Tissue microarrey: a potential cost-effective approach for mismatch repair testing in colorectal cancer. productsSearch results for: Tissue microarrey: a potential cost-effective approach for mismatch repair testing in colorectal cancer.
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2022/12/08
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Tissue microarrey: a potential cost-effective approach for mismatch repair testing in colorectal cancer.
Deficiencies in Mismatch Repair (MMR) proteins are one of the major pathways in the development of colorectal cancer (CRC). MMR status evaluation is recommended in every new CRC patient. However, this is not fully implemented due to high costs. Tissue microarray (TMA) enables allocating tissue cores from few specimens to a single paraffin block. The primary objective of this study was to evaluate the accuracy of TMA MMR immunohistochemistry (IHC) compared to whole slide. The secondary objective was to evaluate and validate automatic digital image analysis software in differentiating pathological and normal TMA cores.Shai Farkash, Naama Schwartz, Natalia Edison, Sophia Greenberg, Hila Belhanes Peled, Wail Sindiany, Judit Krausz