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Search results for: ASK1(Ab-966) Antibody

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#33951750   2021/05/05 To Up

Sialic acid-binding immunoglobulin-like lectin (Siglec)-15 is a rapidly internalised cell-surface antigen expressed by acute myeloid leukaemia cells.

Sialic acid-binding immunoglobulin-like lectin (Siglec)-15 has recently been identified as a critical tumour checkpoint, augmenting the expression and function of programmed death-ligand 1. We raised a monoclonal antibody, A9E8, specific for Siglec-15 using phage display. A9E8 stained myeloid leukaemia cell lines and peripheral cluster of differentiation (CD)33 blasts and CD34 leukaemia stem cells from patients with acute myeloid leukaemia (AML). By contrast, there was minimal expression on healthy donor leucocytes or CD34 stem cells from non-AML donors, suggesting targeting Siglec-15 may have significant therapeutic advantages over its fellow Siglec CD33. After binding, A9E8 was rapidly internalised (half-life of 180 s) into K562 cells. Antibodies to Siglec-15 therefore hold therapeutic potential for AML treatment.
Huan Cao, Andreas Neerincx, Bernard de Bono, Ursula Lakner, Catherine Huntington, John Elvin, Emma Gudgin, Clare Pridans, Mark A Vickers, Brian Huntly, John Trowsdale, Alexander D Barrow

1854 related Products with: Sialic acid-binding immunoglobulin-like lectin (Siglec)-15 is a rapidly internalised cell-surface antigen expressed by acute myeloid leukaemia cells.

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#33951716   // To Up

Association of Systemic or Intravitreal Antivascular Endothelial Growth Factor (Anti-VEGF) and Impaired Wound Healing in Pediatric Patients: Collagen to the Rescue.

Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF) that has been used as a systemic chemotherapy treatment of various malignancies in adults since 2000. It has been used for pediatric patients over the last decade. In addition, bevacizumab is used for neonatal intravitreal administration for retinopathy of prematurity, a major complication of preterm birth, characterized by incomplete and abnormal vascularization of the retina that can lead to retinal detachment and blindness without treatment.
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1195 related Products with: Association of Systemic or Intravitreal Antivascular Endothelial Growth Factor (Anti-VEGF) and Impaired Wound Healing in Pediatric Patients: Collagen to the Rescue.

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#33951642   2021/05/05 To Up

Unusual and Unexpected Allergic Reactions Can Be Unraveled by Molecular Allergy Diagnostics.

The fifth class of immunoglobulin, immunoglobulin E (IgE) was discovered in 1967 and has had immense importance for the understanding, diagnosis, and treatment of allergic disease. More than 50 years have passed and efforts to characterize, standardize, and refine allergens with the aim to improve clinical diagnosis and allergen-specific immunotherapy are still ongoing. Another important breakthrough was made in 1999 with the introduction of component-resolved diagnostics (CRD), making it possible to quantify IgE antibodies against individual allergen proteins for diagnostic purposes at a molecular level. The progress and developments made in allergy diagnosis often originate from clinical observations and case studies. Observant physicians and health-care personnel have reported their findings in the medical literature, which in turn has inspired researchers to become involved in clinical research. Allergists continuously encounter new allergies and are often asked by their patients how to prevent new reactions. In the current article, we focus on recent clinical observations that can now be explained by CRD. The examples taken concern allergic reactions toward peanuts, tree nuts, lemon kernels, health drinks, meat, insects, dog dander, cannabis, and semen. We now have an improved understanding of why patients may react in a serious or unexpected way, as illustrated by these examples, yet many other clinical observations remain unexplained. The aim of this review is to highlight the importance of clinical observations among allergic patients, focusing on systemic, or unusual and unexpected allergic reactions, where component-testing has further refined the diagnosis of IgE-mediated allergy.
Jon R Konradsen, Magnus P Borres, Caroline Nilsson

2002 related Products with: Unusual and Unexpected Allergic Reactions Can Be Unraveled by Molecular Allergy Diagnostics.

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#33951594   2021/03/26 To Up

Use of lemongrass essential oil as a feed additive in quail's nutrition: its effect on growth, carcass, blood biochemistry, antioxidant and immunological indices, digestive enzymes and intestinal microbiota.

