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Search results for: Thyrotropin

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#35017259   2022/01/10 To Up

Oxytocin facilitates allo-parental behavior under stress in laboratory mice.

Oxytocin (Oxt) controls reproductive physiology and various kinds of social behaviors, but the exact contribution of Oxt to different components of parental care still needs to be determined. Here we illustrate the neuroanatomical relations of the parental nurturing-induced neuronal activation with magnocellular oxytocin neurons and fibers in the medial preoptic area (MPOA), the brain region critical for parental and alloparental behaviors. We utilized genetically-targeted mouse lines for , , , to systematically examine the role of Oxt-related signaling in pup-directed behaviors. The -- triple knockout (TKO), and --- quadruple KO (QKO) mice were grossly healthy and fertile, except for their complete deficiency in milk ejection and modest deficiency in parturition secondary to maternal loss of the or genes. In our minimal stress conditions, pup-directed behaviors in TKO and QKO mothers and fathers, virgin females and males were essentially indistinguishable from those of their littermates with other genotypes. However, KO virgin females did show decreased pup retrieval in the pup-exposure assay performed right after restraint stress. This stress vulnerability in the KO was abolished by the additional KO. The general stress sensitivity, as measured by plasma cortisol elevation after restraint stress or by the behavioral performance in the open field and elevated plus maze, were not altered in the KO but were reduced in the KO females, indicating that the balance of neurohypophysial hormones affects the outcome of pup-directed behaviors.Parental care without suckling induces the most significant transcriptional activation in the caregivers' anterior commissural nucleus, the third-largest population of oxytocin neurons in the medial preoptic area, but not in its non-oxytocinergic neurons. The pup-directed behaviors in postpartum mothers, fathers and virgin males and females of (), () and triple knockout mice were essentially normal in our standard experimental conditions with minimal stress. Under stressful conditions, however, KO mice showed decreased parental nurturing behaviors, which was compensated for by combining with the KO.
Yousuke Tsuneoka, Chihiro Yoshihara, Ryuko Ohnishi, Sachine Yoshida, Eri Miyazawa, Masanobu Yamada, Kazuhiko Horiguchi, W Scott Young, Katsuhiko Nishimori, Tadafumi Kato, Kumi O Kuroda

2629 related Products with: Oxytocin facilitates allo-parental behavior under stress in laboratory mice.

100 UG1roll100.00 ug25 mg100 ul1002 mg100ug Lyophilized1 Set1 mg

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#35006119   // To Up

123I Scintigraphy Mirror Image of Graves Disease Induced by Radioiodine Treatment for Toxic Adenoma.

A 61-year-old woman presenting with hyperthyroidism received 131I therapy for a toxic adenoma diagnosed by 123I scintigraphy. Six months later, the patient had a relapse of hyperthyroidism, and 123I scintigraphy showed a mirror image of the first scintigraphy: a high and diffuse uptake in the thyroid gland except for the previously treated nodule. Graves disease was confirmed by elevated thyrotropin receptor antibodies. The patient was cured by a second radioiodine therapy. Radioiodine-induced Graves disease may occur within 6 months of 131I treatment of toxic adenoma and can be treated with a second line of 131I.
Alexandre Lugat, Delphine Drui, Kalyane Bach-Ngohou, Pascale Guillot, Emmanuelle Mourrain-Langlois, Françoise Kraeber-Bodéré, Catherine Ansquer

1309 related Products with: 123I Scintigraphy Mirror Image of Graves Disease Induced by Radioiodine Treatment for Toxic Adenoma.

1 mg1 mg96 tests 15 ml 100 G

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#35002961   2021/12/23 To Up

Clinical and Therapeutic Characteristics of Pituitary TSH-Secreting Adenoma in Adolescent-Onset Patients: Six Case Studies and Literature Review.

Thyrotropin-secreting adenoma (TSH-oma) is a very rare kind of functional pituitary adenoma, especially that which occurs in adolescents. However, its potential clinical and therapeutic characteristics are still unknown.
Yamei Yang, Jie Liu, Kan Deng, Lin Lu, Huijuan Zhu, Xiaolan Lian, Xinjie Bao, Lian Duan, Yong Yao

1467 related Products with: Clinical and Therapeutic Characteristics of Pituitary TSH-Secreting Adenoma in Adolescent-Onset Patients: Six Case Studies and Literature Review.



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#34995343   2022/01/07 To Up

Correction: Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.


Chongbo Yang, Ming Lu, Wenbin Chen, Zhao He, Xu Hou, Mei Feng, Hongjia Zhang, Tao Bo, Xiaoming Zhou, Yong Yu, Haiqing Zhang, Meng Zhao, Laicheng Wang, Chunxiao Yu, Ling Gao, Wenjian Jiang, Qunye Zhang, Jiajun Zhao

1427 related Products with: Correction: Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.

4 Membranes/Box8 Sample Kit4 Membranes/Box100 4 Sample Kit2ug16 Arrays/Slide1-8 Sample Kit5ug96 tests4 Arrays/Slide

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#34981746   2022/01/01 To Up

Cellular and molecular basis of thyroid autoimmunity.

