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Search results for: BAD(Ab-112) Antibody

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#33951642   2021/05/05 To Up

Unusual and Unexpected Allergic Reactions Can Be Unraveled by Molecular Allergy Diagnostics.

The fifth class of immunoglobulin, immunoglobulin E (IgE) was discovered in 1967 and has had immense importance for the understanding, diagnosis, and treatment of allergic disease. More than 50 years have passed and efforts to characterize, standardize, and refine allergens with the aim to improve clinical diagnosis and allergen-specific immunotherapy are still ongoing. Another important breakthrough was made in 1999 with the introduction of component-resolved diagnostics (CRD), making it possible to quantify IgE antibodies against individual allergen proteins for diagnostic purposes at a molecular level. The progress and developments made in allergy diagnosis often originate from clinical observations and case studies. Observant physicians and health-care personnel have reported their findings in the medical literature, which in turn has inspired researchers to become involved in clinical research. Allergists continuously encounter new allergies and are often asked by their patients how to prevent new reactions. In the current article, we focus on recent clinical observations that can now be explained by CRD. The examples taken concern allergic reactions toward peanuts, tree nuts, lemon kernels, health drinks, meat, insects, dog dander, cannabis, and semen. We now have an improved understanding of why patients may react in a serious or unexpected way, as illustrated by these examples, yet many other clinical observations remain unexplained. The aim of this review is to highlight the importance of clinical observations among allergic patients, focusing on systemic, or unusual and unexpected allergic reactions, where component-testing has further refined the diagnosis of IgE-mediated allergy.
Jon R Konradsen, Magnus P Borres, Caroline Nilsson

2382 related Products with: Unusual and Unexpected Allergic Reactions Can Be Unraveled by Molecular Allergy Diagnostics.

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#33951594   2021/03/26 To Up

Use of lemongrass essential oil as a feed additive in quail's nutrition: its effect on growth, carcass, blood biochemistry, antioxidant and immunological indices, digestive enzymes and intestinal microbiota.

The present study was designed to assess the impact of dietary supplementation of lemongrass essential oil (LGEO) on growth performance, carcass traits, liver and kidney function, immunity, antioxidant indices and caecal microbiota of growing quail. A total of 200 Japanese quails at 1-week-old were haphazardly allotted to 5 groups of 40 chicks in five replicates (8 per replicate). The first group was the control group, while LGEO was added at levels of 150, 300, 450, and 600 mg/kg diet in the 2nd, 3rd, 4th and 5th groups, respectively. Dietary supplementation of LGEO (150, 300 and 450 mg/ kg diet) increased body weight at 3 and 5 wk of age, and increased body weight gain during all periods compared with the control group (P < 0.05). All levels of LGEO improved feed conversion ratio during the periods from 1 to 3 and 1 to 5 wk of age. During 3 to 5 wk, feed conversion ratio was improved in quails fed LGEO (300 and 450 mg/kg diet) compared with the control and other treatments. Carcass traits, plasma globulin, alanine aminotransferase, and urea values did not differ among the treatments (P > 0.05), but the activity of aspartate aminotransferase in the plasma was significantly decreased (P < 0.05) in LGEO-treated groups. The total protein and albumin values were significantly increased (P < 0.05) in quails fed levels of LGEO (except 600 mg/kg diet) compared with the control. The inclusion of LGEO in quail diets improved (P < 0.05) plasma lipid profile. The dietary supplementation of LGEO increased (linear and quadratic, P < 0.05) plasma immunoglobulins (IgM, IgG, and IgA) levels, lysozyme values and activities of superoxide dismutase, total antioxidant capacity, reduced glutathione and catalase compared with the control group. The caecal Coliform, E. coli and Salmonella were lowered (P < 0.0001) in the quails treated with all LGEO levels, but the total bacterial count and Lactobacillus count were increased with dietary supplementation of LGEO levels (300 and 450 mg/kg) compared with those in the control group. The activities of digestive enzymes were significantly higher in birds fed the diet supplemented with LGEO levels than those fed the control diet. In conclusion, dietary supplementation of LGEO can improve the performance, lipid profile, immunity and antioxidant indices and decline intestinal pathogens and thus boost the health status of growing quail.
M Alagawany, M T El-Saadony, S S Elnesr, M Farahat, G Attia, M Madkour, F M Reda

1225 related Products with: Use of lemongrass essential oil as a feed additive in quail's nutrition: its effect on growth, carcass, blood biochemistry, antioxidant and immunological indices, digestive enzymes and intestinal microbiota.

0.1ml (1mg/ml)96 assays96 samples100ug100 assays96 samples100 assays50 ug 100 assays100 assays 100ul

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#33951555   2021/04/23 To Up

PD-1 blockade combined with IL-33 enhances the antitumor immune response in a type-1 lymphocyte-mediated manner.

PD-1 immune checkpoint blockade and cytokine IL-33 have shown significant therapeutic effects in tumor immunotherapy. These therapies promote CD8 T cell activation, proliferation, and effector functions. However, there were few research about the combined therapy efficacy. In this study, we established B16-empty vector and B16-IL33 melanoma mouse models and treated with PD-1 monoclonal antibody. We reported that PD-1 blockade combined with cytokine IL-33 further inhibited tumor progression and prolonged the survival of tumor-bearing mice. Mechanistically, the combination therapy was found to further facilitate CD4 and CD8 T lymphocytes accumulation, and enhance the antitumor effects of CD4or CD8tumor-infiltrating lymphocytes by promoting type-1 immune response within the tumor microenvironment using flow cytometry and quantitative real time polymerase chain reaction. Thus, PD-1 blockade combined with IL-33 has application potential in tumor immunotherapy. Further, this study provides a new promising strategy and theoretical basis for tumor combination immunotherapy.
Honghong He, Liyan Shi, Dan Meng, Huijun Zhou, Jingshu Ma, Yixian Wu, Yanshi Wu, Yanzheng Gu, Wei Xie, Jing Zhang, Yibei Zhu

2203 related Products with: PD-1 blockade combined with IL-33 enhances the antitumor immune response in a type-1 lymphocyte-mediated manner.