The present study was designed to assess the impact of dietary supplementation of lemongrass essential oil (LGEO) on growth performance, carcass traits, liver and kidney function, immunity, antioxidant indices and caecal microbiota of growing quail. A total of 200 Japanese quails at 1-week-old were haphazardly allotted to 5 groups of 40 chicks in five replicates (8 per replicate). The first group was the control group, while LGEO was added at levels of 150, 300, 450, and 600 mg/kg diet in the 2nd, 3rd, 4th and 5th groups, respectively. Dietary supplementation of LGEO (150, 300 and 450 mg/ kg diet) increased body weight at 3 and 5 wk of age, and increased body weight gain during all periods compared with the control group (P < 0.05). All levels of LGEO improved feed conversion ratio during the periods from 1 to 3 and 1 to 5 wk of age. During 3 to 5 wk, feed conversion ratio was improved in quails fed LGEO (300 and 450 mg/kg diet) compared with the control and other treatments. Carcass traits, plasma globulin, alanine aminotransferase, and urea values did not differ among the treatments (P > 0.05), but the activity of aspartate aminotransferase in the plasma was significantly decreased (P < 0.05) in LGEO-treated groups. The total protein and albumin values were significantly increased (P < 0.05) in quails fed levels of LGEO (except 600 mg/kg diet) compared with the control. The inclusion of LGEO in quail diets improved (P < 0.05) plasma lipid profile. The dietary supplementation of LGEO increased (linear and quadratic, P < 0.05) plasma immunoglobulins (IgM, IgG, and IgA) levels, lysozyme values and activities of superoxide dismutase, total antioxidant capacity, reduced glutathione and catalase compared with the control group. The caecal Coliform, E. coli and Salmonella were lowered (P < 0.0001) in the quails treated with all LGEO levels, but the total bacterial count and Lactobacillus count were increased with dietary supplementation of LGEO levels (300 and 450 mg/kg) compared with those in the control group. The activities of digestive enzymes were significantly higher in birds fed the diet supplemented with LGEO levels than those fed the control diet. In conclusion, dietary supplementation of LGEO can improve the performance, lipid profile, immunity and antioxidant indices and decline intestinal pathogens and thus boost the health status of growing quail.
M Alagawany, M T El-Saadony, S S Elnesr, M Farahat, G Attia, M Madkour, F M Reda

1661 related Products with: Use of lemongrass essential oil as a feed additive in quail's nutrition: its effect on growth, carcass, blood biochemistry, antioxidant and immunological indices, digestive enzymes and intestinal microbiota.

0.1ml (1mg/ml)96 assays96 samples100 assays100ug96 samples100 assays50 ug 100 assays100 assays 100ul

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#33951576   2021/05/02 To Up

Xiaokang Liuwei Dihuang decoction ameliorates the immune infertility of male rats induced by lipopolysaccharide through regulating the levels of sex hormones, reactive oxygen species, pro-apoptotic and immune factors.

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Xiaoyong Sun, Bin Wu, Liguo Geng, Jinfeng Zhang, Guozheng Qin

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#33951555   2021/04/23 To Up

PD-1 blockade combined with IL-33 enhances the antitumor immune response in a type-1 lymphocyte-mediated manner.

PD-1 immune checkpoint blockade and cytokine IL-33 have shown significant therapeutic effects in tumor immunotherapy. These therapies promote CD8 T cell activation, proliferation, and effector functions. However, there were few research about the combined therapy efficacy. In this study, we established B16-empty vector and B16-IL33 melanoma mouse models and treated with PD-1 monoclonal antibody. We reported that PD-1 blockade combined with cytokine IL-33 further inhibited tumor progression and prolonged the survival of tumor-bearing mice. Mechanistically, the combination therapy was found to further facilitate CD4 and CD8 T lymphocytes accumulation, and enhance the antitumor effects of CD4or CD8tumor-infiltrating lymphocytes by promoting type-1 immune response within the tumor microenvironment using flow cytometry and quantitative real time polymerase chain reaction. Thus, PD-1 blockade combined with IL-33 has application potential in tumor immunotherapy. Further, this study provides a new promising strategy and theoretical basis for tumor combination immunotherapy.
Honghong He, Liyan Shi, Dan Meng, Huijun Zhou, Jingshu Ma, Yixian Wu, Yanshi Wu, Yanzheng Gu, Wei Xie, Jing Zhang, Yibei Zhu

2874 related Products with: PD-1 blockade combined with IL-33 enhances the antitumor immune response in a type-1 lymphocyte-mediated manner.