Autoimmune thyroid disease (AITD) is the most common human autoimmune disease. The two major clinical manifestations of AITD are Graves' disease and Hashimoto's thyroiditis (HT). AITD is characterized by lymphocytic infiltration of the thyroid gland, leading either to follicular cell damage, thyroid gland destruction, and development of hypothyroidism (in HT) or thyroid hyperplasia, induced by thyroid antibodies which activate thyrotropin receptor (TSHR) on thyrocytes, leading to hyperthyroidism. The aim of this review is to present up-to-date picture of the molecular and cellular mechanisms that underlie the pathology of AITD. Based on studies involving patients, animal AITD models, and thyroid cell lines, we discuss the key events leading to the loss of immune tolerance to thyroid autoantigens as well as the signaling cascades leading to the destruction of thyroid gland. Special focus is given on the interplay between the environmental and genetic factors, as well as ncRNAs and microbiome contributing to AITD development. In particular, we describe mechanistic models by which SNPs in genes involved in immune regulation and thyroid function, such as CD40, TSHR, FLT3, and PTPN22, underlie AITD predisposition. The clinical significance of novel diagnostic and prognostic biomarkers based on ncRNAs and microbiome composition is also underscored. Finally, we discuss the possible significance of probiotic supplementation on thyroid function in AITD.
Joanna Bogusławska, Marlena Godlewska, Ewa Gajda, Agnieszka Piekiełko-Witkowska

1122 related Products with: Cellular and molecular basis of thyroid autoimmunity.

1 kit(96 Wells)50 mg100ul 6 ml Ready-to-use 25 mg50 ug 96T100ul100ug

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#34970803   2021/12/31 To Up

Tanycyte specific ablation of diacylglycerol lipase alpha stimulates the hypothalamic-pituitary-thyroid axis by decreasing the endocannabinoid mediated inhibition of TRH release.

In addition to the hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons, a glial cell type, the tanycytes, also play a role in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Tanycytes modulate the feedback regulation of the axis by regulating the local thyroid hormone availability in the median eminence where the hypophysiotropic axons terminate. Recently, we showed that tanycytes produce diacylglycerol lipase alpha (DAGLα), the synthesizing enzyme of the endocannabinoid 2-arachidonoylglycerol (2-AG) that inhibits the release of TRH from the hypophysiotropic terminals in median eminence explants. To determine the importance of the endocannabinoid production of tanycytes, adult male Rax-CreERT2//DAGLα mice were treated with tamoxifen to induce a tanycyte specific decrease of DAGLα expression (T-DAGLα KO). The effect of this genetic manipulation on the activity of the HPT axis was determined. Tanycyte specific decrease of DAGLα expression resulted in an approximately 2-fold increase of TSHβ mRNA level that was accompanied by increased levels of circulating free T4. The TRH mRNA level was, however, not influenced by the genetic manipulation. In addition to the effects on the HPT axis, the T-DAGLα KO mice showed increased fat mass ratio and decreased blood glucose levels. These data indicate that when endocannabinoid release of tanycytes is decreased, the disinhibition of the TRH release induces increased TSH synthesis and higher circulating T4 levels. Thus it suggests that in wild-type mice, tanycytes exert a tonic inhibitory effect on the TRH release of hypophysiotropic axons. Furthermore, the endocannabinoid release of tanycytes also influences glucose homeostasis and fat deposition.
Dóra Kővári, Veronika Penksza, Anett Szilvásy-Szabó, Richárd Sinkó, Balázs Gereben, Ken Mackie, Csaba Fekete

2376 related Products with: Tanycyte specific ablation of diacylglycerol lipase alpha stimulates the hypothalamic-pituitary-thyroid axis by decreasing the endocannabinoid mediated inhibition of TRH release.

2000 IU100.00 ul5mg 5 G500 Units110

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#34969732   // To Up

Thyroid Hormones and Morphological Features of Primary Breast Cancer.

Many experimental studies have suggested the importance of thyroid hormones in breast cancer (BC) morphogenesis. The aim of this study was to evaluate the association of thyroid hormone levels in serum of patients with primary BC with morphological presentations of the disease in pathological specimens and prognosis.
Amichay Meirovitz, Benjamin Nisman, Tanir M Allweis, Einat Carmon, Luna Kadouri, Bella Maly, Ofra Maimon, Tamar Peretz

2240 related Products with: Thyroid Hormones and Morphological Features of Primary Breast Cancer.

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#34967378   // To Up

Syndrome of inappropriate secretion of thyroid-stimulating hormone in a subject with galactorrhea and menstrual disorder and undergoing infertility treatment: Case report.

Syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH) is a rare cause of hyperthyroidism. Thyroid-stimulating hormone (TSH) levels are usually normal or high, and triiodothyronine (FT3) and free thyroxine (FT4) levels are usually high in subjects with SITSH.
Hideaki Kaneto, Shinji Kamei, Fuminori Tatsumi, Masashi Shimoda, Tomohiko Kimura, Atsushi Obata, Takatoshi Anno, Shuhei Nakanishi, Kohei Kaku, Tomoatsu Mune

1482 related Products with: Syndrome of inappropriate secretion of thyroid-stimulating hormone in a subject with galactorrhea and menstrual disorder and undergoing infertility treatment: Case report.

96 assays100.00 ul

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