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#33951473   2021/05/02 To Up

IL-10 producing B cells regulated 1,3-β-glucan induced Th responses in coordinated with Treg.

Repeated exposure to fungi-contaminated dust can lead to multiple adverse effects on the lung, such as hypersensitivity pneumonitis, granuloma even irreversible fibrosis. 1,3-β-glucan, a major cell wall component of fungi, is considered as its exposure biomarker. Existing studies showed that a series of Th responses were involved in 1,3-β-glucan induced hypersensitivity pneumonitis, in which macrophages, Treg, and IL-10 producing B cells were reported to participate. The reciprocal interaction among those critical immune cells in 1,3-β-glucan induced inflammation was not investigated yet. To clarify the regulatory mechanism of IL-10 producing B cells on Th and Treg, the current study set up a primary cell co-culture system. The anti-CD22 antibody was injected intraperitoneally to generate IL-10 producing B cells deficiency mouse model. Cells were isolated and purified from C57BL\6 mice in different groups. Flow cytometry was used to check the phenotype of different cell subtypes. CBA assay and real-time PCR were used to examine the levels of multiple cytokines. Our results indicated that IL-10 producing B cells could modulate the 1,3-β-glucan induced inflammatory response. The modulation of IL-10 producing B cells on Th response after 1,3-β-glucan treatment was cell contact independent. What's more, the modulation pattern of IL-10 producing B cells might be impaired without Treg response. IL-10-producing B cells regulated 1,3-β-glucan induced Th responses in co-ordination with Treg cells.
Qi Zhang, Yiping Lu, Fangwei Liu

1838 related Products with: IL-10 producing B cells regulated 1,3-β-glucan induced Th responses in coordinated with Treg.

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#33951469   // To Up

Immunotherapy breaches low-sugar dieting of tumor Treg cells.

Glycolysis supports effector T cell function but is detrimental to the immunosuppressive activity of regulatory T cells. In a recent issue of Nature, two papers address a role for glucose and lactate availability within the tumor microenvironment for the balance of pro- and anti-tumoral effects of T cells and the efficacy of neoadjuvant cancer immunotherapy.
Clarissa Campbell, Alexander Y Rudensky

2038 related Products with: Immunotherapy breaches low-sugar dieting of tumor Treg cells.

96T/Kit 1.00 flask100 extractions30ml100ug1 mg96T1 x 10^6 cells/vial 100ul1.00 flask

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#33951441   // To Up

Structural basis of tetanus toxin neutralization by native human monoclonal antibodies.

Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 mg each that are equivalent to 250 IU of human anti-TeNT immunoglobulin. TT0170 binds fragment B, and TT0069 and TT0155 bind fragment AB. mAb TT0067 binds fragment C and blocks the binding of TeNT to gangliosides. The co-crystal structure of TT0067 with fragment C of TeNT at a 2.0-Å resolution demonstrates that mAb TT0067 directly occupies the W pocket of one of the receptor binding sites on TeNT, resulting in blocking the binding of TeNT to ganglioside on the surface of host cells. This study reveals at the atomic level the mechanism of action by the TeNT neutralizing antibody. The key neutralization epitope on the fragment C of TeNT identified in our work provides the critical information for the development of fragment C of TeNT as a better and safer tetanus vaccine.
Yueming Wang, Changwen Wu, Jinfang Yu, Shujian Lin, Tong Liu, Lipeng Zan, Nan Li, Po Hong, Xiaoli Wang, Zhenxing Jia, Jason Li, Yao Wang, Ming Zhang, Xiaohui Yuan, Chengming Li, Wenwen Xu, Weihong Zheng, Xinquan Wang, Hua-Xin Liao

2759 related Products with: Structural basis of tetanus toxin neutralization by native human monoclonal antibodies.

100 mL100 ug1 mg250 KU200 ug100 ug200.00 ug1 ml1 mL200 ug1 mg1mg

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#33951434   // To Up

Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection.

New World hantaviruses (NWHs) are endemic in North and South America and cause hantavirus cardiopulmonary syndrome (HCPS), with a case fatality rate of up to 40%. Knowledge of the natural humoral immune response to NWH infection is limited. Here, we describe human monoclonal antibodies (mAbs) isolated from individuals previously infected with Sin Nombre virus (SNV) or Andes virus (ANDV). Most SNV-reactive antibodies show broad recognition and cross-neutralization of both New and Old World hantaviruses, while many ANDV-reactive antibodies show activity for ANDV only. mAbs ANDV-44 and SNV-53 compete for binding to a distinct site on the ANDV surface glycoprotein and show potently neutralizing activity to New and Old World hantaviruses. Four mAbs show therapeutic efficacy at clinically relevant doses in hamsters. These studies reveal a convergent and potently neutralizing human antibody response to NWHs and suggest therapeutic potential for human mAbs against HCPS.
Taylor B Engdahl, Natalia A Kuzmina, Adam J Ronk, Chad E Mire, Matthew A Hyde, Nurgun Kose, Matthew D Josleyn, Rachel E Sutton, Apoorva Mehta, Rachael M Wolters, Nicole M Lloyd, Francisca R Valdivieso, Thomas G Ksiazek, Jay W Hooper, Alexander Bukreyev, James E Crowe

1198 related Products with: Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection.

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