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#36483974   // To Up

Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors.

Photodynamic therapy (PDT) is a minimally invasive form of cancer therapy, and the development of a novel photosensitizer (PS) with optimal properties is important for enhancing PDT efficacy. Folate receptor (FR) membrane protein is frequently overexpressed in 40% of human cancer and a good candidate for tumor-specific targeting. Specific active targeting of PS to FR can be achieved by conjugation with the folate moiety. A folate-linked, near-infrared (NIR)-sensitive probe, folate-Si-rhodamine-1 (FolateSiR-1), was previously developed and is expected to be applicable to NIR-PDT.
Winn Aung, Atsushi B Tsuji, Kenjiro Hanaoka, Tatsuya Higashi

1430 related Products with: Folate receptor-targeted near-infrared photodynamic therapy for folate receptor-overexpressing tumors.

Each100ug100ug Lyophilized100 μg100ul50ug50 ug 100ug100ug Lyophilized0.1 ml1 kg50ug

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#36483737   2022/11/22 To Up

Gypenosides ameliorate ductular reaction and liver fibrosis inhibition of hedgehog signaling.

Ductular reaction (DR) is a common pathological change and thought to have a key role in the pathogenesis and progression of liver fibrosis. Our previous study reported Gypenosides (GPs) ameliorated liver fibrosis, however, the anti-fibrotic mechanisms of GPs are still unclear. Liver fibrosis was induced in rats by carbon tetrachloride combining with 2-acerylaminofluorene (CCl/2-AAF), and Mdr2 knockout ( ) mice to evaluate the anti-fibrotic role of GPs. , WB-F344 cells, a hepatic progenitor cells (HPCs) line, with or without Gli1 overexpressing lentiviral vectors, were induced by sodium butyrate (SB) to validate the mechanism of GPs and NPLC0393, the main ingredient of GPs. Both in CCl/2-AAF-treated rats and mice, GPs obviously reduced the deposition of collagen and hydroxyproline content, inhibited the activation of hepatic stellate cells and inflammatory cell infiltration. Notably, GPs reduced the expressions of Epcam, CK19, CK7, Dhh, Smo, Ptch2, Gli1 and Gli2. Furthermore, CK19 cells co-expressed Gli1, while the number of CK19/Gli1 cells was decreased by GPs. , GPs and NPLC0393 inhibited the differentiation of WB-F344 cells toward a biliary phenotype. Mechanistically, GPs and NPLC0393 protected against DR by inhibiting hedgehog signaling, which was supported by the results that DR, triggered directly by Gli1 overexpressing lentiviral vector was blocked by administration with GPs or NPLC0393. GPs attenuated DR and liver fibrosis by inhibiting hedgehog signaling, which provided more evidences and a novel mechanism of anti-fibrotic effect of GPs.
Yonghong Hu, Xiaoli He, Xiaoxi Zhou, Yue Liang, Yadong Fu, Linzhang Zhang, Jing Fang, Wei Liu, Gaofeng Chen, Yongping Mu, Hua Zhang, Hong Cai, Chenghai Liu, Ping Liu, Jiamei Chen

2336 related Products with: Gypenosides ameliorate ductular reaction and liver fibrosis inhibition of hedgehog signaling.

Inhibitors500 reactions96T2.5 mg10 μg5.0ml (200 PCR reactions)200ug250ul96 reactions4X1.25ml; 200 reactions (2000 Units

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#36483140   2022/11/22 To Up

Promoting self-change in cannabis use disorder: Findings from a randomized trial.

A growing body of literature supports the efficacy of cognitive-behavioral therapy (CBT) and motivational interviewing (MI) for the treatment of problematic cannabis use, diagnostically referred to as cannabis use disorder, though most individuals do not access formal treatment. Stepped-care-type models emphasize interventions across a continuum of severity and there is a need for more treatment options across this continuum. This project focused on the evaluation of the least intensive of the individual interventions - promotion of self-directed recovery.
Magdalen G Schluter, David C Hodgins, Jonathan N Stea, Michelle L Kilborn

1867 related Products with: Promoting self-change in cannabis use disorder: Findings from a randomized trial.

900 tests100 μg100 μg100100 μg1 mg100 μg100ug 25 MG100 μg20 ul (10 mM)50 ul

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#36482855   2022/09/12 To Up

Knocking Down lncRNA HOXA-AS2 Mitigates the Progression of Epilepsy via Regulation of the miR-372-3p/STAT3 Axis.

The purposes of current research are to explore the potential activity of HOXA-AS2, a lncRNA (long non-coding RNA), in epilepsy progression, as well as the mechanisms behind its activity.
Song Lixiang, Li Jiazhen, Sun Zhaoming

1139 related Products with: Knocking Down lncRNA HOXA-AS2 Mitigates the Progression of Epilepsy via Regulation of the miR-372-3p/STAT3 Axis.

1mg12000 IU100.00 ul1500 Units10

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#36482325   2022/12/08 To Up

Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein.

Hepatocellular carcinoma (HCC) is the sixth most commonly diagnosed cancer and third leading cause of cancer-related death worldwide in 2020. Exosomes derived from cancer-associated fibroblasts (CAFs-exo) can promote tumor progression in various human cancers. However, the underlying regulatory mechanism controlling how CAFs-exo can promote HCC progression remains poorly understood.
An-Li Jin, Lin Ding, Wen-Jing Yang, Te Liu, Wei Chen, Tong Li, Chun-Yan Zhang, Bai-Shen Pan, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Wei Guo, Xin-Rong Yang, Bei-Li Wang

1602 related Products with: Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein.

