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Search results for: Thyroid

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#32650266   2020/06/30 To Up

Knowledge-guided synthetic medical image adversarial augmentation for ultrasonography thyroid nodule classification.

Image classification is an important task in many medical applications. Methods based on deep learning have made great achievements in the computer vision domain. However, they typically rely on large-scale datasets which are annotated. How to obtain such great datasets is still a serious problem in medical domain.
Guohua Shi, Jiawen Wang, Yan Qiang, Xiaotang Yang, Juanjuan Zhao, Rui Hao, Wenkai Yang, Qianqian Du, Ntikurako Guy-Fernand Kazihise

1588 related Products with: Knowledge-guided synthetic medical image adversarial augmentation for ultrasonography thyroid nodule classification.

10 10 mg96/kit5 g25 mg 100ul 100 G 15 ml

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#32649848   2020/07/10 To Up

central venous catheter infection mimicking proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA)-associated vasculitis.

A 40-year-old Japanese woman, who underwent total thyroidectomy, had suffered from repeated episodes of fever and microscopic hematuria for 3 years, which had started 3 months after central venous port catheter insertion. On admission, she had malaise and low-grade fever, and was found to have microscopic hematuria, urinary red blood cell casts, multiple pulmonary nodules, and positivity of proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA), which were suggestive to the presence of ANCA-associated small vessel vasculitis. However, her blood culture and subsequent gene analysis revealed the positivity of , and she was diagnosed with bacteremia accompanying PR3-ANCA positivity. Her condition improved after the removal of the catheter and antibiotic treatment. species are categorized to the order and can be misidentified as other without genetic analyses. This case illustrates that chronic infection can cause ANCA production and nephritis, which mimics ANCA-associated vasculitis. Thus, it is critical to diagnose these cases correctly to avoid misdiagnosis and inappropriate treatment, such as immunosuppressive treatment.
Kiyoaki Ochi, Tomoyuki Mukai, Shigeru Ota, Chihiro Hiraiwa, Masahiko Ikeda, Airi Ikeda, Takashi Oda, Youichiro Yamamoto, Toru Ueki

1226 related Products with: central venous catheter infection mimicking proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA)-associated vasculitis.

100ul100ug100ug100μg100μg100μg100μg100 µg200 ug100μg100ug100μg

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#32649804   2020/07/10 To Up

Human riboflavin kinase: Species-specific traits in the biosynthesis of the FMN cofactor.

Human riboflavin kinase (HsRFK) catalyzes vitamin B (riboflavin) phosphorylation to flavin mononucleotide (FMN), obligatory step in flavin cofactor synthesis. HsRFK expression is related to protection from oxidative stress, amyloid-β toxicity, and some malignant cancers progression. Its downregulation alters expression profiles of clock-controlled metabolic-genes and destroys flavins protection on stroke treatments, while its activity reduction links to protein-energy malnutrition and thyroid hormones decrease. We explored specific features of the mechanisms underlying the regulation of HsRFK activity, showing that both reaction products regulate it through competitive inhibition. Fast-kinetic studies show that despite HsRFK binds faster and preferably the reaction substrates, the complex holding both products is kinetically most stable. An intricate ligand binding landscape with all combinations of substrates/products competing with the catalytic complex and exhibiting moderate cooperativity is also presented. These data might contribute to better understanding the molecular bases of pathologies coursing with aberrant HsRFK availability, and envisage that interaction with its client-apoproteins might favor FMN release. Finally, HsRFK parameters differ from those of the so far evaluated bacterial counterparts, reinforcing the idea of species-specific mechanisms in RFK catalysis. These observations support HsRFK as potential therapeutic target because of its key functions, while also envisage bacterial RFK modules as potential antimicrobial targets.
Ernesto Anoz-Carbonell, Maribel Rivero, Victor Polo, Adrián Velázquez-Campoy, Milagros Medina

2580 related Products with: Human riboflavin kinase: Species-specific traits in the biosynthesis of the FMN cofactor.

