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#35045144   2022/01/19 To Up

Impact of cationic surfactant-induced DNA compaction on the characteristics of a minor groove bound flavonol.

3-Hydroxyflavone (3-HF), which binds to the minor groove of DNA, is a strong antioxidant and hence a potent therapeutic and diagnostic agent. A special photo-property, called excited state intramolecular proton transfer (ESIPT), makes the 3-HF derivatives sensitive to the cellular hydrophobic microenvironment. The present study depicts the various changes in the ESIPT of 3-HF due to cationic surfactant-induced compaction of DNA.
Dipanjan Halder, Pradipta Purkayastha

2821 related Products with: Impact of cationic surfactant-induced DNA compaction on the characteristics of a minor groove bound flavonol.

100 μg100ug Lyophilized0.2 mg100ug Lyophilized100ug Lyophilized50 ul100ug Lyophilized100ug Lyophilized100ug Lyophilized100.00 ul 100ul

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#35043969   2022/01/19 To Up

Repeated metal ion measurements and long-term outcome of Durom/MMC total hip arthroplasty.

Background and purpose - Data regarding long-term behavior of metal ion levels in metal-on-metal total hip arthroplasty (MoM THA) patients is scarce. Therefore, we assessed whether there is any change in whole blood (WB) chromium (Cr), and cobalt (Co) ion measurements in Durom and MMC MoM THA patients over time. The secondary aim was to report the clinical outcomes using these devices in a single district. Patients and methods - Durom and MMC cups were used in 249 MoM THAs from 2005 to 2011 in our district. Median follow-up time was 12 years for Durom THA (interquartile range [IQR] = 3) and 9 years for MMC THA (IQR = 1). A random coefficient model was used to compare individual differences in repeated WB Cr and Co ion measurements. The Kaplan-Meier estimator was used to analyze implant survival with any reason for revision as the endpoint. Results - Geometric means of Cr in Durom THA and MMC THA patients decreased from 2.2 ppb (geometric standard deviation [SD] = 1.9) to 1.5 ppb (geometric SD = 2.5, p< 0.001) and from 1.8 ppb (geometric SD = 1.8) to 1.1 ppb (geometric SD = 2.8, p = 0.01) respectively. The geometric means of Co values remained unchanged. The 10-year survival of Durom THA was 82%, and that of MMC THA 89% for any revision reason as endpoint. Interpretation - WB Cr levels decreased over time, and Co levels remained unchanged at long-term follow-up. Despite this we recommend continuing the follow-up of these devices due to relatively low implant survival.
Sakari Pietiläinen, Erno Smedberg, Inari Laaksonen, Mikko S Venäläinen, Petteri Lankinen, Keijo T Mäkelä

2247 related Products with: Repeated metal ion measurements and long-term outcome of Durom/MMC total hip arthroplasty.

100 μg0.1 mg100 μg10 100μg100 μg100μg100μg100 μg100 μg100 μg

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#35043371   2022/01/18 To Up

Effect of energy supplementation on intake, digestibility of diets and performance of grazing lambs during the rainy season.

This study aimed to evaluate different energy sources in multiple supplements on performance, intake, and digestibility of Santa Ines sheep grazing urochloa grass (Urochloa mosambicensis) during the rainy season. The experimental area was divided into seven paddocks of 4 ha each, with an average of dry matter (DM) availability of 3.21 tn/ha. A completely randomized design was carried out, in which there were four treatments, and each treatment was repeated six times. Twenty-four intact lambs (average: 32.0 kg of body weight) were supplemented with a mineral mixture, the control group (MM), mesquite pod meal (MPM), wheat bran (WB), or sorghum grain (SG) as energy sources. The digestibility of DM and crude protein (CP) in MPM and WB is higher than that in MM and SG groups. Neutral detergent fiber (NDF) digestibility was similar between supplemented lambs, and it was higher than the MM. The supplementation promoted higher weight gain than in the control group (0.126 vs. 0.061 g/day, respectively; P < 0.001). The supplementation increased the DM, and CP intake. The NDF intake only increased in the WB group. The CP digestibility was higher for the MPM and WB groups than that for MM and SG ones (P < 0.001). Sheep supplementation in the rainy season increased the average daily gain (ADG). Any supplement tested in the present study can be used during the rainy season. The choice for the supplement will depend on the availability and costs of the mesquite pod meal, sorghum grain, or wheat bran.
Abias Santos Siva, Marcio Dos Santos Pedreira, Herymá Giovane de Oliveira Silva, Antônio Amandio Pinto Garcia Junior, Paulo José Presídio Almeida, Leone Campos Rocha, Jaciara Diavão

2407 related Products with: Effect of energy supplementation on intake, digestibility of diets and performance of grazing lambs during the rainy season.

5 G100ug1 g100 IU 2 ml 96 wells (1 kit)0.1 mg 100 G0.05 mg50 ug

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#35040415   2022/01/18 To Up

Effects of Hydroxychloroquine on Progression of Diabetic Retinopathy in Subjects with Rheumatoid Arthritis and Type 2 Diabetes Mellitus.

