinant TRAIL to nano- and self-targeted TRAIL-based therapies.

TNF-related apoptosis-inducing ligand (TRAIL) selectively induces the apoptosis pathway in tumor cells leading to tumor cell death. Because TRAIL induction can kill tumor cells, cancer researchers have developed many agents to target TRAIL and some of these agents have entered clinical trials in oncology. Unfortunately, these trials have failed for many reasons, including drug resistance, off-target toxicities, short half-life, and specifically in gene therapy due to the limited uptake of TRAIL genes by cancer cells. To address these drawbacks, translational researchers have utilized drug delivery platforms. Although, these platforms can improve TRAIL-based therapies, they are unable to sufficiently translate the full potential of TRAIL-targeting to clinically viable products. Herein, we first summarize the complex biology of TRAIL signaling, including TRAILs cross-talk with other signaling pathways and immune cells. Next, we focus on known resistant mechanisms to TRAIL-based therapies. Then, we discuss how nano-formulation has the potential to enhance the therapeutic efficacy of TRAIL protein. Finally, we specify strategies with the potential to overcome the challenges that cannot be addressed via nanotechnology alone, including the alternative methods of TRAIL-expressing circulating cells, tumor-targeting bacteria, viruses, and exosomes.

2884 related Products with: TRAIL in oncology: From recombinant TRAIL to nano- and self-targeted TRAIL-based therapies.

Recombinant Human TRAIL ( TRAIL (Human) recombinant Recombinant Human TRAIL P TRAIL Apo2L, human recomb Recombinant Human TRAIL ( TRAIL 114-281aa (Human) r Recombinant Human TRAIL P TRAIL Apo2L, human recomb TRAIL (Human) recombinant Recombinant Human TRAIL ( TRAIL 114-281aa (Human) r Recombinant Human TRAIL P

Related Pathways

paperclip

#32084559   // Save this To Up

MicroRNA-27a-3p aggravates renal ischemia/reperfusion injury by promoting oxidative stress via targeting growth factor receptor-bound protein 2.

Renal ischemia-reperfusion (RI/R) injury with high morbidity and mortality is one common clinical disease. Development of drug targets to treat the disorder is critical important. MiR-27a-3p plays important roles in regulating oxidative stress. However, its effects on RI/R injury have not been reported. In this paper, hypoxia/reoxygenation (H/R) models on NRK-52E and HK-2 cells, and RI/R model in C57BL/6 mice were established. The results showed that H/R in vitro decreased cell viability and increased ROS levels in cells, and RI/R caused renal injury and oxidative damage in mice. The expression levels of miR-27a-3p were up-regulated based on real-time PCR and FISH assays in model groups compared with control groups, which directly targeted Grb2 based on dual luciferase reporter assay and co-transfaction test. In addition, miR-27a- 3p markedly reduced Grb2 expression to down-regulate the expression levels of p-PI3K, p-AKT, Nrf2, HO-1, and up-regulate Keap1 expression in model groups. MiR-27a-3p mimics in vitro enhanced H/R-caused oxidative stress via increasing ROS levels and decreasing Grb2 expression to down-regulate PI3K-AKT signal. In contrary, miR-27a-3p inhibitor in vitro significantly reduced H/R-caused oxidative damage via decreasing ROS levels and increasing Grb2 expression to up-regulate PI3K-AKT signal. In vivo, miR-27a- 3p agomir exacerbated RI/R-caused renal damage by decreasing SOD level and increasing Cr, BUN, MDA levels via suppressing Grb2 expression to down-regulate PI3K- AKT signal. However, miR-27a -3p antagomir alleviated RI/R-caused oxidative damage via increasing Grb2 expression to up-regulate PI3k-AKT signal. Grb2siRNA in mice further enhanced RI/R-caused renal injury by increasing Cr, BUN, MDA levels and decreasing SOD level via inhibiting the expression levels of Grb2, Nrf2, HO-1, and increasing Keap1 expression. Our data showed that miR-27a-3p aggravated RI/R injury by promoting oxidative stress via targeting Grb2, which should be considered as one new drug target to treat RI/R injury.

2936 related Products with: MicroRNA-27a-3p aggravates renal ischemia/reperfusion injury by promoting oxidative stress via targeting growth factor receptor-bound protein 2.



Related Pathways

paperclip

#32084550   // Save this To Up

BIOTIN SUPPLEMENTATION CAUSES ERRONEOUS ELEVATIONS OF RESULTS IN SOME COMMERCIAL SERUM 25-HYDROXYVITAMIN D (25OHD) ASSAYS.

The Vitamin D External Quality Assessment Scheme (DEQAS) distributes serum samples globally, on a quarterly basis, to assess participants' performance of specific methods for 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25-(OH)D). DEQAS occasionally circulates samples containing high levels of substances found in certain clinical situations e.g. 25-OH-D, 24,25-(OH)D, hypertriglyceridemia. The increased availability and use of health supplements containing biotin has led to case reports of assay interference in methods utilizing a biotin-streptavidin detection system. In October 2018, DEQAS included a serum sample (545) containing exogenous biotin (concentration =586 μg/L) which was analyzed by a total of 683 laboratories using 35 different methods. The same serum sample (544) without exogenous biotin was also included in the 5-sample set. All methods (760 laboratories) performed satisfactorily on sample 544 giving an All-Laboratory Trimmed Mean = 50.2 ± 6.5 nmol/L (±SD, CV = 12.9%). The target value for this sample 544 (& 555) was 47.4 nmol/L as determined by Centers for Disease Control and Prevention (CDC) Atlanta, Georgia using their LC-MS/MS reference method. In contrast, #545 containing the exogenous biotin was reported by only 683 laboratories and gave an All-Laboratory Trimmed Mean = 66.8 ± 37.6 nmol/L (±SD, CV = 56.3%). As expected, LC-MS/MS methods (143 labs) reported similar results for both 544 = 48.9 ± 4.4 nmol/L (±SD) and 545 = 48.3 ± 4.5 nmol/L (±SD) showing that assays involving chromatographic steps are unaffected by the presence of biotin. Several of the antibody-based assays including Abbott Architect, DiaSorin Liaison, Beckman Unicel and Siemens Centaur are also unaffected by the addition of biotin. Two assays, IDS-iSYS and Roche Total 25OHD, both of which use biotin-streptavidin, exhibit biotin interference yielding values with a significant positive bias for 545 of 102.6 nmol/L ± 78.7 nmol/L (±SD) and 517.8 nmol/L ± 209.8 nmol/L (±SD) respectively. Interestingly, the failure to report sample 545 data from 77 laboratories is due solely to those running Roche Total 25OHD or Roche Vitamin D Total II assays. Given the prevalence of the adversely affected assays (25% of DEQAS users) and the high volume of 25OHD testing, clinicians using these assays should, where possible, only measure 25OHD when patients are off biotin.

1173 related Products with: BIOTIN SUPPLEMENTATION CAUSES ERRONEOUS ELEVATIONS OF RESULTS IN SOME COMMERCIAL SERUM 25-HYDROXYVITAMIN D (25OHD) ASSAYS.

Caspase 8 Inhibitor Drug  EpiQuik Superoxide Dism PLTP Inhibitor Drug Scree Rabbit Anti-Cell death in Caspase 5 Inhibitor Drug Sterile filtered fetal bo CETP Inhibitor Drug Scree Sterile filtered human se Caspase 2 Inhibitor Drug Caspase 10 Inhibitor Drug Caspase 7 Inhibitor Drug Caspase 4 Inhibitor Drug

Related Pathways