100ul1mg4 Arrays/Slide 100ul4 Membranes/Box4 Membranes/Box 100ul4 Membranes/Box2 Pieces/Box4 Arrays/Slide

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#32649802   2020/07/10 To Up

Hyperprolactinaemia attenuates the inhibitory effect of vitamin D/selenomethionine combination therapy on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis: A pilot study.

Vitamin D administered together with selenomethionine has been reported to markedly reduce thyroid antibody titres in patients with autoimmune thyroiditis. Hyperprolactinaemia exerts a complex pro-inflammatory effect. This study was aimed at investigating whether prolactin excess determines the effect of vitamin D/selenomethionine combination therapy on thyroid autoimmunity.
Robert Krysiak, Karolina Kowalcze, Bogusław Okopień

1028 related Products with: Hyperprolactinaemia attenuates the inhibitory effect of vitamin D/selenomethionine combination therapy on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis: A pilot study.

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#32649050   2020/07/10 To Up

Should uncertainty concerning the risk of malignancy be included in diagnostic (nongynecologic) cytopathology reports?

In diagnostic cytology, the known site-specific false positive rates at various anatomical sites for the risk malignancy (ROM) when a confirmed malignant diagnosis is made are comparatively well documented. ROM figures for diagnostic cytology specimens may vary according to the anatomical site of the specimen, the exact nature of the specimen received, the staining method(s) used, and the use of additional laboratory techniques including molecular profiling; furthermore, they often differ to some extent from institution to institution, between differing cytologists within the same institution, and over time. A brief literature review for a selected group of routine diagnostic cytology specimens shows a published ROM for a confirmed malignant diagnosis as follows: bile duct brushings, ~99% (range, 97%-100%); breast fine needle aspiration, 98.5% (range, 92%-100%); serous effusion fluid, 98.9% (range, 90%-100% although lower for squamous cell carcinoma, mesothelioma, and lymphoma), pulmonary endobronchial ultrasound cytology, ~99% (range, 86.6%-100%); thyroid FNA, 98% (range, 97%-99% if NIFTP tumors are excluded), salivary gland FNA, ~90%; (range 57%-100%) and lateral neck cyst FNA, ~99% (range, 95.5%-100%). Because most diagnostic cytology specimens have a small but accepted false-positive rate, this information is vitally important for the clinical management of patients and for shared patient decision making. In our view, the known false-positive rate for a given diagnostic cytology specimen could be included within the cytology report to assist in explaining the limitations of the diagnostic cytology interpretation and help facilitate the clinical decision-making process.
David N Poller, Fernando Schmitt

1673 related Products with: Should uncertainty concerning the risk of malignancy be included in diagnostic (nongynecologic) cytopathology reports?

10.1 mg100ug 1 G 100ul

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#32648604   2020/07/10 To Up

The intramolecular agonist is obligate for activation of glycoprotein hormone receptors.

In contrast to most rhodopsin-like G protein-coupled receptors, the glycoprotein hormone receptors (GPHR) have a large extracellular N-terminus for hormone binding. The hormones do not directly activate the transmembrane domain but mediate their action via a, thus, far only partially known Tethered Agonistic LIgand (TALI). The existence of such an intramolecular agonist was initially indicated by site-directed mutation studies and activating peptides derived from the extracellular hinge region. It is still unknown precisely how TALI is involved in intramolecular signal transmission. We combined systematic mutagenesis studies at the luteinizing hormone receptor and the thyroid-stimulating hormone receptor (TSHR), stimulation with a drug-like agonist (E2) of the TSHR, and structural homology modeling to unravel the functional and structural properties defining the TALI region. Here, we report that TALI (a) is predisposed to constitutively activate GPHR, (b) can by itself rearrange GPHR into a fully active conformation, (c) stabilizes active GPHR conformation, and (d) is not involved in activation of the TSHR by E2. In the active state conformation, TALI forms specific interactions between the N-terminus and the transmembrane domain. We show that stabilization of an active state is dependent on TALI, including activation by hormones and constitutively activating mutations.
Annelie Schulze, Gunnar Kleinau, Susanne Neumann, Patrick Scheerer, Torsten Schöneberg, Antje Brüser

2430 related Products with: The intramolecular agonist is obligate for activation of glycoprotein hormone receptors.