The study was executed to find the effects of hydroxychloroquine, an anti-inflammatory drugs, which was recently approved and used as an add on oral antidiabetic drug for uncontrolled Type 2 Diabetes Mellitus (DM) on an adequate dose of sulfonylurea and metformin, on the progression of diabetic retinopathy (DR) in subjects with Rheumatoid Arthritis and Type 2 Diabetes Mellitus. The primary objective was to evaluate the effect of hydroxychloroquine on onset of Diabetic Retinopathy (DR) and progression of the disease. On the Early Treatment Diabetic Retinopathy Study (ETDRS) best- corrected visual acuity (BCVA) charts 3 or more lines worsening of visual acuity and the development of clinically significant macular edema (CSME) were included as the measures of secondary objective during the analysis.
Arjun Baidya

1272 related Products with: Effects of Hydroxychloroquine on Progression of Diabetic Retinopathy in Subjects with Rheumatoid Arthritis and Type 2 Diabetes Mellitus.

96T20ug200ul96T2000 pcs96 wells (1 kit)1100 μg2

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#35037236   2022/01/17 To Up

IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway.

Metastasis-related in colon cancer 1 (MACC1) is highly expressed in a variety of solid tumours, but its role in pancreatic cancer (PC) remains unknown. Interferon gamma (IFN-γ) affecting MACC1 expression was explored as the potential mechanism following its intervention.
X-Y Shi, X-L Zhang, Q-Y Shi, X Qiu, X-B Wu, B-L Zheng, H-X Jiang, S-Y Qin

1704 related Products with: IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway.

2 Pieces/Box2 Pieces/Box1 mg11 inhibitors2 Pieces/Box2 Pieces/Box

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#35036160   2021/12/20 To Up

miR-15a-5p regulates myocardial fibrosis in atrial fibrillation by targeting Smad7.

At present, there is no effective treatment for myocardial fibrosis in atrial fibrillation (AF). It is reported that miR-15a-5p is abnormally expressed in AF patients but its specific role remains unclear. This study aims to investigate the effect of miR-15a-5p in myocardial fibrosis.
Dan He, Zhong-Bao Ruan, Gui-Xian Song, Ge-Cai Chen, Fei Wang, Mei-Xiang Wang, Mao-Kun Yuan, Li Zhu

2132 related Products with: miR-15a-5p regulates myocardial fibrosis in atrial fibrillation by targeting Smad7.

100 μg50 100 μg100ug Lyophilized100 ug20 100 assays1 pce96 wells (1 kit)2 Pieces/Box100ug Lyophilized

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#35035839   2022/01/07 To Up

Butylphthalide Inhibits TLR4/NF-B Pathway by Upregulation of miR-21 to Have the Neuroprotective Effect.

Stroke is a disease with the highest incidence rate and the highest mortality rate in the world. The study aims to verify the neuroprotective effect of Butylphthalide. The mice were divided into sham group, MCAO group, and MCAO + Butylphthalide-treated group. The mice in MCAO + Butylphthalide-treated group were administered with 70 mg/kg Butylphthalide injection intraperitoneally after cerebral ischemia-reperfusion. The normal saline with the same volume was administered intraperitoneally for the mice in the MCAO group and sham group. The levels of miR-21 in brain tissue and cells were detected by qPCR. The OGD/R injury model of Neuro2A cells was used to simulate the hypoxic-ischemic environment of neurons in vitro. The proliferation rate of Neuro2A cells was detected with CCK-8. The production of ROS was detected with DCFH-DA. Compared with the mice in MCAO group, a decrease ( < 0.01) was observed in the functional neurologic impairment scoring, cerebral infarction volume, and brain loss volume in the mice treated with MCAO + Butylphthalide, but an increase ( < 0.01) was observed in the level of miR-21, which was positively correlated with functional neurologic impairment scoring ( = -0.8933, < 0.001). MTT assay showed that the cell viability of OGD/R + Butylphthalide group was significantly higher than that of other groups ( < 0.001), and the activity of ROS was significantly decreased ( < 0.001). The WB results showed that, compared with OGD/R + miR-NC and control groups, the ratio of Bcl-2/Bax in OGD/R + Butylphthalide group and OGD/R + miR-21 mimics group was significantly higher ( < 0.05), while the ratio of caspase-3/GAPDH was significantly lower ( < 0.05). In conclusion, Butylphthalide has neuroprotective effect on the mouse model of MCAO. It may upregulate the level of miR-21 to inhibit neuronal apoptosis and ROS production and improve the proliferation activity. The specific mechanism may lie in inhibiting TLR4/NF-B pathway.
Lan Zhan, Yu Pang, Hao Jiang, Shicun Zhang, Hongwei Jin, Jing Chen, Cuiying Jia, Hongyan Guo, Zhuang Mu

2312 related Products with: Butylphthalide Inhibits TLR4/NF-B Pathway by Upregulation of miR-21 to Have the Neuroprotective Effect.

11 mg 25 G 1000 ml 25 mg100 extractions1 mg100 ul100ug Lyophilized500 Units

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#35035297   2021/12/29 To Up

The Multiple Sclerosis Data Alliance Catalogue: Enabling Web-Based Discovery of Metadata from Real-World Multiple Sclerosis Data Sources.