100ug Lyophilized100ug Lyophilized 100ul100ug Lyophilized100 μg100ug Lyophilized100 μg100ug Lyophilized100ug Lyophilized

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#36481396   2022/12/05 To Up

Young plasma transfer recovers decreased sperm counts and restores epigenetics in aged testis.

Aging is one of the causes of male infertility, and abnormal global DNA methylation and imprinting defects have been characterized in testis during biological aging. One of the important emerging approaches aims to take advantage of the healing properties of young blood plasma to limit the progression of aging in various organs in the body. We aimed to show whether blood plasma transfer has an effect on DNA methylation and spermatogenetic cell development. In addition, we aimed to show whether the young plasma transfer to old mice has an effect on the rejuvenation of the old and whether the impaired DNA methylation and PCNA expression in old age can be restored.
Kadriye Erdogan, Taha Ceylani, Hikmet Taner Teker, Ahmet Zeki Sengil, Fatma Uysal

2929 related Products with: Young plasma transfer recovers decreased sperm counts and restores epigenetics in aged testis.

1mg 72 tests96T

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#36481247   2022/11/23 To Up

Ferulic acid enhances insulin secretion by potentiating L-type Ca channel activation.

To investigate the effect of ferulic acid, a natural compound, on pancreatic beta cell viability, Ca channels, and insulin secretion.
Katesirin Ruamyod, Wattana B Watanapa, Chanrit Kakhai, Pimchanok Nambundit, Sukrit Treewaree, Parin Wongsanupa

1848 related Products with: Ferulic acid enhances insulin secretion by potentiating L-type Ca channel activation.

100ug100ug96 wells (1 kit)10 mg 100 G 1 G100 mg 25 G100 mg

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#36481205   2022/12/05 To Up

Exosomal long non-coding RNA TRAFD1-4:1 derived from fibroblast-like synoviocytes suppresses chondrocyte proliferation and migration by degrading cartilage extracellular matrix in rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic, autoimmune and systemic inflammatory disease affecting 1% of the population worldwide. Immune suppression of the activity and progress of RA is vital to reduce the disability and mortality rate as well as improve the quality of life of RA patients. However, the immune molecular mechanism of RA has not been clarified yet. Our results indicated that exosomes derived from TNFα-stimulated RA fibroblast-like synoviocytes (RA-FLSs) suppressed chondrocyte proliferation and migration through modulating cartilage extracellular matrix (CECM) determining by MTS assay, cell cycle analysis, Transwell assay and Western blot (WB). Besides, RNA sequencing and verification by qRT-PCR revealed that exosomal long non-coding RNA (lncRNA) tumor necrosis factor-associated factor 1 (TRAF1)-4:1 derived from RA-FLSs treated with TNFα was a candidate lncRNA, which also inhibited chondrocyte proliferation and migration through degrading CECM. Moreover, RNA sequencing and bioinformatics analysis identified that C-X-C motif chemokine ligand 1 (CXCL1) was a target mRNA of miR-27a-3p while miR-27a-3p was a target miRNA of lnc-TRAF1-4:1 in chondrocytes. Mechanistically, lnc-TRAF1-4:1 upregulated CXCL1 expression through sponging miR-27a-3p as a competing endogenous RNA (ceRNA) in chondrocytes identifying by Dual-luciferase reporter gene assay. Summarily, exosomal lncRNA TRAFD1-4:1 derived from RA-FLSs suppressed chondrocyte proliferation and migration through degrading CECM by upregulating CXCL1 as a sponge of miR-27a-3p. This study uncovered a novel RA-related lncRNA and investigated the roles of RA-FLS-derived exosomes and exosomal lnc-TRAF1-4:1 in articular cartilage impairment, which might provide novel therapeutic targets for RA.
Jianhua Ren, Fei Zhang, Shaoshen Zhu, Wenhui Zhang, Jianfeng Hou, Ronghan He, Kun Wang, Zhe Wang, Tangzhao Liang

2535 related Products with: Exosomal long non-coding RNA TRAFD1-4:1 derived from fibroblast-like synoviocytes suppresses chondrocyte proliferation and migration by degrading cartilage extracellular matrix in rheumatoid arthritis.

100μg100μg100ug100ug Lyophilized100ug Lyophilized5 g10ug100ug10 ml100.00 ug100ug Lyophilized1000

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#36480105   2022/12/08 To Up

Role of F-FDG PET/CT and sarcopenia in untreated non-small cell lung cancer with advanced stage.

Sarcopenia is essential in managing advanced stage (III-IV) non-small cell lung cancer (NSCLC) but is laborious to diagnose using currently available method. This study aimed to establish a simple approach to predict sarcopenia using F-FDG PET/CT parameters and clinical characteristics and determine their roles in prognostication in advanced stage NSCLC.
Hui Yuan, Xiaoyue Tan, Xiaolin Sun, Li He, Dongjiang Li, Lei Jiang

2488 related Products with: Role of F-FDG PET/CT and sarcopenia in untreated non-small cell lung cancer with advanced stage.



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#36480009   2022/12/08 To Up

β-catenin-treated peptides effectively inhibit the proliferation of colorectal cancer.

To verify the inhibitory mechanism of β-catenin-designed peptides in colorectal cancer (CRC) tumors.
Liu Hong-Lin, Li Yue-Xi, Liu Xing-Yun, Cheng Niu-Liang, Niu Bo, Yan Shao-Qi, Feng Hui-Min, Liu Hai-Lin

2354 related Products with: β-catenin-treated peptides effectively inhibit the proliferation of colorectal cancer.

Each20 50mg100uL5 g100ug

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