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#33951473   2021/05/02 To Up

IL-10 producing B cells regulated 1,3-β-glucan induced Th responses in coordinated with Treg.

Repeated exposure to fungi-contaminated dust can lead to multiple adverse effects on the lung, such as hypersensitivity pneumonitis, granuloma even irreversible fibrosis. 1,3-β-glucan, a major cell wall component of fungi, is considered as its exposure biomarker. Existing studies showed that a series of Th responses were involved in 1,3-β-glucan induced hypersensitivity pneumonitis, in which macrophages, Treg, and IL-10 producing B cells were reported to participate. The reciprocal interaction among those critical immune cells in 1,3-β-glucan induced inflammation was not investigated yet. To clarify the regulatory mechanism of IL-10 producing B cells on Th and Treg, the current study set up a primary cell co-culture system. The anti-CD22 antibody was injected intraperitoneally to generate IL-10 producing B cells deficiency mouse model. Cells were isolated and purified from C57BL\6 mice in different groups. Flow cytometry was used to check the phenotype of different cell subtypes. CBA assay and real-time PCR were used to examine the levels of multiple cytokines. Our results indicated that IL-10 producing B cells could modulate the 1,3-β-glucan induced inflammatory response. The modulation of IL-10 producing B cells on Th response after 1,3-β-glucan treatment was cell contact independent. What's more, the modulation pattern of IL-10 producing B cells might be impaired without Treg response. IL-10-producing B cells regulated 1,3-β-glucan induced Th responses in co-ordination with Treg cells.
Qi Zhang, Yiping Lu, Fangwei Liu

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#33951469   // To Up

Immunotherapy breaches low-sugar dieting of tumor Treg cells.

Glycolysis supports effector T cell function but is detrimental to the immunosuppressive activity of regulatory T cells. In a recent issue of Nature, two papers address a role for glucose and lactate availability within the tumor microenvironment for the balance of pro- and anti-tumoral effects of T cells and the efficacy of neoadjuvant cancer immunotherapy.
Clarissa Campbell, Alexander Y Rudensky

1283 related Products with: Immunotherapy breaches low-sugar dieting of tumor Treg cells.

1 mg96T1 x 10^6 cells/vial 100ul1.00 flask50mlcultured cells (50 ml)

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#33951434   // To Up

Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection.

New World hantaviruses (NWHs) are endemic in North and South America and cause hantavirus cardiopulmonary syndrome (HCPS), with a case fatality rate of up to 40%. Knowledge of the natural humoral immune response to NWH infection is limited. Here, we describe human monoclonal antibodies (mAbs) isolated from individuals previously infected with Sin Nombre virus (SNV) or Andes virus (ANDV). Most SNV-reactive antibodies show broad recognition and cross-neutralization of both New and Old World hantaviruses, while many ANDV-reactive antibodies show activity for ANDV only. mAbs ANDV-44 and SNV-53 compete for binding to a distinct site on the ANDV surface glycoprotein and show potently neutralizing activity to New and Old World hantaviruses. Four mAbs show therapeutic efficacy at clinically relevant doses in hamsters. These studies reveal a convergent and potently neutralizing human antibody response to NWHs and suggest therapeutic potential for human mAbs against HCPS.
Taylor B Engdahl, Natalia A Kuzmina, Adam J Ronk, Chad E Mire, Matthew A Hyde, Nurgun Kose, Matthew D Josleyn, Rachel E Sutton, Apoorva Mehta, Rachael M Wolters, Nicole M Lloyd, Francisca R Valdivieso, Thomas G Ksiazek, Jay W Hooper, Alexander Bukreyev, James E Crowe

2682 related Products with: Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection.

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