One of the major objectives of the Multiple Sclerosis Data Alliance (MSDA) is to enable better discovery of multiple sclerosis (MS) real-world data (RWD).
Lotte Geys, Tina Parciak, Ashkan Pirmani, Robert McBurney, Hollie Schmidt, Tanja Malbaša, Tjalf Ziemssen, Arnfin Bergmann, Juan I Rojas, Edgardo Cristiano, Juan Antonio García-Merino, Óscar Fernández, Jens Kuhle, Claudio Gobbi, Amber Delmas, Steve Simpson-Yap, Nupur Nag, Bassem Yamout, Nina Steinemann, Pierrette Seeldrayers, Bénédicte Dubois, Ingrid van der Mei, Alexander Stahmann, Jelena Drulovic, Tatjana Pekmezovic, Waldemar Brola, Mar Tintore, Nynke Kalkers, Rumen Ivanov, Magd Zakaria, Maged Abdel Naseer, Wim Van Hecke, Nikolaos Grigoriadis, Marina Boziki, Adriana Carra, Mikolaj A Pawlak, Ruth Dobson, Kerstin Hellwig, Arlene Gallagher, Letizia Leocani, Gloria Dalla Costa, Nise Alessandra de Carvalho Sousa, Bart Van Wijmeersch, Liesbet M Peeters

2160 related Products with: The Multiple Sclerosis Data Alliance Catalogue: Enabling Web-Based Discovery of Metadata from Real-World Multiple Sclerosis Data Sources.

1ml

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#35033753   2022/01/10 To Up

A review on bacterial redox dependent iron transporters and their evolutionary relationship.

Iron is an essential yet toxic micronutrient and its transport across biological membranes is tightly regulated in all living organisms. One such iron transporter, the Ftr-type permeases, is found in both eukaryotic and prokaryotic cells. These Ftr-type transporters are required for iron transport, predicted to form α-helical transmembrane structures, and conserve two ArgGluxxGlu (x = any amino acid) motifs. In the yeast Ftr transporter (Ftr1p), a ferroxidase (Fet3p) is required for iron transport in an oxidation coupled transport step. None of the bacterial Ftr-type transporters (EfeU and FetM from E. coli; cFtr from Campylobacter jejuni; FtrC from Brucella, Bordetella, and Burkholderia spp.) contain a ferroxidase protein. Bioinformatics report predicted periplasmic EfeO and FtrB (from the EfeUOB and FtrABCD systems) as novel cupredoxins. The Cu binding and the ferrous oxidation properties of these proteins are uncharacterized and the other two bacterial Ftr-systems are expressed without any ferroxidase/cupredoxin, leading to controversy about the mode of function of these transporters. Here, we review published data on Ftr-type transporters to gain insight into their functional diversity. Based on original bioinformatics data presented here evolutionary relations between these systems are presented.
Sambuddha Banerjee, Mina N Chanakira, Jonathan Hall, Alexa Kerkan, Saumya Dasgupta, Daniel W Martin

2149 related Products with: A review on bacterial redox dependent iron transporters and their evolutionary relationship.

100ug Lyophilized10 mg1000 tests100ug100ug Lyophilized25 mg10 mg100ul 100ul500 mg100ug Lyophilized

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#35032474   2022/01/12 To Up

Role of systems biology and multi-omics analyses in delineating spatial interconnectivity and temporal dynamicity of ER stress mediated cellular responses.

The endoplasmic reticulum (ER) is a membranous organelle involved in calcium storage, lipid biosynthesis, protein folding and processing. Many patho-physiological conditions and pharmacological agents are known to perturb normal ER function and can lead to ER stress, which severely compromise protein folding mechanism and hence poses high risk of proteotoxicity. Upon sensing ER stress, the different stress signaling pathways interconnect with each other and work together to preserve cellular homeostasis. ER stress response is a part of the integrative stress response (ISR) and might play an important role in the pathogenesis of chronic neurodegenerative diseases, where misfolded protein accumulation and cell death are common. The initiation, manifestation and progression of ER stress mediated unfolded protein response (UPR) is a complex procedure involving multiple proteins, pathways and cellular organelles. To understand the cause and consequences of such complex processes, implementation of an integrative holistic approach is required to identify novel players and regulators of ER stress. As multi-omics data-based systems analyses have shown potential to unravel the underneath molecular mechanism of complex biological systems, it is important to emphasize the utility of this approach in understanding the ER stress biology. In this review we first discuss the ER stress signaling pathways and regulatory players, along with their inter-connectivity. We next highlight the importance of systems and network biology approaches using multi-omics data in understanding ER stress mediated cellular responses. This report would help advance our current understanding of the multivariate spatial interconnectivity and temporal dynamicity of ER stress.
Priyanka Mallick, Sebabrata Maity, Oishee Chakrabarti, Saikat Chakrabarti

2308 related Products with: Role of systems biology and multi-omics analyses in delineating spatial interconnectivity and temporal dynamicity of ER stress mediated cellular responses.

100 UG10 mg1 Set100 mg10 mg100 μg1 mg1 Set2.5 mg1,000 tests1 Set

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