100ug Lyophilized1 ml100ug Lyophilized1 mg100ug Lyophilized0.2 mg100ug Lyophilized100ug Lyophilized100ug Lyophilized250 ml100ug Lyophilized1 g

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#32648488   2020/07/10 To Up

Thyroid-Like Follicular Carcinoma of the Kidney With Low-Grade Sarcomatoid Component: A Hitherto Undescribed Case.

Thyroid-like follicular carcinoma of the kidney (TLFCK) is a rare subtype of renal cell carcinoma, which closely resembles follicular neoplasms of the thyroid and has a distinctive indolent clinical behavior. Until now, a single case of TLFCK with extensive sarcomatoid differentiation has been documented with aggressive clinical course. We present an unusual case of sarcomatoid TLFCK with a low-grade spindle cell component in a 34-year-old male patient, with an indolent course following radical nephrectomy and regional node dissection.
Vidya Rao, Santosh Menon, Ganesh Bakshi, Gagan Prakash, Archi Agarwal, Sangeeta Desai

1822 related Products with: Thyroid-Like Follicular Carcinoma of the Kidney With Low-Grade Sarcomatoid Component: A Hitherto Undescribed Case.



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#32648118   2020/07/09 To Up

Acute tubulointerstitial nephritis induced by the tyrosine kinase inhibitor vandetanib.

Few cases of immunoallergic tubulointerstitial nephritis associated with tyrosine kinase inhibitors have been described. We describe the first report case associated with vandetanib, a tyrosine kinase inhibitor indicated for the treatment of aggressive and symptomatic medullary thyroid cancer (CMT) in patients with locally advanced or metastatic non-resectable disease.
Melissa Pilco Teran, Ana Merino Ribas, Nadia Martin Alemany, Xoana Barros Freiria, Jordi Rubio Casadevall, Ferran Pérez Bueno, Isabel García Méndez, Marcela Castillo Devia, Cristina Noboa Paez, Pere Torguet Escuder, Jordi Calabia Martínez

2754 related Products with: Acute tubulointerstitial nephritis induced by the tyrosine kinase inhibitor vandetanib.

8 inhibitors5 inhibitors0.1ml96T7 inhibitors5 mg5 mg5 mg100ul5 mg25 mg

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#32648083   2020/07/09 To Up

Simplified four-step retropharyngeal approach for the upper cervical spine: technical note.

In this paper, we propose a simplified four-step retropharyngeal approach, whose aim is getting straight to the upper cervical spine minimizing complications.
Pasquale De Bonis, Antonio Musio, Giorgio Mantovani, Angelo Pompucci, Jacopo Visani, Giorgio Lofrese, Alba Scerrati

1808 related Products with: Simplified four-step retropharyngeal approach for the upper cervical spine: technical note.

11,000 tests5 mg500 rxns 500 G50 IU 25 G100 rxns 25 µg100.00 ul

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#32648002   2020/07/09 To Up

Correlation between serum anti-TSH receptor autoantibodies (TRAbs) and the clinical feature of Graves' orbitopathy.

Graves' orbitopathy (GO) is the most common extrathyroidal manifestation of Graves' disease (GD). Several studies support the involvement of TSH receptor autoantibodies (TRAbs) in the pathogenesis of GO, and a correlation between GO features and TRAbs has been reported, but not confirmed by all studies. Thus, we conducted a cross-sectional investigation to determine whether there is a correlation between TRAbs and the clinical features of GO in an initial phase of the eye disease.
F Nicolì, G Lanzolla, M Mantuano, I Ionni, B Mazzi, M Leo, A Sframeli, C Posarelli, M N Maglionico, M Figus, M Nardi, C Marcocci, M Marinò

2738 related Products with: Correlation between serum anti-TSH receptor autoantibodies (TRAbs) and the clinical feature of Graves' orbitopathy.

0.1 mg100ul1 ml200 100.00 ul100ul1000 200 100ug100 100ug Lyophilized0.1 ml

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